{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:41:25Z","timestamp":1791315685907,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007054","name":"Naval Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bioadv.2025.214674","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T23:26:20Z","timestamp":1766273180000},"page":"214674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Injectable silk fibroin hydrogel encapsulating pH-Responsive ZnS nanoparticles for synergistic redox modulation and diabetic wound healing"],"prefix":"10.1016","volume":"182","author":[{"given":"Xi","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2025.214674_bb0005","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1016\/j.cell.2024.06.029","article-title":"Diabetes mellitus\u2014Progress and opportunities in the evolving epidemic","volume":"187","author":"Abel","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bioadv.2025.214674_bb0010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic Foot Ulcers: A Review","volume":"330","author":"Armstrong","year":"2023","journal-title":"Jama"},{"key":"10.1016\/j.bioadv.2025.214674_bb0015","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/wrr.12994","article-title":"Chronic wounds: Treatment consensus","volume":"30","author":"Eriksson","year":"2022","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.bioadv.2025.214674_bb0020","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: Mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioadv.2025.214674_bb0025","first-page":"1","article-title":"Chronic wounds","volume":"8","author":"Falanga","year":"2022","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bioadv.2025.214674_bb0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2337\/dci22-0043","article-title":"Etiology, Epidemiology, and Disparities in the Burden of Diabetic Foot Ulcers","volume":"46","author":"McDermott","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bioadv.2025.214674_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.660145","article-title":"Hydrogel Scaffolds to Deliver Cell Therapies for Wound Healing","volume":"9","author":"Sivaraj","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2025.214674_bb0040","article-title":"Hydrogel-based growth factor delivery platforms: strategies and recent advances","author":"Shan","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioadv.2025.214674_bb0045","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41578-020-0209-x","article-title":"Engineered biomaterials for in situ tissue regeneration","volume":"5","author":"Gaharwar","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.bioadv.2025.214674_bb0050","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: A cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bioadv.2025.214674_bb0055","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/iwj.12557","article-title":"Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process","volume":"14","author":"Dunnill","year":"2017","journal-title":"Int. Wound J."},{"key":"10.1016\/j.bioadv.2025.214674_bb0060","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szab\u00f5","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioadv.2025.214674_bb0065","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1038\/s41467-024-53290-6","article-title":"Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes","volume":"15","author":"Fang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2025.214674_bb0070","doi-asserted-by":"crossref","first-page":"12864","DOI":"10.1021\/acsnano.4c16345","article-title":"In Situ H 2 S-Releasing Stents Optimize Vascular Healing","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2025.214674_bb0075","article-title":"H2S donor functionalized molecular machine for combating multidrug-resistant bacteria infected chronic wounds","author":"Chen","year":"2025","journal-title":"Angew. Chemie - Int. Ed."},{"key":"10.1016\/j.bioadv.2025.214674_bb0080","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2023.05.009","article-title":"Novel ray of hope for diabetic wound healing: Hydrogen sulfide and its releasing agents","volume":"58","author":"Shi","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bioadv.2025.214674_bb0085","doi-asserted-by":"crossref","first-page":"15615","DOI":"10.1021\/acsanm.4c02594","article-title":"pH-Responsive Medical Dressing Based on Zinc Sulfide Nanoparticle\/Silk Fibroin Composite Fibers","volume":"7","author":"Yang","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.bioadv.2025.214674_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122912","article-title":"Zinc sulfide nanoparticles serve as gas slow-release bioreactors for H2S therapy of ischemic stroke","volume":"315","author":"Li","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2025.214674_bb0095","first-page":"88","article-title":"Sustained release of magnesium and zinc ions synergistically accelerates wound healing","volume":"26","author":"Yang","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2025.214674_bb0100","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1524-475X.2006.00179.x","article-title":"Zinc in wound healing: Theoretical, experimental, and clinical aspects","volume":"15","author":"Lansdown","year":"2007","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.bioadv.2025.214674_bb0105","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.2337\/db13-0483","article-title":"Hydrogen sulfide improves wound healing via restoration of endothelial progenitor cell functions and activation of angiopoietin-1 in type 2 diabetes","volume":"63","author":"Liu","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.bioadv.2025.214674_bb0110","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkae067","article-title":"Zn ion-incorporated injected hydrogels with reactive oxygen species and glucose scavenging capacity for diabetic wound healing","volume":"13","author":"Chen","year":"2025","journal-title":"Burns Trauma"},{"key":"10.1016\/j.bioadv.2025.214674_bb0115","article-title":"Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions","volume":"9","author":"Lu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioadv.2025.214674_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301885","article-title":"Multifunctional Hydrogels for the Healing of Diabetic Wounds","volume":"13","author":"Xiang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2025.214674_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.149493","article-title":"Intelligent biobased hydrogels for diabetic wound healing: A review","volume":"484","author":"Wang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2025.214674_bb0130","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1039\/D4CS00776J","article-title":"Hierarchical design of silkworm silk for functional composites","volume":"54","author":"Yang","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioadv.2025.214674_bb0135","article-title":"Silk gel recruits specific cell populations for scarless skin regeneration","volume":"23","author":"Liang","year":"2021","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.bioadv.2025.214674_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202200521","article-title":"Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold","volume":"34","author":"Qian","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioadv.2025.214674_bb0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1039\/D4CS00450G","article-title":"Intrinsic immunomodulatory hydrogels for chronic inflammation","volume":"54","author":"Qian","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioadv.2025.214674_bb0150","doi-asserted-by":"crossref","first-page":"20841","DOI":"10.1021\/acsnano.5c03283","article-title":"Customizable Silk Fibroin-Based Hydrogel Fibrous Scaffold for On-Demand Multifaceted Tissue Repair","volume":"19","author":"He","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2025.214674_bb0155","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1021\/acs.biomac.3c00098","article-title":"Versatile Potential of Photo-Cross-Linkable Silk Fibroin: Roadmap from Chemical Processing Toward Regenerative Medicine and Biofabrication Applications","volume":"24","author":"Amirian","year":"2023","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2025.214674_bb0160","first-page":"1","article-title":"pH-responsive hierarchical H2S-releasing nano-disinfectant with deep-penetrating and anti-inflammatory properties for synergistically enhanced eradication of bacterial biofilms and wound infection","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2025.214674_bb0165","doi-asserted-by":"crossref","first-page":"9278","DOI":"10.1021\/acsanm.4c00795","article-title":"Glucose Oxidase and Catalase-Loaded ZnS Nanozymes for Regulating the Local Microenvironment and Promoting Wound Healing in Diabetes","volume":"7","author":"Zhang","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.bioadv.2025.214674_bb0170","doi-asserted-by":"crossref","first-page":"719","DOI":"10.4155\/tde-2019-0066","article-title":"Challenges and opportunities of pH in chronic wounds","volume":"10","author":"Wallace","year":"2019","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.bioadv.2025.214674_bb0175","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jtv.2024.03.015","article-title":"An observational study of the pH value during the healing process of diabetic foot ulcer","volume":"33","author":"Wang","year":"2024","journal-title":"J. Tissue Viability"},{"key":"10.1016\/j.bioadv.2025.214674_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160904","article-title":"pH-responsive and on-demand hydrogen sulfide-releasing injectable hydrogel for wound healing promotion","volume":"509","author":"Sun","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2025.214674_bb0185","article-title":"Glucose\/ROS cascade-responsive ceria nanozymes for diabetic wound healing","volume":"15","author":"Yu","year":"2022","journal-title":"Mater. Today Bio"}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950825005011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950825005011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:19:34Z","timestamp":1770207574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950825005011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"alternative-id":["S2772950825005011"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2025.214674","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injectable silk fibroin hydrogel encapsulating pH-Responsive ZnS nanoparticles for synergistic redox modulation and diabetic wound healing","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2025.214674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214674"}}