{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:27:33Z","timestamp":1790166453599,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Tianjin Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["23JCYBJC00350"],"award-info":[{"award-number":["23JCYBJC00350"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2405903"],"award-info":[{"award-number":["2022YFC2405903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bioadv.2026.214711","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:52:47Z","timestamp":1767977567000},"page":"214711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A novel antimicrobial peptide AH-12 attenuates mitochondrial response to inflammatory stimuli and prevents periodontitis via antibacterial and anti-inflammatory effects"],"prefix":"10.1016","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8912-476X","authenticated-orcid":false,"given":"Yuanchen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3743-4940","authenticated-orcid":false,"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-2832","authenticated-orcid":false,"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bioadv.2026.214711_bb0005","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990-2010: a systematic review and metaregression","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J. Dent. Res."},{"issue":"9","key":"10.1016\/j.bioadv.2026.214711_bb0010","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jcpe.13506","article-title":"Global, regional, and national burden of severe periodontitis, 1990-2019: an analysis of the global burden of disease study 2019","volume":"48","author":"Chen","year":"2021","journal-title":"J. Clin. Periodontol."},{"issue":"43","key":"10.1016\/j.bioadv.2026.214711_bb0015","doi-asserted-by":"crossref","first-page":"29507","DOI":"10.1021\/acsnano.4c05677","article-title":"Bioinspired glycopeptide hydrogel reestablishing bone homeostasis through mediating osteoclasts and osteogenesis in periodontitis treatment","volume":"18","author":"Zhao","year":"2024","journal-title":"ACS Nano"},{"issue":"22","key":"10.1016\/j.bioadv.2026.214711_bb0020","doi-asserted-by":"crossref","first-page":"14312","DOI":"10.1021\/acsnano.4c00137","article-title":"Sulfated chitosan-modified CuS nanocluster: a versatile nanoformulation for simultaneous antibacterial and bone regenerative therapy in periodontitis","volume":"18","author":"Chen","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2026.214711_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1517154","article-title":"Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic","volume":"15","author":"Cui","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/prd.12579","article-title":"Conventional diagnostic criteria for periodontal diseases (plaque-induced gingivitis and periodontitis)","volume":"95","author":"Heitz-Mayfield","year":"2024","journal-title":"Periodontol. 2000"},{"issue":"5","key":"10.1016\/j.bioadv.2026.214711_bb0035","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/jcpe.13769","article-title":"Prevalence of periodontitis in dentate people between 2011 and 2020: a systematic review and meta-analysis of epidemiological studies","volume":"50","author":"Trindade","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bioadv.2026.214711_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1513983","article-title":"Pathogenic mechanisms and potential applications of extracellular vesicles from periodontal pathogens in periodontitis","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0045","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/prd.12201","article-title":"Nonsurgical and surgical treatment of periodontitis: how many options for one disease?","volume":"75","author":"Graziani","year":"2017","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.bioadv.2026.214711_bb0050","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.mib.2019.10.008","article-title":"Antibiotics: past, present and future","volume":"51","author":"Hutchings","year":"2019","journal-title":"Curr. Opin. Microbiol."},{"issue":"5","key":"10.1016\/j.bioadv.2026.214711_bb0055","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41579-022-00820-y","article-title":"Molecular mechanisms of antibiotic resistance revisited","volume":"21","author":"Darby","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"3","key":"10.1016\/j.bioadv.2026.214711_bb0060","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.cmi.2024.09.025","article-title":"Introducing new antibiotics for multidrug-resistant bacteria: obstacles and the way forward","volume":"31","author":"T\u00e4ngd\u00e9n","year":"2025","journal-title":"Clin. Microbiol. Infect."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/1568026615666150703121700","article-title":"Antimicrobial peptide structure and mechanism of action: a focus on the role of membrane structure","volume":"16","author":"Lee","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bioadv.2026.214711_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1528583","article-title":"Unlocking the power of antimicrobial peptides: advances in production, optimization, and therapeutics","volume":"15","author":"Sadeeq","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.bioadv.2026.214711_bb0075","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11596-019-2042-2","article-title":"Rational design of hybrid peptides: a novel drug design approach","volume":"39","author":"Wang","year":"2019","journal-title":"Curr. Med. Sci."},{"issue":"10","key":"10.1016\/j.bioadv.2026.214711_bb0080","first-page":"1568","article-title":"Design, structural stability. Membrane binding, and antibacterial activity of novel antimicrobial peptides derived from Wuchuanin-A1","volume":"15","author":"Putri","year":"2025","journal-title":"Life (Basel)"},{"key":"10.1016\/j.bioadv.2026.214711_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118173","article-title":"Design and function analysis of novel antimicrobial peptides derived from cathelicidin-DM: insights into structure-function relationships","volume":"300","author":"Luo","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bioadv.2026.214711_bb0090","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1128\/AAC.01199-07","article-title":"The P-113 fragment of histatin 5 requires a specific peptide sequence for intracellular translocation in Candida albicans, which is independent of cell wall binding","volume":"52","author":"Jang","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.bioadv.2026.214711_bb0095","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1128\/AAC.49.3.1249-1252.2005","article-title":"In vitro activity of the histatin derivative P-113 against multidrug-resistant pathogens responsible for pneumonia in immunocompromised patients","volume":"49","author":"Giacometti","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioadv.2026.214711_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114277","article-title":"Cathelicidin LL-37 in periodontitis: current research advances and future prospects - a review","volume":"150","author":"He","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.bioadv.2026.214711_bb0105","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/biomedicines11020504","article-title":"Transforming cross-linked cyclic dimers of KR-12 into stable and potent antimicrobial drug leads","volume":"11","author":"Muhammad","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.bioadv.2026.214711_bb0110","first-page":"887","volume":"16","author":"Lei","year":"2024","journal-title":"Turning cationic antimicrobial peptide KR-12 into self-assembled nanobiotics with potent bacterial killing and LPS neutralizing activities"},{"issue":"18","key":"10.1016\/j.bioadv.2026.214711_bb0115","doi-asserted-by":"crossref","first-page":"10079","DOI":"10.1021\/acs.chemrev.0c00532","article-title":"Stapled helical peptides bearing different anchoring residues","volume":"120","author":"Li","year":"2020","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0120","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s12951-025-03601-w","article-title":"Photosensitive small intestinal submucosal hydrogels loaded with the KR-12-a5 peptide promote periodontal osteogenesis and antimicrobial activity","volume":"23","author":"Ma","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.214711_bb0125","article-title":"An update on periodontal inflammation and bone loss","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioadv.2026.214711_bb0130","article-title":"Are salivary and plasma levels of toll-like receptors 2 and 4 elevated in subjects with chronic periodontitis?: a systematic review and meta-analysis","volume":"2025","author":"Alarc\u00f3n-S\u00e1nchez","year":"2025","journal-title":"Int. J. Inflamm."},{"issue":"11","key":"10.1016\/j.bioadv.2026.214711_bb0135","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1038\/s41593-024-01753-w","article-title":"Inhibiting Ca2+ channels in Alzheimer\u2019s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia","volume":"27","author":"Korte","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bioadv.2026.214711_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176919","article-title":"ML218 modulates calcium binding protein, oxidative stress, and inflammation during ischemia-reperfusion brain injury in mice","volume":"982","author":"Sharma","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.bioadv.2026.214711_bb0145","doi-asserted-by":"crossref","DOI":"10.1172\/JCI181928","article-title":"Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake","volume":"135","author":"Sun","year":"2025","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioadv.2026.214711_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122076","article-title":"Reactive oxygen species trigger inflammasome activation after intracellular microbial interaction","volume":"331","author":"Rosa","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.bioadv.2026.214711_bb0155","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Jianing","year":"2023","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.bioadv.2026.214711_bb0160","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int. Dent. J."},{"key":"10.1016\/j.bioadv.2026.214711_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.it.2018.01.009","article-title":"Orchestration of NLRP3 inflammasome activation by ion fluxes","volume":"39","author":"Gong","year":"2018","journal-title":"Trends Immunol."},{"issue":"7427","key":"10.1016\/j.bioadv.2026.214711_bb0170","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11588","article-title":"The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP","volume":"492","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bioadv.2026.214711_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123781","article-title":"Chaotropic ion-tuned protein\/peptide hydrogel with enhanced trans-barrier delivery for effective periodontitis management via pathogen clearance, immunomodulation, and MSC preservation","volume":"327","author":"Wang","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.214711_bb0180","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.bioadv.2026.214711_bb0185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tibtech.2016.01.002","article-title":"Gelatin-methacryloyl hydrogels: towards biofabrication-based tissue repair","volume":"34","author":"Klotz","year":"2016","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.bioadv.2026.214711_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1310349","article-title":"Augmented wound healing potential of photosensitive GelMA hydrogel incorporating antimicrobial peptides and MXene nanoparticles","volume":"11","author":"Liang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.214711_bb0195","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actbio.2025.02.046","article-title":"A calcitonin gene-related peptide co-crosslinked hydrogel promotes diabetic wound healing by regulating M2 macrophage polarization and angiogenesis","volume":"196","author":"Li","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.214711_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114466","article-title":"Gelatin methacryloyl @MP196\/exos hydrogel induced neutrophil apoptosis and macrophage M2 polarization to inhibit periodontal bone loss","volume":"248","author":"Zhuo","year":"2025","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioadv.2026.214711_bb0205","first-page":"239","article-title":"A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: antibacterial, hemostasis, immune reprogramming, pro-osteo-\/angiogenesis and recruitment","volume":"41","author":"Yang","year":"2024","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0210","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55012-1","article-title":"Burn-related collagen conformational changes in ex vivo porcine skin using Raman spectroscopy","volume":"9","author":"Ye","year":"2019","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.bioadv.2026.214711_bb0215","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.3390\/microorganisms10112114","article-title":"Antibacterial and anti-inflammatory properties of peptide KN-17","volume":"10","author":"Zhang","year":"2022","journal-title":"Microorganisms"},{"issue":"4","key":"10.1016\/j.bioadv.2026.214711_bb0220","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00726-023-03245-w","article-title":"Rational design of stapled antimicrobial peptides","volume":"55","author":"You","year":"2023","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.bioadv.2026.214711_bb0225","article-title":"Antimicrobial peptides and their mimetics: promising candidates of next-generation therapeutic agents combating multidrug-resistant bacteria","volume":"9","author":"Zhang","year":"2025","journal-title":"Adv. Biol. (Weinh)."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0230","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2022.2145729","article-title":"Fusobacterium nucleatum and its associated systemic diseases: epidemiologic studies and possible mechanisms","volume":"15","author":"Fan","year":"2022","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.bioadv.2026.214711_bb0235","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"4","key":"10.1016\/j.bioadv.2026.214711_bb0240","doi-asserted-by":"crossref","first-page":"411","DOI":"10.14744\/eej.2024.75983","article-title":"Efficacy of antimicrobial peptide GH12 on a multispecies endodontic biofilm model: an in-vitro study","volume":"9","author":"Sinha","year":"2024","journal-title":"Eur. Endod. J."},{"key":"10.1016\/j.bioadv.2026.214711_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.108052","article-title":"Antimicrobial and antibiofilm effects of a leucine-substituted rice peptide against Porphyromonas gingivalis and Fusobacterium nucleatum","volume":"209","author":"Aoki-Nonaka","year":"2025","journal-title":"Microb. Pathog."},{"issue":"9","key":"10.1016\/j.bioadv.2026.214711_bb0250","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.3390\/microorganisms11092358","article-title":"The role of Fusobacterium nucleatum in oral and colorectal carcinogenesis","volume":"11","author":"Pignatelli","year":"2023","journal-title":"Microorganisms"},{"issue":"7","key":"10.1016\/j.bioadv.2026.214711_bb0255","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202152891","article-title":"Fusobacterium nucleatum secretes amyloid-like FadA to enhance pathogenicity","volume":"22","author":"Meng","year":"2021","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0260","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41368-022-00213-0","article-title":"Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs","volume":"15","author":"Wang","year":"2023","journal-title":"Int. J. Oral Sci."},{"issue":"5","key":"10.1016\/j.bioadv.2026.214711_bb0265","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.chom.2023.03.018","article-title":"Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles","volume":"31","author":"Hong","year":"2023","journal-title":"Cell Host Microbe"},{"issue":"7","key":"10.1016\/j.bioadv.2026.214711_bb0270","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioadv.2026.214711_bb0275","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.781378","article-title":"Immunomodulation in the treatment of periodontitis: progress and perspectives","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioadv.2026.214711_bb0280","article-title":"Azithromycin regulates Mettl3-mediated NF-\u03baB pathway to enhance M2 polarization of RAW264.7 macrophages and attenuate LPS-triggered cytotoxicity of MLE-12 alveolar cells","volume":"137","author":"Shuna","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.bioadv.2026.214711_bb0285","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.3892\/mmr.2017.7719","article-title":"Regulation of M1-type and M2-type macrophage polarization in RAW264.7 cells by Galectin-9","volume":"16","author":"Lv","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"20","key":"10.1016\/j.bioadv.2026.214711_bb0290","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.3390\/ma17205002","article-title":"Testing mortars for 3D printing: correlation with rheological behavior","volume":"17","author":"Bao","year":"2024","journal-title":"Materials (Basel)"},{"issue":"8","key":"10.1016\/j.bioadv.2026.214711_bb0295","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.3390\/polym15081953","article-title":"Rheological characteristics of starch-based biodegradable blends","volume":"15","author":"Park","year":"2023","journal-title":"Polymers (Basel)"},{"issue":"20","key":"10.1016\/j.bioadv.2026.214711_bb0300","article-title":"Alleviate periodontitis and its comorbidity hypertension using a nanoparticle-embedded functional hydrogel system","volume":"12","author":"Shuo","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"3","key":"10.1016\/j.bioadv.2026.214711_bb0305","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202412240","article-title":"An immunomodulatory hydrogel featuring antibacterial and reactive oxygen species scavenging properties for treating periodontitis in diabetes","volume":"37","author":"Ge","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioadv.2026.214711_bb0310","first-page":"346","article-title":"Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation","volume":"35","author":"Liu","year":"2024","journal-title":"Bioact. Mater."},{"issue":"2","key":"10.1016\/j.bioadv.2026.214711_bb0315","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.clpt.6100247","article-title":"The challenge of treating biofilm-associated bacterial infections","volume":"82","author":"del Pozo","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0320","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000339961","article-title":"Extracellular DNA within a nontypeable Haemophilus influenzae-induced biofilm binds human beta defensin-3 and reduces its antimicrobial activity","volume":"5","author":"Jones","year":"2013","journal-title":"J. Innate Immun."},{"issue":"5","key":"10.1016\/j.bioadv.2026.214711_bb0325","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000239587","article-title":"Permeation of antimicrobial agents through Pseudomonas aeruginosa biofilms: a simple method","volume":"43","author":"Shigeta","year":"1997","journal-title":"Chemotherapy"},{"issue":"19","key":"10.1016\/j.bioadv.2026.214711_bb0330","doi-asserted-by":"crossref","first-page":"10821","DOI":"10.3390\/ijms251910821","article-title":"Enhancing antimicrobial peptide activity through modifications of charge, hydrophobicity, and structure","volume":"25","author":"Gagat","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0335","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s43556-024-00214-x","article-title":"Post-translational modifications of fibrinogen: implications for clotting, fibrin structure and degradation","volume":"5","author":"Nencini","year":"2024","journal-title":"Mol. Biomed."},{"issue":"5","key":"10.1016\/j.bioadv.2026.214711_bb0340","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1128\/AAC.45.5.1367-1373.2001","article-title":"Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin 5","volume":"45","author":"Rothstein","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bioadv.2026.214711_bb0345","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.actbio.2017.05.007","article-title":"Selective phenylalanine to proline substitution for improved antimicrobial and anticancer activities of peptides designed on phenylalanine heptad repeat","volume":"57","author":"Tripathi","year":"2017","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.bioadv.2026.214711_bb0350","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.bioadv.2026.214711_bb0355","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tcb.2022.07.004","article-title":"Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications","volume":"33","author":"Zheng","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bioadv.2026.214711_bb0360","doi-asserted-by":"crossref","DOI":"10.3389\/fmmed.2023.1235188","article-title":"Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease","volume":"3","author":"Popoiu","year":"2023","journal-title":"Front. Mol. Med."},{"issue":"4","key":"10.1016\/j.bioadv.2026.214711_bb0365","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","article-title":"Mitochondria in health, disease, and aging","volume":"103","author":"Harrington","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bioadv.2026.214711_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106761","article-title":"Mitochondria associated ER membranes and cerebral ischemia: molecular mechanisms and therapeutic strategies","volume":"191","author":"Jiang","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"8","key":"10.1016\/j.bioadv.2026.214711_bb0375","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.immuni.2022.06.007","article-title":"Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling","volume":"55","author":"Xian","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.bioadv.2026.214711_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2022.105497","article-title":"Soybean peptide inhibits the biofilm of periodontopathic bacteria via bactericidal activity","volume":"142","author":"Lwin","year":"2022","journal-title":"Arch. Oral Biol."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214711_bb0385","doi-asserted-by":"crossref","first-page":"18313","DOI":"10.1038\/s41598-020-74977-y","article-title":"Quercetin inhibits virulence properties of Porphyromas gingivalis in periodontal disease","volume":"10","author":"Zhiyan He","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bioadv.2026.214711_bb0390","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/tox.21771","article-title":"Cytotoxicity and genotoxicity of chlorhexidine on macrophages in vitro","volume":"29","author":"Li","year":"2014","journal-title":"Environ. Toxicol."},{"issue":"8","key":"10.1016\/j.bioadv.2026.214711_bb0395","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw081","article-title":"Immunomodulatory\/anti-inflammatory effects of a propolis-containing mouthwash on human monocytes","volume":"74","author":"Santiago","year":"2016","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.bioadv.2026.214711_bb0400","article-title":"Insights into the formation of carboxymethyl chitosan-nisin nanogels for sustainable antibacterial activity","volume":"402","author":"Chunhua","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.bioadv.2026.214711_bb0405","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejpb.2021.07.007","article-title":"Management of oral biofilms by nisin delivery in adhesive microdevices","volume":"167","author":"Birk","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826000099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826000099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:20:44Z","timestamp":1770207644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826000099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":81,"alternative-id":["S2772950826000099"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214711","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel antimicrobial peptide AH-12 attenuates mitochondrial response to inflammatory stimuli and prevents periodontitis via antibacterial and anti-inflammatory effects","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214711","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214711"}}