{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:11:55Z","timestamp":1792685515064,"version":"4.5.0"},"reference-count":143,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374295"],"award-info":[{"award-number":["82374295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["SZM2024001"],"award-info":[{"award-number":["SZM2024001"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010881","name":"Suzhou City Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bioadv.2026.214725","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T16:51:13Z","timestamp":1768841473000},"page":"214725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Nanotechnology-driven drug delivery systems for breast cancer: A review"],"prefix":"10.1016","volume":"182","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejie","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maobin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaozhu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaying","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.214725_bb0005","first-page":"151","article-title":"Epidemiological characteristics of and risk factors for breast cancer in the world","volume":"11","author":"Momenimovahed","year":"2019","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"10.1016\/j.bioadv.2026.214725_bb0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13058-021-01400-3","article-title":"Risk of contralateral breast cancer according to first breast cancer characteristics among women in the USA, 1992-2016","volume":"23","author":"Ramin","year":"2021","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.bioadv.2026.214725_bb0015","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.2174\/1381612827666210303141416","article-title":"Recent advances in diagnostic and therapeutic approaches for breast cancer: a comprehensive review","volume":"27","author":"Noor","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bioadv.2026.214725_bb0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1200\/JCO.21.02473","article-title":"Cost-effectiveness of pharmacologic treatment options for women with endocrine-refractory or triple-negative metastatic breast cancer","volume":"41","author":"Wheeler","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0025","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12943-024-02067-y","article-title":"Targeting DKK1 enhances the antitumor activity of paclitaxel and alleviates chemotherapy-induced peripheral neuropathy in breast cancer","volume":"23","author":"Shi","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bioadv.2026.214725_bb0030","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41591-024-03415-7","article-title":"Pembrolizumab and chemotherapy in high-risk, early-stage, ER(+)\/HER2(\u2212) breast cancer: a randomized phase 3 trial","volume":"31","author":"Cardoso","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioadv.2026.214725_bb0035","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/978-981-32-9620-6_26","article-title":"Clinical databases for breast cancer research","volume":"1187","author":"Hwang","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0040","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/978-981-32-9620-6_27","article-title":"Care for breast cancer survivors","volume":"1187","author":"Jeong","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121318","article-title":"Recent advances in chitosan-based materials; the synthesis, modifications and biomedical applications","volume":"321","author":"Iqbal","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.214725_bb0050","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s13346-018-0551-3","article-title":"Metastatic and triple-negative breast cancer: challenges and treatment options","volume":"8","author":"Al-Mahmood","year":"2018","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.bioadv.2026.214725_bb0055","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3390\/ph13120463","article-title":"Non-steroidal anti-inflammatory drugs increase cisplatin, paclitaxel, and doxorubicin efficacy against human cervix cancer cells","volume":"13","author":"Robledo-Cadena","year":"2020","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bioadv.2026.214725_bb0060","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/acs.accounts.0c00313","article-title":"Nanoscale metal-organic frameworks for cancer immunotherapy","volume":"53","author":"Ni","year":"2020","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bioadv.2026.214725_bb0065","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","article-title":"Polymeric nanoparticles for drug delivery","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bioadv.2026.214725_bb0070","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13045-020-00987-y","article-title":"Isolation and characterization of exosomes for cancer research","volume":"13","author":"Zhu","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0075","doi-asserted-by":"crossref","first-page":"23223","DOI":"10.1021\/acsnano.3c06019","article-title":"Stimuli-responsive polymer-based nanosystems for cancer theranostics","volume":"17","author":"Wei","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2026.214725_bb0080","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jconrel.2020.11.015","article-title":"Novel dendritic polyglycerol-conjugated, mesoporous silica-based targeting nanocarriers for co-delivery of doxorubicin and tariquidar to overcome multidrug resistance in breast cancer stem cells","volume":"330","author":"Pan","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.214725_bb0085","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ejmech.2018.12.022","article-title":"Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand","volume":"163","author":"C\u00f4rte-Real","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bioadv.2026.214725_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.10.032","article-title":"Co-delivery of paclitaxel and cisplatin in poly(2-oxazoline) polymeric micelles: implications for drug loading, release, pharmacokinetics and outcome of ovarian and breast cancer treatments","volume":"192","author":"Wan","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.214725_bb0095","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ijpharm.2017.05.016","article-title":"Paclitaxel: what has been done and the challenges remain ahead","volume":"526","author":"Bernabeu","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0100","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jconrel.2020.11.015","article-title":"Novel dendritic polyglycerol-conjugated, mesoporous silica-based targeting nanocarriers for co-delivery of doxorubicin and tariquidar to overcome multidrug resistance in breast cancer stem cells","volume":"330","author":"Pan","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.214725_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2020.102102","article-title":"pH-responsive lipid polymer hybrid nanoparticles (LPHNs) based on poly (\u03b2-amino ester) as a promising candidate to resist breast cancers","volume":"61","author":"Zhang","year":"2021","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/ph13120463","article-title":"Non-steroidal anti-inflammatory drugs increase cisplatin, paclitaxel, and doxorubicin efficacy against human cervix cancer cells","volume":"13","author":"Robledo-Cadena","year":"2020","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bioadv.2026.214725_bb0115","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.actbio.2021.09.002","article-title":"Tumor-targeting pH\/redox dual-responsive nanosystem epigenetically reverses cancer drug resistance by co-delivering doxorubicin and GCN5 siRNA","volume":"135","author":"Yuan","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.214725_bb0120","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1080\/10717544.2021.1960926","article-title":"Star polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer","volume":"28","author":"Guo","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bioadv.2026.214725_bb0125","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s13346-018-0551-3","article-title":"Metastatic and triple-negative breast cancer: challenges and treatment options","volume":"8","author":"Al-Mahmood","year":"2018","journal-title":"Drug Delivery Transl. Res."},{"key":"10.1016\/j.bioadv.2026.214725_bb0130","first-page":"131","article-title":"Anticancer and cardio-protective effects of liposomal doxorubicin in the treatment of breast cancer","volume":"10","author":"Franco","year":"2018","journal-title":"Breast Cancer (Auckl.)"},{"key":"10.1016\/j.bioadv.2026.214725_bb0135","doi-asserted-by":"crossref","first-page":"10293","DOI":"10.1016\/j.jddst.2021.102937","article-title":"Adsorption and sustained release of doxorubicin from N-carboxymethyl chitosan\/polyvinyl alcohol\/poly(\u03b5-caprolactone) composite and core-shell nanofibers","volume":"67","author":"Abasalta","year":"2022","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0140","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1208\/s12249-020-01743-8","article-title":"Targeted delivery of doxorubicin liposomes for HER-2+ breast cancer treatment","volume":"21","author":"Chowdhury","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.bioadv.2026.214725_bb0145","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.3390\/molecules27144632","article-title":"Maleimide-functionalized liposomes: prolonged retention and enhanced efficacy of doxorubicin in breast cancer with low systemic toxicity","volume":"27","author":"Tang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bioadv.2026.214725_bb0150","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.3390\/molecules26051280","article-title":"Reversal of multidrug resistance by apolipoprotein A1-modified doxorubicin liposome for breast cancer treatment","volume":"26","author":"An","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bioadv.2026.214725_bb0155","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1039\/C9BM01794A","article-title":"An acoustic\/thermo-responsive hybrid system for advanced doxorubicin delivery in tumor treatment","volume":"8","author":"Zhang","year":"2020","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0160","article-title":"Folate-coated, long-circulating and pH-sensitive liposomes enhance doxorubicin antitumor effect in a breast cancer animal model","volume":"118","author":"Silva","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioadv.2026.214725_bb0165","article-title":"Co-delivery of Poria cocos extract and doxorubicin as an 'all-in-one' nanocarrier to combat breast cancer multidrug resistance during chemotherapy","volume":"23","author":"Li","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.214725_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119191","article-title":"Coencapsulation of disulfiram and doxorubicin in liposomes strongly reverses multidrug resistance in breast cancer cells","volume":"580","author":"Rolle","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0175","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/acsbiomaterials.2c01142","article-title":"NIR-activated thermosensitive liposome-gold nanorod hybrids for enhanced drug delivery and stimulus sensitivity","volume":"9","author":"Zhang","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.214725_bb0180","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/j.jcis.2021.11.031","article-title":"DNAzyme-based nanoflowers for reversing P-glycoprotein-mediated multidrug resistance in breast cancer","volume":"608","author":"Liang","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0185","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1039\/C9TB02130B","article-title":"DOX-loaded peptide dendritic copolymer nanoparticles for combating multidrug resistance by regulating the lysosomal pathway of apoptosis in breast cancer cells","volume":"8","author":"Wang","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioadv.2026.214725_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235090","article-title":"Doxorubicin-loading core-shell pectin nanocell: a novel nanovehicle for anticancer agent delivery with multidrug resistance reversal","volume":"15","author":"Ouyang","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.214725_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105275","article-title":"Pluronic micelles with suppressing doxorubicin efflux and detoxification for efficiently reversing breast cancer resistance","volume":"146","author":"Cheng","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202007672","article-title":"Synergistic combination of bioactive hydroxyapatite nanoparticles and the chemotherapeutic doxorubicin to overcome tumor multidrug resistance","volume":"17","author":"Dong","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.bioadv.2026.214725_bb0205","article-title":"A 3D in vitro triculture hybrid model recapitulating tumor stromal interaction of triple-negative breast cancer as a high throughput anticancer drug screening platform","volume":"7","author":"Jaiswal","year":"2024","journal-title":"Adv. Ther."},{"key":"10.1016\/j.bioadv.2026.214725_bb0210","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1021\/acsbiomaterials.0c01511","article-title":"Combination therapy of breast cancer by codelivery of doxorubicin and survivin siRNA using polyethylenimine modified silk fibroin nanoparticles","volume":"7","author":"Norouzi","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.214725_bb0215","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.actbio.2021.11.050","article-title":"Stimuli-responsive, dual-function prodrug encapsulated in hyaluronic acid micelles to overcome doxorubicin resistance","volume":"140","author":"Qiu","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.214725_bb0220","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1016\/j.xphs.2022.05.018","article-title":"Development and evaluation of core-shell nanocarrier system for enhancing the cytotoxicity of doxorubicin\/metformin combination against breast cancer cell line","volume":"111","author":"Ibrahim","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2020.110210","article-title":"Formaldehyde-doxorubicin dual polymeric drug delivery system for higher efficacy and limited cardiotoxicity of anthracyclines","volume":"143","author":"Ordonez","year":"2021","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.bioadv.2026.214725_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2021.102521","article-title":"A novel targeted co-delivery system for transfer of epirubicin and antimiR-10b into cancer cells through a linear DNA nanostructure consisting of FOXM1 and AS1411 aptamers","volume":"63","author":"Yaghoobi","year":"2021","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0235","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1208\/s12249-022-02432-4","article-title":"An application of tumor-associated macrophages as immunotherapy targets: sialic acid-modified EPI-loaded liposomes inhibit breast cancer metastasis","volume":"23","author":"Meng","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.bioadv.2026.214725_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118706","article-title":"Terminating the renewal of tumor-associated macrophages: a sialic acid-based targeted delivery strategy for cancer immunotherapy","volume":"571","author":"Ding","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0245","article-title":"Engineered hyaluronic acid-decorated niosomal nanoparticles for controlled and targeted delivery of epirubicin to treat breast cancer","volume":"16","author":"Mansoori-Kermani","year":"2022","journal-title":"Mater. Today Bio"},{"issue":"1","key":"10.1016\/j.bioadv.2026.214725_bb0250","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3390\/pharmaceutics14010169","article-title":"Polyphosphazene-based nanocarriers for the release of camptothecin and epirubicin","volume":"14","author":"Quinones","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.214725_bb0255","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.3390\/polym13081212","article-title":"Development of epirubicin-loaded biocompatible polymer PLA-PEG-PLA nanoparticles: synthesis, characterization, stability, and in vitro anticancerous assessment","volume":"13","author":"Massadeh","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.bioadv.2026.214725_bb0260","doi-asserted-by":"crossref","DOI":"10.1177\/15330338211027898","article-title":"Controllable drug delivery by Na+\/K+ ATPase \u03b11 targeting peptide conjugated DSPE-PEG nanocarriers for breast cancer","volume":"20","author":"Yang","year":"2021","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.bioadv.2026.214725_bb0265","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1049\/nbt2.12012","article-title":"Enhancement of in vitro antitumour activity of epirubicin in HER2+ breast cancer cells using immunoliposome formulation","volume":"15","author":"Khaleseh","year":"2021","journal-title":"IET Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0270","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.2147\/IJN.S260477","article-title":"Self-assembled dual-targeted epirubicin-hybrid polydopamine nanoparticles for combined chemo-photothermal therapy of triple-negative breast cancer","volume":"15","author":"Li","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.214725_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118806","article-title":"Co-delivery of epirubicin and paclitaxel using an estrone-targeted PEGylated liposomal nanoparticle for breast cancer","volume":"573","author":"Tang","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0280","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1021\/acsabm.1c01107","article-title":"Dinarvand, pH-responsive, adorned nanoniosomes for codelivery of cisplatin and epirubicin: synergistic treatment of breast cancer","volume":"5","author":"Moammeri","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioadv.2026.214725_bb0285","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejpb.2022.09.003","article-title":"Quatramer\u2122 mediated co-delivery of PI3-K\u03b4\/HDAC6 dual inhibitor augments the anti-cancer efficacy of epirubicin in breast cancer","volume":"179","author":"Tiwari","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0290","article-title":"Selective inhibition of aminopeptidase N by paclitaxel: insights into enzymatic interactions with cytostatics and analgesics in cancers","volume":"148051","author":"Pawe\u0142czak","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0295","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/ph15010006","article-title":"Co-delivery of letrozole and cyclophosphamide via folic acid-decorated nanoniosomes for breast cancer therapy: synergic effect, augmentation of cytotoxicity, and apoptosis gene expression","volume":"15","author":"Sahrayi","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bioadv.2026.214725_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.129060","article-title":"Host-guest complexation of cyclophosphamide by carboxylatopillar[6]arene for increasing stability and enhancing its curative effect on breast carcinoma","volume":"78","author":"Gao","year":"2022","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bioadv.2026.214725_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119785","article-title":"Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer","volume":"294","author":"Gao","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.214725_bb0310","doi-asserted-by":"crossref","first-page":"33723","DOI":"10.1039\/D1RA04591A","article-title":"Development of a pH-sensitive functionalized metal organic framework: in vitro study for simultaneous delivery of doxorubicin and cyclophosphamide in breast cancer","volume":"11","author":"Singh","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioadv.2026.214725_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112376","article-title":"Novel doxorubicin\/folate-targeted trans-ferulic acid-loaded PLGA nanoparticles combination: in-vivo superiority over standard chemotherapeutic regimen for breast cancer treatment","volume":"145","author":"Helmy","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioadv.2026.214725_bb0320","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.carbpol.2019.04.024","article-title":"Biotin and arginine modified hydroxypropyl-\u03b2-cyclodextrin nanoparticles as novel drug delivery systems for paclitaxel","volume":"216","author":"Yan","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.214725_bb0325","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejpb.2017.02.020","article-title":"Anti-HER2 immunoliposomes for co-delivery of paclitaxel and rapamycin for breast cancer therapy","volume":"115","author":"Eloy","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0330","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ijpharm.2017.05.016","article-title":"Paclitaxel: what has been done and the challenges remain ahead","volume":"526","author":"Bernabeu","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2022.104050","article-title":"Nanoparticles for co-delivery of paclitaxel and curcumin to overcome chemoresistance against breast cancer","volume":"79","author":"Lin","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0340","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ijbiomac.2020.03.060","article-title":"Drug-binding albumins forming stabilized nanoparticles for co-delivery of paclitaxel and resveratrol: in vitro\/in vivo evaluation and binding properties investigation","volume":"153","author":"Zhao","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0345","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1021\/acs.molpharmaceut.9b01148","article-title":"Folic acid-modified nanoerythrocyte for codelivery of paclitaxel and tariquidar to overcome breast cancer multidrug resistance","volume":"17","author":"Zhong","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112574","article-title":"Laser-responsive multi-functional nanoparticles for efficient combinational chemo-photodynamic therapy against breast cancer","volume":"216","author":"Guan","year":"2022","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioadv.2026.214725_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106212","article-title":"Honokiol nanosuspensions loaded thermosensitive hydrogels as the local delivery system in combination with systemic paclitaxel for synergistic therapy of breast cancer","volume":"175","author":"Lu","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0360","first-page":"571","article-title":"Nucleobase-crosslinked poly(2-oxazoline) nanoparticles as paclitaxel carriers with enhanced stability and ultra-high drug loading capacity for breast cancer, Asian","volume":"17","author":"Dong","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0365","first-page":"14590","article-title":"Folic acid and poly(ethylene glycol) decorated paclitaxel nanocrystals exhibit enhanced stability and breast cancer-targeting capability","volume":"13","author":"Zhao","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.214725_bb0370","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/s12951-022-01623-2","article-title":"Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes","volume":"20","author":"Xia","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0375","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3390\/ph16030349","article-title":"Functionalized lipid nanocarriers for simultaneous delivery of docetaxel and tariquidar to chemoresistant cancer cells","volume":"16","author":"Kim","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bioadv.2026.214725_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123045","article-title":"Non-covalent strategies to functionalize polymeric nanoparticles with NGR peptides for targeting breast cancer","volume":"641","author":"Conte","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111760","article-title":"Efficient in vitro and in vivo docetaxel delivery mediated by pH-sensitive LPHNPs for effective breast cancer therapy","volume":"203","author":"Jadon","year":"2021","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioadv.2026.214725_bb0390","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/polym13091416","article-title":"Enhanced cytotoxic activity of docetaxel-loaded silk fibroin nanoparticles against breast cancer cells","volume":"13","author":"Al Saqr","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.bioadv.2026.214725_bb0395","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/03639045.2023.2203252","article-title":"An in-vitro quantitative investigation on the synergistic effect of capsaicin and 5-fluorouracil encapsulated into lipid nanocapsules to treat breast cancer","volume":"49","author":"Radwan","year":"2023","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0400","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.21037\/atm-21-5978","article-title":"5-FU@DHA-UiO-66-NH2 potentiates chemotherapy sensitivity of breast cancer cells through a microRNA let-7a-dependent mechanism","volume":"9","author":"Li","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bioadv.2026.214725_bb0405","doi-asserted-by":"crossref","first-page":"16099","DOI":"10.1016\/j.jallcom.2021.160992","article-title":"A new pH-sensitive CS\/Zn-MOF@GO ternary hybrid compound as a biofriendly and implantable platform for prolonged 5-fluorouracil delivery to human breast cancer cells","volume":"885","author":"Pooresmaeil","year":"2021","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.bioadv.2026.214725_bb0410","doi-asserted-by":"crossref","first-page":"601","DOI":"10.15171\/apb.2019.069","article-title":"Preparation and characterization of silk fibroin nanoparticles as a potential drug delivery system for 5-fluorouracil","volume":"9","author":"Rahmani","year":"2019","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.bioadv.2026.214725_bb0415","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s10876-022-02349-9","article-title":"Development of metal-organic frameworks (ZIF-8) as low-cost carriers for sustained release of hydrophobic and hydrophilic drugs: in vitro evaluation of anti-breast cancer and anti-infection effect","volume":"34","author":"Mazloum-Ardakani","year":"2023","journal-title":"J. Clust. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2021.110270","article-title":"Advanced liposome based PEGylated microgel as a novel release system for 5-fluorouracil against MCF-7 cancer cell","volume":"146","author":"Ulker","year":"2021","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.bioadv.2026.214725_bb0425","doi-asserted-by":"crossref","first-page":"32534","DOI":"10.1039\/D2RA03718A","article-title":"Co-encapsulation of paclitaxel and 5-fluorouracil in folic acid-modified, lipid-encapsulated hollow mesoporous silica nanoparticles for synergistic breast cancer treatment","volume":"12","author":"Yin","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioadv.2026.214725_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2021.102959","article-title":"Functionalized PAMAM-based system for targeted delivery of miR-205 and 5-fluorouracil in breast cancer","volume":"67","author":"Tang","year":"2022","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0435","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijbiomac.2021.12.130","article-title":"Effectiveness of 5-fluorouracil and gemcitabine hydrochloride loaded iron-based chitosan-coated MIL-100 composite as an advanced, biocompatible, pH-sensitive and smart drug delivery system on breast cancer therapy","volume":"198","author":"Resen","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0440","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.ijbiomac.2019.10.120","article-title":"Synthesis of magnetic gold coated poly(\u03b5-caprolactonediol) based polyurethane\/poly(N-isopropylacrylamide)-grafted-chitosan core-shell nanofibers for controlled release of paclitaxel and 5-FU","volume":"150","author":"Farboudi","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0445","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.2147\/IJN.S108633","article-title":"Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma","volume":"11","author":"Li","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.214725_bb0450","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.colsurfb.2016.05.051","article-title":"Fucose decorated solid-lipid nanocarriers mediate efficient delivery of methotrexate in breast cancer therapeutics","volume":"146","author":"Garg","year":"2016","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioadv.2026.214725_bb0455","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1073\/pnas.75.7.3201","article-title":"Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies","volume":"75","author":"Subramanian","year":"1978","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioadv.2026.214725_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132671","article-title":"Hyaluronic acid-conjugated methotrexate and 5-fluorouracil for targeted drug delivery","volume":"273","author":"Shao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0465","first-page":"1247","article-title":"Breast cancer index in premenopausal women with early-stage hormone receptor\u2013positive breast cancer","volume":"10","author":"O'Regan","year":"2024","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0470","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1039\/C6BM00888G","article-title":"Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells","volume":"5","author":"Gulfam","year":"2017","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0475","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1166\/jnn.2013.6080","article-title":"In vitro investigation on the magnetic thermochemotherapy mediated by magnetic nanoparticles combined with methotrexate for breast cancer treatment","volume":"13","author":"Zhao","year":"2013","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0480","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ijpharm.2013.05.015","article-title":"Enhanced antitumor efficacy by methotrexate conjugated pluronic mixed micelles against KBv multidrug resistant cancer","volume":"452","author":"Chen","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0485","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s13205-021-02718-7","article-title":"Fabrication of methotrexate-loaded gold nanoconjugates and its enhanced anticancer activity in breast cancer","volume":"11","author":"Chaudhari","year":"2021","journal-title":"3 Biotech"},{"key":"10.1016\/j.bioadv.2026.214725_bb0490","article-title":"Ultrasound-guided chemoradiotherapy of breast cancer using smart methotrexate-loaded perfluorohexane nanodroplets","volume":"48","author":"Samani","year":"2023","journal-title":"Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.214725_bb0495","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3390\/pharmaceutics14122668","article-title":"Dual-enhanced pluronic nanoformulated methotrexate-based treatment approach for breast cancer: development and evaluation of in vitro and in vivo efficiency","volume":"14","author":"Mansour","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.214725_bb0500","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/21691401.2022.2030746","article-title":"Co-delivery of STAT3 siRNA and methotrexate in breast cancer cells","volume":"50","author":"Shakeran","year":"2022","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0505","article-title":"pH-responsive, magnetic-luminescent core\/shell carriers for co-delivery of anticancer drugs (MTX & DOX) for breast cancer treatment","volume":"770","author":"Ghazimoradi","year":"2022","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.bioadv.2026.214725_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2022.103906","article-title":"Chitosan-coated bovine serum albumin nanocarriers mediate efficient delivery of methotrexate in breast cancer therapeutics","volume":"77","author":"Esim","year":"2022","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0515","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1515\/ntrev-2022-0479","article-title":"Aptamer-functionalized chitosan-coated gold nanoparticle complex as a suitable targeted drug carrier for improved breast cancer treatment","volume":"11","author":"Shahidi","year":"2022","journal-title":"Nanotechnol. Rev."},{"key":"10.1016\/j.bioadv.2026.214725_bb0520","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12951-021-00883-8","article-title":"Hierarchical drug release designed Au@PDA-PEG-MTX NPs for targeted delivery to breast cancer with combined photothermal-chemotherapy","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0525","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/ph13010002","article-title":"Dextran-curcumin nanoparticles as a methotrexate delivery vehicle: a step forward in breast cancer combination therapy","volume":"13","author":"Curcio","year":"2020","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bioadv.2026.214725_bb0530","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/j.jcis.2021.11.031","article-title":"DNAzyme-based nanoflowers for reversing P-glycoprotein-mediated multidrug resistance in breast cancer","volume":"608","author":"Liang","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0535","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1039\/C9TB02130B","article-title":"DOX-loaded peptide dendritic copolymer nanoparticles for combating multidrug resistance by regulating the lysosomal pathway of apoptosis in breast cancer cells","volume":"8","author":"Wang","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioadv.2026.214725_bb0540","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3390\/polym13091416","article-title":"Enhanced cytotoxic activity of docetaxel-loaded silk fibroin nanoparticles against breast cancer cells","volume":"13","author":"Al Saqr","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.bioadv.2026.214725_bb0545","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1080\/10717544.2021.1960926","article-title":"Star polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer","volume":"28","author":"Guo","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bioadv.2026.214725_bb0550","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1208\/s12249-022-02432-4","article-title":"An application of tumor-associated macrophages as immunotherapy targets: sialic acid-modified EPI-loaded liposomes inhibit breast cancer metasta sis","volume":"23","author":"Meng","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.bioadv.2026.214725_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118706","article-title":"Terminating the renewal of tumor-associated macrophages: a sialic acid-based targeted delivery strategy for cancer immunotherapy","volume":"571","author":"Ding","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214725_bb0560","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/CAD.0000000000000782","article-title":"Oxazaphosphorine cytostatics: from serendipity to rational drug design","volume":"30","author":"Voelcker","year":"2019","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.bioadv.2026.214725_bb0565","doi-asserted-by":"crossref","first-page":"14577","DOI":"10.1021\/acsami.1c00184","article-title":"Folic acid and poly(ethylene glycol) decorated paclitaxel nanocrystals exhibit enhanced stability and breast cancer-targeting capability","volume":"13","author":"Zhao","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.214725_bb0570","first-page":"571","article-title":"Nucleobase-crosslinked poly(2-oxazoline) nanoparticles as paclitaxel carriers with enhanced stability and ultra-high drug loading capacity for breast cancer therapy, Asian","volume":"17","author":"Dong","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106212","article-title":"Honokiol nanosuspensions loaded thermosensitive hydrogels as the local delivery system in combination with systemic paclitaxel for synergistic therapy of breast cancer","volume":"175","author":"Lu","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0580","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/s12951-022-01623-2","article-title":"Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes","volume":"20","author":"Xia","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0585","doi-asserted-by":"crossref","first-page":"32534","DOI":"10.1039\/D2RA03718A","article-title":"Co-encapsulation of paclitaxel and 5-fluorouracil in folic acid-modified, lipid-encapsulated hollow mesoporous silica nanoparticles for synergistic breast cancer treatment","volume":"12","author":"Yin","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioadv.2026.214725_bb0590","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/21691401.2022.2030746","article-title":"Co-delivery of STAT3 siRNA and methotrexate in breast cancer cells","volume":"50","author":"Shakeran","year":"2022","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0595","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1056\/NEJMoa052084","article-title":"Epirubicin and cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy for early breast cancer","volume":"355","author":"Poole","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioadv.2026.214725_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2025.106967","article-title":"Drug release of the polyvinylpyrrolidone\/carbon quantum dots\/polyethylene glycol self-assembled nanocarrier: kinetics and the targeted breast cancer studies","volume":"109","author":"Tadayyoni","year":"2025","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.matlet.2025.139596","article-title":"Integrating machine-learning and nanotechnology: imatinib-loaded nanomicelles for targeted therapy in MCF-7 breast cancer","volume":"404","author":"Rahdar","year":"2026","journal-title":"Mater. Lett."},{"key":"10.1016\/j.bioadv.2026.214725_bb0610","first-page":"10872","article-title":"Innovative chitosan-polyacrylic acid-MoS2 nanocomposite for enhanced and pH-responsive quercetin delivery","volume":"39","author":"Pourmadadi","year":"2024","journal-title":"Mater. Today Commun."},{"key":"10.1016\/j.bioadv.2026.214725_bb0615","article-title":"Gold nanobiosensors and machine learning: pioneering breakthroughs in precision breast cancer detection","volume":"12","author":"Sadr","year":"2024","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"10.1016\/j.bioadv.2026.214725_bb0620","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1039\/D3NR03495J","article-title":"Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer","volume":"16","author":"Roostaee","year":"2024","journal-title":"Nanoscale"},{"key":"10.1016\/j.bioadv.2026.214725_bb0625","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12668-025-01980-w","article-title":"Artificial intelligence-assisted design of nanomedicines for breast cancer diagnosis and therapy: advances, challenges, and future directions","volume":"15","author":"Shirzad","year":"2025","journal-title":"BioNanoScience"},{"key":"10.1016\/j.bioadv.2026.214725_bb0630","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1631\/jzus.B1600303","article-title":"Use of liposomal doxorubicin for adjuvant chemotherapy of breast cancer in clinical practice","volume":"18","author":"Zhao","year":"2017","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.bioadv.2026.214725_bb0635","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/theoncologist.8-suppl_2-3","article-title":"Liposomal anthracyclines in metastatic breast cancer: clinical update","volume":"8","author":"Rivera","year":"2003","journal-title":"Oncologist"},{"key":"10.1016\/j.bioadv.2026.214725_bb0640","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/toxres\/tfad072","article-title":"Clinical observation of liposomal doxorubicin on liver and renal function in patients with breast cancer","volume":"12","author":"Li","year":"2023","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.bioadv.2026.214725_bb0645","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jconrel.2022.06.039","article-title":"Aptamer-conjugated nano-liposome for immunogenic chemotherapy with reversal of immunosuppression","volume":"348","author":"Kim","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.214725_bb0650","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jcis.2023.07.149","article-title":"Polysarcosine-coated liposomes attenuating immune response induction and prolonging blood circulation","volume":"651","author":"Hu","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0655","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.xphs.2018.12.016","article-title":"Codelivery of adriamycin and P-gp inhibitor quercetin using PEGylated liposomes to overcome cancer drug resistance","volume":"108","author":"Yu","year":"2019","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0660","article-title":"Efficacy comparisons of solvent-based paclitaxel, liposomal paclitaxel, nanoparticle albumin-bound paclitaxel, and docetaxel after neoadjuvant systemic treatment in breast cancer","volume":"54","author":"Zhang","year":"2023","journal-title":"Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.214725_bb0665","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.3390\/ijms23052860","article-title":"Milk-derived exosomes as nanocarriers to deliver curcumin and resveratrol in breast tissue and enhance their anticancer activity","volume":"23","author":"Esp\u00edn","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.143994","article-title":"Kesharwani, Recent advances in PD-L1 siRNA nanocarriers for cancer therapy","volume":"311","author":"Sristi","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.214725_bb0675","doi-asserted-by":"crossref","first-page":"11909","DOI":"10.1016\/j.carbpol.2022.119097","article-title":"Co-delivery of doxorubicin and siRNA by all-trans retinoic acid conjugated chitosan-based nanocarriers for multiple synergistic antitumor efficacy","volume":"283","author":"Liu","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.214725_bb0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcp.2024.101964","article-title":"Exosomes regulate doxorubicin resistance in breast cancer via miR-34a-5p\/NOTCH1","volume":"76","author":"Chen","year":"2024","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.bioadv.2026.214725_bb0685","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s11427-017-9274-9","article-title":"Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy","volume":"61","author":"Xiang","year":"2018","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0690","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.2174\/0115748855302263240910060240","article-title":"A complete appraisal of polymeric micelle-based nanocarrier for targeting breast cancer: recent strategies and advancements","volume":"20","author":"Ray","year":"2024","journal-title":"Curr. Drug Ther."},{"key":"10.1016\/j.bioadv.2026.214725_bb0695","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3390\/ijms19041183","article-title":"The double face of exosome-carried microRNAs in cancer immunomodulation","volume":"19","author":"Alfonsi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.214725_bb0700","first-page":"1483","article-title":"Internalisation of RGD-engineered extracellular vesicles by glioblastoma cells","volume":"11","author":"Gecys","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.bioadv.2026.214725_bb0705","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41551-019-0485-1","article-title":"Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation","volume":"4","author":"Yang","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.bioadv.2026.214725_bb0710","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12964-022-00959-4","article-title":"A review on exosomes application in clinical trials: perspective, questions, and challenges","volume":"20","author":"Rezaie","year":"2022","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bioadv.2026.214725_bb0715","article-title":"Chemotherapy-elicited exosomal miR-378a-3p and miR-378d to promote breast cancer stemness and chemoresistance via the activation of EZH2\/STAT3 signaling","volume":"39","author":"Zhang","year":"2021","journal-title":"J. Clin. Oncol."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826000233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826000233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:28:14Z","timestamp":1774060094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826000233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":143,"alternative-id":["S2772950826000233"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214725","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanotechnology-driven drug delivery systems for breast cancer: A review","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214725"}}