{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:18:12Z","timestamp":1792729092930,"version":"4.5.0"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PRIN2022_PNRR"],"award-info":[{"award-number":["PRIN2022_PNRR"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universita e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bioadv.2026.214762","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:07:31Z","timestamp":1770278851000},"page":"214762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Thermo-responsive in situ hydrogel enables superior rectal administration and local efficacy of 5-ASA in inflammatory bowel disease"],"prefix":"10.1016","volume":"183","author":[{"given":"Elena","family":"Giuliano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Costagliola di Polidoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Gagliardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Albanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Napolitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Gaetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Zannetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Cosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.214762_bb0005","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10238-025-01558-6","article-title":"Biosimilars versus biological therapy in inflammatory bowel disease: challenges and targeting strategies using drug delivery systems","volume":"25","author":"Aljabri","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.bioadv.2026.214762_bb0010","first-page":"1","article-title":"Application of zein nanoparticles for the treatment of inflammatory bowel diseases","author":"Gagliardi","year":"2025","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.bioadv.2026.214762_bb0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejpb.2021.07.014","article-title":"Mesalazine and inflammatory bowel disease \u2013 from well-established therapies to progress beyond the state of the art","volume":"167","author":"Veloso","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123462","article-title":"Biomaterial-based therapeutic strategies for inflammatory bowel disease","volume":"324","author":"Sun","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.214762_bb0025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00384-024-04748-y","article-title":"Inflammatory bowel disease, colitis, and cancer: unmasking the chronic inflammation link","volume":"39","author":"Shahgoli","year":"2024","journal-title":"Int. J. Color. Dis."},{"key":"10.1016\/j.bioadv.2026.214762_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/nano10122460","article-title":"Inflammatory bowel disease: the emergence of new trends in lifestyle and nanomedicine as the modern tool for pharmacotherapy","volume":"10","author":"Jacob","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.bioadv.2026.214762_bb0035","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijbiomac.2022.12.032","article-title":"Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: a review","volume":"227","author":"Ouyang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.104090","article-title":"Lipid- and polymer-based formulations containing TNF-\u03b1 inhibitors for the treatment of inflammatory bowel diseases","volume":"29","author":"Voci","year":"2024","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bioadv.2026.214762_bb0045","doi-asserted-by":"crossref","first-page":"46090","DOI":"10.1021\/acsami.4c09901","article-title":"Acid-resistant nano-antioxidants based on epigallocatechin gallate alleviate acute intestinal and kidney inflammation","volume":"16","author":"Pan","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.214762_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsps.2023.101910","article-title":"Anti-oxidant and anti-inflammatory potential of different polymer-based mesalamine delayed-release granules in TNBS-induced ulcerative colitis in wistar rats","volume":"32","author":"Ahmed Najar","year":"2024","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.bioadv.2026.214762_bb0055","article-title":"Preparation of MSZ hydrogel and its treatment of colitis","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114722","article-title":"Marine polysaccharides hydrogel with encapsulated mesalazine for the treatment of ulcerative colitis: integrative effects on inflammation, microbiota, and mucosal repair","volume":"253","author":"Xiao","year":"2025","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioadv.2026.214762_bb0065","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.carbpol.2019.02.049","article-title":"Improvement of the therapeutic treatment of inflammatory bowel diseases following rectal administration of mesalazine-loaded chitosan microparticles vs Asamax(\u00ae)","volume":"212","author":"Palma","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.214762_bb0070","article-title":"Alleviating ulcerative colitis via rectal administration: enhancing the therapeutic effects of silk sericin-proanthocyanidins nanoparticles with a Poloxamer thermosensitive in situ gel","volume":"9","author":"Zhang","year":"2025","journal-title":"Int. J. Pharm.: X"},{"key":"10.1016\/j.bioadv.2026.214762_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.158477","article-title":"Self-assembled herbal hydrogel for rectal administration therapy in ulcerative colitis","volume":"503","author":"Lei","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2026.214762_bb0080","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1039\/D3TB02302H","article-title":"Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances","volume":"12","author":"Hu","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioadv.2026.214762_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2024.109736","article-title":"Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis","volume":"35","author":"Yan","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.bioadv.2026.214762_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10030159","article-title":"Mucosal applications of poloxamer 407-based hydrogels: an overview","author":"Giuliano","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.214762_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/mba2.55","article-title":"Recent progress in thermosensitive hydrogels and their applications in drug delivery area","volume":"2","author":"Khan","year":"2023","journal-title":"MedComm \u2013 Biomaterials and Applications"},{"key":"10.1016\/j.bioadv.2026.214762_bb0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.22203\/eCM.v053a07","article-title":"Hydrogel-exosome systems in the treatment of refractory diabetic ulcers: mechanisms, progress, and prospects","volume":"53","year":"2025","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bioadv.2026.214762_bb0105","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2024.2446552","article-title":"Advanced hydrogel material for colorectal cancer treatment","volume":"32","author":"Guo","year":"2025","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bioadv.2026.214762_bb0110","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s11095-006-9104-4","article-title":"A review of poloxamer 407 pharmaceutical and pharmacological characteristics","volume":"23","author":"Dumortier","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bioadv.2026.214762_bb0115","article-title":"Recent advances in drug delivery nanocarriers incorporated in temperature-sensitive Pluronic F-127\u2013a critical review","volume":"72","author":"Jaquilin P J","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/nano10061069","article-title":"Rutin-loaded poloxamer 407-based hydrogels for in situ administration: stability profiles and rheological properties","volume":"10","author":"Giuliano","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.bioadv.2026.214762_bb0125","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3390\/molecules22020246","article-title":"Poloxamer-based thermoreversible gel for topical delivery of emodin: influence of P407 and P188 on solubility of emodin and its application in cellular activity screening","volume":"22","author":"Ban","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bioadv.2026.214762_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2020.112639","article-title":"Gelation behavior, drug solubilization capacity and release kinetics of poloxamer 407 aqueous solutions: the combined effect of copolymer, cosolvent and hydrophobic drug","volume":"303","author":"Djekic","year":"2020","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioadv.2026.214762_bb0135","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1021\/acsabm.4c01452","article-title":"Poloxamer 407-based hydrogels containing rutin increase the in vitro and in vivo wound healing phenomena","volume":"8","author":"Giuliano","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioadv.2026.214762_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.116588","article-title":"Development and characterization of poloxamine 908-hydrogels for potential pharmaceutical applications","volume":"337","author":"Giuliano","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioadv.2026.214762_bb0145","doi-asserted-by":"crossref","first-page":"13494","DOI":"10.1021\/acsami.4c20852","article-title":"All-small-molecule supramolecular hydrogel combining self-delivery and ROS-responsive release for inhibiting tumor growth and postoperative recurrence","volume":"17","author":"Zou","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.214762_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/gels11020101","article-title":"Development and characterization of niaprazine-loaded xanthan gum-based gel for oral administration","volume":"11","author":"Giuliano","year":"2025","journal-title":"Gels"},{"key":"10.1016\/j.bioadv.2026.214762_bb0155","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jconrel.2019.04.011","article-title":"Thermoreversible mucoadhesive polymer-drug dispersion for sustained local delivery of budesonide to treat inflammatory disorders of the GI tract","volume":"303","author":"Antonino","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.214762_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124033","article-title":"Synergism of polysaccharide polymers in antihistamine eye drops: influence on physicochemical properties and in vivo efficacy","volume":"655","author":"Ra\u010di\u0107","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.105125","article-title":"Development and characterization of mucoadhesive-thermoresponsive gels for the treatment of oral mucosa diseases","volume":"142","author":"Pagano","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214762_bb0170","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejpb.2008.04.025","article-title":"A novel poloxamers\/hyaluronic acid in situ forming hydrogel for drug delivery: rheological, mucoadhesive and in vitro release properties","volume":"70","author":"Mayol","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0175","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/jps.10106","article-title":"The use of xanthan gum in an ophthalmic liquid dosage form: rheological characterization of the interaction with mucin","volume":"91","author":"Ceulemans","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214762_bb0180","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0168-3659(02)00273-0","article-title":"Development and in-vitro evaluation of sustained release Poloxamer 407 (P407) gel formulations of ceftiofur","volume":"85","author":"Zhang","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.214762_bb0185","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.colsurfb.2016.09.036","article-title":"In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine","volume":"148","author":"Wang","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.bioadv.2026.214762_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124034","article-title":"DIFUCOSIN: DIclofenac sodium salt loaded FUCOidan-SericIN nanoparticles for the management of chronic inflammatory diseases","volume":"655","author":"Gagliardi","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0195","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jmrt.2022.09.031","article-title":"Preparation and in-vitro characterization of 5-aminosalicylic acid loaded hydrogels for colon specific delivery","volume":"21","author":"Suhail","year":"2022","journal-title":"J. Mater. Res. Technol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0200","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/03639045.2017.1373803","article-title":"A novel vehicle for local protein delivery to the inner ear: injectable and biodegradable thermosensitive hydrogel loaded with PLGA nanoparticles","volume":"44","author":"Dai","year":"2018","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0205","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijbiomac.2020.02.002","article-title":"An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded nanoparticles","volume":"151","author":"Fattahpour","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106843","article-title":"Thermo-activated in situ rectal gel preparation for ibuprofen using eutectic mixture","volume":"200","author":"Firoz","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214762_bb0215","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1208\/s12249-017-0839-5","article-title":"Thermosensitive in situ gel based on solid dispersion for rectal delivery of ibuprofen","volume":"19","author":"Liu","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.bioadv.2026.214762_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132071","article-title":"Rutin-loaded zein gel as a green biocompatible formulation for wound healing application","volume":"269","author":"Gagliardi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/mame.202400341","article-title":"Temperature sensitive Pluronic F127-based gels incorporating natural therapeutic agents","volume":"310","author":"Lupu","year":"2025","journal-title":"Macromol. Mater. Eng."},{"key":"10.1016\/j.bioadv.2026.214762_bb0230","doi-asserted-by":"crossref","DOI":"10.2967\/jnumed.111.096503","article-title":"3\u2032-deoxy-3\u2032-<sup>18<\/sup>F-fluorothymidine PET\/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-x<sub>L<\/sub> inhibitors in non\u2013small cell lung cancer","author":"Zannetti","year":"2012","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bioadv.2026.214762_bb0235","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1158\/1078-0432.CCR-08-0374","article-title":"Gefitinib induction of in vivo detectable signals by Bcl-2\/Bcl-xL modulation of inositol trisphosphate receptor type 3","volume":"14","author":"Zannetti","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bioadv.2026.214762_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14102225","article-title":"Aptamer-functionalized nanoparticles mediate PD-L1 siRNA delivery for effective gene silencing in triple-negative breast cancer cells","volume":"14","author":"Camorani","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.214762_bb0245","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s44164-022-00035-8","article-title":"Inflammatory bowel disease addressed by Caco-2 and monocyte-derived macrophages: an opportunity for an in vitro drug screening assay","volume":"1","author":"Schnur","year":"2022","journal-title":"In Vitro Models"},{"key":"10.1016\/j.bioadv.2026.214762_bb0250","article-title":"Improvement of oral bioavailability of curcumin upon microencapsulation with methacrylic copolymers","volume":"7-2016","author":"Paolino","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0255","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12964-025-02073-7","article-title":"A novel therapeutic approach targeting PD-L1 in HNSCC and bone marrow-derived mesenchymal stem cells hampers pro-metastatic features in vitro: perspectives for blocking tumor-stroma communication and signaling","volume":"23","author":"Ferrara","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bioadv.2026.214762_bb0260","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-90840-4","article-title":"Exploring the effects of paclitaxel-loaded zein nanoparticles on human ovarian carcinoma cells","volume":"15","author":"Scicchitano","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.214762_bb0265","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tiv.2017.08.011","article-title":"Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state","volume":"45","author":"K\u00e4mpfer","year":"2017","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.bioadv.2026.214762_bb0270","doi-asserted-by":"crossref","first-page":"16297","DOI":"10.1021\/acsnano.4c05544","article-title":"Mucoadhesive mesalamine prodrug nanoassemblies to target intestinal macrophages for the treatment of inflammatory bowel disease","volume":"18","author":"Park","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2026.214762_bb0275","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.3390\/cancers12071952","article-title":"New CXCR4 antagonist peptide R (pep R) improves standard therapy in colorectal cancer","volume":"12","author":"D\u2019Alterio","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bioadv.2026.214762_bb0280","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3390\/pharmaceutics12090820","article-title":"Rheology by design: a regulatory tutorial for analytical method validation","volume":"12","author":"Sim\u00f5es","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.214762_bb0285","article-title":"Poloxamer-based drug delivery systems: frontiers for treatment of solid tumors","volume":"32","author":"Pourbakhsh","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioadv.2026.214762_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11030127","article-title":"Evaluation of a methylcellulose and hyaluronic acid hydrogel as a vehicle for rectal delivery of biologics","volume":"11","author":"Aprodu","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.214762_bb0295","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0928-0987(02)00166-5","article-title":"Rheological characterization of Poloxamer 407 lidocaine hydrochloride gels","volume":"17","author":"Ricci","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214762_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/gels7040255","article-title":"Relationship between structure and rheology of hydrogels for various applications","volume":"7","author":"Stojkov","year":"2021","journal-title":"Gels"},{"key":"10.1016\/j.bioadv.2026.214762_bb0305","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1590\/S0100-40422013000800008","article-title":"Formulation and characterization of poloxamer 407\u00ae: thermoreversible gel containing polymeric microparticles and hyaluronic acid","volume":"36","author":"Pereira","year":"2013","journal-title":"Quim Nova"},{"key":"10.1016\/j.bioadv.2026.214762_bb0310","article-title":"Development and evaluation of regorafenib loaded liquid suppository for rectal delivery: in vitro, in vivo analyses","volume":"91","author":"Saleem","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0315","doi-asserted-by":"crossref","DOI":"10.1002\/admi.202200211","article-title":"Recent advances in mucoadhesive interface materials, mucoadhesion characterization, and technologies","volume":"9","author":"Bayer","year":"2022","journal-title":"Adv. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.214762_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16101296","article-title":"In vitro mucoadhesive features of gliadin nanoparticles containing thiamine hydrochloride","volume":"16","author":"Voci","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.214762_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110252","article-title":"New tools to design smart thermosensitive hydrogels for protein rectal delivery in IBD","volume":"106","author":"Garcia-del Rio","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2026.214762_bb0330","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/03639045.2018.1534858","article-title":"Tolmetin sodium-loaded thermosensitive mucoadhesive liquid suppositories for rectal delivery; strategy to overcome oral delivery drawbacks","volume":"45","author":"Akl","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0335","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1208\/s12249-009-9261-y","article-title":"In vitro and in vivo characteristics of a thermogelling rectal delivery system of etodolac","volume":"10","author":"Barakat","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.bioadv.2026.214762_bb0340","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1039\/D1TB00499A","article-title":"Thermosensitive polymer hydrogel as a physical shield on colonic mucosa for colitis treatment","volume":"9","author":"Guo","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioadv.2026.214762_bb0345","article-title":"In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats","volume":"1","author":"Van Hemelryck","year":"2019","journal-title":"Int. J. Pharm.: X"},{"key":"10.1016\/j.bioadv.2026.214762_bb0350","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/08977190903159938","article-title":"Biodegradable thermosensitive injectable PEG-PCL-PEG hydrogel for bFGF antigen delivery to improve humoral immunity","volume":"27","author":"Gong","year":"2009","journal-title":"Growth Factors"},{"key":"10.1016\/j.bioadv.2026.214762_bb0355","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3109\/08977194.2011.624517","article-title":"A novel vaccine delivery system: biodegradable nanoparticles in thermosensitive hydrogel","volume":"29","author":"Wu","year":"2011","journal-title":"Growth Factors"},{"key":"10.1016\/j.bioadv.2026.214762_bb0360","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijpharm.2012.03.054","article-title":"Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nimesulide","volume":"430","author":"Yuan","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0365","article-title":"Stable liposome\u2013hydrogel composites as multistage drug delivery systems","volume":"115","author":"Giuliano","year":"2026","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0370","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijpharm.2018.12.074","article-title":"Advances in orally-delivered pH-sensitive nanocarrier systems; an optimistic approach for the treatment of inflammatory bowel disease","volume":"558","author":"Zeeshan","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0375","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-5173(99)00225-2","article-title":"Effect of additives on the physicochemical properties of liquid suppository bases","volume":"190","author":"Choi","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0380","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0378-5173(97)00386-4","article-title":"Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository","volume":"165","author":"Choi","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105231","article-title":"Platelet lysate-loaded PLGA nanoparticles in a thermo-responsive hydrogel intended for the treatment of wounds","volume":"146","author":"Bernal-Ch\u00e1vez","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214762_bb0390","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/10717540500316003","article-title":"Thermally reversible in situ gelling carbamazepine liquid suppository","volume":"13","author":"El-Kamel","year":"2006","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bioadv.2026.214762_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13030336","article-title":"Mucoadhesive in situ rectal gel loaded with rifampicin: strategy to improve bioavailability and alleviate liver toxicity","volume":"13","author":"Al-Joufi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.214762_bb0400","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-5173(97)00385-2","article-title":"In situ gelling and mucoadhesive liquid suppository containing acetaminophen: enhanced bioavailability","volume":"165","author":"Choi","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0405","first-page":"257","article-title":"Study of drug-drug and drug-food interactions of mesalazine through FTIR and DSC, Dhaka Univ","volume":"18","author":"Alam","year":"2019","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bioadv.2026.214762_bb0410","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.3390\/pharmaceutics14122830","article-title":"Nanoparticles obtained from zein for encapsulation of mesalazine","volume":"14","author":"Lima","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.214762_bb0415","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1007\/s10973-021-10684-8","article-title":"Reconstitution as an alternative method for 5-aminosalicylic acid intercalation in layered double hydroxide for drug delivery","volume":"147","author":"Pontes-Neto","year":"2022","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.bioadv.2026.214762_bb0420","article-title":"Enhancing solubilization of Nebivolol hydrochloride through tuning pluronic F-127 with ionic surfactants: an experimental and theoretical investigation","author":"Raj","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bioadv.2026.214762_bb0425","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s10787-021-00856-1","article-title":"A review of the biological and pharmacological activities of mesalazine or 5-aminosalicylic acid (5-ASA): an anti-ulcer and anti-oxidant drug","volume":"29","author":"Beiranvand","year":"2021","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bioadv.2026.214762_bb0430","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202301391","article-title":"Recent advances in cell-based in vitro models to recreate human intestinal inflammation","volume":"10","author":"Macedo","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2026.214762_bb0435","doi-asserted-by":"crossref","first-page":"84","DOI":"10.22203\/eCM.v050a05","article-title":"Intestinal stem cells (ISCs): ISCs-derived organoids for disease modeling and therapy","volume":"50","year":"2025","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bioadv.2026.214762_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119846","article-title":"Temperature-sensitive hydrogel for rectal perfusion improved the therapeutic effect of Kangfuxin liquid on DSS-induced ulcerative colitis mice: the inflammation alleviation and the colonic mucosal barriers repair","volume":"589","author":"Xue","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0445","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.acthis.2013.04.010","article-title":"Topical pluronic F-127 gel application enhances cutaneous wound healing in rats","volume":"116","author":"Kant","year":"2014","journal-title":"Acta Histochem."},{"key":"10.1016\/j.bioadv.2026.214762_bb0450","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1093\/ibd\/izaa213","article-title":"Toward molecular imaging of intestinal pathology","volume":"26","author":"Le Fur","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.bioadv.2026.214762_bb0455","first-page":"15.25.1","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.bioadv.2026.214762_bb0460","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/jsre.2001.6223","article-title":"Role of appendix and spleen in experimental colitis","volume":"101","author":"Krieglstein","year":"2001","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bioadv.2026.214762_bb0465","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0378-5173(03)00362-4","article-title":"Effect of sodium chloride on the release, absorption and safety of diclofenac sodium delivered by poloxamer gel","volume":"263","author":"Park","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214762_bb0470","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0168-3659(98)00189-8","article-title":"Increased bioavailability of propranolol in rats by retaining thermally gelling liquid suppositories in the rectum","volume":"59","author":"Ryu","year":"1999","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.214762_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.130464","article-title":"Improving drug utilization platform with injectable mucoadhesive hydrogel for treating ulcerative colitis","volume":"424","author":"Zhao","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2026.214762_bb0480","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.1021\/acsbiomaterials.1c00792","article-title":"Self-cross-linked hydrogel of cysteamine-grafted \u03b3-polyglutamic acid stabilized tripeptide KPV for alleviating TNBS-induced ulcerative colitis in rats","volume":"7","author":"Sun","year":"2021","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.214762_bb0485","series-title":"Evaluation of the mesalazine-loaded nanoparticles-embedded BSA hydrogels for the ulcerative colitis treatment","author":"Guler","year":"2024"},{"key":"10.1016\/j.bioadv.2026.214762_bb0490","doi-asserted-by":"crossref","first-page":"14126","DOI":"10.1039\/D5RA00216H","article-title":"Thermo-responsive methylcellulose\/hyaluronic acid\u2013mesalamine hydrogel in targeted drug delivery for ulcerative colitis","volume":"15","author":"Kuo","year":"2025","journal-title":"RSC Adv."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826000609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826000609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T23:01:49Z","timestamp":1772924509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826000609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":98,"alternative-id":["S2772950826000609"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214762","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thermo-responsive in situ hydrogel enables superior rectal administration and local efficacy of 5-ASA in inflammatory bowel disease","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214762","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214762"}}