{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:00:58Z","timestamp":1789189258014,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bioadv.2026.214865","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:20:40Z","timestamp":1775136040000},"page":"214865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A magnolol\/BMSC-integrated collagen hydrogel with dual anti-inflammatory and regenerative functions for corneal repair"],"prefix":"10.1016","volume":"185","author":[{"given":"Xiaojie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longbao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanming","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bioadv.2026.214865_bb0005","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202402224","article-title":"The human cornea: unraveling its structural, chemical, and biochemical complexities","volume":"22","author":"Raut","year":"2025","journal-title":"Chem. Biodivers."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214865_bb0010","article-title":"Tissue adhesives for wound closure","volume":"2","author":"Kong","year":"2023","journal-title":"Smart Med."},{"key":"10.1016\/j.bioadv.2026.214865_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114454","article-title":"Exosomes derived from adipose mesenchymal stem cells promote corneal injury repair and inhibit the formation of scars by anti-apoptosis","volume":"247","author":"Ma","year":"2025","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"11","key":"10.1016\/j.bioadv.2026.214865_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1762","article-title":"Neutrophil pyroptosis regulates corneal wound healing and post-injury neovascularisation","volume":"14","author":"Chen","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bioadv.2026.214865_bb0025","article-title":"Current microfluidic platforms for reverse engineering of cornea","volume":"20","author":"Li","year":"2023","journal-title":"Mater. Today Bio"},{"issue":"9","key":"10.1016\/j.bioadv.2026.214865_bb0030","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.4103\/IJO.IJO_1942_23","article-title":"Corneal blindness and eye banking: current strategies and best practices","volume":"71","author":"Anitha","year":"2023","journal-title":"Indian J. Ophthalmol."},{"issue":"9","key":"10.1016\/j.bioadv.2026.214865_bb0035","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.3390\/cells12091280","article-title":"Corneal regeneration using gene therapy approaches","volume":"12","author":"Sarkar","year":"2023","journal-title":"Cells"},{"issue":"23","key":"10.1016\/j.bioadv.2026.214865_bb0040","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1111\/bph.14024","article-title":"Principles of pharmacology in the eye","volume":"174","author":"Awwad","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.bioadv.2026.214865_bb0045","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1021\/acs.molpharmaceut.3c00598","article-title":"Role of polymeric micelles in ocular drug delivery: an overview of decades of research","volume":"20","author":"Binkhathlan","year":"2023","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.bioadv.2026.214865_bb0050","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1089\/jop.2023.0161","article-title":"Novel drug delivery Systems for the Management of fungal keratitis","volume":"40","author":"Ruan","year":"2024","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.bioadv.2026.214865_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101090","article-title":"Corneal stromal repair and regeneration","volume":"91","author":"Mohan","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bioadv.2026.214865_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107709","article-title":"Corneal injury: clinical and molecular aspects","volume":"186","author":"Barrientez","year":"2019","journal-title":"Exp. Eye Res."},{"issue":"16","key":"10.1016\/j.bioadv.2026.214865_bb0065","doi-asserted-by":"crossref","first-page":"12615","DOI":"10.3390\/ijms241612615","article-title":"The role of sensory innervation in homeostatic and injury-induced corneal epithelial renewal","volume":"24","author":"Feinberg","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"51","key":"10.1016\/j.bioadv.2026.214865_bb0070","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adt1643","article-title":"Biologically inspired bioactive hydrogels for scarless corneal repair","volume":"10","author":"Huang","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioadv.2026.214865_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115206","article-title":"Corneal regeneration strategies: from stem cell therapy to tissue engineered stem cell scaffolds","volume":"165","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.bioadv.2026.214865_bb0080","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1016\/j.actbio.2014.05.010","article-title":"Banded structures in collagen vitrigels for corneal injury repair","volume":"10","author":"Xia","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.214865_bb0085","first-page":"640","article-title":"MiRNA 24-3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogels for corneal epithelial healing","volume":"25","author":"Sun","year":"2023","journal-title":"Bioact. Mater."},{"issue":"5","key":"10.1016\/j.bioadv.2026.214865_bb0090","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1021\/acsbiomaterials.2c00050","article-title":"Novel application of photo-crosslinked Urocanic-acid-modified chitosan in corneal wounds","volume":"8","author":"Lee","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"7","key":"10.1016\/j.bioadv.2026.214865_bb0095","doi-asserted-by":"crossref","DOI":"10.1177\/03000605231190473","article-title":"Application of biomaterials and nanotechnology in corneal tissue engineering","volume":"51","author":"Soleimani","year":"2023","journal-title":"J. Int. Med. Res."},{"issue":"11","key":"10.1016\/j.bioadv.2026.214865_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/mi12111336","article-title":"Tissue engineering meets nanotechnology: molecular mechanism modulations in cornea regeneration","volume":"12","author":"Mijanovi\u0107","year":"2021","journal-title":"Micromachines"},{"key":"10.1016\/j.bioadv.2026.214865_bb0105","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jtos.2025.03.004","article-title":"Bringing ophthalmology into the scientific world: novel nanoparticle-based strategies for ocular drug delivery","volume":"37","author":"Abbasi","year":"2025","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bioadv.2026.214865_bb0110","doi-asserted-by":"crossref","first-page":"0485","DOI":"10.34133\/research.0485","article-title":"Bioinspired wet adhesive Proanthocyanidins microneedles for ocular wound healing","volume":"7","author":"Kong","year":"2024","journal-title":"Research"},{"issue":"16","key":"10.1016\/j.bioadv.2026.214865_bb0115","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1055\/a-0642-1966","article-title":"Safety and toxicology of Magnolol and Honokiol","volume":"84","author":"Sarrica","year":"2018","journal-title":"Planta Med."},{"key":"10.1016\/j.bioadv.2026.214865_bb0120","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.molimm.2018.11.008","article-title":"Magnolol attenuates the inflammation and enhances phagocytosis through the activation of MAPK, NF-\u03baB signal pathways in vitro and in vivo","volume":"105","author":"Chen","year":"2019","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214865_bb0125","first-page":"1847130","article-title":"Insights on the multifunctional activities of Magnolol","volume":"2019","author":"Zhang","year":"2019","journal-title":"Biomed. Res. Int."},{"issue":"3","key":"10.1016\/j.bioadv.2026.214865_bb0130","doi-asserted-by":"crossref","DOI":"10.1088\/2043-6262\/ace3b9","article-title":"Stability of soluble honokiol loaded PLGA-PEG nanoparticles under normal and accelerated-aging conditions","volume":"14","author":"Minh","year":"2023","journal-title":"Adv. Nat. Sci. Nanosci. Nanotechnol."},{"issue":"23","key":"10.1016\/j.bioadv.2026.214865_bb0135","doi-asserted-by":"crossref","first-page":"24055","DOI":"10.1021\/acsnano.3c09034","article-title":"A versatile hydrogel with antibacterial and sequential drug-releasing capability for the programmable healing of infectious keratitis","volume":"17","author":"Meng","year":"2023","journal-title":"ACS Nano"},{"issue":"23","key":"10.1016\/j.bioadv.2026.214865_bb0140","doi-asserted-by":"crossref","first-page":"14933","DOI":"10.3390\/ijms232314933","article-title":"Innate immune system activation, inflammation and corneal wound healing","volume":"23","author":"Fortingo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bioadv.2026.214865_bb0145","first-page":"1917","article-title":"Prevalence and antibiotic susceptibility of pathogenic bacteria associated with ocular infections in adult patients","volume":"77","author":"Kareem Rhumaid","year":"2022","journal-title":"Arch. Razi Inst."},{"issue":"2","key":"10.1016\/j.bioadv.2026.214865_bb0150","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jfma.2020.09.002","article-title":"In vitro antimicrobial and antipro-inflammation potential of honokiol and magnolol against oral pathogens and macrophages","volume":"120","author":"Chiu","year":"2021","journal-title":"J. Formos. Med. Assoc."},{"issue":"5","key":"10.1016\/j.bioadv.2026.214865_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202513261","article-title":"A customized Janus hydrogel with both anti-fibrosis and anti-infection properties for suture-free and care-free corneal injury repair","volume":"36","author":"Qie","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"24","key":"10.1016\/j.bioadv.2026.214865_bb0160","doi-asserted-by":"crossref","first-page":"2113383","DOI":"10.1002\/adfm.202113383","article-title":"A light-curable and tunable extracellular matrix hydrogel for in situ suture-free corneal repair","volume":"32","author":"Yazdanpanah","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"4","key":"10.1016\/j.bioadv.2026.214865_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202517275","article-title":"Bioinspired Design of a wet-Adhesive Cornea Glue Based on recombinant human protein networks","volume":"36","author":"Resch","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"4","key":"10.1016\/j.bioadv.2026.214865_bb0170","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1634\/stemcells.2007-0737","article-title":"The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury","volume":"26","author":"Oh","year":"2008","journal-title":"Stem Cells"},{"issue":"29","key":"10.1016\/j.bioadv.2026.214865_bb0175","doi-asserted-by":"crossref","first-page":"26500","DOI":"10.1021\/acsnano.5c04606","article-title":"Human corneal Lenticules decorated with mesenchymal-stem-cells-encapsulated microneedles for cornea stroma regeneration","volume":"19","author":"Hu","year":"2025","journal-title":"ACS Nano"}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826001639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826001639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:01:41Z","timestamp":1780430501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826001639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"alternative-id":["S2772950826001639"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214865","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A magnolol\/BMSC-integrated collagen hydrogel with dual anti-inflammatory and regenerative functions for corneal repair","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214865","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214865"}}