{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:04:59Z","timestamp":1780434299178,"version":"3.54.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bioadv.2026.214895","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T15:13:25Z","timestamp":1776698005000},"page":"214895","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Plasma-sprayed 45S5-bioactive glass coating provides superior anti-biofilm activity compared to hydroxyapatite coating while maintaining host cell cytocompatibility and antibacterial immune activation"],"prefix":"10.1016","volume":"185","author":[{"given":"Elisabeth","family":"Seebach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Philippe","family":"Kretzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Bormann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Gibmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Va\u00dfen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Kunisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Renkawitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Westhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.214895_bb0005","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.K.01417","article-title":"Management of periprosthetic joint infection: the current knowledge: AAOS exhibit selection","volume":"94","author":"Parvizi","year":"2012","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bioadv.2026.214895_bb0010","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.2106\/JBJS.L.00789","article-title":"Periprosthetic joint infection increases the risk of one-year mortality","volume":"95","author":"Zmistowski","year":"2013","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bioadv.2026.214895_bb0015","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1186\/s13018-021-02766-y","article-title":"Poor outcomes of revision total knee arthroplasty in patients with septic loosening compared to patients with aseptic loosening","volume":"16","author":"Baek","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bioadv.2026.214895_bb0020","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1007\/s11999-010-1251-6","article-title":"Revision hip arthroplasty: infection is the most common cause of failure","volume":"468","author":"Jafari","year":"2010","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bioadv.2026.214895_bb0025","series-title":"The German Arthroplasty Registry (EPRD): Annual Report","author":"Grimberg","year":"2023"},{"key":"10.1016\/j.bioadv.2026.214895_bb0030","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/1471-2474-13-251","article-title":"Risk factors for revision of primary total hip arthroplasty: a systematic review","volume":"13","author":"Prokopetz","year":"2012","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bioadv.2026.214895_bb0035","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1016\/j.otsr.2015.05.012","article-title":"Patient-specific risk factors for infection in arthroplasty procedure","volume":"102","author":"Marmor","year":"2016","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"10.1016\/j.bioadv.2026.214895_bb0040","article-title":"Outcomes and risk factors in prosthetic joint infections by multidrug-resistant gram-negative bacteria: a retrospective cohort study","volume":"10","author":"da Silva","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.bioadv.2026.214895_bb0045","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1302\/0301-620X.93B11.27321","article-title":"The extent of the bone defect affects the outcome of femoral reconstruction in revision surgery with impacted bone grafting: a five- to 17-year follow-up study","volume":"93","author":"Garcia-Cimbrelo","year":"2011","journal-title":"J. Bone Joint Surg. (Br.)"},{"key":"10.1016\/j.bioadv.2026.214895_bb0050","first-page":"2569","article-title":"Antibacterial metals and alloys for potential biomedical implants","volume":"6","author":"Zhang","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.214895_bb0055","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3390\/coatings12081125","article-title":"Surface bio-functionalization of anti-bacterial titanium implants: a review","volume":"12","author":"Sui","year":"2022","journal-title":"Coatings"},{"key":"10.1016\/j.bioadv.2026.214895_bb0060","article-title":"Antibacterial coatings on orthopedic implants","volume":"19","author":"Chen","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioadv.2026.214895_bb0065","first-page":"261","article-title":"Bioactive glass coatings on metallic implants for biomedical applications","volume":"4","author":"Oliver","year":"2019","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.214895_bb0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4236\/njgc.2013.32011","article-title":"Chronology of bioactive glass development and clinical applications","volume":"3","author":"Hench","year":"2013","journal-title":"New J. Glass Ceram."},{"key":"10.1016\/j.bioadv.2026.214895_bb0075","first-page":"1","article-title":"Bioactive glass: mechanisms of bone bonding","volume":"91","author":"Greenspan","year":"1999","journal-title":"Tandl\u00e4kartidningen \u01fark"},{"key":"10.1016\/j.bioadv.2026.214895_bb0080","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D","article-title":"Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution","volume":"55","author":"Xynos","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bioadv.2026.214895_bb0085","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s10856-006-0432-z","article-title":"The story of Bioglass","volume":"17","author":"Hench","year":"2006","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioadv.2026.214895_bb0090","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1016\/j.actbio.2012.08.023","article-title":"Review of bioactive glass: from Hench to hybrids","volume":"9","author":"Jones","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.214895_bb0095","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10856-008-3564-5","article-title":"Study on antibacterial effect of 45S5 Bioglass","volume":"20","author":"Hu","year":"2009","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioadv.2026.214895_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213521","article-title":"A comparative in vitro and in vivo analysis of the biological properties of the 45S5-, 1393-, and 0106-B1-bioactive glass compositions using human bone marrow-derived stromal cells and a rodent critical size femoral defect model","volume":"153","author":"Kunisch","year":"2023","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.bioadv.2026.214895_bb0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.actbio.2018.05.019","article-title":"Tackling bioactive glass excessive in vitro bioreactivity: preconditioning approaches for cell culture tests","volume":"75","author":"Ciraldo","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.214895_bb0110","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1111\/jace.17124","article-title":"New insights into the crystallization process of sol-gel\u2013derived 45S5 bioactive glass","volume":"103","author":"Nawaz","year":"2020","journal-title":"J. Am. Ceram. Soc."},{"key":"10.1016\/j.bioadv.2026.214895_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.109895","article-title":"Mechanical properties of bioactive glasses, ceramics, glass-ceramics and composites: state-of-the-art review and future challenges","volume":"104","author":"Kaur","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2026.214895_bb0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13018-023-04377-1","article-title":"Clinical and radiographic outcomes of long monoblock, hydroxyapatite-coated stem in revision hip arthroplasty with extended trochanteric osteotomy: a multicenter study","volume":"19","author":"Xin","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bioadv.2026.214895_bb0125","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1503\/cjs.002318","article-title":"Use of the Corail stem for revision total hip arthroplasty: evaluation of clinical outcomes and cost","volume":"62","author":"Wood","year":"2019","journal-title":"Can. J. Surg."},{"key":"10.1016\/j.bioadv.2026.214895_bb0130","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0257-8972(95)02463-8","article-title":"Characteristics of plasma-sprayed bioactive glass coatings on Ti-6A1-4V alloy: an in vitro study","volume":"79","author":"Lee","year":"1996","journal-title":"Surf. Coat. Technol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0135","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.1007\/s10853-014-8519-2","article-title":"45S5 bioactive glass coatings by atmospheric plasma spraying obtained from feedstocks prepared by different routes","volume":"49","author":"L\u00f3pez Calvo","year":"2014","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.bioadv.2026.214895_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/cells8060633","article-title":"Pooling of patient-derived mesenchymal stromal cells reduces inter-individual confounder-associated variation without negative impact on cell viability, proliferation and osteogenic differentiation","volume":"8","author":"Widholz","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bioadv.2026.214895_bb0145","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0150","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1128\/jcm.22.6.996-1006.1985","article-title":"Adherence of coagulase-negative Staphylococci to plastic tissue culture plates: a quantitative model for the adherence of Staphylococci to medical devices","volume":"22","author":"Christensen","year":"1985","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0155","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in immunoregulation and therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioadv.2026.214895_bb0160","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148548","article-title":"The role of itaconate in host defense and inflammation","volume":"132","author":"Peace","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioadv.2026.214895_bb0165","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12866-022-02617-8","article-title":"Comparison of antibacterial and antibiofilm activity of bioactive glass compounds S53P4 and 45S5","volume":"22","author":"Zhou","year":"2022","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0170","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3390\/ma11020326","article-title":"Recent evidence on bioactive glass antimicrobial and antibiofilm activity: a mini-review","volume":"11","author":"Drago","year":"2018","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.bioadv.2026.214895_bb0175","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s11666-019-00857-1","article-title":"Beyond traditional coatings: a review on thermal-sprayed functional and smart coatings","volume":"28","author":"Tejero-Martin","year":"2019","journal-title":"J. Therm. Spray Technol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.b.35577","article-title":"Bioactive glasses as alternatives to hydroxyapatite for bone implant coatings: a comparative study","volume":"113","author":"Garrido","year":"2025","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.bioadv.2026.214895_bb0185","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ad2210","article-title":"A comparative analysis of the cytocompatibility, protein adsorption, osteogenic and angiogenic properties of the 45S5- and S53P4-bioactive glass compositions","volume":"19","author":"Westhauser","year":"2024","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.bioadv.2026.214895_bb0190","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/jbm.a.36846","article-title":"Primary osteoblasts, osteoblast precursor cells or osteoblast-like cell lines: which human cell types are (most) suitable for characterizing 45S5-bioactive glass?","volume":"108","author":"Wilkesmann","year":"2020","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bioadv.2026.214895_bb0195","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/jbm.a.35238","article-title":"Osteogenic differentiation of umbilical cord and adipose derived stem cells onto highly porous 45S5 Bioglass(R)-based scaffolds","volume":"103","author":"Detsch","year":"2015","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bioadv.2026.214895_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.109781","article-title":"Bioglass 45S5: structural characterization of short range order and analysis of biocompatibility with adipose-derived mesenchymal stromal cells in vitro and in vivo","volume":"103","author":"Rodrigues","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bioadv.2026.214895_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2016.00041","article-title":"Human mesenchymal stem cell morphology and migration on microtextured titanium","volume":"4","author":"Banik","year":"2016","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0210","first-page":"249","article-title":"Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium","volume":"4","author":"Long","year":"2019","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.214895_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114489","article-title":"Antibacterial and osteogenic gain strategy on titanium surfaces for preventing implant-related infections","volume":"249","author":"Osman","year":"2025","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioadv.2026.214895_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/coatings12091317","article-title":"Plasma-sprayed hydroxyapatite coatings and their biological properties","volume":"12","author":"Kowalski","year":"2022","journal-title":"Coatings"},{"key":"10.1016\/j.bioadv.2026.214895_bb0225","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jor.22463","article-title":"Efficacy of antibacterial bioactive glass S53P4 against S. aureus biofilms grown on titanium discs in vitro","volume":"32","author":"Coraca-Huber","year":"2014","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bioadv.2026.214895_bb0230","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/jac\/dkv327","article-title":"Antibiofilm agents against MDR bacterial strains: is bioactive glass BAG-S53P4 also effective?","volume":"71","author":"Bortolin","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bioadv.2026.214895_bb0235","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2217\/fmb.14.20","article-title":"Antibiofilm activity of bioactive glass S53P4","volume":"9","author":"Drago","year":"2014","journal-title":"Future Microbiol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0240","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/11\/1\/015006","article-title":"The influence of pH and fluid dynamics on the antibacterial efficacy of 45S5 Bioglass","volume":"11","author":"Begum","year":"2016","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.bioadv.2026.214895_bb0245","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41579-020-0414-z","article-title":"Mechano-bactericidal actions of nanostructured surfaces","volume":"19","author":"Linklater","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0250","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jcis.2008.11.025","article-title":"Mobile and immobile adhesion of staphylococcal strains to hydrophilic and hydrophobic surfaces","volume":"331","author":"Boks","year":"2009","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.bioadv.2026.214895_bb0255","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.resmic.2005.01.007","article-title":"Quantitative analysis of adhesion and biofilm formation on hydrophilic and hydrophobic surfaces of clinical isolates of Staphylococcus epidermidis","volume":"156","author":"Cerca","year":"2005","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0260","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1600-0463.2012.02900.x","article-title":"Effect of alkaline pH on staphylococcal biofilm formation","volume":"120","author":"Nostro","year":"2012","journal-title":"APMIS"},{"key":"10.1016\/j.bioadv.2026.214895_bb0265","article-title":"Reduced sodium portions favor osteogenic properties and cytocompatibility of 45S5-based bioactive glass particles","volume":"8","author":"Tsitlakidis","year":"2023","journal-title":"Biomimetics (Basel)"},{"key":"10.1016\/j.bioadv.2026.214895_bb0270","article-title":"Bioactive manganese-decorated titanium implants for osteoporotic bone regeneration","volume":"24","author":"Wang","year":"2024","journal-title":"Mater. Today Adv."},{"key":"10.1016\/j.bioadv.2026.214895_bb0275","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jbm.a.30262","article-title":"Effect of particulate bioactive glasses on human macrophages and monocytes in vitro","volume":"73","author":"Day","year":"2005","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bioadv.2026.214895_bb0280","doi-asserted-by":"crossref","DOI":"10.1007\/s10856-025-06861-y","article-title":"Unraveling the immunomodulatory and metabolic effects of bioactive glass S53P4 on macrophages in vitro","volume":"36","author":"Kajander","year":"2025","journal-title":"J. Mater. Sci.-Mater. Med."},{"key":"10.1016\/j.bioadv.2026.214895_bb0285","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1007\/s10753-023-01824-3","article-title":"Bacterial and metabolic factors of staphylococcal planktonic and biofilm environments differentially regulate macrophage immune activation","volume":"46","author":"Seebach","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.bioadv.2026.214895_bb0290","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.4049\/jimmunol.181.6.3733","article-title":"Macrophage polarization in bacterial infections","volume":"181","author":"Benoit","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.30579\/mbse.2019.2.1.1","article-title":"M1 and M2 polarization of macrophages: a mini-review","volume":"2","author":"Lee","year":"2019","journal-title":"Med. Biol. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.214895_bb0300","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.3389\/fimmu.2019.01724","article-title":"Chronic implant-related bone infections-can immune modulation be a therapeutic strategy?","volume":"10","author":"Seebach","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioadv.2026.214895_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008354","article-title":"Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance","volume":"16","author":"Yamada","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bioadv.2026.214895_bb0310","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.5435\/JAAOS-D-16-00636","article-title":"Staphylococcal biofilms and immune polarization during prosthetic joint infection","volume":"25","author":"Gries","year":"2017","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.bioadv.2026.214895_bb0315","doi-asserted-by":"crossref","first-page":"217772","DOI":"10.1016\/j.canlet.2025.217772","article-title":"Macrophage polarization in cancer and beyond: from inflammatory signaling pathways to potential therapeutic strategies","volume":"625","author":"Bai","year":"2025","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bioadv.2026.214895_bb0320","article-title":"Advances in the role of STAT3 in macrophage polarization","volume":"14 - 2023","author":"Xia","year":"2023","journal-title":"Front. Immunol."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826001937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826001937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:06:41Z","timestamp":1780430801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826001937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":64,"alternative-id":["S2772950826001937"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214895","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma-sprayed 45S5-bioactive glass coating provides superior anti-biofilm activity compared to hydroxyapatite coating while maintaining host cell cytocompatibility and antibacterial immune activation","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214895","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"214895"}}