{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:06:53Z","timestamp":1786115213082,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473371"],"award-info":[{"award-number":["82473371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405020"],"award-info":[{"award-number":["82405020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060780"],"award-info":[{"award-number":["82060780"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["021093002886"],"award-info":[{"award-number":["021093002886"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["Z2023063"],"award-info":[{"award-number":["Z2023063"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bioadv.2026.214965","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:22:34Z","timestamp":1779376954000},"page":"214965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A novel peptide from Periplaneta americana: Development of a long-acting formulation for ulcerative colitis therapy"],"prefix":"10.1016","volume":"187","author":[{"given":"Tingmei","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bioadv.2026.214965_bb0005","first-page":"1","article-title":"Dysregulated programmed cell death of intestinal epithelial cells in ulcerative colitis: molecular mechanisms and novel therapeutic interventions (Review)","volume":"56","author":"Wu","year":"2025","journal-title":"Int. J. Mol. Med."},{"issue":"10","key":"10.1016\/j.bioadv.2026.214965_bb0010","doi-asserted-by":"crossref","DOI":"10.1172\/JCI192640","article-title":"Promoting mucosal healing by targeting TMEM219-dependent intestinal epithelial stem cell defects in inflammatory bowel disease","volume":"135","author":"Schlegel","year":"2025","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214965_bb0015","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20204005","article-title":"Revealing mechanism of Caulis Sargentodoxae for the treatment of ulcerative colitis based on network pharmacology approach","volume":"41","author":"Liu","year":"2021","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bioadv.2026.214965_bb0020","article-title":"Natural-Derived Polysaccharides From Plants, Mushrooms, and Seaweeds for the Treatment of Inflammatory Bowel Disease","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.bioadv.2026.214965_bb0025","article-title":"Effects of the Traditional Chinese Medicine Formula Ento-PB in Experimental Models of Ulcerative Colitis","volume":"17","author":"Che","year":"2022","journal-title":"Nat. Prod. Commun."},{"issue":"5","key":"10.1016\/j.bioadv.2026.214965_bb0030","doi-asserted-by":"crossref","DOI":"10.1590\/acb370505","article-title":"The ethanol extract of Periplaneta Americana L. improves ulcerative colitis induced by a combination of chronic stress and TNBS in rats","volume":"37","author":"Zhang","year":"2022","journal-title":"Acta Cir. Bras."},{"issue":"3","key":"10.1016\/j.bioadv.2026.214965_bb0035","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s10787-022-00955-7","article-title":"Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcerative colitis via immunoregulatory and PI3K\/AKT\/NF-\u03baB signaling pathways","volume":"30","author":"Ni","year":"2022","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.bioadv.2026.214965_bb0040","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1080\/13880209.2023.2220351","article-title":"Antioxidative effect of Periplaneta americana extract on dextran sulfate sodium-induced ulcerative colitis through activation of the Nrf2 signal","volume":"61","author":"Wu","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.bioadv.2026.214965_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125888","article-title":"Novel enabling strategies for oral peptide delivery","volume":"681","author":"\u00d6ngoren","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214965_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124994","article-title":"Liposomes and niosomes: new trends and applications in the delivery of bioactive agents for cancer therapy","volume":"668","author":"Kodel","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214965_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123918","article-title":"Anionic liposome formulation for oral delivery of thuricin CD, a potential antimicrobial peptide therapeutic","volume":"654","author":"Viera Herrera","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214965_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113851","article-title":"Liposome composition in drug delivery design, synthesis, characterization, and clinical application","volume":"176","author":"Large","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioadv.2026.214965_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123149","article-title":"In situ gel-forming oil as rectally delivering platform of hydrophobic therapeutics for ulcerative colitis therapy","volume":"642","author":"Zhao","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214965_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-39013-3","article-title":"Temperature-triggered in situ forming lipid mesophase gel for local treatment of ulcerative colitis","volume":"14","author":"Carone","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2026.214965_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125640","article-title":"Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review","volume":"677","author":"Pouso","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214965_bb0080","article-title":"An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2026.214965_bb0085","article-title":"Active ingredients isolated from Periplaneta americana L. inhibit the inflammation of the colonic mucosa and regulate the gut microbiota in DSS-induced ulcerative colitis in mice","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.bioadv.2026.214965_bb0090","doi-asserted-by":"crossref","DOI":"10.1007\/s00432-024-05732-3","article-title":"The involvement of RIPK4 in TNF-\u03b1-stimulated IL-6 and IL-8 production by melanoma cells","volume":"150","author":"Madej","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.bioadv.2026.214965_bb0095","first-page":"1211","article-title":"Preparation and characterization of liposomes containing Periplaneta extract and their therapeutic effect on ulcerative colitis","volume":"39","author":"L","year":"2023","journal-title":"J. Nanjing Univ. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214965_bb0100","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-024-03716-1","article-title":"Bone marrow mesenchymal stem cell-derived exosomes shuttle microRNAs to endometrial stromal fibroblasts that promote tissue proliferation \/regeneration\/ and inhibit differentiation","volume":"15","author":"Bonavina","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"10","key":"10.1016\/j.bioadv.2026.214965_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/gels11100839","article-title":"Rheological and Thermal Properties of Salecan\/Sanxan Composite Hydrogels for Food and Biomedical Applications","volume":"11","author":"Zhang","year":"2025","journal-title":"Gels"},{"key":"10.1016\/j.bioadv.2026.214965_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123560","article-title":"Release of liposomes from hyaluronic acid-based hybrid systems: Effects of liposome surface and size","volume":"648","author":"Jaudoin","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.214965_bb0115","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skaf188","article-title":"Reducing dextran sodium sulfate interference with gene expression quantification in a mouse model of colitis","volume":"103","author":"Hechter","year":"2025","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.bioadv.2026.214965_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105128","article-title":"hUC-MSCs therapy for Crohn\u2019s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study","volume":"103","author":"Sun","year":"2024","journal-title":"eBioMedicine"},{"issue":"3","key":"10.1016\/j.bioadv.2026.214965_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.103199","article-title":"Protocol for assessing GD2 on formalin-fixed paraffin-embedded tissue sections using immunofluorescence staining","volume":"5","author":"Kailayangiri","year":"2024","journal-title":"STAR Protocols"},{"key":"10.1016\/j.bioadv.2026.214965_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1661040","article-title":"Aurantii Fructus extract alleviates DSS-induced colitis in mice via regulating NF-\u03baB and Nrf2\/HO-1 signaling pathways and modulating intestinal microbiota","volume":"12","author":"Yu","year":"2025","journal-title":"Front. Nutr."},{"issue":"5","key":"10.1016\/j.bioadv.2026.214965_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12050989","article-title":"Ruscogenin attenuates ulcerative colitis in mice by inhibiting caspase-1-dependent pyroptosis via the TLR4\/NF-kappaB signaling pathway","volume":"12","author":"Li","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bioadv.2026.214965_bb0140","doi-asserted-by":"crossref","first-page":"1481273","DOI":"10.3389\/fphar.2024.1481273","article-title":"Zhili decoction ameliorates ulcerative colitis by modulating gut microbiota and related metabolite, and inhibiting the TLR4\/NF-kappaB\/NLRP3 pathway","author":"Tan","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioadv.2026.214965_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fgstr.2024.1452430","article-title":"Innate immune cells in the pathogenesis of inflammatory bowel disease - from microbial metabolites to immune modulation","volume":"3","author":"Mousa","year":"2024","journal-title":"Front. Gastroenterol."},{"issue":"1","key":"10.1016\/j.bioadv.2026.214965_bb0150","article-title":"EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2026.214965_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1665530","article-title":"Fundamental and emerging insights into innate and adaptive immunity in inflammatory bowel diseases","volume":"16","author":"Monteleone","year":"2025","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bioadv.2026.214965_bb0160","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.molmed.2024.01.001","article-title":"Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation","volume":"30","author":"Hausmann","year":"2024","journal-title":"Trends Mol. Med."},{"issue":"14","key":"10.1016\/j.bioadv.2026.214965_bb0165","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.178525","article-title":"Chlorination of epithelial tight junction proteins by neutrophil myeloperoxidase promotes barrier dysfunction and mucosal inflammation","volume":"9","author":"Cartwright","year":"2024","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bioadv.2026.214965_bb0170","article-title":"Advanced oral drug delivery systems for gastrointestinal targeted delivery: the design principles and foundations","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.214965_bb0175","article-title":"Stability characterization for pharmaceutical liposome product development with focus on regulatory considerations: an update","volume":"624","author":"VGS","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.bioadv.2026.214965_bb0180","article-title":"Recent Advances in the Application of Hydrogels as Drug Carriers in Inflammatory Bowel Disease: A Review","volume":"26","author":"Zhang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.bioadv.2026.214965_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/polym14235197","article-title":"Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier","volume":"14","author":"Putro","year":"2022","journal-title":"Polymers"},{"issue":"1","key":"10.1016\/j.bioadv.2026.214965_bb0190","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/ibd\/izae232","article-title":"Intestinal Epithelial Tight Junction Barrier Regulation by Novel Pathways","volume":"31","author":"Arumugam","year":"2025","journal-title":"Inflamm. Bowel Dis."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826002633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826002633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:59:16Z","timestamp":1785977956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826002633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":38,"alternative-id":["S2772950826002633"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214965","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel peptide from Periplaneta americana: Development of a long-acting formulation for ulcerative colitis therapy","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214965","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"214965"}}