{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:59:04Z","timestamp":1789559944915,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570342"],"award-info":[{"award-number":["82570342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["PWZxq2022-02"],"award-info":[{"award-number":["PWZxq2022-02"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioadv.2026.214979","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:13:38Z","timestamp":1779952418000},"page":"214979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Lactate dehydrogenase A inhibition-induced metabolic reprogramming combined with targeted ceria nanozymes protects against myocardial ischemia-reperfusion injury"],"prefix":"10.1016","volume":"188","author":[{"given":"Cheng","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenggui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunli","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.214979_bb0005","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-025-02430-5","article-title":"Z-DNA-binding protein 1 exacerbates myocardial ischemia\u2013reperfusion injury by inducing noncanonical cardiomyocyte PANoptosis","volume":"10","author":"Zhang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioadv.2026.214979_bb0010","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/CIRCRESAHA.124.326029","article-title":"GUCY1A1-LDHA axis suppresses ferroptosis in cardiac ischemia-reperfusion injury","volume":"137","author":"Yin","year":"2025","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioadv.2026.214979_bb0015","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/CIRCULATIONAHA.125.075254","article-title":"Effect of remote ischemic preconditioning on myocardial injury in noncardiac surgery: the PRINCE randomized clinical trial","volume":"152","author":"Greco","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.bioadv.2026.214979_bb0020","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1093\/eurheartj\/ehaf374","article-title":"Ferroptosis in cardiovascular disease: regulatory mechanisms and therapeutic implications","volume":"46","author":"Zhao","year":"2025","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bioadv.2026.214979_bb0025","doi-asserted-by":"crossref","DOI":"10.1172\/JCI184134","article-title":"Mechanisms of postischemic cardiac death and protection following myocardial injury","volume":"135","author":"Mastoor","year":"2025","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioadv.2026.214979_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122368","article-title":"Biomaterials-mediated targeted therapeutics of myocardial ischemia-reperfusion injury","volume":"303","author":"Luo","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.214979_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.151438","article-title":"N-acetyl-L-cysteine-modified macrophage membrane-coated VEGF sustained-release nanoparticles for treatment of myocardial infarction: a biomimetic nano-buffer for neutralization of detrimental factors and promotion of mature angiogenesis","volume":"489","author":"Zhu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2026.214979_bb0040","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrendo.2017.80","article-title":"Regulation of hepatic glucose metabolism in health and disease","volume":"13","author":"Petersen","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bioadv.2026.214979_bb0045","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: the ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bioadv.2026.214979_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115271","article-title":"Energy metabolism: a critical target of cardiovascular injury","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioadv.2026.214979_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157387","article-title":"Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer","volume":"148","author":"Hu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bioadv.2026.214979_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202409499","article-title":"Dexmedetomidine ameliorates myocardial ischemia-reperfusion injury by inhibiting MDH2 lactylation via regulating metabolic reprogramming","volume":"11","author":"She","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2026.214979_bb0065","first-page":"0705","article-title":"Lactate-induced mitochondrial calcium uptake 3 aggravates myocardial ischemia-reperfusion injury by promoting neutrophil extracellular trap formation","volume":"8","author":"Zhang","year":"2025","journal-title":"Research (Wash. D. C.)"},{"key":"10.1016\/j.bioadv.2026.214979_bb0070","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1007\/s12265-025-10671-6","article-title":"Hypoxia aggravates myocardial ischemia\/reperfusion injury through the promotion of ferroptosis via ACSL4 lactylation","volume":"18","author":"Lv","year":"2025","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.bioadv.2026.214979_bb0075","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/s12265-025-10628-9","article-title":"Hypoxia\/reoxygenation-induced glycolysis mediates myocardial ischemia-reperfusion injury through promoting the lactylation of GPX4","volume":"18","author":"Wang","year":"2025","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.bioadv.2026.214979_bb0080","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/CIRCRESAHA.122.321227","article-title":"L-2-hydroxyglutarate protects against cardiac injury via metabolic remodeling","volume":"131","author":"He","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioadv.2026.214979_bb0085","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1097\/MS9.0000000000000326","article-title":"L-2-hydroxyglutaric aciduria - review of literature and case series","volume":"85","author":"Ahmed","year":"2023","journal-title":"Ann. Med. Surg. (Lond.)"},{"key":"10.1016\/j.bioadv.2026.214979_bb0090","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1158\/0008-5472.CAN-20-2562","article-title":"Hypoxia-driven oncometabolite L-2HG maintains stemness-differentiation balance and facilitates immune evasion in pancreatic cancer","volume":"81","author":"Gupta","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioadv.2026.214979_bb0095","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1158\/2159-8290.CD-13-0696","article-title":"L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer","volume":"4","author":"Shim","year":"2014","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bioadv.2026.214979_bb0100","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1111\/cas.15468","article-title":"Development of a novel lactate dehydrogenase A inhibitor with potent antitumor activity and immune activation","volume":"113","author":"Du","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bioadv.2026.214979_bb0105","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCRESAHA.118.313249","article-title":"Metabolic maturation of human pluripotent stem cell-derived cardiomyocytes by inhibition of HIF1\u03b1 and LDHA","volume":"123","author":"Hu","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioadv.2026.214979_bb0110","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1002\/ptr.7925","article-title":"Salvianolic acid A diminishes LDHA-driven aerobic glycolysis to restrain myofibroblasts activation and cardiac fibrosis via blocking Akt\/GSK-3\u03b2\/HIF-1\u03b1 axis","volume":"37","author":"Hailiwu","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bioadv.2026.214979_bb0115","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70022","article-title":"Lactate regulates pathological cardiac hypertrophy via histone lactylation modification","volume":"28","author":"Zhao","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioadv.2026.214979_bb0120","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41392-025-02347-z","article-title":"NADPH oxidase 1\/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts","volume":"10","author":"Amengual","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bioadv.2026.214979_bb0125","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bioadv.2026.214979_bb0130","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1073\/pnas.1002178107","article-title":"NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioadv.2026.214979_bb0135","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.yjmcc.2006.05.003","article-title":"Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart","volume":"41","author":"Gupte","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bioadv.2026.214979_bb0140","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12351","article-title":"Protective effects of metformin against myocardial ischemia-reperfusion injury via AMPK-dependent suppression of NOX4","volume":"24","author":"Shi","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bioadv.2026.214979_bb0145","article-title":"A cardiac-targeted nanozyme interrupts the inflammation-free radical cycle in myocardial infarction","volume":"36","author":"Liu","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioadv.2026.214979_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129199","article-title":"A colorimetric smartphone-based platform for pesticides detection using Fe-N\/C single-atom nanozyme as oxidase mimetics","volume":"436","author":"Ge","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.bioadv.2026.214979_bb0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1021\/acscentsci.1c00866","article-title":"Fe-curcumin nanozyme-mediated reactive oxygen species scavenging and anti-inflammation for acute lung injury","volume":"8","author":"Yuan","year":"2022","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.bioadv.2026.214979_bb0160","doi-asserted-by":"crossref","first-page":"11283","DOI":"10.1021\/acsnano.7b05723","article-title":"Anionic cerium oxide nanoparticles protect plant photosynthesis from abiotic stress by scavenging reactive oxygen species","volume":"11","author":"Wu","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2026.214979_bb0165","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12951-025-03197-1","article-title":"Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models","volume":"23","author":"Zhu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.214979_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.164177","article-title":"Cardiomyocyte mitochondria targeted biomimetic nanozyme system with calcium ion chelating agent to treat myocardial ischemia\u2013reperfusion injury model in mice","volume":"517","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2026.214979_bb0175","article-title":"Single-atom enzymes: from evolutionary insights, precision engineering to breakthroughs in biomedical applications","volume":"21","author":"Xu","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.bioadv.2026.214979_bb0180","doi-asserted-by":"crossref","first-page":"25613","DOI":"10.1038\/srep25613","article-title":"Distribution of systemically administered nanoparticles reveals a size-dependent effect immediately following cardiac ischaemia-reperfusion injury","volume":"6","author":"Lundy","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.214979_bb0185","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.2147\/IJN.S328723","article-title":"Nanoparticles: promising tools for the treatment and prevention of myocardial infarction","volume":"16","author":"Pan","year":"2021","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.214979_bb0190","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3389\/fbioe.2020.00687","article-title":"Nanoparticle-mediated drug delivery for treatment of ischemic heart disease","volume":"8","author":"Fan","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.214979_bb0195","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1038\/s41467-024-50312-1","article-title":"Inhalable cardiac targeting peptide modified nanomedicine prevents pressure overload heart failure in male mice","volume":"15","author":"Weng","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2026.214979_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122890","article-title":"Anti-pyroptosis biomimetic nanoplatform loading puerarin for myocardial infarction repair: from drug discovery to drug delivery","volume":"314","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.214979_bb0205","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1038\/s41418-025-01544-1","article-title":"MARCH8\/NSUN6\/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma","volume":"32","author":"He","year":"2025","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bioadv.2026.214979_bb0210","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1016\/j.apsb.2021.04.006","article-title":"Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis","volume":"11","author":"Yu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioadv.2026.214979_bb0215","article-title":"Proton-driven deformability enables nanozyme-integrated vaccine for enhanced tumor immunotherapy","volume":"38","author":"An","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioadv.2026.214979_bb0220","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1186\/s12951-024-03047-6","article-title":"An antioxidant nanozyme for targeted cardiac fibrosis therapy post myocardial infarction","volume":"22","author":"Gu","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.214979_bb0225","article-title":"Beyond enzyme mimics: Engineering photo-responsive nanozymes for therapeutic innovation","volume":"38","author":"Ding","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioadv.2026.214979_bb0230","doi-asserted-by":"crossref","first-page":"2305979","DOI":"10.1002\/advs.202305979","article-title":"A single-atom manganese nanozyme Mn-N\/C promotes anti-tumor immune response via eliciting type I interferon signaling","volume":"11","author":"Qiao","year":"2024","journal-title":"Adv. Sci."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826002773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826002773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T21:30:08Z","timestamp":1786051808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826002773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":46,"alternative-id":["S2772950826002773"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214979","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactate dehydrogenase A inhibition-induced metabolic reprogramming combined with targeted ceria nanozymes protects against myocardial ischemia-reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.214979","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"214979"}}