{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:34:04Z","timestamp":1786120444104,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009879","name":"Emilia-Romagna Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioadv.2026.215029","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:51:06Z","timestamp":1781801466000},"page":"215029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Drug-loaded biomorphic scaffolds for tissue regeneration and targeted antitumor therapy in bone metastasis models"],"prefix":"10.1016","volume":"188","author":[{"given":"Claudia","family":"Cocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bergamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Montesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mercatali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Dapporto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Tavoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Spadazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"De Vita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Miserocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Vanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Sbanchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilisa","family":"Cortesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Casadei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Morozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ballardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ania Naila","family":"Guerrieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lucarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bellotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gambarotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide Maria","family":"Donati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Veronesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Dominici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Sprio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tampieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bongiovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Liverani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.215029_bb0005","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1200\/JCO.2009.25.9820","article-title":"Metastatic behavior of breast cancer subtypes","volume":"28","author":"Kennecke","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-020-00216-3","article-title":"Bone metastases","volume":"6","author":"Coleman","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bioadv.2026.215029_bb0015","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrc3125","article-title":"Unravelling the complexity of metastasis - molecular understanding and targeted therapies","volume":"11","author":"Sethi","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bioadv.2026.215029_bb0020","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Coleman","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bioadv.2026.215029_bb0025","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-015-0122-0","article-title":"Bone metastases in patients with metastatic renal cell carcinoma: are they always associated with poor prognosis?","volume":"34","author":"Santoni","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bioadv.2026.215029_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083026","article-title":"Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey","volume":"8","author":"Santini","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215029_bb0035","doi-asserted-by":"crossref","first-page":"6436","DOI":"10.1038\/sj.onc.1209886","article-title":"mTOR and cancer therapy","volume":"25","author":"Easton","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.bioadv.2026.215029_bb0040","first-page":"248","article-title":"Targeting bone metastatic cancer: role of the mTOR pathway","volume":"1845","author":"Bertoldo","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bioadv.2026.215029_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17111827","article-title":"The effect of everolimus in an in vitro model of triple negative breast cancer and osteoclasts","volume":"17","author":"Mercatali","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215029_bb0050","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031252","article-title":"The biology of bone metastasis","volume":"8","author":"Esposito","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215029_bb0055","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.pharmthera.2013.10.006","article-title":"Targeting tumor-stromal interactions in bone metastasis","volume":"141","author":"Esposito","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bioadv.2026.215029_bb0060","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(10)62344-6","article-title":"Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study","volume":"377","author":"Fizazi","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.bioadv.2026.215029_bb0065","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1200\/JCO.2010.29.7101","article-title":"Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study","volume":"28","author":"Stopeck","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.breast.2024.103826","article-title":"Adjuvant denosumab for early breast cancer-Evidence and controversy","volume":"78","author":"Moretti","year":"2024","journal-title":"Breast"},{"key":"10.1016\/j.bioadv.2026.215029_bb0075","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s00590-019-02446-y","article-title":"What\u2019s new in management of bone metastases?","volume":"29","author":"Errani","year":"2019","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00590-016-1857-9","article-title":"Treatment for long bone metastases based on a systematic literature review","volume":"27","author":"Errani","year":"2017","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0085","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2106\/00004623-199701000-00010","article-title":"The results of transplantation of intercalary allografts after resection of tumors. A long-term follow-up study","volume":"79","author":"Ortiz-Cruz","year":"1997","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bioadv.2026.215029_bb0090","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1245\/s10434-015-4881-9","article-title":"Complications and postoperative mortality rate after surgery for pathological femur fracture related to bone metastasis: Analysis of a nationwide database","volume":"23","author":"Tsuda","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0095","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jmst.2019.07.024","article-title":"Materials evolution of bone plates for internal fixation of bone fractures: A review","volume":"36","author":"Li","year":"2020","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0100","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ceramint.2016.09.216","article-title":"Development and characterization of zirconia-alumina composites for orthopedic implants","volume":"43","author":"Sequeira","year":"2017","journal-title":"Ceram. Int."},{"key":"10.1016\/j.bioadv.2026.215029_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2474-15-69","article-title":"Treatment and outcome of malignant bone tumors of the proximal humerus: biological versus endoprosthetic reconstruction","author":"Liu","year":"2014","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bioadv.2026.215029_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2017.01.076","article-title":"Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response","volume":"53","author":"Bouler","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215029_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065083","article-title":"The impact of hydroxyapatite sintering temperature on its microstructural, mechanical, and biological properties","volume":"24","author":"Trzaskowska","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215029_bb0120","first-page":"224","article-title":"Bone grafts and biomaterials substitutes for bone defect repair: A review","volume":"2","author":"Wang","year":"2017","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.215029_bb0125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.21037\/atm.2019.04.41","article-title":"Advances in personalized treatment of metastatic spine disease","volume":"7","author":"Ahangar","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bioadv.2026.215029_bb0130","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1302\/0301-620X.71B5.2584251","article-title":"Methotrexate diffusion from acrylic cement. Local chemotherapy for bone tumours","volume":"71","author":"Hernigou","year":"1989","journal-title":"J. Bone Joint Surg. (Br.)"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215029_bb0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/17434440.2018.1456336","article-title":"Drug-eluting implants for the suppression of metastatic bone disease: current insights","volume":"15","author":"Pountos","year":"2018","journal-title":"Expert Rev. Med. Devices"},{"key":"10.1016\/j.bioadv.2026.215029_bb0140","first-page":"391","article-title":"Mn3O4-potentiated bifunctional hydrogel for mild temperature-controlled tumor ablation and osteogenesis","volume":"55","author":"Zhao","year":"2025","journal-title":"Bioact. Mater."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215029_bb0145","article-title":"Ferritin-based nanocomposite hydrogel promotes tumor penetration and enhances cancer chemoimmunotherapy","volume":"11","author":"Liu","year":"2024","journal-title":"Adv Sci (Weinh)."},{"key":"10.1016\/j.bioadv.2026.215029_bb0150","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jconrel.2015.08.049","article-title":"Controlled drug release for tissue engineering","volume":"219","author":"Rambhia","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.215029_bb0155","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1039\/C8BM01145A","article-title":"Heterogeneous chemistry in the 3-D state: an original approach to generate bioactive, mechanically-competent bone scaffolds","volume":"7","author":"Tampieri","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2026.215029_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.734486","article-title":"Bone Regeneration in Load-Bearing Segmental Defects, Guided by Biomorphic, Hierarchically Structured Apatitic Scaffold","volume":"9","author":"Kon","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0165","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.jeurceramsoc.2019.11.015","article-title":"Hierarchical porosity inherited by natural sources affects the mechanical and biological behaviour of bone scaffolds","volume":"40","author":"Sprio","year":"2020","journal-title":"J. Eur. Ceram. Soc."},{"key":"10.1016\/j.bioadv.2026.215029_bb0170","article-title":"Ceramics with the signature of wood: a mechanical insight","volume":"5","author":"Bigoni","year":"2020","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioadv.2026.215029_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119334","article-title":"Hierarchically designed bone scaffolds: From internal cues to external stimuli","volume":"218","author":"Du","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215029_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.728907","article-title":"Biomorphic transformations: A leap forward in getting nanostructured 3-D bioceramics","volume":"9","author":"Sprio","year":"2021","journal-title":"Front. Chem."},{"key":"10.1016\/j.bioadv.2026.215029_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1412584","article-title":"Preliminary osteogenic and antibacterial investigations of wood derived antibiotic-loaded bone substitute for the treatment of infected bone defects","volume":"12","author":"Salamanna","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0190","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.3390\/ijms18081655","article-title":"Tumor-stroma crosstalk in bone tissue: The osteoclastogenic potential of a breast cancer cell line in a Co-culture system and the role of EGFR inhibition","volume":"18","author":"Mercatali","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215029_bb0195","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/ten.tec.2013.0250","article-title":"Transportation conditions for prompt use of ex vivo expanded and freshly harvested clinical-grade bone marrow mesenchymal stromal\/stem cells for bone regeneration","volume":"20","author":"Veronesi","year":"2014","journal-title":"Tissue Eng. Part C Methods"},{"key":"10.1016\/j.bioadv.2026.215029_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1251\/bpo114","article-title":"Rapid and simple comparison of messenger RNA levels using real-time PCR","volume":"8","author":"Dussault","year":"2006","journal-title":"Biol. Proced. Online"},{"key":"10.1016\/j.bioadv.2026.215029_bb0205","doi-asserted-by":"crossref","first-page":"12976","DOI":"10.1038\/s41598-020-69862-7","article-title":"An in-silico study of cancer cell survival and spatial distribution within a 3D microenvironment","volume":"10","author":"Cortesi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.215029_bb0210","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1038\/s41598-023-42486-3","article-title":"A comparative analysis of 2D and 3D experimental data for the identification of the parameters of computational models","volume":"13","author":"Cortesi","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.215029_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e29395","article-title":"Driving cell response through deep learning, a study in simulated 3D cell cultures","volume":"10","author":"Cortesi","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bioadv.2026.215029_bb0220","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cej.2012.11.107","article-title":"Study of the hydrothermal transformation of wood-derived calcium carbonate into 3D hierarchically organized hydroxyapatite","volume":"217","author":"Ruffini","year":"2013","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2026.215029_bb0225","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0142-9612(96)87284-X","article-title":"Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents","volume":"17","author":"Mooney","year":"1996","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215029_bb0230","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/leu.2014.30","article-title":"Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children\u2019s Oncology Group study AALL0031","volume":"28","author":"Schultz","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.bioadv.2026.215029_bb0235","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.msec.2019.01.096","article-title":"Nanostructured magnetic Mg2SiO4-CoFe2O4 composite scaffold with multiple capabilities for bone tissue regeneration","volume":"99","author":"Bigham","year":"2019","journal-title":"Mater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.215029_bb0240","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.colsurfb.2012.09.017","article-title":"Air jet spinning of hydroxyapatite\/poly(lactic acid) hybrid nanocomposite membrane mats for bone tissue engineering","volume":"102","author":"Abdal-hay","year":"2013","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioadv.2026.215029_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110579","article-title":"Hierarchical porous Mg2SiO4-CoFe2O4 nanomagnetic scaffold for bone cancer therapy and regeneration: Surface modification and in vitro studies","volume":"109","author":"Bigham","year":"2020","journal-title":"Mater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.215029_bb0250","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.3892\/ol.2017.6355","article-title":"Cytotoxic effects of zoledronic acid-loaded hydroxyapatite and bone cement in malignant tumors","volume":"14","author":"Koto","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bioadv.2026.215029_bb0255","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1055\/s-0029-1214162","article-title":"Local antibiotic therapy in osteomyelitis","volume":"23","author":"Gogia","year":"2009","journal-title":"Semin. Plast. Surg."},{"key":"10.1016\/j.bioadv.2026.215029_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22071063","article-title":"Pamidronate-conjugated biodegradable branched copolyester carriers: synthesis and characterization","volume":"22","author":"Oledzka","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bioadv.2026.215029_bb0265","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1016\/j.biomaterials.2011.04.010","article-title":"An injectable calcium phosphate cement for the local delivery of paclitaxel to bone","volume":"32","author":"Lopez-Heredia","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215029_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/ma11091485","article-title":"Nanoporous 3D-printed scaffolds for local doxorubicin delivery in bone metastases secondary to prostate cancer","volume":"11","author":"Ahangar","year":"2018","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.bioadv.2026.215029_bb0275","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2147\/nano.2006.1.4.541","article-title":"Less harmful acidic degradation of poly(lacticco-glycolic acid) bone tissue engineering scaffolds through titania nanoparticle addition","volume":"1","author":"Liu","year":"2006","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.215029_bb0280","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1039\/b900333a","article-title":"From wood to bone: multi-step process to convert wood hierarchical structures into biomimetic hydroxyapatite scaffolds for bone tissue engineering","volume":"19","author":"Tampieri","year":"2009","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.bioadv.2026.215029_bb0285","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2024-264131","article-title":"Distal femoral bone defect treatment using an engineered hydroxyapatite cylinder scaffold made from rattan wood","volume":"18","author":"Pitsilos","year":"2025","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.bioadv.2026.215029_bb0290","doi-asserted-by":"crossref","DOI":"10.1093\/bmb\/ldae023","article-title":"Safety and performance of a novel synthetic biomimetic scaffold for iliac crest defect reconstruction during surgical treatment of pelvic girdle pain: a first-in-human trial","volume":"153","author":"Giannoudis","year":"2025","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bioadv.2026.215029_bb0295","article-title":"Bone defect filling with a novel rattan-wood based not-sintered hydroxyapatite and beta-tricalcium phosphate material (b.Bone\u2122) after tricortical bone graft harvesting - a consecutive clinical case series of 9 patients","volume":"44","author":"Alt","year":"2023","journal-title":"Trauma Case Rep."},{"key":"10.1016\/j.bioadv.2026.215029_bb0300","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1080\/14656566.2023.2214677","article-title":"Evaluating everolimus for the treatment of breast cancer. Evaluating everolimus for the treatment of breast cancer","volume":"24","author":"Moreau-Bachelard","year":"2023","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.bioadv.2026.215029_bb0305","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.annonc.2024.05.537","article-title":"Renal cell carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"35","author":"Powles","year":"2024","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0310","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/labinvest.2016.49","article-title":"Explant culture of sarcoma patients\u2019 tissue","volume":"96","author":"Muff","year":"2016","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bioadv.2026.215029_bb0315","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1068091","article-title":"3D tumor explant as a novel platform to investigate therapeutic pathways and predictive biomarkers in cancer patients","volume":"13","author":"Rodolfo","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioadv.2026.215029_bb0320","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-58339-2","article-title":"Dynamic changes of receptor activator of nuclear factor-\u03baB expression in circulating tumor cells during denosumab predict treatment effectiveness in metastatic breast cancer","volume":"10","author":"Pantano","year":"2020","journal-title":"Sci. Rep."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826003274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826003274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T21:41:15Z","timestamp":1786052475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826003274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":64,"alternative-id":["S2772950826003274"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215029","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug-loaded biomorphic scaffolds for tissue regeneration and targeted antitumor therapy in bone metastasis models","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"215029"}}