{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:34:27Z","timestamp":1786120467820,"version":"build-2736575974"},"reference-count":175,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020206","name":"Shandong Provincial Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioadv.2026.215033","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:38:35Z","timestamp":1781912315000},"page":"215033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Engineering the \u201cpro-healing niche\u201d: Hydrogel-driven immunometabolic reprogramming for diabetic foot ulcers"],"prefix":"10.1016","volume":"188","author":[{"given":"Ziming","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongtong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.215033_bb0005","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba4311","article-title":"Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes","volume":"6","author":"Chen","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioadv.2026.215033_bb0010","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41586-024-07237-y","article-title":"CGRP sensory neurons promote tissue healing via neutrophils and macrophages","volume":"628","author":"Lu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bioadv.2026.215033_bb0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic foot ulcers","volume":"330","author":"Armstrong","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.bioadv.2026.215033_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3644","article-title":"Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update)","volume":"40","author":"Chen","year":"2024","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bioadv.2026.215033_bb0025","doi-asserted-by":"crossref","unstructured":"L. Ba, S. \u00c9, A. Zg, A.-S. J, D. M, E. Jm, K. S, L. La, M. M, van A. Sa, U.-R. V, P. Ejg, Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update), Diabetes Metab. Res. Rev. 36 Suppl 1 (2020) e3280. doi:https:\/\/doi.org\/10.1002\/dmrr.3280.","DOI":"10.1002\/dmrr.3280"},{"key":"10.1016\/j.bioadv.2026.215033_bb0030","article-title":"Guidelines on offloading foot ulcers in persons with diabetes (IWGDF 2023 update)","volume":"40","author":"Bus","year":"2024","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bioadv.2026.215033_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113440","article-title":"Immune microenvironment and fibroblast subpopulation in diabetic wound healing","volume":"28","author":"Gan","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.bioadv.2026.215033_bb0040","article-title":"Microenvironment-based diabetic foot ulcer nanomedicine","volume":"10","author":"Huang","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0045","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.4239\/wjd.v15.i11.2177","article-title":"Macrophages: key players in diabetic wound healing","volume":"15","author":"Zhou","year":"2024","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.bioadv.2026.215033_bb0050","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkaf053","article-title":"The role of glucose metabolism in wound healing: an overview","volume":"13","author":"Zhang","year":"2025","journal-title":"Burns Trauma"},{"key":"10.1016\/j.bioadv.2026.215033_bb0055","doi-asserted-by":"crossref","first-page":"eabn7006","DOI":"10.1126\/sciadv.abn7006","article-title":"ECM-mimetic immunomodulatory hydrogel for methicillin-resistant staphylococcus aureus-infected chronic skin wound healing","volume":"8","author":"Liu","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioadv.2026.215033_bb0060","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1007\/s10439-017-1893-6","article-title":"Fluorinated methacrylamide chitosan hydrogels enhance cellular wound healing processes","volume":"45","author":"Akula","year":"2017","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bioadv.2026.215033_bb0065","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nri.2016.49","article-title":"Neutrophil migration in infection and wound repair: going forward in reverse","volume":"16","author":"de Oliveira","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0070","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1016\/j.ymthe.2022.07.016","article-title":"Macrophages as a therapeutic target to promote diabetic wound healing","volume":"30","author":"Sharifiaghdam","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bioadv.2026.215033_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1264716","article-title":"Monocytes and T cells incorporated in full skin equivalents to study innate or adaptive immune reactions after burn injury","volume":"14","author":"Mulder","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/cells11192953","article-title":"Macrophage-mediated inflammation in skin wound healing","volume":"11","author":"Hassanshahi","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bioadv.2026.215033_bb0085","first-page":"49","article-title":"Regulatory T cells in skin regeneration and wound healing","volume":"10","author":"Knoedler","year":"2023","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0090","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170706","article-title":"GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing","volume":"133","author":"Yu","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioadv.2026.215033_bb0095","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bioadv.2026.215033_bb0100","doi-asserted-by":"crossref","unstructured":"L. Su, J. Zheng, Y. Wang, W. Zhang, D. Hu, Emerging progress on the mechanism and technology in wound repair, Biomed. Pharmacother. 117 (2019) 109191. doi:https:\/\/doi.org\/10.1016\/j.biopha.2019.109191.","DOI":"10.1016\/j.biopha.2019.109191"},{"key":"10.1016\/j.bioadv.2026.215033_bb0105","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00011-020-01328-y","article-title":"Macrophage mediation in normal and diabetic wound healing responses","volume":"69","author":"Ganesh","year":"2020","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0110","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-018-0725-5","article-title":"Macrophages, wound healing, and fibrosis: recent insights","volume":"20","author":"Smigiel","year":"2018","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.bioadv.2026.215033_bb0115","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"wound repair Regen.: off. Publ. Wound Heal. Soc. [and] Eur. Tissue Repair Soc."},{"key":"10.1016\/j.bioadv.2026.215033_bb0120","article-title":"Kinsenoside-loaded microneedle accelerates diabetic wound healing by reprogramming macrophage metabolism via inhibiting IRE1\u03b1\/XBP1 signaling axis","volume":"12","author":"Lu","year":"2025","journal-title":"Adv. Sci. Weinh. Baden-Wurtt. Ger."},{"key":"10.1016\/j.bioadv.2026.215033_bb0125","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/01.bcr.0000440705.91099.cc","article-title":"Burn wound \u03b3\u03b4 T-cells support a Th2 and Th17 immune response","volume":"35","author":"Rani","year":"2014","journal-title":"J. Burn Care Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119243","article-title":"San huang xiao yan recipe promoted wound healing in diabetic ulcer mice by inhibiting Th17 cell differentiation","volume":"341","author":"Deng","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0135","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231425","article-title":"CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17","volume":"221","author":"Cavagnero","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bioadv.2026.215033_bb0140","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13287-021-02206-y","article-title":"mTOR inhibitor INK128 promotes wound healing by regulating MDSCs","volume":"12","author":"Li","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioadv.2026.215033_bb0145","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.2005","article-title":"The mammalian target of rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling","volume":"12","author":"Delgoffe","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202500681","article-title":"Hydrogel-based tumor tissue microarchitecture reshapes dendritic cell metabolic profile and functions","volume":"14","author":"Quartey","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0155","doi-asserted-by":"crossref","unstructured":"P. Y, C. L, C. Y, T. Er, Z. S, Y. Y, L. K, W. J, L. X, Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies, Front. Cell Dev. Biol. 13 (2025). doi:https:\/\/doi.org\/10.3389\/fcell.2025.1625474.","DOI":"10.3389\/fcell.2025.1625474"},{"key":"10.1016\/j.bioadv.2026.215033_bb0160","doi-asserted-by":"crossref","unstructured":"S. V, S. J, K. Y, K. A, V. K, M. M, S. Ak, Integrated insights into gene expression dynamics and transcription factor roles in diabetic and diabetic-infectious wound healing using rat model, Life Sci. 368 (2025). doi:https:\/\/doi.org\/10.1016\/j.lfs.2025.123508.","DOI":"10.1016\/j.lfs.2025.123508"},{"key":"10.1016\/j.bioadv.2026.215033_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2025.108973","article-title":"The role of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers - a literature review","volume":"39","author":"Mackay","year":"2025","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.bioadv.2026.215033_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25042172","article-title":"Fibroblasts in diabetic foot ulcers","volume":"25","author":"Voza","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","article-title":"HIF-1 and mechanisms of hypoxia sensing","volume":"13","author":"Semenza","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0180","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00109-013-0993-5","article-title":"Ocular neovascularization","volume":"91","author":"Campochiaro","year":"2013","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.bioadv.2026.215033_bb0185","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1600-079X.2009.00742.x","article-title":"Melatonin suppresses tumor angiogenesis by inhibiting HIF-1alpha stabilization under hypoxia","volume":"48","author":"Park","year":"2010","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0190","article-title":"Hypoxia-induced retinal neovascularization in zebrafish embryos: a potential model of retinopathy of prematurity","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS One"},{"issue":"Suppl. 1","key":"10.1016\/j.bioadv.2026.215033_bb0195","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/dmrr.2742","article-title":"Disturbed hypoxic responses as a pathogenic mechanism of diabetic foot ulcers","volume":"32","author":"Catrina","year":"2016","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bioadv.2026.215033_bb0200","doi-asserted-by":"crossref","unstructured":"J.S. Chin, L. Madden, S.Y. Chew, D.L. Becker, Drug therapies and delivery mechanisms to treat perturbed skin wound healing, Adv. Drug Deliv. Rev. 149\u2013150 (2019) 2\u201318. doi:https:\/\/doi.org\/10.1016\/j.addr.2019.03.006.","DOI":"10.1016\/j.addr.2019.03.006"},{"key":"10.1016\/j.bioadv.2026.215033_bb0205","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.7150\/ijms.5630","article-title":"The possible mechanisms underlying the impairment of HIF-1\u03b1 pathway signaling in hyperglycemia and the beneficial effects of certain therapies","volume":"10","author":"Xiao","year":"2013","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0210","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s40618-019-01053-2","article-title":"Expression of miR-217 and HIF-1\u03b1\/VEGF pathway in patients with diabetic foot ulcer and its effect on angiogenesis of diabetic foot ulcer rats","volume":"42","author":"Lin","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.bioadv.2026.215033_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0254921","article-title":"Impact of microRNA-210 on wound healing among the patients with diabetic foot ulcer","volume":"16","author":"Pichu","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215033_bb0220","article-title":"Short and prolonged exposure to hyperglycaemia in human fibroblasts and endothelial cells: metabolic and osmotic effects","volume":"53","author":"N","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0225","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.180.7.4697","article-title":"Hypoxia and hypoxia-inducible factor-1\u03b1 modulate lipopolysaccharide-induced dendritic cell activation and function","volume":"180","author":"Jantsch","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0230","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.4049\/jimmunol.174.12.7592","article-title":"TCR engagement increases hypoxia-inducible factor-1\u03b1 protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells","volume":"174","author":"Nakamura","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106826","article-title":"SerpinB1 expression in Th17 cells depends on hypoxia-inducible factor 1-alpha","volume":"87","author":"Hou","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0240","doi-asserted-by":"crossref","first-page":"21797","DOI":"10.1074\/jbc.C000023200","article-title":"Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc","volume":"275","author":"Osthus","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioadv.2026.215033_bb0245","doi-asserted-by":"crossref","first-page":"7381","DOI":"10.1128\/MCB.00440-07","article-title":"Hypoxia-inducible factor 1 and dysregulated c-myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1","volume":"27","author":"Kim","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0250","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1464-5491.2010.03123.x","article-title":"Wound fluid lactate concentration: a helpful marker for diagnosing soft-tissue infection in diabetic foot ulcers? Preliminary findings","volume":"28","author":"L\u00f6ffler","year":"2011","journal-title":"Diabet. Med."},{"key":"10.1016\/j.bioadv.2026.215033_bb0255","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/1753-0407.13372","article-title":"Mechanisms of diabetic foot ulceration: a review","volume":"15","author":"Deng","year":"2023","journal-title":"J. Diabetes"},{"key":"10.1016\/j.bioadv.2026.215033_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110133","article-title":"Epigenetic regulation of Nrf2-mediated angiogenesis in diabetic foot ulcer progression: role of histone deacetylases","volume":"760","author":"Harithpriya","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bioadv.2026.215033_bb0265","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s13018-025-05914-w","article-title":"Exploring the mechanism by which UCHL3 alleviates diabetic foot ulcers: FOXM1\/NLRP3 inflammasome-mediated angiogenesis and endothelial cell pyroptosis","volume":"20","author":"Liao","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0270","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1161\/CIRCRESAHA.117.311819","article-title":"Lactate promotes synthetic phenotype in vascular smooth muscle cells","volume":"121","author":"Yang","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0275","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg3505","article-title":"Lactate and IL6 define separable paths of inflammatory metabolic adaptation","volume":"7","author":"Dichtl","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioadv.2026.215033_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1593390","article-title":"A comprehensive characterization of metabolic signatures-hypoxia, glycolysis, and lactylation-in non-healing diabetic foot ulcers","volume":"12","author":"Hu","year":"2025","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0285","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1158\/0008-5472.CAN-19-1789","article-title":"A tumor agnostic therapeutic strategy for hexokinase 1-null\/hexokinase 2-positive cancers","volume":"79","author":"Xu","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0290","doi-asserted-by":"crossref","DOI":"10.1177\/09636897221106998","article-title":"Hypoxic tumor-derived exosomes induce M2 macrophage polarization via PKM2\/AMPK to promote lung cancer progression","volume":"31","author":"Zhou","year":"2022","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bioadv.2026.215033_bb0295","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00109-022-02280-6","article-title":"Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro","volume":"101","author":"Sych","year":"2023","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.bioadv.2026.215033_bb0300","doi-asserted-by":"crossref","first-page":"15050","DOI":"10.1021\/acsami.4c21635","article-title":"Controlled release of cold atmospheric plasma by gelatin scaffold enhances wound healing via macrophage modulation","volume":"17","author":"Zhang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.215033_bb0305","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1016\/j.ajpath.2015.04.016","article-title":"The macrophage phagocytic receptor CD36 promotes fibrogenic pathways on removal of apoptotic cells during chronic kidney injury","volume":"185","author":"Pennathur","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0310","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105796","article-title":"Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization","volume":"172","author":"Wu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0320","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bioadv.2026.215033_bb0325","article-title":"Lactylation, a novel metabolic reprogramming code: current status and prospects","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0330","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1007\/s00018-018-2784-1","article-title":"Biochemistry of proinflammatory macrophage activation","volume":"75","author":"Nonnenmacher","year":"2018","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"10.1016\/j.bioadv.2026.215033_bb0335","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1109456","article-title":"Mapping intellectual structure and research hotspots in the field of fibroblast-associated DFUs: a bibliometric analysis","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0340","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.tem.2021.05.003","article-title":"The emerging role of metabolism in fibrosis","volume":"32","author":"Henderson","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bioadv.2026.215033_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1420136","article-title":"Integrating bioinformatics and multiple machine learning to identify mitophagy-related targets for the diagnosis and treatment of diabetic foot ulcers: evidence from transcriptome analysis and drug docking","volume":"11","author":"Guo","year":"2024","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0350","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/iwj.12557","article-title":"Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process","volume":"14","author":"Dunnill","year":"2015","journal-title":"Int. Wound J."},{"key":"10.1016\/j.bioadv.2026.215033_bb0355","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12050981","article-title":"Unfolding the interactions between endoplasmic reticulum stress and oxidative stress","volume":"12","author":"Ong","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.bioadv.2026.215033_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/antiox7080098","article-title":"Targeting oxidative stress and mitochondrial dysfunction in the treatment of impaired wound healing: a systematic review","volume":"7","author":"Cano Sanchez","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.bioadv.2026.215033_bb0365","article-title":"Platelet lysate-sodium hyaluronate gel promotes diabetic foot wound healing by regulating oxidative stress and autophagy","volume":"20","author":"Wang","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215033_bb0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230374","article-title":"Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in patients with diabetes mellitus type 2 infected with epstein-barr virus","volume":"15","author":"Dworza\u0144ski","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215033_bb0375","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101820","article-title":"Hydrogels and hydrogel nanocomposites: enhancing healthcare through human and environmental treatment","volume":"11","author":"Gutierrez","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0380","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/jbm.a.35914","article-title":"Biomaterial microarchitecture: a potent regulator of individual cell behavior and multicellular organization","volume":"105","author":"Hogrebe","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bioadv.2026.215033_bb0385","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1038\/ncomms7365","article-title":"Substrate stress relaxation regulates cell spreading","volume":"6","author":"Chaudhuri","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2026.215033_bb0390","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1021\/acsbiomaterials.0c00854","article-title":"Soft hydrogels for balancing cell proliferation and differentiation","volume":"6","author":"Wei","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.215033_bb0395","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb5069","article-title":"Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation","volume":"6","author":"Matera","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioadv.2026.215033_bb0400","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nbt.3462","article-title":"Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates","volume":"34","author":"Vegas","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0405","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10856-005-0526-z","article-title":"Comparison of bone marrow cell growth on 2D and 3D alginate hydrogels","volume":"16","author":"Barralet","year":"2005","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioadv.2026.215033_bb0410","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.actbio.2019.02.048","article-title":"Material stiffness influences the polarization state, function and migration mode of macrophages","volume":"89","author":"Sridharan","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0415","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41467-021-20953-7","article-title":"In situ mechanical reinforcement of polymer hydrogels via metal-coordinated crosslink mineralization","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2026.215033_bb0420","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature21392","article-title":"Enzymatic mineralization generates ultrastiff and tough hydrogels with tunable mechanics","volume":"543","author":"Rauner","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bioadv.2026.215033_bb0425","doi-asserted-by":"crossref","first-page":"E5792","DOI":"10.1073\/pnas.1612277113","article-title":"Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization","volume":"113","author":"Xiao","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioadv.2026.215033_bb0430","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1021\/acsbiomaterials.0c01431","article-title":"Biomechanics of wound healing in an equine limb model: effect of location and treatment with a peptide-modified collagen-chitosan hydrogel","volume":"7","author":"Sparks","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.215033_bb0435","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1021\/acs.biomac.2c01157","article-title":"Silk fibroin-based tough hydrogels with strong underwater adhesion for fast hemostasis and wound sealing","volume":"24","author":"Lu","year":"2023","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2026.215033_bb0440","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ac0fc9","article-title":"Architected fibrous scaffolds for engineering anisotropic tissues","volume":"13","author":"Reid","year":"2021","journal-title":"Biofabrication"},{"key":"10.1016\/j.bioadv.2026.215033_bb0445","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1021\/acsbiomaterials.8b01359","article-title":"Directed collective cell migration using three-dimensional bioprinted micropatterns on thermoresponsive surfaces for myotube formation","volume":"5","author":"Du","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.215033_bb0450","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1039\/D1LC00812A","article-title":"Microfluidic technologies for nanoparticle formation","volume":"22","author":"Tian","year":"2022","journal-title":"Lab Chip"},{"key":"10.1016\/j.bioadv.2026.215033_bb0455","first-page":"300","article-title":"Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy","volume":"17","author":"Han","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0460","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1021\/nn304966z","article-title":"Nanotopography modulates mechanotransduction of stem cells and induces differentiation through focal adhesion kinase","volume":"7","author":"Teo","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2026.215033_bb0465","doi-asserted-by":"crossref","unstructured":"L. Y, L. L, Z. X, H. S, C. S, H. G, P. St, L. Y, L. L, Z. X, H. S, C. S, H. G, P. S, 3D-printed conductive hydrogel scaffolds for bone regeneration: electromechanical coupling, neurovascular integration, and immunomodulatory strategies, Biomater. Adv. 179 (2026). doi:https:\/\/doi.org\/10.1016\/j.bioadv.2025.214497.","DOI":"10.1016\/j.bioadv.2025.214497"},{"key":"10.1016\/j.bioadv.2026.215033_bb0470","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1242\/dev.02230","article-title":"Regulation of somitogenesis by ena\/VASP proteins and FAK during xenopus development","volume":"133","author":"Kragtorp","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.bioadv.2026.215033_bb0475","article-title":"Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators","volume":"23","author":"Lm","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bioadv.2026.215033_bb0480","doi-asserted-by":"crossref","unstructured":"Y. M, H. Lm, J. Cc, Y. Hj, B. Mc, Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement, J. Cell Biol. 171 (2005). doi:https:\/\/doi.org\/10.1083\/jcb.200505018.","DOI":"10.1083\/jcb.200505018"},{"key":"10.1016\/j.bioadv.2026.215033_bb0485","article-title":"Retrograde fluxes of focal adhesion proteins in response to cell migration and mechanical signals","volume":"18","author":"Wh","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bioadv.2026.215033_bb0490","doi-asserted-by":"crossref","unstructured":"D. Tao, H. Wang, S. Chang, J. Cheng, N. Da, L. Zhang, J. Yang, W. Wang, F. Xu, B. Li, Matrix viscoelasticity orchestrates osteogenesis via mechanotransduction mediated metabolic switch in macrophages, Adv. Healthc. Mater. 14 (2025) e2405097. doi:https:\/\/doi.org\/10.1002\/adhm.202405097.","DOI":"10.1002\/adhm.202405097"},{"key":"10.1016\/j.bioadv.2026.215033_bb0495","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1096\/fj.06-8004com","article-title":"Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIF-regulated tissue permeability factor during hypoxia","volume":"21","author":"Rosenberger","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.bioadv.2026.215033_bb0500","article-title":"Molecular modulation of cell migration via chitosan-based hydrogels: toward smart biomaterial for wound regeneration","volume":"24","author":"Hosseinkhani","year":"2026","journal-title":"J. Appl. Biomater. Funct. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0505","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1002\/jbmr.1703","article-title":"Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport","volume":"27","author":"Shinohara","year":"2012","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0510","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tcb.2015.06.002","article-title":"Regulation of mTORC1 by PI3K signaling","volume":"25","author":"Dibble","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0515","article-title":"Supramolecular hydrogel with ultra-rapid cell-mediated network adaptation for enhancing cellular metabolic energetics and tissue regeneration","volume":"36","author":"Li","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0520","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1748-1716.2009.01972.x","article-title":"LKB1 and AMP-activated protein kinase control of mTOR signalling and growth","volume":"196","author":"Shaw","year":"2009","journal-title":"Acta Physiol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0525","doi-asserted-by":"crossref","first-page":"47355","DOI":"10.1021\/acsami.0c16478","article-title":"A hydrogel-integrated culture device to interrogate T cell activation with physicochemical cues","volume":"12","author":"Chin","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.215033_bb0530","doi-asserted-by":"crossref","first-page":"9718","DOI":"10.1039\/D0TB01570A","article-title":"Material properties of disulfide-crosslinked hyaluronic acid hydrogels influence prostate cancer cell growth and metabolism","volume":"8","author":"Tam","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioadv.2026.215033_bb0535","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.msec.2019.01.051","article-title":"Amination degree of gelatin is critical for establishing structure-property-function relationships of biodegradable thermogels as intracameral drug delivery systems","volume":"98","author":"Luo","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bioadv.2026.215033_bb0540","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/jbm.a.31661","article-title":"Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration","volume":"85","author":"Stachowiak","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bioadv.2026.215033_bb0545","article-title":"Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release","volume":"411","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2026.215033_bb0550","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ijbiomac.2020.10.129","article-title":"Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment","volume":"166","author":"Yang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0555","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2021.11.027","article-title":"A spatiotemporal release platform based on pH\/ROS stimuli-responsive hydrogel in wound repairing","volume":"341","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.215033_bb0560","article-title":"Self-healing hydrogels: the next paradigm shift in tissue engineering?","volume":"6","author":"Talebian","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0565","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jconrel.2020.05.010","article-title":"Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing","volume":"324","author":"Hu","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.215033_bb0570","article-title":"Stretchable multiresponsive hydrogel with actuatable, shape memory, and self-healing properties","volume":"5","author":"Zhang","year":"2018","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0575","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1021\/bm200423f","article-title":"Synthesis of multiresponsive and dynamic chitosan-based hydrogels for controlled release of bioactive molecules","volume":"12","author":"Zhang","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioadv.2026.215033_bb0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125727","article-title":"ROS-responsive nanocomposite hydrogel dressing accelerates diabetic wound healing through modulation of the inflammatory microenvironment","volume":"678","author":"Qin","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.215033_bb0585","doi-asserted-by":"crossref","first-page":"12889","DOI":"10.2147\/IJN.S513585","article-title":"Synergistic wound healing: unraveling the multi-target effects of traditional Chinese medicine and its biomaterials on chronic wound pathways","volume":"20","author":"Shen","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.215033_bb0590","first-page":"508","article-title":"Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair","volume":"62","author":"Lin","year":"2026","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0595","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.addr.2007.08.038","article-title":"Controlled drug delivery in tissue engineering","volume":"60","author":"Biondi","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioadv.2026.215033_bb0600","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202500720","article-title":"Ultrasound-triggered nanocomposite \u201clever\u201d hydrogels with a full repair system accelerates diabetic foot ulcer repair","volume":"12","author":"Shen","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.137753","article-title":"Dual functional photocatalytic hydrogel coupled with hydrogen evolution and glucose depletion for diabetic wound therapy","volume":"695","author":"Shen","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0610","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jconrel.2024.11.047","article-title":"Photo-controlled multifunctional hydrogel for photothermal sterilization and microenvironment amelioration of infected diabetic wounds","volume":"377","author":"Yang","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.215033_bb0615","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12951-025-03451-6","article-title":"Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism","volume":"23","author":"Gao","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0620","doi-asserted-by":"crossref","unstructured":"Nanozymes-armed probiotic Lactobacillus plantarum coordinates ferroptosis-like bacterial death for diabetic wound therapy, Research (n.d.). doi:10.34133\/research.1258 (accessed May 30, 2026).","DOI":"10.34133\/research.1258"},{"key":"10.1016\/j.bioadv.2026.215033_bb0625","first-page":"251","article-title":"Macrophage metabolism reprogramming EGCG-cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration","volume":"29","author":"Li","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0630","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123182","article-title":"Glucose-regulating hydrogel for immune modulation and angiogenesis through metabolic reprogramming and LARP7-SIRT1 pathway in infected diabetic wounds","volume":"318","author":"Liao","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215033_bb0635","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1186\/s12951-025-03818-9","article-title":"A metabolic reprogramming and trained immunity hydrogel mimic cluster missiles to eliminate infection and treat infected diabetic wounds","volume":"23","author":"Yu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0640","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202500734","article-title":"Self-healing hydrogel dressing with solubilized flavonoids for whole layer regeneration of diabetic wound","volume":"14","author":"Zeng","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0645","first-page":"876","article-title":"Mevalonate pathway-triggered phase transition of injectable hydrogel for cholesterol-downregulated therapy of osteoarthritis","volume":"51","author":"Robby","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0650","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.ijbiomac.2022.09.039","article-title":"Functional gelatin hydrogel scaffold with degraded-release of glutamine to enhance cellular energy metabolism for cartilage repair","volume":"221","author":"Yang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0655","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-14433-7","article-title":"Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase","volume":"11","author":"Palmieri","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2026.215033_bb0660","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.bioadv.2026.215033_bb0665","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123640","article-title":"A multifunctional hydrogel promotes diabetic wound healing by remodeling iron balance and energy metabolism","volume":"326","author":"Jin","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215033_bb0670","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1039\/D4TB00261J","article-title":"Micro-environment triple-responsive hyaluronic acid hydrogel dressings to promote antibacterial activity, collagen deposition, and angiogenesis for diabetic wound healing","volume":"12","author":"Wang","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.bioadv.2026.215033_bb0675","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14102065","article-title":"New horizons of macrophage immunomodulation in the healing of diabetic foot ulcers","volume":"14","author":"Lin","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.215033_bb0680","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13051076","article-title":"Diabetic foot ulcers: pathophysiology, immune dysregulation, and emerging therapeutic strategies","volume":"13","author":"Dawi","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.bioadv.2026.215033_bb0685","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/acs.accounts.0c00864","article-title":"Strategy for treatment of infected diabetic foot ulcers","volume":"54","author":"Chang","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0690","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1055\/a-1493-0458","article-title":"Neuropeptides, inflammation, biofilms, and diabetic foot ulcers","volume":"130","author":"Yang","year":"2022","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.bioadv.2026.215033_bb0695","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/wrr.12752","article-title":"Human macrophage response to microbial supernatants from diabetic foot ulcers","volume":"27","author":"Deusenbery","year":"2019","journal-title":"wound repair Regen.: off. Publ. Wound Heal. Soc. [and] Eur. Tissue Repair Soc."},{"key":"10.1016\/j.bioadv.2026.215033_bb0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122964","article-title":"Self-healing ppy-hydrogel promotes diabetic skin wound healing through enhanced sterilization and macrophage orchestration triggered by NIR","volume":"315","author":"Chu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215033_bb0705","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.actbio.2023.05.025","article-title":"Ultra-stretchable, tissue-adhesive, shape-adaptive, self-healing, on-demand removable hydrogel dressings with multiple functions for infected wound healing in regions of high mobility","volume":"166","author":"Liu","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0710","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/cmi.2015.116","article-title":"Impaired T-cell differentiation in diabetic foot ulceration","volume":"14","author":"Moura","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0715","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-025-03261-w","article-title":"Biomimetic gene delivery system coupled with extracellular vesicle-encapsulated AAV for improving diabetic wound through promoting vascularization and remodeling of inflammatory microenvironment","volume":"23","author":"He","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0720","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202402092","article-title":"Novel supramolecular hydrogel for infected diabetic foot ulcer treatment","volume":"13","author":"Zhang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0725","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.34133\/research.1248","article-title":"Hypoxia-challenged sEVs-engineered nanofiber scaffolds accelerate diabetic wound healing via reversing cellular dysfunction of skin repair cells","volume":"9","author":"Guo","year":"2026","journal-title":"Research"},{"key":"10.1016\/j.bioadv.2026.215033_bb0730","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115056","article-title":"C1q\/TNF-related protein-9 promotes diabetic wound healing by enhancing dendritic cell efferocytosis via the ATF3\/SLC7A11 signaling axis","volume":"161","author":"Zhang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0735","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41586-022-04754-6","article-title":"Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes","volume":"606","author":"Maschalidi","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bioadv.2026.215033_bb0740","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1039\/D2BM01881K","article-title":"Injectable thermosensitive hydrogel to modulate tolerogenic dendritic cells under hyperglycemic condition","volume":"11","author":"Zhu","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0745","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124330","article-title":"Chemodynamic therapy combined with endogenous ferroptosis based on \u201csea urchin-like\u201d copper sulfide hydrogel for enhancing anti-tumor efficacy","volume":"660","author":"Li","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.215033_bb0750","article-title":"A bioresponsive hydrogel remodels the hypoxic-immune microenvironment via synergistic phototherapy for chronic wound regeneration","author":"Xue","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0755","article-title":"Platelet-rich plasma for wound healing in diabetic patients","volume":"61","author":"Zanzov","year":"2025","journal-title":"Med. (Kaunas Lith.)"},{"key":"10.1016\/j.bioadv.2026.215033_bb0760","doi-asserted-by":"crossref","DOI":"10.12968\/jowc.2023.0318","article-title":"Enhancing diabetic foot wound healing with topical macrophage-regulating cream (ON101): a case series","volume":"34","author":"Ng","year":"2025","journal-title":"J. Wound Care"},{"key":"10.1016\/j.bioadv.2026.215033_bb0765","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00018-025-05814-6","article-title":"RCN1 downregulation-driven endoplasmic reticulum stress impairs endothelial function and diabetic foot ulcer healing","volume":"82","author":"Weng","year":"2025","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"key":"10.1016\/j.bioadv.2026.215033_bb0770","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1111\/dom.15544","article-title":"Hydrogel dressings for diabetic foot ulcer: a systematic review and meta-analysis","volume":"26","author":"Zhao","year":"2024","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bioadv.2026.215033_bb0775","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118498","article-title":"Innovative therapies for diabetic foot ulcers: application and prospects of smart dressings","volume":"191","author":"Zhao","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioadv.2026.215033_bb0780","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2337\/dci22-0043","article-title":"Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers","volume":"46","author":"McDermott","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bioadv.2026.215033_bb0785","doi-asserted-by":"crossref","DOI":"10.1186\/s12913-024-10873-9","article-title":"Economic burden of diabetic foot ulcer: a case of Iran","volume":"24","author":"Hashempour","year":"2024","journal-title":"BMC Health Serv. Res."},{"key":"10.1016\/j.bioadv.2026.215033_bb0790","article-title":"Diverse antibacterial treatments beyond antibiotics for diabetic foot ulcer therapy","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215033_bb0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117498","article-title":"Dysbiosis and diabetic foot ulcers: a metabolic perspective of Staphylococcus aureus infection","volume":"180","author":"Liu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bioadv.2026.215033_bb0800","doi-asserted-by":"crossref","unstructured":"S. Ji, X. Liu, J. Huang, J. Bao, Z. Chen, C. Han, D. Hao, J. Hong, D. Hu, Y. Jiang, S. Ju, H. Li, Z. Li, G. Liang, Y. Liu, G. Luo, G. Lv, X. Ran, Z. Shi, J. Tang, A. Wang, G. Wang, J. Wang, X. Wang, B. Wen, J. Wu, H. Xu, M. Xu, X. Ye, L. Yuan, Y. Zhang, S. Xiao, Z. Xia, Consensus on the application of negative pressure wound therapy of diabetic foot wounds Burns Trauma 9 (2021) tkab018. doi:https:\/\/doi.org\/10.1093\/burnst\/tkab018.","DOI":"10.1093\/burnst\/tkab018"},{"key":"10.1016\/j.bioadv.2026.215033_bb0805","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1021\/acsbiomaterials.4c00470","article-title":"Nanozymes for the therapeutic treatment of diabetic foot ulcers","volume":"10","author":"Xiao","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.215033_bb0810","doi-asserted-by":"crossref","unstructured":"P. Sl, M. M, M. D, S. Am, S. G, Role of anaerobes in polymicrobial communities and biofilms complicating diabetic foot ulcers, Int. Wound J. 15 (2018). doi:https:\/\/doi.org\/10.1111\/iwj.12926.","DOI":"10.1111\/iwj.12926"},{"key":"10.1016\/j.bioadv.2026.215033_bb0815","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkae065","article-title":"Single-cell RNA sequencing reveals the impaired epidermal differentiation and pathological microenvironment in diabetic foot ulcer","volume":"13","author":"Liu","year":"2025","journal-title":"Burns Trauma"},{"key":"10.1016\/j.bioadv.2026.215033_bb0820","doi-asserted-by":"crossref","first-page":"352","DOI":"10.5578\/mb.20250315","article-title":"The relationship between HIF-1\u03b1, MMP-9, and IL-8 levels and the development of diabetic foot ulcers","volume":"59","author":"P\u00fcr","year":"2025","journal-title":"Mikrobiyol. Bul."},{"key":"10.1016\/j.bioadv.2026.215033_bb0825","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ijbiomac.2018.08.011","article-title":"Association of hypoxia inducible factor-1 alpha exon 12 mutation in diabetic patients with and without diabetic foot ulcer","volume":"119","author":"Pichu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116992","article-title":"Multi-response optimization of alginate bleaching technology extracted from brown seaweeds by an eco-friendly agent","volume":"251","author":"Yamashita","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.215033_bb0835","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/polb.20212","article-title":"Effect of the degree of deacetylation and the substitution of carboxymethyl chitosan on its aggregation behavior","volume":"43","author":"Chen","year":"2005","journal-title":"J. Polym. Sci. B Polym. Phys."},{"key":"10.1016\/j.bioadv.2026.215033_bb0840","first-page":"23379","article-title":"Radiation-induced skin injury: pathogenesis, treatment, and management","volume":"12","author":"Yang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bioadv.2026.215033_bb0845","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/jid.2012.410","article-title":"A synthetic superoxide dismutase\/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin","volume":"133","author":"Doctrow","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bioadv.2026.215033_bb0850","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.freeradbiomed.2019.09.018","article-title":"Redox dysregulation in the pathogenesis of chronic venous ulceration","volume":"149","author":"Lyons","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioadv.2026.215033_bb0855","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jvsv.2017.03.015","article-title":"Pathophysiology of venous ulceration","volume":"5","author":"Crawford","year":"2017","journal-title":"J. Vasc. Surg., Venous Lymphat. Disord."},{"key":"10.1016\/j.bioadv.2026.215033_bb0860","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/wrr.12133","article-title":"Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers","volume":"22","author":"McInnes","year":"2014","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.bioadv.2026.215033_bb0865","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202415886","article-title":"An off-the-shelf artificial proregenerative macrophage for pressure ulcer treatment","volume":"12","author":"Su","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2026.215033_bb0870","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mehy.2016.03.012","article-title":"Potential efficiency of antioxidants to prevent pressure ulcers. A neglected hypothesis","volume":"91","author":"Bonne","year":"2016","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bioadv.2026.215033_bb0875","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135776","article-title":"ECM-mimetic glucomannan hydrogel promotes pressure ulcer healing by scavenging ROS, promoting angiogenesis and regulating macrophages","volume":"280","author":"Sun","year":"2024","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826003316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826003316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T21:41:36Z","timestamp":1786052496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826003316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":175,"alternative-id":["S2772950826003316"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215033","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering the \u201cpro-healing niche\u201d: Hydrogel-driven immunometabolic reprogramming for diabetic foot ulcers","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"215033"}}