{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:33:45Z","timestamp":1786120425537,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024872","name":"Toegepaste en Technische Wetenschappen, NWO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["16711"],"award-info":[{"award-number":["16711"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bioadv.2026.215041","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:44:25Z","timestamp":1782258265000},"page":"215041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Adding beta-tricalcium phosphate ceramic to additive manufactured 3D porous Ti6Al4V scaffolds enhances osteogenic activity of human mesenchymal stromal cells in vitro"],"prefix":"10.1016","volume":"188","author":[{"given":"David C.","family":"Koper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.W.H.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Habibovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Moroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.215041_bb0005","doi-asserted-by":"crossref","unstructured":"Li, J., Cui, X., Hooper, G. J., Lim, K. S. & Woodfield, T. B. F. Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: a review. J. Mech. Behav. Biomed. Mater. 105, 103671 (2020).","DOI":"10.1016\/j.jmbbm.2020.103671"},{"issue":"84","key":"10.1016\/j.bioadv.2026.215041_bb0010","article-title":"Biomaterials for regenerative cranioplasty: current state of clinical application and future challenges","volume":"15","author":"He","year":"2024","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.bioadv.2026.215041_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.586406","article-title":"Toward Biomimetic Scaffolds for Tissue Engineering: 3D Printing Techniques in Regenerative Medicine","volume":"8","author":"Chung","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215041_bb0020","doi-asserted-by":"crossref","unstructured":"Fishero, B., Kohli, N., Das, A., Christophel, J. & Cui, Q. Current concepts of bone tissue engineering for craniofacial bone defect repair. Craniomaxillofac. Trauma Reconstr. 08, 023\u2013030 (2014).","DOI":"10.1055\/s-0034-1393724"},{"key":"10.1016\/j.bioadv.2026.215041_bb0025","doi-asserted-by":"crossref","unstructured":"Nikolova, M. P. & Apostolova, M. D. Advances in multifunctional bioactive coatings for metallic bone implants. Materials 16, 183 (2022).","DOI":"10.3390\/ma16010183"},{"issue":"546","key":"10.1016\/j.bioadv.2026.215041_bb0030","article-title":"Development of bioactive scaffolds for orthopedic applications by designing additively manufactured titanium porous structures: a critical review","volume":"8","author":"Kiselevskiy","year":"2023","journal-title":"Biomimetics"},{"key":"10.1016\/j.bioadv.2026.215041_bb0035","doi-asserted-by":"crossref","first-page":"20220826","DOI":"10.1515\/biol-2022-0826","article-title":"Preparation of Cu2+\/TA\/HAP composite coating with anti-bacterial and osteogenic potential on 3D-printed porous Ti alloy scaffolds for orthopedic applications","volume":"19","author":"Haitao","year":"2024","journal-title":"Open Life Sci."},{"key":"10.1016\/j.bioadv.2026.215041_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052049","article-title":"Evaluation of Biological Properties of Electron Beam Melted Ti6Al4V Implant with Biomimetic Coating In Vitro and In Vivo","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215041_bb0045","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1039\/D1MA00675D","article-title":"Advances in implant surface modifications to improve osseointegration","volume":"2","author":"Zhu","year":"2021","journal-title":"Mater. Adv."},{"issue":"170","key":"10.1016\/j.bioadv.2026.215041_bb0050","article-title":"Titanium\u2013tissue interface reaction and its control with surface treatment","volume":"7","author":"Hanawa","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215041_bb0055","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1016\/j.biomaterials.2007.02.020","article-title":"Bone ingrowth in porous titanium implants produced by 3D fiber deposition","volume":"28","author":"Li","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215041_bb0060","doi-asserted-by":"crossref","unstructured":"Wieding, J., Wolf, A. & Bader, R. Numerical optimization of open-porous bone scaffold structures to match the elastic properties of human cortical bone. J. Mech. Behav. Biomed. Mater. 37, 56\u201368 (2014).","DOI":"10.1016\/j.jmbbm.2014.05.002"},{"key":"10.1016\/j.bioadv.2026.215041_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110289","article-title":"Influence of the pore size and porosity of selective laser melted Ti6Al4V ELI porous scaffold on cell proliferation, osteogenesis and bone ingrowth","volume":"106","author":"Chen","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2026.215041_bb0070","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1016\/j.biomaterials.2005.02.002","article-title":"Porosity of 3D biomaterial scaffolds and osteogenesis","volume":"26","author":"Karageorgiou","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215041_bb0075","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.msec.2015.10.069","article-title":"Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment","volume":"59","author":"Taniguchi","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2026.215041_bb0080","first-page":"22","article-title":"A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications","volume":"4","author":"Alizadeh-Osgouei","year":"2019","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.215041_bb0085","doi-asserted-by":"crossref","DOI":"10.1177\/09636897241236030","article-title":"Cross talk between cells and the current bioceramics in bone regeneration: a comprehensive review","volume":"33","author":"Khayatan","year":"2024","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bioadv.2026.215041_bb0090","doi-asserted-by":"crossref","first-page":"D37","DOI":"10.1016\/S0020-1383(00)80022-4","article-title":"Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements","volume":"31","author":"Bohner","year":"2000","journal-title":"Injury"},{"key":"10.1016\/j.bioadv.2026.215041_bb0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40824-018-0149-3","article-title":"Bioactive calcium phosphate materials and applications in bone regeneration","volume":"23","author":"Jeong","year":"2019","journal-title":"Biomater. Res."},{"key":"10.1016\/j.bioadv.2026.215041_bb0100","first-page":"430","article-title":"Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms","volume":"21","author":"Barradas","year":"2011","journal-title":"Eur. Cells Mater."},{"key":"10.1016\/j.bioadv.2026.215041_bb0105","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/jbm.b.30136","article-title":"Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors","volume":"72B","author":"Ogose","year":"2005","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"12","key":"10.1016\/j.bioadv.2026.215041_bb0110","article-title":"Use of \u201ccustom made\u201d porous hydroxyapatite implants for cranioplasty: postoperative analysis of complications in 1549 patients","volume":"4","author":"Stefini","year":"2013","journal-title":"Surg. Neurol. Int."},{"key":"10.1016\/j.bioadv.2026.215041_bb0115","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00701-014-2319-y","article-title":"Spontaneous fractures in custom-made porous hydroxyapatite cranioplasty implants: is fragility the only culprit?","volume":"157","author":"Zanotti","year":"2015","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.bioadv.2026.215041_bb0120","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12289-014-1205-8","article-title":"Titanium based cranial reconstruction using incremental sheet forming","volume":"9","author":"Lu","year":"2016","journal-title":"Int. J. Mater. Form."},{"key":"10.1016\/j.bioadv.2026.215041_bb0125","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.jcms.2014.08.006","article-title":"Interval cranioplasty with patient-specific implants and autogenous bone grafts \u2013 success and cost analysis","volume":"42","author":"Lethaus","year":"2014","journal-title":"J. Craniomaxillofac. Surg."},{"key":"10.1016\/j.bioadv.2026.215041_bb0130","article-title":"Types and biological effects of titanium alloys in prosthodontics","volume":"67","author":"Chonin","year":"2025","journal-title":"Folia Med."},{"key":"10.1016\/j.bioadv.2026.215041_bb0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jmst.2020.11.005","article-title":"Powder metallurgy with space holder for porous titanium implants: A review","volume":"76","author":"Rodriguez-Contreras","year":"2021","journal-title":"J. Mater. Sci. Technol."},{"issue":"148","key":"10.1016\/j.bioadv.2026.215041_bb0140","article-title":"Additive manufacturing of bone scaffolds","volume":"5","author":"Yang","year":"2018","journal-title":"Int. J. Bioprint."},{"issue":"7514","key":"10.1016\/j.bioadv.2026.215041_bb0145","article-title":"A review of the metal additive manufacturing processes","volume":"16","author":"Tebianian","year":"2023","journal-title":"Materials"},{"key":"10.1016\/j.bioadv.2026.215041_bb0150","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.actbio.2021.03.021","article-title":"3D porous Ti6Al4V-beta-tricalcium phosphate scaffolds directly fabricated by additive manufacturing","volume":"126","author":"Li","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215041_bb0155","doi-asserted-by":"crossref","unstructured":"Li, J. P., Wijn, J. R. de, Blitterswijk, C. A. V. & Groot, K. de. Porous Ti6Al4V scaffold directly fabricating by rapid prototyping: preparation and in vitro experiment. Biomaterials 27, 1223\u20131235 (2006).","DOI":"10.1016\/j.biomaterials.2005.08.033"},{"key":"10.1016\/j.bioadv.2026.215041_bb0160","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.actbio.2019.11.020","article-title":"Improving cell distribution on 3D additive manufactured scaffolds through engineered seeding media density and viscosity","volume":"101","author":"C\u00e1mara-Torres","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215041_bb0165","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/SCS.0b013e3181cf606b","article-title":"Pediatric Cranial Vault Defects","volume":"21","author":"Biskup","year":"2010","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.bioadv.2026.215041_bb0170","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00701-018-3514-z","article-title":"A randomised controlled trial comparing autologous cranioplasty with custom-made titanium cranioplasty: long-term follow-up","volume":"160","author":"Honeybul","year":"2018","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.bioadv.2026.215041_bb0175","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1097\/SCS.0000000000003025","article-title":"Cranioplasty: review of materials","volume":"27","author":"Zanotti","year":"2016","journal-title":"J. Craniofac. Surg."},{"issue":"234","key":"10.1016\/j.bioadv.2026.215041_bb0180","article-title":"\u03b2-Tricalcium phosphate as alveolar bone grafting in cleft lip\/palate: a systematic review","volume":"11","author":"Nugraha","year":"2023","journal-title":"Dent. J."},{"issue":"1824","key":"10.1016\/j.bioadv.2026.215041_bb0185","article-title":"Evaluation of two beta-tricalcium phosphates with different particle dimensions in human maxillary sinus floor elevation: a prospective, randomized clinical trial","volume":"15","author":"Mendes","year":"2022","journal-title":"Materials"},{"key":"10.1016\/j.bioadv.2026.215041_bb0190","doi-asserted-by":"crossref","first-page":"S456","DOI":"10.4103\/jpbs.JPBS_603_20","article-title":"Preservation of Alveolar Ridge using Graft Material after Tooth Extraction: A Clinical Trial","volume":"13","author":"Kumar","year":"2021","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.bioadv.2026.215041_bb0195","doi-asserted-by":"crossref","unstructured":"Li, J. P., Wijn, J. R. de, Blitterswijk, C. A. van & Groot, K. de. The effect of scaffold architecture on properties of direct 3D fiber deposition of porous Ti6Al4V for orthopedic implants. J. Biomed. Mater. Res. A 92A, 33\u201342 (2010).","DOI":"10.1002\/jbm.a.32330"},{"key":"10.1016\/j.bioadv.2026.215041_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1127162","article-title":"Study on the influence of scaffold morphology and structure on osteogenic performance","volume":"11","author":"Zhou","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215041_bb0205","article-title":"Osseointegration of functionally graded Ti6Al4V porous implants: Histology of the pore network","volume":"155","author":"Deering","year":"2023","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.bioadv.2026.215041_bb0210","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/jbm.a.37709","article-title":"Chemical etching of Ti-6Al-4V biomaterials fabricated by selective laser melting enhances mesenchymal stromal cell mineralization","volume":"112","author":"O\u2019Keeffe","year":"2024","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.bioadv.2026.215041_bb0215","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1021\/acsami.5b00331","article-title":"Improving Osteointegration and Osteogenesis of Three-Dimensional Porous Ti6Al4V Scaffolds by Polydopamine-Assisted Biomimetic Hydroxyapatite Coating","volume":"7","author":"Li","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.215041_bb0220","doi-asserted-by":"crossref","first-page":"17964","DOI":"10.1021\/acsami.6b05893","article-title":"Tailored surface treatment of 3D printed porous Ti6Al4V by microarc oxidation for enhanced osseointegration via optimized bone in-growth patterns and interlocked bone\/implant interface","volume":"8","author":"Xiu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.215041_bb0225","doi-asserted-by":"crossref","unstructured":"Yavari, S. A. et al. Bone regeneration performance of surface-treated porous titanium. Biomaterials 35, 6172\u20136181 (2014).","DOI":"10.1016\/j.biomaterials.2014.04.054"},{"key":"10.1016\/j.bioadv.2026.215041_bb0230","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/bit.25919","article-title":"Combining 3D human in vitro methods for a 3Rs evaluation of novel titanium surfaces in orthopaedic applications","volume":"113","author":"Stevenson","year":"2016","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.bioadv.2026.215041_bb0235","doi-asserted-by":"crossref","unstructured":"Mondal, D., Nguyen, L., Oh, I. & Lee, B. Microstructure and biocompatibility of composite biomaterials fabricated from titanium and tricalcium phosphate by spark plasma sintering. J. Biomed. Mater. Res. A 101A, 1489\u20131501 (2013).","DOI":"10.1002\/jbm.a.34455"},{"key":"10.1016\/j.bioadv.2026.215041_bb0240","article-title":"Porous titanium\/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair","volume":"166","author":"Oliver-Urrutia","year":"2025","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.bioadv.2026.215041_bb0245","doi-asserted-by":"crossref","unstructured":"Milivojevic, M. et al. Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects. Biomed. Mater. 18, 065020 (2023).","DOI":"10.1088\/1748-605X\/ad02d2"},{"key":"10.1016\/j.bioadv.2026.215041_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120374","article-title":"Osteogenic Differentiation of Human Mesenchymal Stem Cells in Mineralized Alginate Matrices","volume":"10","author":"Westhrin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215041_bb0255","unstructured":"Lian, J. B. & Stein, G. S. Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation. Iowa Orthop. J. 15, 118\u201340 (1995)."},{"key":"10.1016\/j.bioadv.2026.215041_bb0260","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.2741\/2296","article-title":"Signaling and transcriptional regulation in osteoblast commitment and differentiation","volume":"12","author":"Huang","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bioadv.2026.215041_bb0265","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrg3185","article-title":"Insights into the regulation of protein abundance from proteomic and transcriptomic analyses","volume":"13","author":"Vogel","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bioadv.2026.215041_bb0270","doi-asserted-by":"crossref","first-page":"12724","DOI":"10.1021\/acsomega.1c07225","article-title":"Alkaline Phosphatase Activity of Serum Affects Osteogenic Differentiation Cultures","volume":"7","author":"Ansari","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.bioadv.2026.215041_bb0275","doi-asserted-by":"crossref","unstructured":"Beck, G. R., Moran, E. & Knecht, N. Inorganic phosphate regulates multiple genes during osteoblast differentiation, including Nrf2. Exp. Cell Res. 288, 288\u2013300 (2003).","DOI":"10.1016\/S0014-4827(03)00213-1"},{"key":"10.1016\/j.bioadv.2026.215041_bb0280","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1582-4934.2007.00103.x","article-title":"Calcium phosphate surfaces promote osteogenic differentiation of mesenchymal stem cells","volume":"12","author":"M\u00fcller","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioadv.2026.215041_bb0285","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1016\/j.actbio.2013.06.014","article-title":"Calcium phosphate ceramics in bone tissue engineering: A review of properties and their influence on cell behavior","volume":"9","author":"Samavedi","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215041_bb0290","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10856-021-06572-0","article-title":"Revealing the influence of electron beam melted Ti-6Al-4V scaffolds on osteogenesis of human bone marrow-derived mesenchymal stromal cells","volume":"32","author":"\u00d8degaard","year":"2021","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioadv.2026.215041_bb0295","doi-asserted-by":"crossref","unstructured":"Tsao, Y.-T. et al. Osteocalcin mediates biomineralization during osteogenic maturation in human mesenchymal stromal cells. Int. J. Mol. Sci. 18, 159 (2017).","DOI":"10.3390\/ijms18010159"},{"key":"10.1016\/j.bioadv.2026.215041_bb0300","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1089\/ten.teb.2016.0454","article-title":"Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro","volume":"23","author":"Blair","year":"2017","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.bioadv.2026.215041_bb0305","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3945\/an.112.001834","article-title":"Vitamin K-Dependent Carboxylation of Osteocalcin: Friend or Foe?","volume":"3","author":"Gundberg","year":"2012","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.bioadv.2026.215041_bb0310","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/1873-3468.14618","article-title":"Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin-inducing activity","volume":"597","author":"Mizuguchi","year":"2023","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bioadv.2026.215041_bb0315","doi-asserted-by":"crossref","unstructured":"Rutkovskiy, A., Stensl\u00f8kken, K.-O. & Vaage, I. J. Osteoblast differentiation at a glance. Med. Sci. Monit. Basic Res. 22, 95\u2013106 (2016).","DOI":"10.12659\/MSMBR.901142"},{"key":"10.1016\/j.bioadv.2026.215041_bb0320","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s00223-013-9698-6","article-title":"Role of Osteopontin in Modulation of Hydroxyapatite Formation","volume":"93","author":"Hunter","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bioadv.2026.215041_bb0325","doi-asserted-by":"crossref","unstructured":"Iline-Vul, T. et al. Osteopontin regulates biomimetic calcium phosphate crystallization from disordered mineral layers covering apatite crystallites. Sci. Rep. 10, 15722 (2020).","DOI":"10.1038\/s41598-020-72786-x"},{"key":"10.1016\/j.bioadv.2026.215041_bb0330","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bone.2014.05.020","article-title":"Osteopontin binds multiple calcium ions with high affinity and independently of phosphorylation status","volume":"66","author":"Kl\u00e4ning","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bioadv.2026.215041_bb0335","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/stem.1567","article-title":"An Osteopontin-Integrin Interaction Plays a Critical Role in Directing Adipogenesis and Osteogenesis by Mesenchymal Stem Cells","volume":"32","author":"Chen","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.bioadv.2026.215041_bb0340","doi-asserted-by":"crossref","unstructured":"Lee, M. N. et al. Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression. Exp. Mol. Med. 50, 1\u201316 (2018).","DOI":"10.1038\/s12276-018-0170-6"},{"key":"10.1016\/j.bioadv.2026.215041_bb0345","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40824-019-0180-z","article-title":"Role of offset and gradient architectures of 3-D melt electrowritten scaffold on differentiation and mineralization of osteoblasts","volume":"24","author":"Abbasi","year":"2020","journal-title":"Biomater. Res."},{"key":"10.1016\/j.bioadv.2026.215041_bb0350","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1016\/j.actbio.2012.07.048","article-title":"Influence of select extracellular matrix proteins on mesenchymal stem cell osteogenic commitment in three-dimensional contexts","volume":"8","author":"Becerra-Bayona","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215041_bb0355","doi-asserted-by":"crossref","unstructured":"C\u00e1mara-Torres, M. et al. Effect of highly loaded nanohydroxyapatite composite scaffolds prepared via melt extrusion additive manufacturing on the osteogenic differentiation of human mesenchymal stromal cells. bioRxiv 2021.01.21.427568 (2021) doi:https:\/\/doi.org\/10.1101\/2021.01.21.427568.","DOI":"10.1101\/2021.01.21.427568"},{"key":"10.1016\/j.bioadv.2026.215041_bb0360","article-title":"The effects of surface treatments on electron beam melted Ti-6Al-4V disks on osteogenesis of human mesenchymal stromal cells","volume":"147","author":"\u00d8degaard","year":"2023","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.bioadv.2026.215041_bb0365","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1021\/acsbiomaterials.9b00909","article-title":"Study of Bone Regeneration and Osteointegration Effect of a Novel Selective Laser-Melted Titanium-Tantalum-Niobium-Zirconium Alloy Scaffold","volume":"5","author":"Guo","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioadv.2026.215041_bb0370","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.a.37860","article-title":"Mimicking Nature: Effect of Architectural Design Inspired by Cancellous Bone on the Biological Response of hMSC Cultured on Titanium Scaffolds Fabricated by Laser Beam Powder Bed Fusion","volume":"113","author":"Idaszek","year":"2025","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.bioadv.2026.215041_bb0375","doi-asserted-by":"crossref","unstructured":"Graziani, G. et al. Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy. Bioact. Mater. 6, 2629\u20132642 (2021).","DOI":"10.1016\/j.bioactmat.2020.12.019"},{"key":"10.1016\/j.bioadv.2026.215041_bb0380","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.colsurfb.2018.12.047","article-title":"Adhesion, proliferation, and osteogenic differentiation of human mesenchymal stem cells on additively manufactured Ti6Al4V alloy scaffolds modified with calcium phosphate nanoparticles","volume":"176","author":"Chudinova","year":"2019","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bioadv.2026.215041_bb0385","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1016\/j.biomaterials.2014.07.015","article-title":"Differential regulation of osteogenic differentiation of stem cells on surface roughness gradients","volume":"35","author":"Faia-Torres","year":"2014","journal-title":"Biomaterials"}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826003390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826003390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T21:40:53Z","timestamp":1786052453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826003390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":77,"alternative-id":["S2772950826003390"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215041","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adding beta-tricalcium phosphate ceramic to additive manufactured 3D porous Ti6Al4V scaffolds enhances osteogenic activity of human mesenchymal stromal cells in vitro","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"215041"}}