{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:20:29Z","timestamp":1788279629127,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12102238"],"award-info":[{"award-number":["12102238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203221"],"award-info":[{"award-number":["82203221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A6009"],"award-info":[{"award-number":["U23A6009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12272252"],"award-info":[{"award-number":["12272252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["202403021221158"],"award-info":[{"award-number":["202403021221158"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bioadv.2026.215130","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:52:27Z","timestamp":1787410347000},"page":"215130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A stiffness-tunable 3D alginate-collagen-hyaluronic acid model reveals the matrix-dependent chondroprotection of quercetin in osteoarthritis"],"prefix":"10.1016","volume":"189","author":[{"given":"Genlai","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaru","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanyou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.215130_bb0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jare.2025.01.053","article-title":"Advances in the pathology and treatment of osteoarthritis","volume":"78","author":"Peng","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bioadv.2026.215130_bb0010","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s13679-023-00520-5","article-title":"Obesity, metabolic syndrome, and osteoarthritis-an updated review","volume":"12","author":"Sampath","year":"2023","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.bioadv.2026.215130_bb0015","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.joca.2023.06.005","article-title":"Fundamentals of osteoarthritis: inflammatory mediators in osteoarthritis","volume":"31","author":"De Roover","year":"2023","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bioadv.2026.215130_bb0020","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.joca.2021.12.003","article-title":"Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review","volume":"30","author":"Dainese","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bioadv.2026.215130_bb0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.matbio.2018.05.008","article-title":"Osteoarthritis as a disease of the cartilage pericellular matrix","volume":"71","author":"Guilak","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1393550","article-title":"The metabolic characteristics and changes of chondrocytes in vivo and in vitro in osteoarthritis","volume":"15","author":"Adam","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23116316","article-title":"Cartilage homeostasis and osteoarthritis","volume":"23","author":"Fujii","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215130_bb0045","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.joca.2024.05.008","article-title":"Repurposing drugs for the treatment of osteoarthritis","volume":"32","author":"Kuswanto","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bioadv.2026.215130_bb0050","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41584-020-00523-9","article-title":"Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines","volume":"17","author":"Arden","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0055","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/os.13021","article-title":"Osteotomy around the knee: the surgical treatment of osteoarthritis","volume":"13","author":"Peng","year":"2021","journal-title":"Orthop. Surg."},{"key":"10.1016\/j.bioadv.2026.215130_bb0060","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.0254","article-title":"Evaluation of exercise interventions and outcomes after hip arthroplasty: a systematic review and Meta-analysis","volume":"4","author":"Saueressig","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bioadv.2026.215130_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202030","article-title":"An in vitro engineered osteochondral model as tool to study osteoarthritis environment","volume":"12","author":"Scalzone","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215130_bb0070","article-title":"Medicinal plants and their secondary metabolites in alleviating knee osteoarthritis: a systematic review","volume":"105","author":"Wang","year":"2022","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.bioadv.2026.215130_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1619589","article-title":"Efficacy of botanical extracts for knee osteoarthritis: a network meta-analysis of randomized controlled trials","volume":"16","author":"Yan","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0080","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1159\/000525494","article-title":"Quercetin and osteoarthritis: a mechanistic review on the present documents","volume":"107","author":"Samadi","year":"2022","journal-title":"Pharmacology"},{"key":"10.1016\/j.bioadv.2026.215130_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101989","article-title":"Therapeutic potential of senolytic agent quercetin in osteoarthritis: a systematic review and meta-analysis of preclinical studies","volume":"90","author":"Yamaura","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bioadv.2026.215130_bb0090","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1142\/S0192415X23500891","article-title":"Regulatory effects of quercetin on bone homeostasis: research updates and future perspectives","volume":"51","author":"Xi","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.bioadv.2026.215130_bb0095","doi-asserted-by":"crossref","first-page":"10795","DOI":"10.2147\/IJN.S538490","article-title":"Hydrogel-based microspheres for intra-articular osteoarthritis therapy: multifunctional carriers for drug delivery and cartilage repair: a comprehensive review","volume":"20","author":"Zhao","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.215130_bb0100","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1097\/JS9.0000000000002076","article-title":"Innovative hydrogel solutions for articular cartilage regeneration: a comprehensive review","volume":"110","author":"Kang","year":"2024","journal-title":"Int. J. Surg. (London, England)"},{"key":"10.1016\/j.bioadv.2026.215130_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112005","article-title":"Chondroprotective effects of apolipoprotein D in knee osteoarthritis mice through the PI3K\/AKT\/mTOR signaling pathway","volume":"133","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26209877","article-title":"Protective effects of Lindera obtusiloba leaf extract on osteoarthritis in mouse primary chondrocytes and a medial Meniscus destabilization model","volume":"26","author":"Oh","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215130_bb0115","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11926-019-0837-6","article-title":"The role of chondrocyte morphology and volume in controlling phenotype-implications for osteoarthritis, cartilage repair, and cartilage engineering","volume":"21","author":"Hall","year":"2019","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.bioadv.2026.215130_bb0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bcp.2019.02.036","article-title":"Chondrocyte dedifferentiation and osteoarthritis (OA)","volume":"165","author":"Charlier","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0125","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.arr.2016.04.011","article-title":"Preserving the longevity of long-lived type II collagen and its implication for cartilage therapeutics","volume":"28","author":"Tiku","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bioadv.2026.215130_bb0130","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.joca.2006.07.003","article-title":"HC-gp39 contributes to chondrocyte differentiation by inducing SOX9 and type II collagen expressions","volume":"15","author":"Jacques","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bioadv.2026.215130_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216468","article-title":"Inflammatory and metabolic signaling interfaces of the hypertrophic and senescent chondrocyte phenotypes associated with osteoarthritis","volume":"24","author":"Horv\u00e1th","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215130_bb0140","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.joca.2019.01.008","article-title":"Changes in stiffness and biochemical composition of the pericellular matrix as a function of spatial chondrocyte organisation in osteoarthritic cartilage","volume":"27","author":"Danalache","year":"2019","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bioadv.2026.215130_bb0145","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20231730","article-title":"Alteration in cartilage matrix stiffness as an indicator and modulator of osteoarthritis","volume":"44","author":"Song","year":"2024","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bioadv.2026.215130_bb0150","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/jcmm.17672","article-title":"Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades","volume":"27","author":"Wang","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioadv.2026.215130_bb0155","article-title":"Retuning mitochondrial apoptosis\/mitophagy balance via SIRT3-energized and microenvironment-modulated hydrogel microspheres to impede osteoarthritis","volume":"12","author":"Xia","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215130_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103719","article-title":"Quercetin attenuates lipopolysaccharide-induced hepatic inflammation by modulating autophagy and necroptosis","volume":"103","author":"Yu","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.bioadv.2026.215130_bb0165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.freeradbiomed.2020.03.029","article-title":"Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes","volume":"153","author":"D\u2019Adamo","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioadv.2026.215130_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120064","article-title":"The protective effect of quercetin on macrophage pyroptosis via TLR2\/Myd88\/NF-\u03baB and ROS\/AMPK pathway","volume":"291","author":"Luo","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.bioadv.2026.215130_bb0175","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.spinee.2024.09.017","article-title":"Senolytics cocktail dasatinib and quercetin alleviate chondrocyte senescence and facet joint osteoarthritis in mice","volume":"25","author":"Zhao","year":"2025","journal-title":"The spine journal : official journal of the North American Spine Society"},{"key":"10.1016\/j.bioadv.2026.215130_bb0180","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.actbio.2025.02.034","article-title":"Matrix metalloproteinases accelerate pericellular matrix breakdown and disrupt mechanotransduction in osteoarthritis","volume":"195","author":"Nieuwstraten","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215130_bb0185","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1016\/j.bpj.2010.03.037","article-title":"Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy","volume":"98","author":"Darling","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.bioadv.2026.215130_bb0190","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1098\/rsif.2012.0314","article-title":"Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage","volume":"9","author":"Wilusz","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.bioadv.2026.215130_bb0195","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jbiomech.2012.09.003","article-title":"Depth-dependent anisotropy of the micromechanical properties of the extracellular and pericellular matrices of articular cartilage evaluated via atomic force microscopy","volume":"46","author":"McLeod","year":"2013","journal-title":"J. Biomech."},{"key":"10.1016\/j.bioadv.2026.215130_bb0200","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jbiomech.2004.04.012","article-title":"Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage","volume":"38","author":"Alexopoulos","year":"2005","journal-title":"J. Biomech."},{"key":"10.1016\/j.bioadv.2026.215130_bb0205","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.joca.2016.02.001","article-title":"Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology","volume":"24","author":"Felka","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bioadv.2026.215130_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2019.109409","article-title":"Assessment of biomechanical properties of the extracellular and pericellular matrix and their interconnection throughout the course of osteoarthritis","volume":"97","author":"Danalache","year":"2019","journal-title":"J. Biomech."},{"key":"10.1016\/j.bioadv.2026.215130_bb0215","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00223-020-00670-x","article-title":"Models of osteoarthritis: relevance and new insights","volume":"109","author":"Samvelyan","year":"2021","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bioadv.2026.215130_bb0220","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s12195-025-00872-z","article-title":"Metabolomic profiling and characterization of a novel 3D culture system for studying chondrocyte Mechanotransduction","volume":"18","author":"Brahmachary","year":"2025","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.bioadv.2026.215130_bb0225","article-title":"From chondrocytes to chondrons, maintenance of phenotype and matrix production in a composite 3D hydrogel scaffold","volume":"8","author":"Amr","year":"2022","journal-title":"Gels (Basel, Switzerland)"},{"key":"10.1016\/j.bioadv.2026.215130_bb0230","first-page":"504","article-title":"Osteoarthritis: cartilage matrix stiffness regulates chondrocyte metabolism and OA pathogenesis","volume":"11","author":"Onuora","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0235","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41413-024-00333-9","article-title":"Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3","volume":"12","author":"Fu","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.bioadv.2026.215130_bb0240","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jot.2024.01.007","article-title":"Quercetin-3-O-\u03b2-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation","volume":"45","author":"Mao","year":"2024","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.bioadv.2026.215130_bb0245","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12967-024-05086-x","article-title":"Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-\u03baB axis and influencing autophagy","volume":"22","author":"Pan","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bioadv.2026.215130_bb0250","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","article-title":"Autophagy in inflammation, infection, and immunometabolism","volume":"54","author":"Deretic","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.bioadv.2026.215130_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114739","article-title":"Ginseng root extract attenuates inflammation by inhibiting the MAPK\/NF-\u03baB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo","volume":"283","author":"Yang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1060721","article-title":"Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K\/AKT\/mTOR signaling pathway and enhancement of autophagy","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bioadv.2026.215130_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015285","article-title":"Tibolone improves locomotor function in a rat model of spinal cord injury by modulating apoptosis and autophagy","volume":"24","author":"S\u00e1nchez-Torres","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215130_bb0270","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.397","article-title":"Autophagy regulates odontoblast differentiation by suppressing NF-\u03baB activation in an inflammatory environment","volume":"7","author":"Pei","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bioadv.2026.215130_bb0275","article-title":"Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPAR\u03b3\/PGC-1\u03b1\/NF-\u03baB axis to improve acute liver failure","volume":"143","author":"Wu","year":"2024","journal-title":"Int. Immunopharmacol."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:45:02Z","timestamp":1788277502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826004309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":55,"alternative-id":["S2772950826004309"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215130","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A stiffness-tunable 3D alginate-collagen-hyaluronic acid model reveals the matrix-dependent chondroprotection of quercetin in osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"215130"}}