{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:55:24Z","timestamp":1790902524459,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["99999.008666\/2014\\u201308"],"award-info":[{"award-number":["99999.008666\/2014\\u201308"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["Proc. 2017\/24300\\u20134"],"award-info":[{"award-number":["Proc. 2017\/24300\\u20134"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["Proc. 2015\/50.280\\u20135"],"award-info":[{"award-number":["Proc. 2015\/50.280\\u20135"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-032189"],"award-info":[{"award-number":["POCI-01-0145-FEDER-032189"]}],"id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/200.865\/2021"],"award-info":[{"award-number":["E-26\/200.865\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/010.000981\\u20132019"],"award-info":[{"award-number":["E-26\/010.000981\\u20132019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\\u221226\/203.179\/2017 (232897)"],"award-info":[{"award-number":["E\\u221226\/203.179\/2017 (232897)"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/010\/002989\/2014"],"award-info":[{"award-number":["E-26\/010\/002989\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["204.587\/2021 (268814)"],"award-info":[{"award-number":["204.587\/2021 (268814)"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["Process Sei E\\u221226\/204.586\/2021"],"award-info":[{"award-number":["Process Sei E\\u221226\/204.586\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"Programa Operacional Tem\u00e1tico Factores de Competitividade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bioadv.2026.215135","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:45:57Z","timestamp":1787615157000},"page":"215135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Titanium dioxide nanoparticles alter mesenchymal stem cell function and exosome signalling: Possible implications in periprosthetic osteolysis"],"prefix":"10.1016","volume":"190","author":[{"given":"Wanderson","family":"de Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gemini-Piperni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Grenho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Wiechers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Bizon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia A.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria.H.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Scapin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds.A.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Granjeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana R.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.215135_bb0005","doi-asserted-by":"crossref","DOI":"10.1039\/D2BM01854C","article-title":"Titanium dioxide nanoparticles affect osteoblast-derived exosome cargos and impair osteogenic differentiation of human mesenchymal stem cells","author":"de Souza","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2026.215135_bb0010","article-title":"Osteoblasts-derived exosomes as potential novel communicators in particle-induced periprosthetic osteolysis","volume":"28","author":"de Souza","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioadv.2026.215135_bb0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41368-023-00256-x","article-title":"Titanium particles in peri-implantitis: distribution, pathogenesis and prospects","volume":"15","author":"Chen","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.bioadv.2026.215135_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202000412","article-title":"Metal-specific biomaterial accumulation in human Peri-implant bone and bone marrow","volume":"7","author":"Schoon","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2026.215135_bb0025","doi-asserted-by":"crossref","first-page":"401","DOI":"10.30574\/wjarr.2021.12.2.0598","article-title":"Systemic toxicity of metal ions release from specific types of implanted medical devices: systemic review of clinical studies","volume":"12","author":"Matusiewicz","year":"2021","journal-title":"World J. Adv. Res. Rev."},{"key":"10.1016\/j.bioadv.2026.215135_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.colcom.2023.100716","article-title":"The effects of Ti and ta particle surface chemistry on inflammation, osteogenesis and osteoclastogenesis in vitro and in vivo","volume":"54","author":"Huang","year":"2023","journal-title":"Colloid Interface Sci. Commun."},{"key":"10.1016\/j.bioadv.2026.215135_bb0035","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1089\/biores.2017.0017","article-title":"Local cellular responses to titanium dioxide from orthopedic implants","volume":"6","author":"Yao","year":"2017","journal-title":"Biores. Open Access"},{"key":"10.1016\/j.bioadv.2026.215135_bb0040","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2106\/00004623-199306000-00004","article-title":"The differences in toxicity and release of bone-resorbing mediators induced by titanium and cobalt-chromium-alloy wear particles","volume":"75","author":"Haynes","year":"1993","journal-title":"J. Bone Joint Surg."},{"key":"10.1016\/j.bioadv.2026.215135_bb0045","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1302\/0301-620X.95B8.31229","article-title":"The role of osteoblasts in peri-prosthetic osteolysis","volume":"95-B","author":"O\u2019Neill","year":"2013","journal-title":"Bone Joint J."},{"key":"10.1016\/j.bioadv.2026.215135_bb0050","doi-asserted-by":"crossref","first-page":"13842","DOI":"10.1038\/s41598-019-50236-7","article-title":"Alternating differentiation and dedifferentiation between mature osteoblasts and osteocytes","volume":"9","author":"Sawa","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.215135_bb0055","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1302\/2046-3758.56.BJR-2015-0014.R1","article-title":"Circulating exosome levels in the diagnosis of steroid-induced osteonecrosis of the femoral head","volume":"5","author":"Zhu","year":"2016","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.bioadv.2026.215135_bb0060","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/jcmm.13039","article-title":"The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodelling","volume":"21","author":"Xie","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioadv.2026.215135_bb0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejpb.2019.02.014","article-title":"Human primary macrophages scavenge AuNPs and eliminate it through exosomes. A natural shuttling for nanomaterials","volume":"137","author":"Logozzi","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioadv.2026.215135_bb0070","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s11658-022-00384-y","article-title":"The role of macrophage subtypes and exosomes in immunomodulation","volume":"27","author":"Gharavi","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bioadv.2026.215135_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.715461","article-title":"The biogenesis, biological functions, and applications of macrophage-derived exosomes","volume":"8","author":"Shan","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bioadv.2026.215135_bb0080","doi-asserted-by":"crossref","DOI":"10.1038\/srep23615","article-title":"Trojan-like internalization of anatase titanium dioxide nanoparticles by human osteoblast cells","volume":"6","author":"Ribeiro","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.215135_bb0085","doi-asserted-by":"crossref","first-page":"9309","DOI":"10.1038\/s41598-019-45797-6","article-title":"The two faces of titanium dioxide nanoparticles bio-camouflage in 3D bone spheroids","volume":"9","author":"Souza","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.215135_bb0090","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/acs.langmuir.5b03955","article-title":"Effects of line and pillar Array microengineered SiO 2 thin films on the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells","volume":"32","author":"Carvalho","year":"2016","journal-title":"Langmuir"},{"key":"10.1016\/j.bioadv.2026.215135_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202502518","article-title":"A novel microfluidic system for 3D epidermis and full-thickness skin growth for nanoparticle safety assessment","volume":"15","author":"Costa","year":"2026","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215135_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215135_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-15-293","article-title":"Jvenn: an interactive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.bioadv.2026.215135_bb0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11914-022-00720-3","article-title":"Macrophage polarization and the Osteoimmunology of Periprosthetic Osteolysis","volume":"20","author":"Goodman","year":"2022","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bioadv.2026.215135_bb0115","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10787-013-0192-6","article-title":"Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management","volume":"21","author":"Howie","year":"2013","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bioadv.2026.215135_bb0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cis.2014.09.001","article-title":"Interactions between mammalian cells and nano- or micro-sized wear particles: Physico-chemical views against biological approaches","volume":"213","author":"Prokopovich","year":"2014","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.bioadv.2026.215135_bb0125","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/jbm.b.33243","article-title":"Wear particles and ions from cemented and uncemented titanium-based hip prostheses\u2014a histological and chemical analysis of retrieval material","volume":"103","author":"Grosse","year":"2015","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.bioadv.2026.215135_bb0130","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.1038\/boneres.2016.14","article-title":"A review of UHMWPE wear-induced osteolysis: the role for early detection of the immune response","volume":"4","author":"Kandahari","year":"2016","journal-title":"Bone Res."},{"key":"10.1016\/j.bioadv.2026.215135_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19095681","article-title":"Titanium dioxide: structure, impact, and toxicity","volume":"19","author":"Racovita","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.bioadv.2026.215135_bb0140","series-title":"Nanoscale Engineering of Biomaterials: Properties and Applications","first-page":"3","article-title":"Interactions between the physiological environment and titanium-based implant materials: From understanding to control","author":"Ferraris","year":"2022"},{"key":"10.1016\/j.bioadv.2026.215135_bb0145","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.2147\/IJN.S38992","article-title":"Effects of titanium nanoparticles on adhesion, migration, proliferation, and differentiation of mesenchymal stem cells","author":"Cai","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.215135_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135814","article-title":"Single-cell transcriptomics uncovers the impacts of titanium dioxide nanoparticles on human bone marrow stromal cells","volume":"440","author":"Xiang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2026.215135_bb0155","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s13273-020-00084-8","article-title":"Toxic effect of titanium dioxide nanoparticles on human mesenchymal stem cells","volume":"16","author":"Adriana-Berenice","year":"2020","journal-title":"Mol. Cell. Toxicol."},{"key":"10.1016\/j.bioadv.2026.215135_bb0160","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.actbio.2018.08.021","article-title":"Autophagic response to cellular exposure to titanium dioxide nanoparticles","volume":"79","author":"Popp","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215135_bb0165","article-title":"Nanomaterial exposure, extracellular vesicle biogenesis and adverse cellular outcomes: a scoping review","volume":"12","author":"Lima","year":"2022","journal-title":"Nanomaterials (Basel, Switzerland)"},{"key":"10.1016\/j.bioadv.2026.215135_bb0170","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.etap.2016.10.013","article-title":"Contribution of oxidative stress to TiO 2 nanoparticle-induced toxicity","volume":"48","author":"Song","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.bioadv.2026.215135_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144829","article-title":"Titanium dioxide nanoparticles increase superoxide anion production by acting on NADPH oxidase","volume":"10","author":"Masoud","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215135_bb0180","first-page":"1","article-title":"Titanium dioxide nanoparticles induce mitochondrial dynamic imbalance and damage in HT22 cells","volume":"2019","author":"Zhao","year":"2019","journal-title":"J. Nanomater."},{"key":"10.1016\/j.bioadv.2026.215135_bb0185","doi-asserted-by":"crossref","first-page":"25039","DOI":"10.1039\/C9RA04037D","article-title":"TiO 2 nanoparticles generate superoxide and alter gene expression in human lung cells","volume":"9","author":"Jayaram","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.bioadv.2026.215135_bb0190","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/abbs\/gmaa098","article-title":"ROS signaling cascades: dual regulations for osteoclast and osteoblast","volume":"52","author":"Tao","year":"2020","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.bioadv.2026.215135_bb0195","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s00198-011-1728-5","article-title":"Runx2 promotes both osteoblastogenesis and novel osteoclastogenic signals in ST2 mesenchymal progenitor cells","volume":"23","author":"Baniwal","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bioadv.2026.215135_bb0200","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1002\/jbm.a.36448","article-title":"TiO 2 nanoparticles disrupt cell adhesion and the architecture of cytoskeletal networks of human osteoblast-like cells in a size dependent manner","volume":"106","author":"Ibrahim","year":"2018","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bioadv.2026.215135_bb0210","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1002\/2211-5463.13678","article-title":"Titanium particles inhibit bone marrow mesenchymal stem cell osteogenic differentiation through the <scp>MAPK<\/scp> signaling pathway","volume":"13","author":"Tong","year":"2023","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bioadv.2026.215135_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0334156","article-title":"The influence of titanium particles on the functionality of osteocytes in bone remodeling: an in-vitro study","volume":"20","author":"Almabrok","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215135_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/min9020068","article-title":"Biomineralization forming process and bio-inspired nanomaterials for biomedical application: a review","volume":"9","author":"Chen","year":"2019","journal-title":"Minerals"},{"key":"10.1016\/j.bioadv.2026.215135_bb0225","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1203\/PDR.0b013e3181d476ce","article-title":"Pathological calcification and replicating calcifying-nanoparticles: general approach and correlation","volume":"67","author":"\u00c7ift\u00e7io\u011flu","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bioadv.2026.215135_bb0230","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00210-024-03357-4","article-title":"Exosomes derived from bone marrow mesenchymal stem cells induce the proliferation and osteogenic differentiation and regulate the inflammatory state in osteomyelitis in vitro model","volume":"398","author":"Liang","year":"2025","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.bioadv.2026.215135_bb0235","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1182\/blood.V96.5.1873","article-title":"Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines","volume":"96","author":"Weitzmann","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bioadv.2026.215135_bb0240","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/imm.13351","article-title":"Dual effect of IL-7\/IL-7R signalling on the osteoimmunological system: a potential therapeutic target for rheumatoid arthritis","volume":"164","author":"Xu","year":"2021","journal-title":"Immunology"},{"key":"10.1016\/j.bioadv.2026.215135_bb0245","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10753-013-9782-0","article-title":"Effect of IL-15 and natural killer cells on osteoclasts and osteoblasts in a mouse Coculture","volume":"37","author":"Takeda","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.bioadv.2026.215135_bb0250","doi-asserted-by":"crossref","DOI":"10.1093\/jbmrpl\/ziae120","article-title":"Targeting the osteoclastogenic cytokine IL-9 as a novel immunotherapeutic strategy in mitigating inflammatory bone loss in post-menopausal osteoporosis","volume":"8","author":"Sapra","year":"2024","journal-title":"JBMR Plus"},{"key":"10.1016\/j.bioadv.2026.215135_bb0255","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.actbio.2017.08.046","article-title":"Inhibitory effects of melatonin on titanium particle-induced inflammatory bone resorption and osteoclastogenesis via suppression of NF-\u03baB signaling","volume":"62","author":"Ping","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215135_bb0260","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12967-016-0950-5","article-title":"Immune response and innervation signatures in aseptic hip implant loosening","volume":"14","author":"Vasconcelos","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bioadv.2026.215135_bb0265","article-title":"Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation","volume":"13","author":"Wang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bioadv.2026.215135_bb0270","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1021\/acs.jproteome.6b00981","article-title":"Proteomics profiling of exosomes from primary mouse osteoblasts under proliferation versus mineralization conditions and characterization of their uptake into prostate Cancer cells","volume":"16","author":"Bilen","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bioadv.2026.215135_bb0275","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/1097-4652(200008)184:2<207::AID-JCP8>3.0.CO;2-U","article-title":"Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-?2?1 integrin interaction","volume":"184","author":"Mizuno","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bioadv.2026.215135_bb0280","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.bone.2009.08.058","article-title":"Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts","volume":"46","author":"Alford","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.bioadv.2026.215135_bb0285","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1247\/csf.26.227","article-title":"Phase-independent inhibition by retinoic acid of mineralization correlated with loss of Tetranectin expression in a human osteoblastic cell line","volume":"26","author":"Iba","year":"2001","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.bioadv.2026.215135_bb0290","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1083\/jcb.127.6.1767","article-title":"A potential role for tetranectin in mineralization during osteogenesis","volume":"127","author":"Wewer","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bioadv.2026.215135_bb0295","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1210\/jcem-66-1-187","article-title":"Human serum \u03b1 2 HS-glycoprotein modulates in vitro bone resorption*","volume":"66","author":"COLCLASURE","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bioadv.2026.215135_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imbio.2012.01.020","article-title":"Does complement play a role in bone development and regeneration?","volume":"218","author":"Schoengraf","year":"2013","journal-title":"Immunobiology"},{"key":"10.1016\/j.bioadv.2026.215135_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113367","article-title":"Role of the complement system in the response to orthopedic biomaterials","volume":"19","author":"M\u00f6dinger","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215135_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.111932","article-title":"Osteoclast differentiation and formation induced by titanium implantation through complement C3a","volume":"122","author":"Liu","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2026.215135_bb0315","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cyto.2008.05.007","article-title":"IL-6 receptor expression and IL-6 effects change during osteoblast differentiation","volume":"43","author":"Li","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.bioadv.2026.215135_bb0320","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1677\/joe.0.1750683","article-title":"Osteoblast differentiation influences androgen and estrogen receptor-alpha and -beta expression","volume":"175","author":"Wiren","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bioadv.2026.215135_bb0325","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/jbmr.419","article-title":"Microtubule assembly affects bone mass by regulating both osteoblast and osteoclast functions: Stathmin deficiency produces an osteopenic phenotype in mice","volume":"26","author":"Liu","year":"2011","journal-title":"J. Bone Miner. Res."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:22:44Z","timestamp":1790900564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826004358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":64,"alternative-id":["S2772950826004358"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215135","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Titanium dioxide nanoparticles alter mesenchymal stem cell function and exosome signalling: Possible implications in periprosthetic osteolysis","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"215135"}}