{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:55:28Z","timestamp":1790902528015,"version":"4.1.0"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["25107"],"award-info":[{"award-number":["25107"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bioadv.2026.215161","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:31:11Z","timestamp":1788733871000},"page":"215161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A multifunctional injectable hemostatic hydrogel for sustained tranexamic acid delivery and ROS attenuation in intracerebral hemorrhage"],"prefix":"10.1016","volume":"190","author":[{"given":"Ali","family":"Golkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Tabesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Jahanbakhshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh","family":"Hajisoltani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Poorkhalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.bioadv.2026.215161_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12206637","article-title":"Challenges in coagulation management in neurosurgical diseases: a scoping review, development, and implementation of coagulation management strategies","volume":"12","author":"Germans","year":"2023","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-021-00264-3","article-title":"Trauma-induced coagulopathy","volume":"7","author":"Moore","year":"2021","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"6","key":"10.1016\/j.bioadv.2026.215161_bb0015","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/neuros\/nyab358","article-title":"Coagulopathy and progression of intracranial hemorrhage in traumatic brain injury: mechanisms, impact, and therapeutic considerations","volume":"89","author":"Maegele","year":"2021","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bioadv.2026.215161_bb0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jss.2017.05.027","article-title":"Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy","volume":"217","author":"Stettler","year":"2017","journal-title":"J. Surg. Res."},{"issue":"12","key":"10.1016\/j.bioadv.2026.215161_bb0025","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1016\/j.jtha.2023.05.028","article-title":"Mechanisms and management of the coagulopathy of trauma and sepsis: trauma-induced coagulopathy, sepsis-induced coagulopathy, and disseminated intravascular coagulation","volume":"21","author":"Iba","year":"2023","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215161_bb0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1474-4422(22)00338-6","article-title":"Intracerebral haemorrhage expansion: definitions, predictors, and prevention","volume":"22","author":"Morotti","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bioadv.2026.215161_bb0035","article-title":"Hematoma expansion in intracerebral hemorrhage: an update on prediction and treatment","volume":"11","author":"Li","year":"2020","journal-title":"Front. Neurol."},{"issue":"21","key":"10.1016\/j.bioadv.2026.215161_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e39907","article-title":"An updated review for clinical and radiological predictors of acute intraparenchymal hematoma progression in cerebral contusion","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"},{"issue":"8","key":"10.1016\/j.bioadv.2026.215161_bb0045","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.121.319949","article-title":"Cerebral hemorrhage: pathophysiology, treatment, and future directions","volume":"130","author":"Magid-Bernstein","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.bioadv.2026.215161_bb0050","article-title":"Oxidative stress following intracerebral hemorrhage: from molecular mechanisms to therapeutic targets","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"issue":"1\u20133","key":"10.1016\/j.bioadv.2026.215161_bb0055","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/ars.2021.0072","article-title":"Targeting oxidative stress and inflammatory response for blood\u2013brain barrier protection in intracerebral hemorrhage","volume":"37","author":"Chen","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bioadv.2026.215161_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.853589","article-title":"Secondary brain injury by oxidative stress after cerebral hemorrhage: recent advances","volume":"16","author":"Shao","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bioadv.2026.215161_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105948","article-title":"Brain edema formation and therapy after intracerebral hemorrhage","volume":"176","author":"Wan","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"8","key":"10.1016\/j.bioadv.2026.215161_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21082721","article-title":"Traumatic brain injury and blood\u2013brain barrier (BBB): underlying pathophysiological mechanisms and the influence of cigarette smoking as a premorbid condition","volume":"21","author":"Sivandzade","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215161_bb0075","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s12264-023-01118-6","article-title":"Ion Channel dysregulation following intracerebral hemorrhage: X. Zhang et al.: ion channel dysregulation and ICH","volume":"40","author":"Zhang","year":"2024","journal-title":"Neurosci. Bull."},{"issue":"8","key":"10.1016\/j.bioadv.2026.215161_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/biology12081139","article-title":"Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?","volume":"12","author":"Freire","year":"2023","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0085","article-title":"Healthy young human plasma-derived exosomes enhance neural stem cell therapy by suppressing pyroptosis via TXNIP\/NLRP3 after intracerebral hemorrhage","volume":"24","author":"Chen","year":"2026","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215161_bb0090","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.scib.2024.06.005","article-title":"CSF multi-omics of intracerebral hemorrhage from onset to reperfusion underscores lipid metabolism in functional outcome","volume":"70","author":"Jiang","year":"2025","journal-title":"Sci. Bull."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215161_bb0095","first-page":"353","article-title":"Tranexamic acid: a clinical review","volume":"47","author":"Ng","year":"2015","journal-title":"Anestezjol. Intens. Ter."},{"key":"10.1016\/j.bioadv.2026.215161_bb0100","first-page":"3","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial","volume":"9","author":"Bautista","year":"2012","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1089\/jop.1994.10.47","article-title":"In situ-forming gels for ophthalmic drug delivery","volume":"10","author":"Kumar","year":"1994","journal-title":"J. Ocul. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215161_bb0110","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/(SICI)1097-4636(20000605)50:3<388::AID-JBM13>3.0.CO;2-F","article-title":"Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins","volume":"50","author":"Eliaz","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215161_bb0115","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ejpb.2004.03.019","article-title":"In situ-forming hydrogels\u2014review of temperature-sensitive systems","volume":"58","author":"Ruel-Gari\u00e9py","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bioadv.2026.215161_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.158039","article-title":"An injectable extracellular matrix-mimicking conductive hydrogel for sequential treatment of ischemic stroke","volume":"502","author":"Wang","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215161_bb0125","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.apsb.2025.01.005","article-title":"NO-releasing double-crosslinked responsive hydrogels accelerate the treatment and repair of ischemic stroke","volume":"15","author":"Guo","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bioadv.2026.215161_bb0130","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.biomaterials.2016.06.008","article-title":"Localized sequence-specific release of a chemopreventive agent and an anticancer drug in a time-controllable manner to enhance therapeutic efficacy","volume":"101","author":"Pan","year":"2016","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.bioadv.2026.215161_bb0135","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jconrel.2012.04.016","article-title":"In situ forming implants\u2014an attractive formulation principle for parenteral depot formulations","volume":"161","author":"Kempe","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.215161_bb0140","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jconrel.2015.11.014","article-title":"Engineered in-situ depot-forming hydrogels for intratumoral drug delivery","volume":"220","author":"Fakhari","year":"2015","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215161_bb0145","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1021\/acs.molpharmaceut.2c01062","article-title":"Polyaspartic acid-stabilized CaCO3-containing in situ hydrogel for protection and treatment of gastric ulcer","volume":"20","author":"Xu","year":"2023","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15010257","article-title":"pH-responsive hydrogel as a potential oral delivery system of baicalin for prolonging gastroprotective activity","volume":"15","author":"Xu","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.215161_bb0155","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2147\/IJN.S400798","article-title":"Sustained-release esketamine based nanoparticle-hydrogel delivery system for neuropathic pain management","author":"Zhang","year":"2023","journal-title":"Int. J. Nanomedicine"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215161_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ma14040858","article-title":"A review on the adaption of alginate-gelatin hydrogels for 3D cultures and bioprinting","volume":"14","author":"\u0141abowska","year":"2021","journal-title":"Materials"},{"issue":"3","key":"10.1016\/j.bioadv.2026.215161_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/polym13030433","article-title":"Dynamic mechanical control of alginate-fibronectin hydrogels with dual crosslinking: covalent and ionic","volume":"13","author":"Trujillo","year":"2021","journal-title":"Polymers"},{"issue":"3","key":"10.1016\/j.bioadv.2026.215161_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/gels10030190","article-title":"Injectable hydrogels for nervous tissue repair\u2014a brief review","volume":"10","author":"Politr\u00f3n-Zepeda","year":"2024","journal-title":"Gels"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215161_bb0175","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/ibra.12137","article-title":"Potential injectable hydrogels as biomaterials for central nervous system injury: a narrative review","volume":"9","author":"Sarma","year":"2023","journal-title":"Ibrain"},{"issue":"2","key":"10.1016\/j.bioadv.2026.215161_bb0180","doi-asserted-by":"crossref","first-page":"272","DOI":"10.14245\/ns.2244186.093","article-title":"The role of alginate hydrogels as a potential treatment modality for spinal cord injury: a comprehensive review of the literature","volume":"19","author":"Jarrah","year":"2022","journal-title":"Neurospine"},{"key":"10.1016\/j.bioadv.2026.215161_bb0185","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.actbio.2022.03.053","article-title":"Probing soft fibrous materials by indentation","volume":"163","author":"Merson","year":"2023","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0190","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41392-021-00830-x","article-title":"Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity","volume":"6","author":"Cao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215161_bb0195","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202200554","article-title":"Injectable polyzwitterionic lubricant for complete prevention of cardiac adhesion","volume":"23","author":"Wang","year":"2023","journal-title":"Macromol. Biosci."},{"issue":"32","key":"10.1016\/j.bioadv.2026.215161_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202402073","article-title":"MXene-based responsive hydrogels and applications in wound healing","volume":"9","author":"Wang","year":"2024","journal-title":"ChemistrySelect"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0205","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41467-025-67580-0","article-title":"A bio-adaptive physical hydrogel enables dynamic tissue engineering for tracheal reconstruction","volume":"17","author":"Tang","year":"2025","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.bioadv.2026.215161_bb0210","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1016\/j.actbio.2010.04.011","article-title":"Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan\u2013polyethylene glycol diacrylate hybrid hydrogels","volume":"6","author":"Zhong","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215161_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125929","article-title":"Dual cross-linked hydrogels as promising materials for drug delivery","volume":"683","author":"Damm","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioadv.2026.215161_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144498","article-title":"Strong and tough chitosan-based conductive hydrogels cross-linked by dual ionic networks for flexible strain sensors","volume":"315","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215161_bb0225","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.addr.2018.03.007","article-title":"In situ forming injectable hydrogels for drug delivery and wound repair","volume":"127","author":"Dimatteo","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0230","doi-asserted-by":"crossref","DOI":"10.1038\/srep32456","article-title":"Development of functionalized multi-walled carbon-nanotube-based alginate hydrogels for enabling biomimetic technologies","volume":"6","author":"Joddar","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.215161_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2025.118237","article-title":"Fabrication of pH-sensitive gelatin\/sodium alginate composite microbeads for potential delivery of resveratrol","volume":"230","author":"Liu","year":"2025","journal-title":"LWT"},{"key":"10.1016\/j.bioadv.2026.215161_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2020.103979","article-title":"Alginate-based hydrogels show the same complex mechanical behavior as brain tissue","volume":"111","author":"Distler","year":"2020","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"10","key":"10.1016\/j.bioadv.2026.215161_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14102255","article-title":"Hemostatic alginate\/nano-hydroxyapatite composite aerogel loaded with tranexamic acid for the potential protection against alveolar osteitis","volume":"14","author":"El Halawany","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioadv.2026.215161_bb0250","first-page":"314","article-title":"Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment","volume":"23","author":"Haghniaz","year":"2023","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0255","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1038\/s41467-023-41594-y","article-title":"Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment","volume":"14","author":"Vinikoor","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2026.215161_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.algal.2023.102986","article-title":"An improved phenol-sulfuric acid method for the quantitative measurement of total carbohydrates in algal biomass","volume":"70","author":"Chen","year":"2023","journal-title":"Algal Res."},{"key":"10.1016\/j.bioadv.2026.215161_bb0265","article-title":"Two-step digestion pathways of hydrogels from pea proteins","volume":"703","author":"Schirone","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.bioadv.2026.215161_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122629","article-title":"Enhancing cell activities through integration of polyanionic alginate or hyaluronic acid derivatives with triboelectric nanogenerators","volume":"346","author":"Shakibi","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"12","key":"10.1016\/j.bioadv.2026.215161_bb0275","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1089\/neu.2009.0968","article-title":"Novel model of frontal impact closed head injury in the rat","volume":"26","author":"Kilbourne","year":"2009","journal-title":"J. Neurotrauma"},{"issue":"6","key":"10.1016\/j.bioadv.2026.215161_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9060585","article-title":"Local experimental intracerebral hemorrhage in rats","volume":"9","author":"Vasilevskaya","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.bioadv.2026.215161_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.sna.2025.117016","article-title":"Vacuum-assisted electrochemotherapy: a promising secure method for intraoperative cavity site margin therapy","volume":"395","author":"Abadijoo","year":"2025","journal-title":"Sens. Actuators A Phys."},{"key":"10.1016\/j.bioadv.2026.215161_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118360","article-title":"Alginate modification via click chemistry for biomedical applications","volume":"270","author":"Deng","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.215161_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2023.108510","article-title":"Irreversible electroporation for post-operative margin therapy to prevent cancer recurrence based on triboelectric nanogenerator driven balloon catheter","volume":"112","author":"Khayamian","year":"2023","journal-title":"Nano Energy"},{"key":"10.1016\/j.bioadv.2026.215161_bb0300","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.msec.2018.11.051","article-title":"Biodegradable and injectable hydrogels as an immunosuppressive drug delivery system","volume":"98","author":"Kim","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215161_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/colloids6040051","article-title":"Isolation and structural characterization of alginates from the kelp species Laminaria ochroleuca and Saccorhiza polyschides from the Atlantic Coast of Morocco","volume":"6","author":"Kaidi","year":"2022","journal-title":"Colloids Interfaces"},{"issue":"11","key":"10.1016\/j.bioadv.2026.215161_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113545","article-title":"Characterization of Ecklonia cava alginate films containing cinnamon essential oils","volume":"19","author":"Baek","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bioadv.2026.215161_bb0315","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1021\/bm060010d","article-title":"Effect of Ca2+, Ba2+, and Sr2+ on alginate microbeads","volume":"7","author":"M\u00f8rch","year":"2006","journal-title":"Biomacromolecules"},{"issue":"3","key":"10.1016\/j.bioadv.2026.215161_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/polym13030354","article-title":"Alginate\/\u03ba-carrageenan-based edible films incorporated with clove essential oil: physico-chemical characterization and antioxidant-antimicrobial activity","volume":"13","author":"Prasetyaningrum","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.bioadv.2026.215161_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2025.107343","article-title":"Sequential recovery of alginate from fucoidan extraction by-products of Nizamuddinia zanardinii seaweed using green extraction methods","volume":"117","author":"Alboofetileh","year":"2025","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.bioadv.2026.215161_bb0330","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.saa.2013.09.044","article-title":"Interactions of fish gelatin and chitosan in uncrosslinked and crosslinked with EDC films: FT-IR study","volume":"117","author":"Staroszczyk","year":"2014","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"issue":"11","key":"10.1016\/j.bioadv.2026.215161_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e32135","article-title":"In situ forming an injectable hyaluronic acid hydrogel for drug delivery and synergistic tumor therapy","volume":"10","author":"Fan","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bioadv.2026.215161_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.brain.2022.100056","article-title":"Age-dependent viscoelastic characterization of rat brain cortex","volume":"3","author":"Xue","year":"2022","journal-title":"Brain Multiphys."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215161_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25030756","article-title":"An interpenetrating alginate\/gelatin network for three-dimensional (3D) cell cultures and organ bioprinting","volume":"25","author":"Chen","year":"2020","journal-title":"Molecules"},{"issue":"1\u20133","key":"10.1016\/j.bioadv.2026.215161_bb0350","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.molstruc.2008.04.026","article-title":"Spectrophotometric techniques to determine tranexamic acid: kinetic studies using ninhydrin and direct measuring using ferric chloride","volume":"891","author":"Arayne","year":"2008","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bioadv.2026.215161_bb0355","series-title":"Controlled Release Polymeric Formulations","author":"Paul","year":"1976"},{"key":"10.1016\/j.bioadv.2026.215161_bb0360","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.msec.2014.02.026","article-title":"Supramolecular cyclodextrin pseudorotaxane hydrogels: a candidate for sustained release?","volume":"39","author":"Chee","year":"2014","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bioadv.2026.215161_bb0365","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0168-3659(85)90051-3","article-title":"Kinetics of drug release from hydrogel matrices","volume":"2","author":"Lee","year":"1985","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0370","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12959-023-00540-0","article-title":"Tranexamic acid for haemostasis and beyond: does dose matter?","volume":"21","author":"Lam","year":"2023","journal-title":"Thromb. J."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0375","doi-asserted-by":"crossref","DOI":"10.3390\/gels9010002","article-title":"Advances in hemostatic hydrogels that can adhere to wet surfaces","volume":"9","author":"Han","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.bioadv.2026.215161_bb0380","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.627351","article-title":"A composite hydrogel based on pectin\/cellulose via chemical cross-linking for hemorrhage","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215161_bb0385","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12028-012-9681-5","article-title":"Treatment of intracerebral hemorrhage with tranexamic acid after thrombolysis with tissue plasminogen activator","volume":"17","author":"French","year":"2012","journal-title":"Neurocrit. Care"},{"key":"10.1016\/j.bioadv.2026.215161_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115307","article-title":"Tranexamic acid improves psoriasis-like skin inflammation: evidence from in vivo and in vitro studies","volume":"166","author":"Hseu","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215161_bb0395","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202400301","article-title":"An alginate\/gelatin injectable hydrogel containing Au nanoparticles for transplantation of embryonic mouse cardiomyocytes in myocardial repair","volume":"25","author":"Pournemati","year":"2025","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.bioadv.2026.215161_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122495","article-title":"Intraoperative application of intelligent, responsive, self-assembling hydrogel rectifies oxygen and energy metabolism in traumatically injured brain","volume":"306","author":"Han","year":"2024","journal-title":"Biomaterials"},{"issue":"29","key":"10.1016\/j.bioadv.2026.215161_bb0405","doi-asserted-by":"crossref","first-page":"33756","DOI":"10.1021\/acsami.2c04930","article-title":"Reactive oxygen species scavenging functional hydrogel delivers procyanidins for the treatment of traumatic brain injury in mice","volume":"14","author":"Huang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0410","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1186\/s13287-025-04691-x","article-title":"ROS-responsive 3D biological scaffold delivers hypoxia-primed extracellular vesicles for targeted modulation of neuroinflammation in intracerebral hemorrhage","volume":"16","author":"Zhang","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bioadv.2026.215161_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2024.100521","article-title":"Improving the dichloro-dihydro-fluorescein (DCFH) assay for the assessment of intracellular reactive oxygen species formation by nanomaterials","volume":"35","author":"Ruijter","year":"2024","journal-title":"NanoImpact"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0420","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2026.2663263","article-title":"Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30\/MAPK pathway","volume":"58","author":"Lin","year":"2026","journal-title":"Ann. Med."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0425","doi-asserted-by":"crossref","DOI":"10.1186\/s40360-026-01160-w","article-title":"Tranexamic acid inhibits mitochondrial DNA release and reduces inflammatory response in an in vitro model of OGD\/R-induced Caco-2 cell injury","volume":"27","author":"Wang","year":"2026","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"3\u20136","key":"10.1016\/j.bioadv.2026.215161_bb0430","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.vph.2011.03.003","article-title":"The annexin A2 system and vascular homeostasis","volume":"54","author":"Flood","year":"2011","journal-title":"Vascul. Pharmacol."},{"issue":"5","key":"10.1016\/j.bioadv.2026.215161_bb0435","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/1873-3468.12964","article-title":"Role of mitochondrial ROS in the brain: from physiology to neurodegeneration","volume":"592","author":"Angelova","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bioadv.2026.215161_bb0440","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00267","article-title":"Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial ROS homeostasis mediated by AMPK\/Nrf2\/Sirt3 signaling pathway","volume":"11","author":"Gao","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bioadv.2026.215161_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2025.109458","article-title":"The impacts of tranexamic acid on immune system during trauma","volume":"255","author":"Abolhassani","year":"2025","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215161_bb0450","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10787-024-01619-4","article-title":"Effects of tranexamic acid on postoperative knee activity and stress, and inflammation cytokines in patients undergoing total knee arthroplasty","volume":"33","author":"Ma","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.bioadv.2026.215161_bb0455","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/jamasurg.2024.6048","article-title":"Safety and efficacy of tranexamic acid in general surgery","volume":"160","author":"Park","year":"2025","journal-title":"JAMA Surg."},{"key":"10.1016\/j.bioadv.2026.215161_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114009","article-title":"A review of the pathology and treatment of TBI and PTSD","volume":"351","author":"Monsour","year":"2022","journal-title":"Exp. Neurol."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:29:23Z","timestamp":1790900963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826004619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":92,"alternative-id":["S2772950826004619"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215161","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multifunctional injectable hemostatic hydrogel for sustained tranexamic acid delivery and ROS attenuation in intracerebral hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"215161"}}