{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:55:31Z","timestamp":1790902531995,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301152"],"award-info":[{"award-number":["82301152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bioadv.2026.215165","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:31:00Z","timestamp":1788733860000},"page":"215165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Biomimetic bilayer electrospun membrane simulating periodontal complex for orchestrated bone and fibrous tissue regeneration"],"prefix":"10.1016","volume":"190","author":[{"given":"Wang","family":"Yuning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ruoxi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weng","family":"Yuteng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Shuyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yanhuizhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bioadv.2026.215165_bb0005","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/jcpe.13761","article-title":"Chronic oral diseases burden: the confluence of caries and periodontitis throughout life","volume":"50","author":"Costa","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bioadv.2026.215165_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2026.156401","article-title":"Ferroptosis in periodontitis: mechanism, role, and therapeutic potential","volume":"281","author":"Tan","year":"2026","journal-title":"Pathol. Res. Pract."},{"issue":"6","key":"10.1016\/j.bioadv.2026.215165_bb0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1600-0501.2010.01922.x","article-title":"Guided bone regeneration: biological principle and therapeutic applications","volume":"21","author":"Retzepi","year":"2010","journal-title":"Clin. Oral Implants Res."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215165_bb0020","first-page":"297","article-title":"Recent advances in periodontal regeneration: a biomaterial perspective","volume":"5","author":"Liang","year":"2020","journal-title":"Bioact. Mater."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215165_bb0025","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.joen.2009.12.012","article-title":"Guided tissue regeneration in periapical surgery","volume":"36","author":"Lin","year":"2010","journal-title":"J. Endodont."},{"key":"10.1016\/j.bioadv.2026.215165_bb0030","article-title":"A multifunctional quercetin\/polycaprolactone electrospun fibrous membrane for periodontal bone regeneration","volume":"24","author":"Hu","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"16","key":"10.1016\/j.bioadv.2026.215165_bb0035","doi-asserted-by":"crossref","first-page":"23707","DOI":"10.1021\/acsami.5c02557","article-title":"Biodegradable piezoelectric Janus membrane enabling dual antibacterial and osteogenic functions for periodontitis therapy","volume":"17","author":"Li","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioadv.2026.215165_bb0040","article-title":"Dual-network silk fibroin\/quercetin hydrogel for periodontitis treatment","author":"Zhang","year":"2026","journal-title":"J. Dent. Res."},{"issue":"8","key":"10.1016\/j.bioadv.2026.215165_bb0045","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/ten.tec.2022.0106","article-title":"Challenges and tissue engineering strategies of periodontal-guided tissue regeneration","volume":"28","author":"Liu","year":"2022","journal-title":"Tissue Eng. Part C Methods"},{"issue":"12","key":"10.1016\/j.bioadv.2026.215165_bb0050","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.6026\/973206300181181","article-title":"Recent advances in GTR scaffolds","volume":"18","author":"Bajpai","year":"2022","journal-title":"Bioinformation"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12951-023-01982-4","article-title":"Nanosilicate-functionalized nanofibrous membrane facilitated periodontal regeneration potential by harnessing periodontal ligament cell-mediated osteogenesis and immunomodulation","volume":"21","author":"Xu","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0060","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/s13287-024-04003-9","article-title":"Dental stem cell dynamics in periodontal ligament regeneration: from mechanism to application","volume":"15","author":"Wen","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12565-019-00502-5","article-title":"Three-dimensional ultrastructural imaging and quantitative analysis of the periodontal ligament","volume":"95","author":"Hirashima","year":"2020","journal-title":"Anat. Sci. Int."},{"issue":"6","key":"10.1016\/j.bioadv.2026.215165_bb0070","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/jre.12477","article-title":"The intricate anatomy of the periodontal ligament and its development: lessons for periodontal regeneration","volume":"52","author":"de Jong","year":"2017","journal-title":"J. Periodontal Res."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41368-025-00354-y","article-title":"Exploring the mechanical and biological interplay in the periodontal ligament","volume":"17","author":"Wen","year":"2025","journal-title":"Int. J. Oral Sci."},{"issue":"11","key":"10.1016\/j.bioadv.2026.215165_bb0080","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.dental.2022.09.011","article-title":"Self-assembling peptide-laden electrospun scaffolds for guided mineralized tissue regeneration","volume":"38","author":"de Souza Araujo","year":"2022","journal-title":"Dent. Mater."},{"key":"10.1016\/j.bioadv.2026.215165_bb0085","doi-asserted-by":"crossref","DOI":"10.20517\/2347-9264.2020.176","article-title":"Current and future trends in periodontal tissue engineering and bone regeneration","volume":"8","author":"Galli","year":"2021","journal-title":"Plast. Aesthet. Res."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215165_bb0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/09506608.2021.1946236","article-title":"Innovations in craniofacial bone and periodontal tissue engineering \u2014 from electrospinning to converged biofabrication","volume":"67","author":"Aytac","year":"2022","journal-title":"Int. Mater. Rev."},{"issue":"28","key":"10.1016\/j.bioadv.2026.215165_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202502888","article-title":"Recent advances in dual-function Janus membranes for guided periodontal and bone regeneration","volume":"14","author":"Li","year":"2025","journal-title":"Adv. Healthc. Mater."},{"issue":"40","key":"10.1016\/j.bioadv.2026.215165_bb0100","article-title":"Biodegradable zinc-based alloys for guided bone regeneration membranes: feasibility, current status, and future prospects","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"10","key":"10.1016\/j.bioadv.2026.215165_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ma14102558","article-title":"Hard dental tissues regeneration\u2014approaches and challenges","volume":"14","author":"Olaru","year":"2021","journal-title":"Materials (Basel)"},{"issue":"13","key":"10.1016\/j.bioadv.2026.215165_bb0110","article-title":"Programmable electro-assembly of collagen: constructing porous Janus films with customized dual signals for immunomodulation and tissue regeneration in periodontitis treatment","volume":"11","author":"Lei","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215165_bb0115","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cden.2022.05.011","article-title":"Biomaterials for periodontal regeneration","volume":"66","author":"Deng","year":"2022","journal-title":"Dent. Clin. N. Am."},{"issue":"28","key":"10.1016\/j.bioadv.2026.215165_bb0120","article-title":"Electrospinning and nanofiber technology: fundamentals, innovations, and applications","volume":"37","author":"Cho","year":"2025","journal-title":"Adv. Mater."},{"issue":"Pt B","key":"10.1016\/j.bioadv.2026.215165_bb0125","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jconrel.2015.09.008","article-title":"Current strategies for sustaining drug release from electrospun nanofibers","volume":"220","author":"Chou","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.215165_bb0130","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.2147\/DDDT.S419361","article-title":"Macro, micro, and nano-inspired bioactive polymeric biomaterials in therapeutic, and regenerative orofacial applications","volume":"17","author":"Atia","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215165_bb0135","doi-asserted-by":"crossref","DOI":"10.1115\/1.4048810","article-title":"Tissue engineering for periodontal ligament regeneration: biomechanical specifications","volume":"143","author":"Gauthier","year":"2021","journal-title":"J. Biomech. Eng."},{"issue":"Pt 3","key":"10.1016\/j.bioadv.2026.215165_bb0140","article-title":"Electrospun gelatin-based biomimetic scaffold with spatially aligned and three-layer architectures for vascular tissue engineering","volume":"242","author":"Guo","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215165_bb0145","article-title":"Multi-material electrospinning: from methods to biomedical applications","volume":"21","author":"Xing","year":"2023","journal-title":"Mater. Today Bio"},{"issue":"36","key":"10.1016\/j.bioadv.2026.215165_bb0150","doi-asserted-by":"crossref","first-page":"26077","DOI":"10.1039\/D4RA04043K","article-title":"Electrospinning technology: a promising approach for tendon-bone interface tissue engineering","volume":"14","author":"Liang","year":"2024","journal-title":"RSC Adv."},{"issue":"4S1","key":"10.1016\/j.bioadv.2026.215165_bb0155","doi-asserted-by":"crossref","first-page":"4S3","DOI":"10.1016\/S0929-693X(24)00151-9","article-title":"Biology of bone mineralization and ectopic calcifications: the same actors for different plays","volume":"31","author":"Lafage-Proust","year":"2024","journal-title":"Arch. Pediatr."},{"issue":"8","key":"10.1016\/j.bioadv.2026.215165_bb0160","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nmat3362","article-title":"The predominant role of collagen in the nucleation, growth, structure and orientation of bone apatite","volume":"11","author":"Wang","year":"2012","journal-title":"Nat. Mater."},{"issue":"10","key":"10.1016\/j.bioadv.2026.215165_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/polym14102123","article-title":"Bone mineralization in electrospun-based bone tissue engineering","volume":"14","author":"Lim","year":"2022","journal-title":"Polymers (Basel)"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12951-021-01228-1","article-title":"Emerging zero-dimensional to four-dimensional biomaterials for bone regeneration","volume":"20","author":"Fang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.215165_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2020.102157","article-title":"Biodegradable calcium phosphate nanoparticles for cancer therapy","volume":"279","author":"Khalifehzadeh","year":"2020","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.bioadv.2026.215165_bb0180","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.cej.2018.04.045","article-title":"In situ modulation of crystallinity and nano-structures to enhance the stability and osseointegration of hydroxyapatite coatings on Ti-6Al-4V implants","volume":"347","author":"Xia","year":"2018","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bioadv.2026.215165_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1170097","article-title":"Hydrothermally reinforcing hydroxyaptatite and bioactive glass on carbon nanofiber scafold for bone tissue engineering","volume":"11","author":"Abd El-Aziz","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215165_bb0190","article-title":"Modulating the crystallinity of biphasic calcium phosphate composites balances surface and ionic cues to enhance osteogenesis via integrin-mediated cytoskeletal signaling","volume":"35","author":"Liang","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"Pt 2","key":"10.1016\/j.bioadv.2026.215165_bb0195","article-title":"Protective effect of an oriented PCL electrospun membrane loaded with red ginseng polysaccharides and magnetic nanoparticles against nerve injury of mice","volume":"310","author":"Sun","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0200","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1021\/acsami.2c18893","article-title":"Periodontal ligament-mimetic fibrous scaffolds regulate YAP-associated fibroblast behaviors and promote regeneration of periodontal defect in relation to the scaffold topography","volume":"15","author":"Kim","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.bioadv.2026.215165_bb0205","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.identj.2024.02.013","article-title":"Composite PCL scaffold with 70% beta-TCP as suitable structure for bone replacement","volume":"74","author":"Ghezzi","year":"2024","journal-title":"Int. Dent. J."},{"key":"10.1016\/j.bioadv.2026.215165_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2020.108153","article-title":"Virus and chlorine adsorption onto guanidine modified cellulose nanofibers using covalent and hydrogen bonding","volume":"498","author":"Mi","year":"2020","journal-title":"Carbohydr. Res."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215165_bb0215","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jbm.a.35222","article-title":"An investigation of common crosslinking agents on the stability of electrospun collagen scaffolds","volume":"103","author":"Huang","year":"2015","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0220","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.actbio.2008.06.016","article-title":"Regulation of material properties in electrospun scaffolds: role of cross-linking and fiber tertiary structure","volume":"5","author":"Newton","year":"2009","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioadv.2026.215165_bb0225","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ijbiomac.2012.10.002","article-title":"Properties and modification of porous 3-D collagen\/hydroxyapatite composites","volume":"52","author":"Sionkowska","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215165_bb0230","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/jbm.a.34394","article-title":"Preparation and characterization of collagen-nanohydroxyapatite biocomposite scaffolds by cryogelation method for bone tissue engineering applications","volume":"101A","author":"Rodrigues","year":"2013","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"18","key":"10.1016\/j.bioadv.2026.215165_bb0235","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1080\/09205063.2013.822247","article-title":"Development and evaluation of cross-linked collagen-hydroxyapatite scaffolds for tissue engineering","volume":"24","author":"Panda","year":"2013","journal-title":"J. Biomater. Sci. Polym. Ed."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0240","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0142-9612(03)00472-1","article-title":"Glutaraldehyde cross-linked hydroxyapatite\/collagen self-organized nanocomposites","volume":"25","author":"Kikuchi","year":"2004","journal-title":"Biomaterials"},{"issue":"47","key":"10.1016\/j.bioadv.2026.215165_bb0245","doi-asserted-by":"crossref","first-page":"17741","DOI":"10.1073\/pnas.0604237103","article-title":"Cooperative deformation of mineral and collagen in bone at the nanoscale","volume":"103","author":"Gupta","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioadv.2026.215165_bb0250","doi-asserted-by":"crossref","first-page":"e20190544","DOI":"10.1590\/1678-7757-2019-0544","article-title":"Direct resin composite restoration of endodontically-treated permanent molars in adolescents: bite force and patient-specific finite element analysis","volume":"28","author":"Rodrigues","year":"2020","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.bioadv.2026.215165_bb0255","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.colsurfb.2018.09.038","article-title":"Inorganic apatite nanomaterial: modified surface phenomena and its role in developing collagen based polymeric bio-composite (Coll-PLGA\/HAp) for biological applications","volume":"172","author":"Selvaraju","year":"2018","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"12","key":"10.1016\/j.bioadv.2026.215165_bb0260","article-title":"Electro-sorting create heterogeneity: constructing a multifunctional Janus film with integrated compositional and microstructural gradients for guided bone regeneration","volume":"11","author":"Lei","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bioadv.2026.215165_bb0265","doi-asserted-by":"crossref","DOI":"10.1177\/00220345261464526","article-title":"A bioactive Janus barrier membrane rejuvenates bone regeneration in aging","author":"Zhang","year":"2026","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0270","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.dental.2025.09.017","article-title":"Gas diffusion-mediated single-sided in situ gradient mineralized silk fibroin membrane for enhanced guided bone regeneration","volume":"42","author":"Li","year":"2026","journal-title":"Dent. Mater."},{"issue":"6","key":"10.1016\/j.bioadv.2026.215165_bb0275","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/rb\/rbaa041","article-title":"In vitro genotoxicity evaluation and metabolic study of residual glutaraldehyde in animal-derived biomaterials","volume":"7","author":"Shi","year":"2020","journal-title":"Regener. Biomater."},{"issue":"5","key":"10.1016\/j.bioadv.2026.215165_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/polym15051079","article-title":"Effect of electrospun PLGA\/collagen scaffolds on cell adhesion, viability, and collagen release: potential applications in tissue engineering","volume":"15","author":"Guzman-Soria","year":"2023","journal-title":"Polymers (Basel)"},{"issue":"11","key":"10.1016\/j.bioadv.2026.215165_bb0285","doi-asserted-by":"crossref","first-page":"8401","DOI":"10.1021\/am501309d","article-title":"\u201cClick\u201d immobilization of a VEGF-mimetic peptide on decellularized endothelial extracellular matrix to enhance angiogenesis","volume":"6","author":"Wang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"24","key":"10.1016\/j.bioadv.2026.215165_bb0290","doi-asserted-by":"crossref","first-page":"16347","DOI":"10.1074\/jbc.M603439200","article-title":"Cyclin D1-cdk4 induce runx2 ubiquitination and degradation","volume":"281","author":"Shen","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215165_bb0295","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/jcb.21900","article-title":"Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation","volume":"105","author":"Pregizer","year":"2008","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215165_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/ma16030956","article-title":"Fabrication, structural and biological characterization of zinc-containing bioactive glasses and their use in membranes for guided bone regeneration","volume":"16","author":"Gavinho","year":"2023","journal-title":"Materials (Basel)"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215165_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/ma16041364","article-title":"3D-printed soft membrane for periodontal guided tissue regeneration","volume":"16","author":"Vahdatinia","year":"2023","journal-title":"Materials (Basel)"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0310","doi-asserted-by":"crossref","first-page":"20748","DOI":"10.1038\/s41598-024-71435-x","article-title":"Collagen protein-chitosan nerve conduits with neuroepithelial stem cells promote peripheral nerve regeneration","volume":"14","author":"Yun","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0315","doi-asserted-by":"crossref","DOI":"10.1080\/14686996.2023.2186690","article-title":"Optimizing the biodegradability and osteogenesis of biogenic collagen membrane via fluoride-modified polymer-induced liquid precursor process","volume":"24","author":"Li","year":"2023","journal-title":"Sci. Technol. Adv. Mater."},{"issue":"6","key":"10.1016\/j.bioadv.2026.215165_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/polym9060189","article-title":"Poly(lactic-co-glycolic acid): applications and future prospects for periodontal tissue regeneration","volume":"9","author":"Sun","year":"2017","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.bioadv.2026.215165_bb0325","article-title":"Micro-nano integrated platforms for osteoarthritis therapy: from spatial manipulation to cellular reprogramming","volume":"37","author":"Shi","year":"2026","journal-title":"Mater. Today Bio"},{"issue":"32","key":"10.1016\/j.bioadv.2026.215165_bb0330","doi-asserted-by":"crossref","first-page":"18124","DOI":"10.1039\/C9RA02765C","article-title":"Mimicking growth factors: role of small molecule scaffold additives in promoting tissue regeneration and repair","volume":"9","author":"Goonoo","year":"2019","journal-title":"RSC Adv."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0335","article-title":"Electrical stimulation therapy and HA\/TCP composite scaffolds modulate the Wnt pathways in bone regeneration of critical-sized defects","volume":"10","author":"Helaehil","year":"2023","journal-title":"Bioengineering (Basel)"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215165_bb0340","article-title":"Bone tissue engineering and nanotechnology: a promising combination for bone regeneration","volume":"13","author":"Bauso","year":"2024","journal-title":"Biology (Basel)"},{"issue":"6","key":"10.1016\/j.bioadv.2026.215165_bb0345","first-page":"1007","article-title":"Beta-tricalcium phosphate ceramic triggers fast and robust bone formation by human mesenchymal stem cells","volume":"13","author":"Pereira","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215165_bb0350","article-title":"3D fabrication and characterization of phosphoric acid scaffold with a HA\/beta-TCP weight ratio of 60:40 for bone tissue engineering applications","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215165_bb0355","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1038\/s41598-025-87988-4","article-title":"3D nanocomposites of beta-TCP-H3BO3-Cu with improved mechanical and biological performances for bone regeneration applications","volume":"15","author":"Avinashi","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215165_bb0360","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/jre.12716","article-title":"Quantitative characterizations of the Sharpey\u2019s fibers of rat molars","volume":"55","author":"Liang","year":"2020","journal-title":"J. Periodontal Res."},{"issue":"7","key":"10.1016\/j.bioadv.2026.215165_bb0365","first-page":"448","article-title":"Influence of proximal two-wall bone defect on periodontal ligament stresses under normal occlusal forces","volume":"53","author":"Wang","year":"2018","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"10.1016\/j.bioadv.2026.215165_bb0370","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2026.1802077","article-title":"Aligned PLGA\/nHA fiber scaffolds for enhancing osteogenic differentiation of human periodontal ligament stem cells","volume":"14","author":"Zhai","year":"2026","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215165_bb0375","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.actbio.2015.07.023","article-title":"Incorporation of aligned PCL\u2013PEG nanofibers into porous chitosan scaffolds improved the orientation of collagen fibers in regenerated periodontium","volume":"25","author":"Jiang","year":"2015","journal-title":"Acta Biomater."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:28:18Z","timestamp":1790900898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826004656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":75,"alternative-id":["S2772950826004656"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215165","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomimetic bilayer electrospun membrane simulating periodontal complex for orchestrated bone and fibrous tissue regeneration","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"215165"}}