{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:55:49Z","timestamp":1790902549203,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572792"],"award-info":[{"award-number":["82572792"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025T180638"],"award-info":[{"award-number":["2025T180638"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2023GXNSFAA026396"],"award-info":[{"award-number":["2023GXNSFAA026396"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["yzjj2024qn03"],"award-info":[{"award-number":["yzjj2024qn03"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bioadv.2026.215169","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:57:27Z","timestamp":1789120647000},"page":"215169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fabrication of a novel carboxymethyl chitosan-manganese complex and its multidimensional regulatory effects on the joint microenvironment in early osteoarthritis"],"prefix":"10.1016","volume":"190","author":[{"given":"Zhaoquan","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qili","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huicheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingsheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjun","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.215169_bb0005","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1177\/0363546514533777","article-title":"Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents","volume":"43","author":"Gallagher","year":"2015","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.bioadv.2026.215169_bb0010","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1038\/s41598-025-91783-6","article-title":"Global, regional, and national epidemiology of osteoarthritis in working-age individuals: insights from the global burden of disease study 1990\u20132021","volume":"15","author":"Ma","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.215169_bb0015","first-page":"1","article-title":"Diagnosing, treating and monitoring the inflammatory endotype in osteoarthritis clinical trials","author":"Thudium","year":"2025","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.bioadv.2026.215169_bb0020","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.7150\/ijms.107057","article-title":"Novel insights into the role of ferroptosis in temporomandibular joint osteoarthritis and knee osteoarthritis","volume":"22","author":"Zhang","year":"2025","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.bioadv.2026.215169_bb0025","article-title":"Breaking down osteoarthritis: exploring inflammatory and mechanical signaling pathways","volume":"15","author":"Batarfi","year":"2025","journal-title":"Life (Basel)"},{"key":"10.1016\/j.bioadv.2026.215169_bb0030","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s13770-022-00437-5","article-title":"Thermosensitive hydrogel loaded with primary chondrocyte-derived exosomes promotes cartilage repair by regulating macrophage polarization in osteoarthritis","volume":"19","author":"Sang","year":"2022","journal-title":"Tissue Eng. Regen. Med."},{"key":"10.1016\/j.bioadv.2026.215169_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.643953","article-title":"Chitosan-based nanoparticles against viral infections","volume":"11","author":"Boroumand","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bioadv.2026.215169_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202302293","article-title":"Nanofiber composite microchannel-containing injectable hydrogels for cartilage tissue regeneration","volume":"12","author":"Liu","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioadv.2026.215169_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114067","article-title":"Multifunctional mPDA@Mel-AB\/BG hydrogels: integrating ROS scavenging, inflammation suppression, and cartilage repair for osteoarthritis therapy","volume":"386","author":"Wang","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bioadv.2026.215169_bb0050","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ijbiomac.2021.08.226","article-title":"An injectable hydrogel having proteoglycan-like hierarchical structure supports chondrocytes delivery and chondrogenesis","volume":"190","author":"Thomas","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215169_bb0055","doi-asserted-by":"crossref","first-page":"174","DOI":"10.22203\/eCM.v031a12","article-title":"Morphogenetically active scaffold for osteochondral repair (polyphosphate\/alginate\/N,O-carboxymethyl chitosan)","volume":"31","author":"M\u00fcller","year":"2016","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bioadv.2026.215169_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10306","article-title":"Carboxymethyl chitosan prolongs adenovirus-mediated expression of IL-10 and ameliorates hepatic fibrosis in a mouse model","volume":"7","author":"Gou","year":"2022","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.bioadv.2026.215169_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2025.100605","article-title":"Twelve-month efficacy of carboxymethyl-chitosan in refractory knee osteoarthritis: a randomized controlled trial (PIONEER)","volume":"7","author":"Van Overschelde","year":"2025","journal-title":"Osteoarthr. Cartil. Open"},{"key":"10.1016\/j.bioadv.2026.215169_bb0070","article-title":"The impact of trace elements on osteoarthritis","volume":"8","author":"Li","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.bioadv.2026.215169_bb0075","first-page":"42","article-title":"Potential bioactive coating system for high-performance absorbable magnesium bone implants","volume":"12","author":"Sarian","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.215169_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26157493","article-title":"Trace elements-role in joint function and impact on joint diseases","volume":"26","author":"Bryli\u0144ski","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215169_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119821","article-title":"Carboxymethyl chitosan-assisted MnO(x) nanoparticles: synthesis, characterization, detection and cartilage repair in early osteoarthritis","volume":"294","author":"Lin","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.215169_bb0090","article-title":"MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways","volume":"30","author":"Guo","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bioadv.2026.215169_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123526","article-title":"A multifunctional metformin loaded carboxymethyl chitosan\/tannic acid\/manganese composite hydrogel with promising capabilities for age-related bone defect repair","volume":"358","author":"Chen","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.215169_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202270257","article-title":"Osteoimmunity-regulating biomimetically hierarchical scaffold for augmented bone regeneration","volume":"34","author":"Zhang","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioadv.2026.215169_bb0105","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.freeradbiomed.2025.03.013","article-title":"Role of manganese in brain health and disease: focus on oxidative stress","volume":"232","author":"Martins","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioadv.2026.215169_bb0110","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ijbiomac.2017.03.132","article-title":"Preparation, characterization and antibacterial applications of carboxymethyl chitosan\/CuO nanocomposite hydrogels","volume":"101","author":"Wahid","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215169_bb0115","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ijbiomac.2016.03.044","article-title":"Synthesis and characterization of antibacterial carboxymethyl chitosan\/ZnO nanocomposite hydrogels","volume":"88","author":"Wahid","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215169_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117869","article-title":"Synthesis of carboxymethyl chitosan-strontium complex and its therapeutic effects on relieving osteoarthritis","volume":"261","author":"Liu","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.215169_bb0125","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.carres.2009.12.010","article-title":"Metal-carboxylate interactions in metal-alginate complexes studied with FTIR spectroscopy","volume":"345","author":"Papageorgiou","year":"2010","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bioadv.2026.215169_bb0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0368-2048(94)02375-1","article-title":"Evaluation of Mn3s X-ray photoelectron spectroscopy for characterization of manganese complexes","volume":"74","author":"Fujiwara","year":"1995","journal-title":"J. Electron Spectrosc. Relat. Phenom."},{"key":"10.1016\/j.bioadv.2026.215169_bb0135","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.saa.2011.03.023","article-title":"Synthesis, spectral, thermal and magnetic studies of Mn(II), Ni(II) and Cu(II) complexes with some benzopyran-4-one Schiff bases","volume":"79","author":"El-Ansary","year":"2011","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bioadv.2026.215169_bb0140","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s10856-022-06695-y","article-title":"Chondrogenic potential of manganese-loaded composite scaffold combined with chondrocytes for articular cartilage defect","volume":"33","author":"Wei","year":"2022","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioadv.2026.215169_bb0145","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk6610","article-title":"Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration","volume":"10","author":"Du","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioadv.2026.215169_bb0150","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2147\/IJN.S289707","article-title":"Metabolic conversion and removal of manganese ferrite nanoparticles in RAW264.7 cells and induced alteration of metal transporter gene expression","volume":"16","author":"Zhang","year":"2021","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bioadv.2026.215169_bb0155","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adv4238","article-title":"Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1\u03b2 and restoring sirtuin-3","volume":"11","author":"Deng","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bioadv.2026.215169_bb0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioadv.2026.215169_bb0165","doi-asserted-by":"crossref","first-page":"12842","DOI":"10.1021\/acsnano.3c04241","article-title":"Calcitriol-loaded multifunctional nanospheres with superlubricity for advanced osteoarthritis treatment","volume":"17","author":"Xie","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2026.215169_bb0170","doi-asserted-by":"crossref","first-page":"17209","DOI":"10.1021\/acsnano.5c10942","article-title":"Microfluidics-enabled nanoparticle for multiscale synergetic osteoarthritis therapy","volume":"20","author":"Xie","year":"2026","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2026.215169_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119467","article-title":"Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress","volume":"224","author":"Kumar","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215169_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.03.044","article-title":"Carboxymethyl-chitosan protects rabbit chondrocytes from interleukin-1beta-induced apoptosis","volume":"541","author":"Chen","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioadv.2026.215169_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29184360","article-title":"Medical applications and cellular mechanisms of action of carboxymethyl chitosan hydrogels","volume":"29","author":"Kruczkowska","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.bioadv.2026.215169_bb0190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/jfb6010033","article-title":"Anticancer and anti-inflammatory properties of chitin and chitosan oligosaccharides","volume":"6","author":"Azuma","year":"2015","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.bioadv.2026.215169_bb0195","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.carbpol.2012.07.076","article-title":"Biomedical applications of carboxymethyl chitosans","volume":"91","author":"Upadhyaya","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.215169_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119993","article-title":"Effect of molecular structure and ionization state on aggregation of carboxymethyl chitosan: a molecular dynamics study","volume":"297","author":"Lei","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bioadv.2026.215169_bb0205","first-page":"1","article-title":"Targeting lipopolysaccharides in gram-negative sepsis: therapeutic advances and challenges","author":"Akele","year":"2025","journal-title":"J. Drug Target."},{"key":"10.1016\/j.bioadv.2026.215169_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.585146","article-title":"Lipopolysaccharide recognition in the crossroads of TLR4 and caspase-4\/11 mediated inflammatory pathways","volume":"11","author":"Zamyatina","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioadv.2026.215169_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113432","article-title":"Preventive effects of matrine on LPS-induced inflammation in RAW 264.7 cells and intestinal damage in mice through the TLR4\/NF-\u03baB\/MAPK pathway","volume":"143","author":"Mao","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bioadv.2026.215169_bb0220","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12951-025-03270-9","article-title":"Microenvironment-responsive NIR-IIb multifunctional nanozyme platform for bacterial imaging and specialized anti-anaerobic bacteria periodontal therapy","volume":"23","author":"Lin","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bioadv.2026.215169_bb0225","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.1021\/acsnano.4c18099","article-title":"Yeast-inspired orally-administered nanocomposite scavenges oxidative stress and restores gut immune homeostasis for inflammatory bowel disease treatment","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2026.215169_bb0230","article-title":"Immunomodulatory biomaterials for osteoarthritis: targeting inflammation and enhancing cartilage regeneration","volume":"34","author":"Zhao","year":"2025","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.bioadv.2026.215169_bb0235","article-title":"Microenvironment-responsive nanozyme for all stages of infectious chronic wound management through macrophage reprogramming","volume":"36","author":"Wu","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioadv.2026.215169_bb0240","doi-asserted-by":"crossref","first-page":"15449","DOI":"10.1021\/acsnano.6c03635","article-title":"Asymmetrically coordinated cu single-atom nanozyme to accelerate inflammation and immune homeostasis modulation in acute myocardial infarction","volume":"20","author":"Lin","year":"2026","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioadv.2026.215169_bb0245","first-page":"354","article-title":"3D-printed manganese dioxide incorporated scaffold promotes osteogenic-angiogenic coupling for refractory bone defect by remodeling osteo-regenerative microenvironment","volume":"44","author":"Yang","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioadv.2026.215169_bb0250","article-title":"Engineering hyaluronic acid for the development of new treatment strategies for osteoarthritis","volume":"23","author":"Kim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215169_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031566","article-title":"Overview of first-line and second-line pharmacotherapies for osteoarthritis with special focus on intra-articular treatment","volume":"23","author":"Nowaczyk","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioadv.2026.215169_bb0260","doi-asserted-by":"crossref","first-page":"13989","DOI":"10.1007\/s10853-026-12670-7","article-title":"Theranostic MnO2 nanoparticles alleviate oxidative stress and visualize cartilage in osteoarthritis","volume":"61","author":"Chen","year":"2026","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.bioadv.2026.215169_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202517083","article-title":"Injectable chondroitin sulfate methacrylate hydrogel microspheres co-loaded with GLPM nanozyme, dexamethasone, and stem cells for synergistic osteoarthritis therapy","volume":"13","author":"Feng","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioadv.2026.215169_bb0270","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202203240","article-title":"Biodegradable hollow-structured nanozymes modulate phenotypic polarization of macrophages and relieve hypoxia for treatment of osteoarthritis","volume":"18","author":"Xiong","year":"2022","journal-title":"Small"}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:28:41Z","timestamp":1790900921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826004693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":54,"alternative-id":["S2772950826004693"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215169","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fabrication of a novel carboxymethyl chitosan-manganese complex and its multidimensional regulatory effects on the joint microenvironment in early osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"215169"}}