{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:26:00Z","timestamp":1793697960713,"version":"4.5.1"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009467","name":"University of the Witwatersrand, Johannesburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009467","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001336","name":"University of the Witwatersrand Johannesburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bioadv.2026.215176","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:23:23Z","timestamp":1789453403000},"page":"215176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transforming growth factor-\u03b23 in primate tissue induction: Heterotopic osteogenesis, periodontal cementogenesis and the limits of clinical translation; A personal historical perspective"],"prefix":"10.1016","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8167-3594","authenticated-orcid":false,"given":"Ugo","family":"Ripamonti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-898X","authenticated-orcid":false,"given":"Laura C.","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioadv.2026.215176_bb0005","series-title":"Encyclopaedia of Hormones","first-page":"80","article-title":"Osteogenic proteins of the transforming growth factor-\u03b2 supergene family","author":"Ripamonti","year":"2003"},{"issue":"6","key":"10.1016\/j.bioadv.2026.215176_bb0010","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.biomaterials.2005.09.021","article-title":"Soluble osteogenic molecular signals and the induction of bone formation","volume":"27","author":"Ripamonti","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215176_bb0015","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.1016\/j.biomaterials.2014.07.053","article-title":"Re-evaluating the induction of bone formation in primates","volume":"35","author":"Ripamonti","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215176_bb0020","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1097\/SCS.0000000000006568","article-title":"Long-term follow-up of paediatric mandibular reconstruction with human transforming growth factor-\u03b23","volume":"31","author":"Ferretti","year":"2020","journal-title":"J. Craniofac. Surg."},{"issue":"7","key":"10.1016\/j.bioadv.2026.215176_bb0025","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.bjoms.2009.08.043","article-title":"Osteoinduction: translating preclinical promise into clinical reality","volume":"48","author":"Ferretti","year":"2010","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bioadv.2026.215176_bb0030","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1097\/SCS.0000000000007429","article-title":"Special Editorial: The conundrum of human osteoinduction: is the bone induction principle failing clinical translation?","volume":"32","author":"Ferretti","year":"2021","journal-title":"J. Craniofac. Surg."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215176_bb0035","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/SCS.0000000000008299","article-title":"Osteogenic competence and potency of the bone induction principle: inductive substrates that initiate \u201cBone: Formation by autoinduction\u201d","volume":"33","author":"Ripamonti","year":"2022","journal-title":"J Craniofac Surg"},{"issue":"8","key":"10.1016\/j.bioadv.2026.215176_bb0040","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1097\/SCS.0000000000011742","article-title":"The biological and clinical grand challenges for craniomandibulofacial reconstruction: the dream of bone tissue engineering","volume":"36","author":"Ripamonti","year":"2025","journal-title":"J Craniofac Surg."},{"key":"10.1016\/j.bioadv.2026.215176_bb0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bioadv.2025.214262","article-title":"Global morphogenesis regulating tissue architecture and organogenesis","volume":"172","author":"Ripamonti","year":"2025","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.bioadv.2026.215176_bb0050","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1582-4934.2008.00126.x","article-title":"The induction of endochondral bone formation by transforming growth factor-\u03b23: experimental studies in the non-human primate Papio ursinus","volume":"12","author":"Ripamonti","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioadv.2026.215176_bb0055","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.1073\/pnas.90.13.6004","article-title":"Drosophila TGF-\u03b2 superfamily proteins induce endochondral bone formation in mammals","volume":"90","author":"Sampath","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4885","key":"10.1016\/j.bioadv.2026.215176_bb0060","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","article-title":"Novel regulators of bone formation: molecular clones and activities","volume":"242","author":"Wozney","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.bioadv.2026.215176_bb0065","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bst0280345","article-title":"Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside","volume":"28","author":"Reddi","year":"2000","journal-title":"Biochem. Soc. Trans."},{"issue":"8","key":"10.1016\/j.bioadv.2026.215176_bb0070","first-page":"358","article-title":"Inductive surface geometries: beyond morphogens and stem cells","volume":"74","author":"Ripamonti","year":"2019","journal-title":"South Afr. Dent. J."},{"key":"10.1016\/j.bioadv.2026.215176_bb0075","first-page":"37","article-title":"The chemical basis of morphogenesis","volume":"237","author":"Turing","year":"1952","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"issue":"3698","key":"10.1016\/j.bioadv.2026.215176_bb0080","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"issue":"28","key":"10.1016\/j.bioadv.2026.215176_bb0085","doi-asserted-by":"crossref","first-page":"20352","DOI":"10.1016\/S0021-9258(19)88709-4","article-title":"Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro","volume":"267","author":"Sampath","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioadv.2026.215176_bb0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)80193-2","article-title":"Bone morphogenesis and modeling: soluble signals sculpt osteosomes in the solid state","volume":"89","author":"Reddi","year":"1997","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bioadv.2026.215176_bb0095","doi-asserted-by":"crossref","first-page":"7599","DOI":"10.1073\/pnas.78.12.7599","article-title":"Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation","volume":"78","author":"Sampath","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioadv.2026.215176_bb0100","doi-asserted-by":"crossref","first-page":"6591","DOI":"10.1073\/pnas.80.21.6591","article-title":"Homology of bone inductive proteins from human, monkey, bovine and rat extracellular matrix","volume":"80","author":"Sampath","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioadv.2026.215176_bb0105","first-page":"47","article-title":"Bone morphogenetic proteins: applications in plastic and reconstructive surgery","volume":"11","author":"Ripamonti","year":"1995","journal-title":"Adv. Plast. Reconstr. Surg."},{"key":"10.1016\/j.bioadv.2026.215176_bb0110","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00003086-196707000-00026","article-title":"The bone induction principle","volume":"53","author":"Urist","year":"1967","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"7","key":"10.1016\/j.bioadv.2026.215176_bb0115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0167-7799(01)01665-1","article-title":"Delivering on the promise of bone morphogenetic proteins","volume":"19","author":"Li","year":"2001","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.bioadv.2026.215176_bb0120","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1359\/jbmr.2000.15.9.1798","article-title":"Long term evaluation of bone formation by osteogenic protein-1 in the baboon and relative efficacy of bone-derived bone morphogenetic proteins delivered by irradiated xenogeneic collagenous matrices","volume":"15","author":"Ripamonti","year":"2000","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl 1 (Pt 2)","key":"10.1016\/j.bioadv.2026.215176_bb0125","first-page":"S116","article-title":"Bone induction by BMPs\/OPs and related family members. The critical role of delivery systems","volume":"83-A","author":"Ripamonti","year":"2001","journal-title":"J. Bone Joint Surg. [A]"},{"key":"10.1016\/j.bioadv.2026.215176_bb0130","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/scitranslmed.aar4953","article-title":"A BMP\/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix","volume":"11","author":"Seeherman","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioadv.2026.215176_bb0135","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/08977199609003228","article-title":"Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7)","volume":"13","author":"Ripamonti","year":"1996","journal-title":"Growth Factors"},{"key":"10.1016\/j.bioadv.2026.215176_bb0140","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1582-4934.2005.tb00388.x","article-title":"Bone induction by recombinant human osteogenic protein-1 (hOP-1, BMP-7) in the primate Papio ursinus with expression of mRNA of gene products of the TGF-\u03b2 superfamily","volume":"9","author":"Ripamonti","year":"2005","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioadv.2026.215176_bb0145","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.biomaterials.2015.01.058","article-title":"Profiling bone morphogenetic proteins and transforming growth factor-\u03b2s by hTGF-\u03b23 pre-treated coral-derived macroporous bioreactors: the power of one","volume":"49","author":"Ripamonti","year":"2015","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215176_bb0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/jcpe.12642","article-title":"Cementogenesis and osteogenesis in periodontal tissue regeneration by recombinant human transforming growth factor-\u03b23: a pilot study in Papio ursinus","volume":"44","author":"Ripamonti","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bioadv.2026.215176_bb0155","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-0765.2008.01158.x","article-title":"Cementogenesis and the induction of periodontal tissue regeneration by the osteogenic proteins of the transforming growth factor-\u03b2 supergene family","volume":"44","author":"Ripamonti","year":"2009","journal-title":"J. Periodontal Res."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215176_bb0160","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-0765.2008.01086.x","article-title":"Induction of cementogenesis and periodontal ligament regeneration by recombinant human transforming growth factor-\u03b23 in Matrigel with rectus abdominis responding cells","volume":"44","author":"Ripamonti","year":"2009","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.bioadv.2026.215176_bb0165","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/jre.12596","article-title":"Developmental pathways of periodontal tissue regeneration. Developmental diversities of tooth morphogenesis do also map capacity of periodontal tissue regeneration?","volume":"54","author":"Ripamonti","year":"2019","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.bioadv.2026.215176_bb0170","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/jre.12356","article-title":"Re-defining the induction of periodontal tissue regeneration in primates by the osteogenic proteins of the transforming growth factor-\u03b2 supergene family","volume":"51","author":"Ripamonti","year":"2016","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.bioadv.2026.215176_bb0175","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00000441-188909000-00001","article-title":"On the healing of aseptic bone cavities by implantation of antiseptic decalcified bone","volume":"98","author":"Senn","year":"1889","journal-title":"Am J Med Sci"},{"issue":"6","key":"10.1016\/j.bioadv.2026.215176_bb0180","first-page":"705","article-title":"A study of bone regeneration","volume":"67","author":"Levander","year":"1938","journal-title":"Surg. Gynecol. Obstet."},{"issue":"3927","key":"10.1016\/j.bioadv.2026.215176_bb0185","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/155148a0","article-title":"Tissue Induction","volume":"155","author":"Levander","year":"1945","journal-title":"Nature"},{"key":"10.1016\/j.bioadv.2026.215176_bb0190","article-title":"Bone grafting by decalcified bone chips","volume":"718","author":"Murray","year":"1890","journal-title":"Lancet"},{"key":"10.1016\/j.bioadv.2026.215176_bb0195","article-title":"A case of bone grafting with decalcified bone chips: remarks","volume":"618","author":"Miller","year":"1890","journal-title":"Lancet"},{"key":"10.1016\/j.bioadv.2026.215176_bb0200","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1089\/ten.tea.2017.0321","article-title":"Biomimetic functionalized surfaces and the induction of bone formation","volume":"23","author":"Ripamonti","year":"2017","journal-title":"Tissue Eng. A"},{"issue":"6","key":"10.1016\/j.bioadv.2026.215176_bb0205","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1177\/00220345710500060601","article-title":"Bone morphogenetic protein","volume":"50","author":"Urist","year":"1971","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bioadv.2026.215176_bb0210","series-title":"Eternal Molecular Biology Editorial Published: 2024-06-10","author":"Hargittai","year":"2024"},{"key":"10.1016\/j.bioadv.2026.215176_bb0215","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/17453674408991069","article-title":"Experimental investigations into post-foetal osteogenesis","volume":"15","author":"Bertelsen","year":"1944","journal-title":"Acta Othop. Scand."},{"key":"10.1016\/j.bioadv.2026.215176_bb0220","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1302\/0301-620X.45B2.402","article-title":"The role of the vessels in osteogenesis","volume":"45B","author":"Trueta","year":"1963","journal-title":"J. Bone Joint Surg."},{"key":"10.1016\/j.bioadv.2026.215176_bb0225","first-page":"825","article-title":"Sulla produzione eteroplastica dell\u2019 osso","volume":"27","author":"Sacerdotti","year":"1901","journal-title":"Riv. Accad. Med. Torino"},{"key":"10.1016\/j.bioadv.2026.215176_bb0230","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00003086-196807000-00002","article-title":"The formation of bone under the influence of epithelium of the urinary tract","volume":"59","author":"Huggins","year":"1968","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bioadv.2026.215176_bb0235","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/194698a0","article-title":"Humoral nature of osteogenic activity of transitional epithelium","volume":"194","author":"Friedenstein","year":"1962","journal-title":"Nature"},{"key":"10.1016\/j.bioadv.2026.215176_bb0240","first-page":"31","article-title":"Osteogenic activity of transplanted transitional epithelium","volume":"45","author":"Friedenstein","year":"1961","journal-title":"Acta Anat. (Basel)"},{"key":"10.1016\/j.bioadv.2026.215176_bb0245","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1126\/science.127.3301.755","article-title":"Extraction of an osteogenic inductor from bone","volume":"127","author":"Moss","year":"1958","journal-title":"Science"},{"key":"10.1016\/j.bioadv.2026.215176_bb0250","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1359\/jbmr.1997.12.10.1584","article-title":"Recombinant transforming growth factor-\u03b21 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation","volume":"12","author":"Ripamonti","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bioadv.2026.215176_bb0255","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1089\/ten.2006.0167","article-title":"Recapitulating development: a template for periodontal tissue engineering","volume":"13","author":"Ripamonti","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioadv.2026.215176_bb0260","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1600-0765.1994.tb01246.x","article-title":"Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus)","volume":"29","author":"Ripamonti","year":"1994","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.bioadv.2026.215176_bb0265","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.add9665","article-title":"The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function","volume":"378","author":"Lim","year":"2022","journal-title":"Science"},{"issue":"6242","key":"10.1016\/j.bioadv.2026.215176_bb0270","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa5838","article-title":"BMP gradients: a paradigm for morphogen-mediated developmental patterning","volume":"348","author":"Bier","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bioadv.2026.215176_bb0275","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1046\/j.0909-8836.1999.eos107508.x","article-title":"Immunolocalization of bone morphogenetic protein-2, -3 and osteogenic protein-1 during murine tooth morphogenesis and other craniofacial structures","volume":"107","author":"Thomadakis","year":"1999","journal-title":"Eur. J. Oral Sci."},{"key":"10.1016\/j.bioadv.2026.215176_bb0280","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1034\/j.1600-0722.2001.00041.x","article-title":"Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein-1 and bone morphogenetic protein-2. A pilot study in Chacma baboons (Papio ursinus)","volume":"109","author":"Ripamonti","year":"2001","journal-title":"Eur. J. Oral Sci."},{"issue":"6","key":"10.1016\/j.bioadv.2026.215176_bb0285","doi-asserted-by":"crossref","first-page":"331","DOI":"10.17159\/2519-0105\/2021\/v76no6a4","article-title":"The induction of bone formation: from bone morphogenetic proteins to the transforming growth factor-\u03b23 protein \u2013 redundancy, pleiotropy and the induction of cementogenesis","volume":"76","author":"Ripamonti","year":"2021","journal-title":"S. Afr. Dent. J."},{"key":"10.1016\/j.bioadv.2026.215176_bb0290","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0003-9969(95)00110-7","article-title":"Induction of cementogenesis by recombinant human osteogenic protein-1 (hOP-1\/BMP-7) in the baboon (Papio ursinus)","volume":"41","author":"Ripamonti","year":"1996","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bioadv.2026.215176_bb0295","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.biomaterials.2016.07.018","article-title":"The synergistic Induction of bone formation by the osteogenic proteins of the TGF-\u03b2 supergene family","volume":"104","author":"Ripamonti","year":"2016","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215176_bb0300","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/(SICI)1097-0185(20000501)259:1<97::AID-AR11>3.0.CO;2-O","article-title":"Osteogenic protein-1, a bone morphogenetic protein, induces angiogenesis in the chick chorioallantoic membrane and synergizes with basic fibroblast growth factor and transforming growth factor-\u00df1","volume":"259","author":"Ramoshebi","year":"2000","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bioadv.2026.215176_bb0305","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev-cellbio-092910-154148","article-title":"Morphogen gradients: from generation to interpretation","volume":"27","author":"Rogers","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bioadv.2026.215176_bb0310","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fphys.2012.00172","article-title":"A macroscopic bioreactor super activated by the recombinant human transforming growth factor-\u03b23","volume":"3","author":"Ripamonti","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bioadv.2026.215176_bb0315","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1016\/j.biomaterials.2010.04.037","article-title":"Synergistic induction of bone formation by hOP-1, hTGF-\u03b23 and inhibition by zoledronate in macroporous coral-derived hydroxyapatites","volume":"31","author":"Ripamonti","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215176_bb0320","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1097\/SCS.0b013e3181b09ca6","article-title":"Transforming growth factor-\u03b2 isoforms and the induction of bone formation: implications for reconstructive craniofacial surgery","volume":"20","author":"Ripamonti","year":"2009","journal-title":"J Craniofac Surg"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215176_bb0325","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/08977190009028971","article-title":"Induction of endochondral bone formation by recombinant human transforming growth factor-\u03b22 in the baboon (Papio ursinus)","volume":"17","author":"Ripamonti","year":"2000","journal-title":"Growth Factors"},{"key":"10.1016\/j.bioadv.2026.215176_bb0330","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1016\/j.biomaterials.2013.12.062","article-title":"The induction of bone formation by the recombinant human transforming growth factor-\u03b23","volume":"35","author":"Klar","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioadv.2026.215176_bb0335","series-title":"NRF Blue Skies Funding Instrument \u2013 Concept Notes","article-title":"Transfiguration of neoplastic tumoral masses into bone for superior surgical debridement","author":"Ripamonti","year":"2014"},{"key":"10.1016\/j.bioadv.2026.215176_bb0340","series-title":"Osteogenic Device for inducing bone formation in clinical contexts","year":"2003"},{"key":"10.1016\/j.bioadv.2026.215176_bb0345","series-title":"Induction of Bone Formation in Primates. The Transforming Growth Factor-beta","first-page":"47","article-title":"Rapid induction of bone formation by the transforming growth factor \u03b23 isoform. Supergene Family","author":"Ripamonti","year":"2016"},{"issue":"2","key":"10.1016\/j.bioadv.2026.215176_bb0350","doi-asserted-by":"crossref","first-page":"82","DOI":"10.17159\/sadj.v78i02.16188","article-title":"Neoplastic tissue transfiguration in vivo by recombinant human transforming growth factor-\u03b23","volume":"78","author":"Ripamonti","year":"2023","journal-title":"S, Afr, Dent. J."},{"issue":"26","key":"10.1016\/j.bioadv.2026.215176_bb0355","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM198612253152606","article-title":"Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing","volume":"315","author":"Dvorak","year":"1986","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.bioadv.2026.215176_bb0360","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrm2455","article-title":"Cancer as an overhealing wound: and old hypothesis revisited","volume":"9","author":"Sch\u04d3fer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bioadv.2026.215176_bb0365","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/521284","article-title":"The amazing power of cancer cells to recapitulate extraembryonic functions: the cuckoo\u2019s tricks","author":"Arias","year":"2012","journal-title":"J. Oncol."},{"issue":"13","key":"10.1016\/j.bioadv.2026.215176_bb0370","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1158\/1078-0432.CCR-19-3642","article-title":"Intratumoral immunotherapy for early-stage solid tumours","volume":"26","author":"Hong","year":"2020","journal-title":"Clin. Cancer Res."},{"issue":"23","key":"10.1016\/j.bioadv.2026.215176_bb0375","doi-asserted-by":"crossref","first-page":"14976","DOI":"10.1073\/pnas.222470799","article-title":"Biological models and genes of tumor reversion: cellular reprogramming through tpt1\/TCTP and SIAH-1","volume":"99","author":"Tuynder","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioadv.2026.215176_bb0380","first-page":"6","article-title":"Introductory remarks on cartilages, bones and on \u201cBone: formation by autoinduction\u201d","volume":"73","author":"Ripamonti","year":"2018","journal-title":"South Afr. Dent. J."},{"key":"10.1016\/j.bioadv.2026.215176_bb0385","first-page":"11","article-title":"Sharks, shark cartilages and shark teeth: A collaborative Africa USA study to attempt to induce \u201cBone: formation by autoinduction\u201d in cartilaginous fishes","volume":"73","author":"Ripamonti","year":"2018","journal-title":"South Afr. Dent."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215176_bb0390","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1021\/bi00350a005","article-title":"Basement membrane complexes with biological activity","volume":"25","author":"Kleinman","year":"1986","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.bioadv.2026.215176_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4827(92)90397-Q","article-title":"Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components","volume":"202","author":"Vukicevic","year":"1992","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215176_bb0400","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1582-4934.2007.00036.x","article-title":"Bone loss in the ovariectomized baboon Papio ursinus: densitometry, histomorphometry and biochemistry","volume":"11","author":"Dal Mas","year":"2007","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bioadv.2026.215176_bb0405","article-title":"Tissue engineering of bone by novel substrata instructing gene expression during de novo bone formation","author":"Ripamonti","year":"2002","journal-title":"Sci. Afr."},{"issue":"47","key":"10.1016\/j.bioadv.2026.215176_bb0410","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202508734","article-title":"Rethinking Matrigel: the complex journey to matrix alternatives in organoid culture","volume":"12","author":"Wolff","year":"2025","journal-title":"Adv. Sci."},{"issue":"28","key":"10.1016\/j.bioadv.2026.215176_bb0415","doi-asserted-by":"crossref","first-page":"17281","DOI":"10.1016\/S0021-9258(17)44900-3","article-title":"Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen","volume":"65","author":"Paralkar","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioadv.2026.215176_bb0420","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1073\/pnas.88.8.3397","article-title":"Identification and characterization of cellular binding proteins (receptors) for recombinant human bone morphogenetic protein 2B, an initiator of bone differentiation cascade","volume":"88","author":"Paralkar","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.bioadv.2026.215176_bb0425","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0012-1606(91)90081-D","article-title":"Transforming growth factor beta type 1 binds to collagen IV of basement membrane matrix: implications for development","volume":"143","author":"Paralkar","year":"1991","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215176_bb0430","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1006\/bbrc.1994.1100","article-title":"Localization of osteogenic protein-1 (bone morphogenetic protein-7) during human embryonic development: high affinity binding to basement membranes","volume":"198","author":"Vukicevic","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215176_bb0435","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0092-8674(90)90176-F","article-title":"Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: regulation by discrete domains of laminin","volume":"63","author":"Vukicevic","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.bioadv.2026.215176_bb0440","doi-asserted-by":"crossref","first-page":"13377","DOI":"10.1016\/S0021-9258(18)80003-5","article-title":"Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation","volume":"264","author":"Luyten","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bioadv.2026.215176_bb0445","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0934-8832(11)80033-8","article-title":"Initiation of bone regeneration in adult baboons by osteogenin, a bone morphogenetic protein","volume":"12","author":"Ripamonti","year":"1992","journal-title":"Matrix"},{"issue":"3","key":"10.1016\/j.bioadv.2026.215176_bb0450","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1525-142X.2009.00327.x","article-title":"The mosasaur tooth attachment apparatus as paradigm for the evolution of the gnathostome periodontium","volume":"11","author":"Luan","year":"2009","journal-title":"Evol. Dev."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215176_bb0455","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tcb.2014.11.007","article-title":"Regulation of tissue morphogenesis by endothelial cell-derived signals","volume":"25","author":"Ramasamy","year":"2015","journal-title":"Trends Cell Biol."},{"issue":"6419","key":"10.1016\/j.bioadv.2026.215176_bb0460","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1126\/science.aar4800","article-title":"Endothelial cell adaptation in regeneration","volume":"362","author":"Gomez-Salinero","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.bioadv.2026.215176_bb0465","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bioadv.2026.215176_bb0470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/10454411920030010101","article-title":"Growth and morphogenetic factors related to bone induction. Role of osteogenin and related bone morphogenetic proteins in craniofacial and periodontal bone repair","volume":"3","author":"Ripamonti","year":"1992","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.bioadv.2026.215176_bb0475","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","article-title":"The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation","volume":"108","author":"Nakashima","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bioadv.2026.215176_bb0480","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue cells feel and respond to the stiffness of their substrate","volume":"310","author":"Disher","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bioadv.2026.215176_bb0485","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nmeth.1487","article-title":"Mechanical regulation of cell function with geometrically modulated elastomeric substrates","volume":"7","author":"Fu","year":"2010","journal-title":"Nat. Methods"},{"issue":"9","key":"10.1016\/j.bioadv.2026.215176_bb0490","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nmeth0910-695","article-title":"Stem cells feel the difference","volume":"7","author":"Buxboim","year":"2010","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.bioadv.2026.215176_bb0495","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/jcp.22770","article-title":"Cementum protein 1 (CEMP1) induces a cementoblastic phenotype and reduces osteoblastic differentiation in periodontal ligament cells","volume":"227","author":"Komaki","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bioadv.2026.215176_bb0500","doi-asserted-by":"crossref","first-page":"335","DOI":"10.7150\/ijbs.10874","article-title":"Osterix controls cementoblasts differentiation through downregulation of Wnt-signaling via enhancing DKK1 expression","volume":"11","author":"Cao","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bioadv.2026.215176_bb0505","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/jre.12554","article-title":"MicroRNA-3064-3p regulates the differentiation of cementoblasts through targeting DKK1","volume":"53","author":"Wang","year":"2018","journal-title":"J. Periodontal Res."},{"issue":"49","key":"10.1016\/j.bioadv.2026.215176_bb0510","doi-asserted-by":"crossref","first-page":"E5262","DOI":"10.1073\/pnas.1420463111","article-title":"Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation","volume":"111","author":"Tan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bioadv.2026.215176_bb0515","doi-asserted-by":"crossref","first-page":"26046","DOI":"10.1038\/srep26046","article-title":"TGF-\u03b2 signalling regulates cementum formation through Osterix expression","volume":"6","author":"Choi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bioadv.2026.215176_bb0520","doi-asserted-by":"crossref","first-page":"18813","DOI":"10.1073\/pnas.0507417102","article-title":"TGF-\u03b2 regulates the mechanical properties and composition of the bone matrix","volume":"102","author":"Balooch","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6673","key":"10.1016\/j.bioadv.2026.215176_bb0525","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg5579","article-title":"Morphogens enable interacting supracellular phases that generate organ architecture","volume":"382","author":"Yang","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.bioadv.2026.215176_bb0530","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202003390","article-title":"Crosstalk between bone and nerves within bone","volume":"8","author":"Wan","year":"2021","journal-title":"Adv. Sci."},{"issue":"10","key":"10.1016\/j.bioadv.2026.215176_bb0535","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/nm.4162","article-title":"Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats","volume":"22","author":"Zhang","year":"2016","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.bioadv.2026.215176_bb0540","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.4103\/1673-5374.160114","article-title":"Beta-nerve growth factor promotes neurogenesis and angiogenesis during the repair of bone defects","volume":"10","author":"Chen","year":"2015","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215176_bb0545","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1038\/s41467-019-11455-8","article-title":"Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization","volume":"10","author":"Thrivikraman","year":"2019","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bioadv.2026.215176_bb0550","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.11607\/jomi.9803","article-title":"Pediatric mandibular defect rehabilitation by human transforming growth factor-\u03b23 with an implant-supported prosthesis","volume":"37","author":"Ferretti","year":"2022","journal-title":"Int. J. Oral Maxillofac. Implants"},{"issue":"3","key":"10.1016\/j.bioadv.2026.215176_bb0555","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.bjoms.2015.12.014","article-title":"Reconstruction of 56 mandibular defects with autologous compressed particulate corticocancellous bone grafts","volume":"54","author":"Ferretti","year":"2016","journal-title":"Br. J. Oral Maxillofac. Surg."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215176_bb0560","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/ten.teb.2015.0357","article-title":"A review of the clinical side effects of bone morphogenetic protein-2","volume":"22","author":"James","year":"2016","journal-title":"Tissue Eng. B Rev."}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:29:15Z","timestamp":1793694555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826004760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":112,"alternative-id":["S2772950826004760"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215176","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transforming growth factor-\u03b23 in primate tissue induction: Heterotopic osteogenesis, periodontal cementogenesis and the limits of clinical translation; A personal historical perspective","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"215176"}}