{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:30:44Z","timestamp":1793694644787,"version":"4.5.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society Inc","doi-asserted-by":"publisher","award":["RSG-21-032-01-CSM"],"award-info":[{"award-number":["RSG-21-032-01-CSM"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials Advances"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bioadv.2026.215178","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:47:59Z","timestamp":1789573679000},"page":"215178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Protein-modified hyaluronic acid hydrogels to elucidate microenvironment-mediated chemotherapy response in triple negative brain metastatic breast cancer"],"prefix":"10.1016","volume":"191","author":[{"given":"Paromita","family":"Sarker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Dornan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyas S.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bioadv.2026.215178_bb0005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gendis.2018.05.001","article-title":"Breast cancer development and progression: risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis","volume":"5","author":"Feng","year":"2018","journal-title":"Genes Dis."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215178_bb0010","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"Ca-Cancer J Clin."},{"key":"10.1016\/j.bioadv.2026.215178_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1215426","article-title":"Neurotoxicity-sparing radiotherapy for brain metastases in breast cancer: a narrative review","volume":"13","author":"Buczek","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioadv.2026.215178_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-018-0055-y","article-title":"Brain metastases","volume":"5","author":"Achrol","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"2","key":"10.1016\/j.bioadv.2026.215178_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089389","article-title":"Effect of age and biological subtype on the risk and timing of Brain metastasis in breast Cancer patients","volume":"9","author":"Hung","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.bioadv.2026.215178_bb0030","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/jamaoncol.2017.0001","article-title":"Brain metastases in newly diagnosed breast cancer a population-based study","volume":"3","author":"Martin","year":"2017","journal-title":"JAMA Oncol."},{"issue":"12","key":"10.1016\/j.bioadv.2026.215178_bb0035","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s41416-019-0619-y","article-title":"Impact of breast cancer molecular subtypes on the incidence, kinetics and prognosis of central nervous system metastases in a large multicentre real-life cohort","volume":"121","author":"Darlix","year":"2019","journal-title":"Brit J Cancer."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215178_bb0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11060-023-04276-9","article-title":"Systematic review of the management of brain metastases from hormone receptor positive breast cancer","volume":"162","author":"Jusino","year":"2023","journal-title":"J. Neuro-Oncol."},{"issue":"3","key":"10.1016\/j.bioadv.2026.215178_bb0045","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.18632\/oncotarget.13907","article-title":"The role of tumor microenvironment in therapeutic resistance","volume":"8","author":"Son","year":"2017","journal-title":"Oncotarget"},{"issue":"1\u20132","key":"10.1016\/j.bioadv.2026.215178_bb0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.drup.2012.01.006","article-title":"The tumor microenvironment is a dominant force in multidrug resistance","volume":"15","author":"Correia","year":"2012","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bioadv.2026.215178_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107753","article-title":"Tumor microenvironment as a therapeutic target in cancer","volume":"221","author":"Xiao","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215178_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18794-x","article-title":"Concepts of extracellular matrix remodelling in tumour progression and metastasis","volume":"11","author":"Winkler","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioadv.2026.215178_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.908247","article-title":"Revisiting the tenascins: exploitable as cancer targets?","volume":"12","author":"Tucker","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioadv.2026.215178_bb0070","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2147\/OTT.S293685","article-title":"Understanding patterns of brain metastasis in triple-negative breast cancer and exploring potential therapeutic targets","volume":"14","author":"Lv","year":"2021","journal-title":"Onco. Targets Ther."},{"issue":"5","key":"10.1016\/j.bioadv.2026.215178_bb0075","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-022-04259-5","article-title":"The extracellular matrix molecule tenascin-C modulates cell cycle progression and motility of adult neural stem\/progenitor cells from the subependymal zone","volume":"79","author":"Schaberg","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bioadv.2026.215178_bb0080","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-40128-1","article-title":"Tissue-specific extracellular matrix accelerates the formation of neural networks and communities in a neuron-glia co-culture on a multi-electrode array","volume":"9","author":"Lam","year":"2019","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.bioadv.2026.215178_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087049","article-title":"Extracellular matrix regulation in physiology and in Brain disease","volume":"24","author":"Soles","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215178_bb0090","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4161\/cam.22826","article-title":"The laminin family","volume":"7","author":"Aumailley","year":"2013","journal-title":"Cell Adhes. Migr."},{"issue":"6","key":"10.1016\/j.bioadv.2026.215178_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2024.189181","article-title":"Biomechanical properties of laminins and their impact on cancer progression","volume":"1879","author":"Nonnast","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.bioadv.2026.215178_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.674199","article-title":"The extracellular matrix glycoprotein tenascin C and adult neurogenesis","volume":"9","author":"Tucic","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.bioadv.2026.215178_bb0105","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1038\/sj.cdd.4401849","article-title":"ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through \u03b21 integrin-dependent activation of PI3-kinase","volume":"13","author":"Hodkinson","year":"2006","journal-title":"Cell Death Differ."},{"issue":"1\u20132","key":"10.1016\/j.bioadv.2026.215178_bb0110","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/19336918.2015.1008332","article-title":"Tenascin-C and integrins in cancer","volume":"9","author":"Yoshida","year":"2015","journal-title":"Cell Adhes. Migr."},{"issue":"5","key":"10.1016\/j.bioadv.2026.215178_bb0115","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.biocel.2004.12.002","article-title":"Potential oncogenic action of tenascin-C in tumorigenesis","volume":"37","author":"Orend","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215178_bb0120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.12691\/ajmbr-3-2-2","article-title":"Tenascin-C (TNC) promotes breast cancer cell invasion and proliferation: functional effects of TNC knockdown in highly invasive breast cancer cell lines","volume":"3","author":"Alharth","year":"2015","journal-title":"Am. J. Med. Biol. Res."},{"key":"10.1016\/j.bioadv.2026.215178_bb0125","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-018-4446-y","article-title":"Neuropilin-1 promotes the oncogenic integrin \u03b23 pathway and modulates chemoresistance in breast cancer cells","volume":"18","author":"Naik","year":"2018","journal-title":"Bmc Cancer"},{"issue":"4","key":"10.1016\/j.bioadv.2026.215178_bb0130","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1158\/0008-5472.CAN-17-1597","article-title":"Tenascin-C promotes tumor cell migration and metastasis through integrin \u03b19\u03b21-mediated YAP inhibition","volume":"78","author":"Sun","year":"2018","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.bioadv.2026.215178_bb0135","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm.2379","article-title":"Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs","volume":"17","author":"Oskarsson","year":"2011","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.bioadv.2026.215178_bb0140","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/cne.23965","article-title":"Extracellular matrix protein expression is brain region dependent","volume":"524","author":"Dauth","year":"2016","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215178_bb0145","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41698-025-00956-z","article-title":"Defining the extracellular matrix for targeted immunotherapy in adult and pediatric brain cancer","volume":"9","author":"Day","year":"2025","journal-title":"Npj Precis Oncol."},{"key":"10.1016\/j.bioadv.2026.215178_bb0150","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.actbio.2020.02.039","article-title":"An invitro hyaluronic acid hydrogel based platform to model dormancy in brain metastatic breast cancer cells","volume":"107","author":"Narkhede","year":"2020","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.bioadv.2026.215178_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/cells9092113","article-title":"Hyaluronic acid biomaterials for central nervous system regenerative medicine","volume":"9","author":"Jensen","year":"2020","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.bioadv.2026.215178_bb0160","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1021\/acsbiomaterials.5c00644","article-title":"Glucocorticoid receptor signaling mediates resistance to therapy in matrix rigidity-induced dormant brain metastatic breast cancer spheroids","volume":"11","author":"Luna","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"15","key":"10.1016\/j.bioadv.2026.215178_bb0165","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1039\/D4BM00342J","article-title":"Matrix stiffness influences response to chemo and targeted therapy in brain metastatic breast cancer cells","volume":"12","author":"Yakati","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioadv.2026.215178_bb0170","series-title":"Paclitaxel","author":"Awosika","year":"2026"},{"issue":"Pt 4","key":"10.1016\/j.bioadv.2026.215178_bb0175","article-title":"Structurally decoupled hyaluronic acid hydrogels for studying matrix metalloproteinase-mediated invasion of metastatic breast cancer cells","volume":"277","author":"Goodarzi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215178_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2020.109870","article-title":"Fabrication of micro-porous hyaluronic acid hydrogels through salt leaching","volume":"135","author":"Coogan","year":"2020","journal-title":"Eur. Polym. J."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215178_bb0185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s44385-025-00043-9","article-title":"An in vitro hydrogel-based model to study dormancy associated drug resistance in metastatic breast cancer spheroids","volume":"2","author":"Sarker","year":"2025","journal-title":"Npj biomedical Innovations."},{"issue":"23","key":"10.1016\/j.bioadv.2026.215178_bb0190","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1039\/D0BM00969E","article-title":"Matrix stiffness and cluster size collectively regulate dormancy versus proliferation in brain metastatic breast cancer cell clusters","volume":"8","author":"Kondapaneni","year":"2020","journal-title":"Biomater. Sci."},{"issue":"6","key":"10.1016\/j.bioadv.2026.215178_bb0195","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.ccell.2026.03.016","article-title":"Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes","volume":"44","author":"Jassowicz","year":"2026","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.bioadv.2026.215178_bb0200","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"Voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.bioadv.2026.215178_bb0205","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"9","key":"10.1016\/j.bioadv.2026.215178_bb0210","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/1759-7714.15243","article-title":"Single-cell sequencing reveals the immune landscape of breast cancer patients with brain metastasis","volume":"15","author":"Zhou","year":"2024","journal-title":"Thorac Cancer."},{"issue":"1","key":"10.1016\/j.bioadv.2026.215178_bb0215","article-title":"Extracellular matrix and its therapeutic potential for cancer treatment","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.bioadv.2026.215178_bb0220","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1021\/acsabm.4c01386","article-title":"Regulation of Brain metastatic breast Cancer cell dormancy versus proliferation on hyaluronic acid hydrogels via laminin and laminin-derived peptides","volume":"8","author":"Goodarzi","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bioadv.2026.215178_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150142","article-title":"Laminin I mediates resistance to lapatinib in HER2-positive brain metastatic breast cancer cells","volume":"720","author":"Gurung","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.bioadv.2026.215178_bb0230","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ajpath.2010.10.015","article-title":"Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells","volume":"178","author":"Nagaharu","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"8","key":"10.1016\/j.bioadv.2026.215178_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2013.27","article-title":"Binding of alphavbeta1 and alphavbeta6 integrins to tenascin-C induces epithelial-mesenchymal transition-like change of breast cancer cells","volume":"2","author":"Katoh","year":"2013","journal-title":"Oncogenesis"},{"issue":"Pt 1","key":"10.1016\/j.bioadv.2026.215178_bb0240","article-title":"Localized glioblastoma therapy using a tenascin-C inhibitor peptide-modified hyaluronic acid hydrogel","volume":"340","author":"Loureiro","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bioadv.2026.215178_bb0245","article-title":"Integrin signaling in cancer cell survival and chemoresistance","volume":"2012","author":"Aoudjit","year":"2012","journal-title":"Chemother. Res. Pract."},{"issue":"10","key":"10.1016\/j.bioadv.2026.215178_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2024.08.015","article-title":"Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain","volume":"42","author":"Gan","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bioadv.2026.215178_bb0255","article-title":"The role of tenascin-C in tumor microenvironments and its potential as a therapeutic target","volume":"13","author":"Wang","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"issue":"36","key":"10.1016\/j.bioadv.2026.215178_bb0260","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1038\/sj.onc.1204554","article-title":"Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells","volume":"20","author":"Aoudjit","year":"2001","journal-title":"Oncogene"}],"container-title":["Biomaterials Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772950826004784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:24:08Z","timestamp":1793694248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772950826004784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":52,"alternative-id":["S2772950826004784"],"URL":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215178","relation":{},"ISSN":["2772-9508"],"issn-type":[{"value":"2772-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protein-modified hyaluronic acid hydrogels to elucidate microenvironment-mediated chemotherapy response in triple negative brain metastatic breast cancer","name":"articletitle","label":"Article Title"},{"value":"Biomaterials Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioadv.2026.215178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"215178"}}