{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:39:13Z","timestamp":1790757553811,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.biocel.2003.08.010","type":"journal-article","created":{"date-parts":[[2003,11,27]],"date-time":"2003-11-27T08:37:11Z","timestamp":1069922231000},"page":"365-371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["The islet \u03b2-cell"],"prefix":"10.1016","volume":"36","author":[{"given":"Rohit N","family":"Kulkarni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2003.08.010_BIB1","unstructured":"Banting, F. G., & Best, C. H., 1990. The Journal of Laboratory and Clinical Medicine, 115, 254."},{"key":"10.1016\/j.biocel.2003.08.010_BIB2","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1210\/endo.141.6.7567","article-title":"Perspective: Postnatal pancreatic beta cell growth","volume":"141","author":"Bonner-Weir","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2003.08.010_BIB3","unstructured":"Bonner-Weir, S., & Smith, F. E. (1994). Islets of Langerhans: morphology and its implications. In C. R. Kahn & G. C. Weir (Eds.), Joslin\u2019s Diabetes Mellitus (pp. 15\u201328)."},{"key":"10.1016\/j.biocel.2003.08.010_BIB4","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1073\/pnas.97.8.4023","article-title":"Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression","volume":"97","author":"Da Silva Xavier","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2003.08.010_BIB5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/bj20021812","article-title":"Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression","volume":"371","author":"Da Silva Xavier","year":"2003","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2003.08.010_BIB6","first-page":"201","article-title":"Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells","volume":"46","author":"Fishman","year":"2002","journal-title":"The International Journal of Developmental Biology"},{"key":"10.1016\/j.biocel.2003.08.010_BIB7","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2337\/diabetes.52.3.767","article-title":"The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas","volume":"52","author":"Geng","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.biocel.2003.08.010_BIB8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0925-4773(02)00330-1","article-title":"Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis","volume":"120","author":"Gu","year":"2003","journal-title":"Mechanisms of Development"},{"key":"10.1016\/j.biocel.2003.08.010_BIB9","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/dev.129.10.2447","article-title":"Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors","volume":"129","author":"Gu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.biocel.2003.08.010_BIB10","first-page":"97","article-title":"Defining the cell lineages of the islets of Langerhans using transgenic mice","volume":"46","author":"Herrera","year":"2002","journal-title":"The International Journal of Developmental Biology"},{"key":"10.1016\/j.biocel.2003.08.010_BIB11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1385\/ENDO:19:3:267","article-title":"A delacour pancreatic cell lineage analyses in mice","volume":"19","author":"Herrera","year":"2002","journal-title":"Endocrine"},{"key":"10.1016\/j.biocel.2003.08.010_BIB12","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ncb951","article-title":"Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells","volume":"5","author":"Ishihara","year":"2003","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.biocel.2003.08.010_BIB13","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nm867","article-title":"NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice","volume":"9","author":"Kojima","year":"2003","journal-title":"Nature Medicine"},{"key":"10.1016\/j.biocel.2003.08.010_BIB14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1042\/bst0300317","article-title":"Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function","volume":"30","author":"Kulkarni","year":"2002","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.biocel.2003.08.010_BIB15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0092-8674(00)80546-2","article-title":"Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes","volume":"96","author":"Kulkarni","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2003.08.010_BIB16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng872","article-title":"Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass","volume":"31","author":"Kulkarni","year":"2002","journal-title":"Nature Genetics"},{"key":"10.1016\/j.biocel.2003.08.010_BIB17","doi-asserted-by":"crossref","first-page":"E259","DOI":"10.1152\/ajpendo.00393.2002","article-title":"Stem\/progenitor cells derived from adult tissues: Potential for the treatment of diabetes mellitus","volume":"284","author":"Lechner","year":"2003","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"10.1016\/j.biocel.2003.08.010_BIB18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00006676-200203000-00006","article-title":"Heterogeneous cell renewal of pancreas in mice: [(3)H]-thymidine autoradiographic investigation","volume":"24","author":"Magami","year":"2002","journal-title":"Pancreas"},{"key":"10.1016\/j.biocel.2003.08.010_BIB19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00125-001-0728-y","article-title":"Regulation of insulin gene transcription","volume":"45","author":"Melloul","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.biocel.2003.08.010_BIB20","first-page":"259","article-title":"Contributions to the microscopic anatomy of the pancreas by Paul Langerhans (Berlin, 1869)","volume":"5","author":"Morrison","year":"1937","journal-title":"Bulletin of the Institute of the History of Medicine"},{"key":"10.1016\/j.biocel.2003.08.010_BIB21","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1073\/pnas.102168499","article-title":"Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA","volume":"99","author":"Olbrot","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2003.08.010_BIB22","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/BF00281987","article-title":"The insulin factory: A tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited","volume":"28","author":"Orci","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.biocel.2003.08.010_BIB23","doi-asserted-by":"crossref","first-page":"D1","DOI":"10.2741\/Rane","article-title":"Cell cycle control of pancreatic beta cell proliferation","volume":"5","author":"Rane","year":"2000","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.biocel.2003.08.010_BIB24","doi-asserted-by":"crossref","first-page":"34168","DOI":"10.1074\/jbc.M112478200","article-title":"A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin","volume":"277","author":"Rizzo","year":"2002","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2003.08.010_BIB25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0098-2997(01)00013-9","article-title":"Nutrient-secretion coupling in the pancreatic islet beta-cell: Recent advances","volume":"22","author":"Rutter","year":"2001","journal-title":"Molecular Aspects of Medicine"},{"key":"10.1016\/j.biocel.2003.08.010_BIB26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s001090050118","article-title":"The beta cell transcription factors and development of the pancreas","volume":"75","author":"Sander","year":"1997","journal-title":"Journal of Molecular Medicine"},{"key":"10.1016\/j.biocel.2003.08.010_BIB27","doi-asserted-by":"crossref","first-page":"14189","DOI":"10.1073\/pnas.251558998","article-title":"Dissecting the transcriptional network of pancreatic islets during development and differentiation","volume":"98","author":"Shih","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2003.08.010_BIB28","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1172\/JCI0215276","article-title":"Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor","volume":"110","author":"Xuan","year":"2002","journal-title":"Journal of Clinical Investigation"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272503002917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272503002917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:23:16Z","timestamp":1761182596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272503002917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S1357272503002917"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2003.08.010","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The islet \u03b2-cell","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2003.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}