{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:05:23Z","timestamp":1791291923257,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.biocel.2004.04.014","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T14:25:12Z","timestamp":1087914312000},"page":"2563-2573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt\u2013Jakob disease: a brain biopsy study"],"prefix":"10.1016","volume":"36","author":[{"given":"Beata","family":"Sikorska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel P.","family":"Liberski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierric","family":"Giraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2004.04.014_BIB1","first-page":"25","article-title":"Apoptosis and autophagy in nigral neurons of patients with Parkinson\u2019s disease","volume":"12","author":"Anglade","year":"1997","journal-title":"Histology and Histopathology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB2","first-page":"665","article-title":"Spiroplasma-like inclusions in Creutzfeldt\u2013Jakob disease","volume":"103","author":"Bastian","year":"1987","journal-title":"Archives of Pathology and Laboratory Medicine"},{"key":"10.1016\/j.biocel.2004.04.014_BIB3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2990.2000.026002143.x","article-title":"Dendritic and synaptic alterations of hippocampal pyramidal neurones in scrapie-infected mice","volume":"26","author":"Belichenko","year":"2000","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB4","first-page":"165","article-title":"Etude anatomo clinique d\u2019un cas de maladie de Creutzfeldt\u2013Jakob. Aspects ultra-structuraux","volume":"121","author":"Brion","year":"1969","journal-title":"Review of Neurology (Paris)"},{"key":"10.1016\/j.biocel.2004.04.014_BIB5","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1242\/jcs.113.7.1189","article-title":"Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments","volume":"113","author":"Bursch","year":"2000","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2004.04.014_BIB6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/sj.cdd.4400852","article-title":"The autophagosomal-lysosomal compartment in programmed cell death","volume":"8","author":"Bursch","year":"2001","journal-title":"Cell Death Differentiation"},{"key":"10.1016\/j.biocel.2004.04.014_BIB7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00174615","article-title":"Developmental cell death: morphological diversity and multiple mechanisms","volume":"181","author":"Clarke","year":"1990","journal-title":"Anatomy and Embryology (Berlin)"},{"key":"10.1016\/j.biocel.2004.04.014_BIB8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/emboj\/cdg045","article-title":"Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells","volume":"22","author":"Cohen","year":"2003","journal-title":"EMBO Journal"},{"key":"10.1016\/j.biocel.2004.04.014_BIB9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.neuro.24.1.519","article-title":"Prion diseases of humans and animals: their causes and molecular basis","volume":"24","author":"Collinge","year":"2001","journal-title":"Annual Review of Neurosciences"},{"key":"10.1016\/j.biocel.2004.04.014_BIB10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/088307389400900419","article-title":"Neuropathology of Rett syndrome: case report with neuronal and mitochondrial abnormalities in the brain","volume":"9","author":"Cornford","year":"1994","journal-title":"Journal of Child Neurology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB11","first-page":"331","article-title":"Ultrastructural features of human cerebral cortex","volume":"121","author":"Cragg","year":"1976","journal-title":"Journal of Anatomy"},{"key":"10.1016\/j.biocel.2004.04.014_BIB12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S1357-2725(02)00382-5","article-title":"Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions","volume":"35","author":"Fuertes","year":"2003","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB13","first-page":"202","article-title":"Association de maladies d\u2019Alzheimer et de Creutzfeldt\u2013Jakob","volume":"77","author":"Gachez","year":"1977","journal-title":"Acta Neurologica Belgica"},{"key":"10.1016\/j.biocel.2004.04.014_BIB14","doi-asserted-by":"crossref","unstructured":"Ghadially, F. (1988). Heterolysosomes and autolysosomes. In F. Ghadially (Ed.), Ultrastructural pathology of the cell and matrix (vol. 2, pp. 594\u2013599). London: Butterworths.","DOI":"10.1016\/B978-0-407-01572-2.50008-3"},{"key":"10.1016\/j.biocel.2004.04.014_BIB15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF00688263","article-title":"An electron and light microscopic study of the numbers of dystrophic neurites and vacuoles in the hippocampus of mice infected intracerebrally with scrapie","volume":"73","author":"Gibson","year":"1987","journal-title":"Acta Neuropathalogica (Berlin)"},{"key":"10.1016\/j.biocel.2004.04.014_BIB16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00005072-196510000-00003","article-title":"Electron microscopic study in two cases of Jakob\u2013Creutzfeldt disease","volume":"24","author":"Gonatas","year":"1965","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1750-3639.2002.tb00452.x","article-title":"Mechanisms of cell death in neurodegenerative diseases: fashion, fiction, and facts","volume":"12","author":"Graeber","year":"2002","journal-title":"Brain Pathology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1091\/mbc.11.1.255","article-title":"Biogenesis of multilamellar bodies via autophagy","volume":"11","author":"Hariri","year":"2000","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.biocel.2004.04.014_BIB19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1083\/jcb.200109094","article-title":"DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death","volume":"157","author":"Inbal","year":"2002","journal-title":"Journal of Cell Biology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1034\/j.1600-0463.2002.100110.x","article-title":"Pathological diagnosis of variant Creutzfeldt\u2013Jakob disease","volume":"110","author":"Ironside","year":"2002","journal-title":"APMIS"},{"key":"10.1016\/j.biocel.2004.04.014_BIB21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2990.2000.00216.x","article-title":"Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus","volume":"26","author":"Jeffrey","year":"2000","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3233\/JAD-2001-3106","article-title":"Problems of cell death in neurodegeneration and Alzheimer\u2019s Disease","volume":"3","author":"Jellinger","year":"2001","journal-title":"Journal of Alzheimers Disease"},{"key":"10.1016\/j.biocel.2004.04.014_BIB23","unstructured":"Jellinger, K. (1973). Neuroaxonal dystrophy. Its natural history and related disorders. In H. M. Zimmermann (Ed.), Progress in neuropathology (vol. 2, pp. 129\u2013180). New York: Grune & Stratton."},{"key":"10.1016\/j.biocel.2004.04.014_BIB24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.55782\/ane-2001-1379","article-title":"Apoptosis in relation to neuronal loss in experimental Creutzfeldt\u2013Jakob disease in mice","volume":"61","author":"Jesionek-Kupnicka","year":"2001","journal-title":"Acta Neurobiologiae Experimentalis (Warsz)"},{"key":"10.1016\/j.biocel.2004.04.014_BIB25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00005072-198301000-00003","article-title":"Ultrastructural findings in experimental Creutzfeldt\u2013Jakob disease in guinea pigs","volume":"42","author":"Kim","year":"1983","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00687042","article-title":"Serial ultrastructural study of experimental Creutzfeldt\u2013Jakob disease in guinea pigs","volume":"69","author":"Kim","year":"1986","journal-title":"Acta Neuropathalogica (Berlin)"},{"key":"10.1016\/j.biocel.2004.04.014_BIB27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.cellbio.15.1.1","article-title":"Vacuolar import of proteins and organelles from the cytoplasm","volume":"15","author":"Klionsky","year":"1999","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB28","doi-asserted-by":"crossref","first-page":"E207","DOI":"10.1038\/35041139","article-title":"Conformational disease","volume":"2","author":"Kopito","year":"2000","journal-title":"Nature of Cell Biology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB29","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/BF00713525","article-title":"Caudate nucleus pathology in Parkinson\u2019s disease: ultrastructural and biochemical findings in biopsy material","volume":"83","author":"Lach","year":"1992","journal-title":"Acta Neuropathalogica (Berlin)"},{"key":"10.1016\/j.biocel.2004.04.014_BIB30","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1212\/WNL.31.5.538","article-title":"Golgi and electron microscopic studies of spongiform encephalopathy","volume":"31","author":"Landis","year":"1981","journal-title":"Neurology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/1074-5521(95)90074-8","article-title":"The chemistry of scrapie infection: implications of the \u201cice 9\u201d metaphor","volume":"2","author":"Lansbury","year":"1995","journal-title":"Chemistry and Biology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB32","first-page":"897","article-title":"Autophagy in neurons: a review","volume":"17","author":"Larsen","year":"2002","journal-title":"Histology and Histopathology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB33","first-page":"897","article-title":"Autophagy in neurons: a review","volume":"17","author":"Larsen","year":"2002","journal-title":"Histology and Histopathology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0022-510X(83)90020-5","article-title":"Creutzfeldt\u2013Jakob disease. Failure to detect spiroplasmas by cultivation and serological tests","volume":"59","author":"Leach","year":"1983","journal-title":"Journal of Neurological Sciences"},{"key":"10.1016\/j.biocel.2004.04.014_BIB35","unstructured":"Liberski, P. P. (Ed.). (1993). Light and electron microscopic neuropathology of slow virus disorders (pp. 1\u2013430). Boca Raton: CRC Press."},{"key":"10.1016\/j.biocel.2004.04.014_BIB36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.55782\/ane-2002-1438","article-title":"Prion diseases: a dual view of the prion hypothesis as seen from a distance","volume":"62","author":"Liberski","year":"2002","journal-title":"Acta Neurobiologiae Experimentalis (Warsz)"},{"key":"10.1016\/j.biocel.2004.04.014_BIB37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0014-4886(89)90086-1","article-title":"Scrapie as a model for neuroaxonal dystrophy: ultrastructural studies","volume":"106","author":"Liberski","year":"1989","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB38","doi-asserted-by":"crossref","unstructured":"Liberski, P. P., Yanagihara, R., Gibbs Jr., C. J., & Gajdusek, D. C. (1989b). Neuroaxonal dystrophy: an ultrastructural link between subacute spongiform virus encephalopathies and Alzheimer\u2019s disease. In K. Iqbal, H. M. Wisniewski, & B. Winblad (Eds.), Alzheimer\u2019s disease and related disorders (pp. 549\u2013557). Alan R. Liss Inc.","DOI":"10.1097\/00002093-198802030-00155"},{"key":"10.1016\/j.biocel.2004.04.014_BIB39","unstructured":"Liberski, P. P., Yanagihara, R., Wells, G. A. H., & Gajdusek, D. C. (1993). Neuronal degeneration in unconventional slow virus disorders. In P. P. Liberski (Ed.), Light and electron microscopic neuropathology of slow virus disorders (pp. 349\u2013371). Boca Raton: CRC Press."},{"key":"10.1016\/j.biocel.2004.04.014_BIB40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0021-9975(92)90023-N","article-title":"Ultrastructural pathology of axons and myelin in experimental scrapie in hamsters and bovine spongiform encephalopathy in cattle and a comparison with the panencephalopathic type of Creutzfeldt\u2013Jakob disease","volume":"106","author":"Liberski","year":"1992","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB41","first-page":"105","article-title":"Reactive and degenerative changes of tissues surrounding a brain tumor","volume":"33","author":"Majchrowska","year":"1995","journal-title":"Folia Neuropathologica"},{"key":"10.1016\/j.biocel.2004.04.014_BIB42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S1357-2725(02)00343-6","article-title":"Role of the Apg12 conjugation system in mammalian autophagy","volume":"35","author":"Mizushima","year":"2003","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB43","first-page":"113","article-title":"Autophagy: a barrier or an adaptive response to cancer","volume":"17","author":"Ogier-Denis","year":"2003","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2004.04.014_BIB44","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1093\/hmg\/ddg346","article-title":"Autophagy regulates the processing of amino terminal huntingtin fragments","volume":"12","author":"Qin","year":"2003","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.biocel.2004.04.014_BIB45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF00319849","article-title":"A quantitative electron-microscopic study of atypical structures in normal human cortex","volume":"148","author":"Rees","year":"1975","journal-title":"Anatomy and Embryology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1128\/EC.01.1.11-21.2002","article-title":"Autophagy in the eukaryotic cell","volume":"1","author":"Reggiori","year":"2002","journal-title":"Eukaryotic Cell"},{"key":"10.1016\/j.biocel.2004.04.014_BIB47","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.neurobiolaging.2003.08.002","article-title":"Synaptic pathology in Alzheimer\u2019s disease: a review of ultrastructural studies","volume":"24","author":"Scheff","year":"2003","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.biocel.2004.04.014_BIB48","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0002-9440(10)65460-0","article-title":"Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer\u2019s disease. Evidence for apoptotic cell death","volume":"155","author":"Stadelmann","year":"1999","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB49","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB50","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S1357-2725(02)00380-1","article-title":"Intracellular localization of proteasomes","volume":"35","author":"Wojcik","year":"2003","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.biocel.2004.04.014_BIB51","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-8","article-title":"Cell death: the significance of apoptosis","volume":"68","author":"Wyllie","year":"1980","journal-title":"International Review on Cytology"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272504001682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272504001682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:27:10Z","timestamp":1761182830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272504001682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S1357272504001682"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2004.04.014","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt\u2013Jakob disease: a brain biopsy study","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2004.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}