{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T01:22:55Z","timestamp":1773624175007,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.biocel.2004.08.002","type":"journal-article","created":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T15:29:25Z","timestamp":1096385365000},"page":"1117-1129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Insulin in aging and cancer: antidiabetic drug diabenol as geroprotector and anticarcinogen"],"prefix":"10.1016","volume":"37","author":[{"given":"Irina G.","family":"Popovich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Zabezhinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Egormin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita L.","family":"Tyndyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan V.","family":"Anikin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A.","family":"Spasov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna V.","family":"Semenchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatoly I.","family":"Yashin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir N.","family":"Anisimov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2004.08.002_bib1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/carcin\/1.12.975","article-title":"The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats","volume":"1","author":"Alexandrov","year":"1980","journal-title":"Carcinogenesis"},{"issue":"6","key":"10.1016\/j.biocel.2004.08.002_bib2","first-page":"42","article-title":"Effect of buformin and diphenylhydantoin on life span, estrus function and spontaneous tumor incidence in female rats","volume":"26","author":"Anisimov","year":"1980","journal-title":"Voprosy Onkologii"},{"key":"10.1016\/j.biocel.2004.08.002_bib3","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0531-5565(03)00169-4","article-title":"Insulin\/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention","volume":"38","author":"Anisimov","year":"2003","journal-title":"Experimental Gerontology"},{"issue":"3","key":"10.1016\/j.biocel.2004.08.002_bib4","first-page":"40","article-title":"Inhibitory effect of phenformin on the development of mammary tumors induced by N-nitrosomethylurea in rats","volume":"2","author":"Anisimov","year":"1980","journal-title":"Experimental Onkology"},{"key":"10.1016\/j.biocel.2004.08.002_bib5","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/BF00836263","article-title":"Inhibition of blastomogenic effect of 7,12-dimethylbenz(a)anthracene in female rats by buformin, dipheninhydantoin, polypeptide pineal extract and L-DOPA","volume":"89","author":"Anisimov","year":"1980","journal-title":"Bulletin of Experimental Biology and Medicine"},{"issue":"8","key":"10.1016\/j.biocel.2004.08.002_bib6","first-page":"54","article-title":"Effect of phenformin on the blastomogenic action of 1,2-dimethylhydrazine in rats","volume":"26","author":"Anisimov","year":"1980","journal-title":"Voprosy Onkologii"},{"issue":"6","key":"10.1016\/j.biocel.2004.08.002_bib7","first-page":"26","article-title":"Inhibition by phenformin of the radiation carcinogenesis in female rats","volume":"4","author":"Anisimov","year":"1982","journal-title":"Experimental Onkology"},{"issue":"4","key":"10.1016\/j.biocel.2004.08.002_bib8","first-page":"254","article-title":"Spontaneous tumors in outbred LIO rats","volume":"8","author":"Anisimov","year":"1989","journal-title":"Journal of Experimental and Clinical Cancer Research"},{"key":"10.1016\/j.biocel.2004.08.002_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ijc.10570","article-title":"Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2\/neu transgenic mice","volume":"101","author":"Anisimov","year":"2002","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.biocel.2004.08.002_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1023\/A:1026299318315","article-title":"Insulin and longevity: antidiabetic biguanides as geroprotectors","volume":"4","author":"Anisimov","year":"2003","journal-title":"Biogerontology"},{"issue":"9","key":"10.1016\/j.biocel.2004.08.002_bib11","first-page":"11","article-title":"Synthesis and pharmacological activity of 1- and 10-N-substituted 1(10),2,3,4,-tetrahydropyrimido[1,2-a]benzimidazoles","volume":"36","author":"Anisimova","year":"2002","journal-title":"Chemico-Pharmaceutical Journal"},{"key":"10.1016\/j.biocel.2004.08.002_bib12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1701-2163(16)30402-9","article-title":"Metformin and polycystic ovary syndrome: a literature review","volume":"24","author":"Awartani","year":"2002","journal-title":"Journal of Obstetrics and Gynecology Canada"},{"key":"10.1016\/j.biocel.2004.08.002_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1022448532248","article-title":"Insulin-like growth factor 1 (IGF-1) and aging: controverses and new insights","volume":"4","author":"Bartke","year":"2003","journal-title":"Biogerontology"},{"key":"10.1016\/j.biocel.2004.08.002_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00839318","article-title":"Influence of anticarcinogenic agents on the transplacental carcinogenic effect of N-nitroso-N-ethylurea","volume":"100","author":"Bespalov","year":"1985","journal-title":"Bulletin of Experimental Biology and Medicine"},{"key":"10.1016\/j.biocel.2004.08.002_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0232-1513(89)80090-8","article-title":"Spontaneous tumors in NMRI mice from carcinogenicity studies","volume":"36","author":"Bomhard","year":"1989","journal-title":"Experimental Pathology"},{"key":"10.1016\/j.biocel.2004.08.002_bib16","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase","volume":"303","author":"Brunet","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biocel.2004.08.002_bib17","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.lfs.2003.07.015","article-title":"Effects of phenformin on the proliferation of human tumor cell lines","volume":"74","author":"Caraci","year":"2003","journal-title":"Life Science"},{"key":"10.1016\/j.biocel.2004.08.002_bib18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jemt.10211","article-title":"Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling","volume":"59","author":"Chiba","year":"2002","journal-title":"Microscopy Research and Technique"},{"key":"10.1016\/j.biocel.2004.08.002_bib19","doi-asserted-by":"crossref","unstructured":"Cohen, H. Y., Miller, C., Bitterman, K. J., et al. (2004). Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science, http:\/\/www.sciencexpress.org\/17June\/Page1\/10.1126\/Science.1099196.","DOI":"10.1126\/science.1099196"},{"key":"10.1016\/j.biocel.2004.08.002_bib20","first-page":"385","article-title":"Colorectal cancer mortality and factors related to the insulin resistance syndrome","volume":"11","author":"Colangelo","year":"2002","journal-title":"Cancer Epidemiology, Biomarkers and Prevention"},{"key":"10.1016\/j.biocel.2004.08.002_bib21","series-title":"Analysis of survival data","author":"Cox","year":"1996"},{"key":"10.1016\/j.biocel.2004.08.002_bib22","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(71)91721-1","article-title":"Age-associated elevation of hypothalamic threshold to feedback control and its role in development, aging and disease","volume":"1","author":"Dilman","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.biocel.2004.08.002_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0047-6374(78)90015-5","article-title":"Ageing, metabolic immunodepression and carcinogenesis","volume":"8","author":"Dilman","year":"1978","journal-title":"Mechanisms of Ageing and Development"},{"key":"10.1016\/j.biocel.2004.08.002_bib24","series-title":"a new rationale for an intervention","article-title":"Development, aging and disease","author":"Dilman","year":"1994"},{"key":"10.1016\/j.biocel.2004.08.002_bib25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000212423","article-title":"Effect of treatment with phenofromin, dyphenylhydantoin or L-DOPA on life span and tumor incidence in C3H\/Sn mice","volume":"26","author":"Dilman","year":"1980","journal-title":"Gerontology"},{"key":"10.1016\/j.biocel.2004.08.002_bib26","first-page":"1","article-title":"Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats","volume":"48","author":"Dilman","year":"1978","journal-title":"Archives of Geschwulstforsch"},{"key":"10.1016\/j.biocel.2004.08.002_bib27","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/0470846542.ch14","article-title":"Glucose tolerance, glucose utilization and insulin secretion in aging","volume":"242","author":"Elahi","year":"2002","journal-title":"Novartis Foundation Symposium"},{"key":"10.1016\/j.biocel.2004.08.002_bib28","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0891-5849(00)00438-X","article-title":"Hyperinsulinemia: the missing link among oxidative stress and age-related diseases?","volume":"29","author":"Facchini","year":"2000","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.biocel.2004.08.002_bib29","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1210\/jcem.86.8.7763","article-title":"Insulin resistance as a predictor of age-related diseases","volume":"86","author":"Facchini","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.biocel.2004.08.002_bib30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/dmrr.282","article-title":"Metformin decreases platelet superoxide anion production in diabetic patients","volume":"18","author":"Gargiulo","year":"2002","journal-title":"Diabetes Metabolism Research and Reviews"},{"key":"10.1016\/j.biocel.2004.08.002_bib31","unstructured":"Gart, J. J., Krewski, D., Lee, P. N., Tarone, S., & Wahrendorf, J. (1986). Statistical methods in cancer research. Vol. III. The design and analysis of long-term animal experiments (p. 79). IARC, Lyon: IARC Scientific Publication."},{"key":"10.1016\/j.biocel.2004.08.002_bib32","unstructured":"Gauss system and graphic manual. (1994). Maple Valley: Aptech Systems Inc."},{"key":"10.1016\/j.biocel.2004.08.002_bib33","unstructured":"Goubler, E. V. (1978). Computing methods of pathology analysis and recognition. Leningrad: Meditsina."},{"key":"10.1016\/j.biocel.2004.08.002_bib34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00000441-200203000-00004","article-title":"Insulin: a novel factor in carcinogenesis","volume":"323","author":"Gupta","year":"2002","journal-title":"American Journal of the Medical Sciences"},{"key":"10.1016\/j.biocel.2004.08.002_bib35","doi-asserted-by":"crossref","unstructured":"Hadley, E. C., Dutta, C., Finkelstein, J., et al. (2001). Human implications of caloric restriction's effect on laboratory animals: an overview of opportunities for research. Journal of Gerontology Ser. A, 56A(Special issue I), 5\u20136.","DOI":"10.1093\/gerona\/56.suppl_1.5"},{"key":"10.1016\/j.biocel.2004.08.002_bib36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sitruins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2004.08.002_bib37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1101\/gad.1052903","article-title":"How does calorie restriction work?","volume":"17","author":"Koubova","year":"2003","journal-title":"Genes and Development"},{"key":"10.1016\/j.biocel.2004.08.002_bib38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00002018-199411040-00002","article-title":"Comparative tolerability profilesof oral antidiabeticagents","volume":"11","author":"Krentz","year":"1994","journal-title":"Drug Safety"},{"key":"10.1016\/j.biocel.2004.08.002_bib39","doi-asserted-by":"crossref","unstructured":"Kruse, J. A. (2004). Review: metformin does not increase risk for lactic acidosis or increase lactate levels in type 2 diabetes. ACP Journal Club, 141, 7.","DOI":"10.7326\/ACPJC-2004-141-1-007"},{"key":"10.1016\/j.biocel.2004.08.002_bib40","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1126\/science.1077991","article-title":"Evolutionary medicine: from dwarf model systems to healthy centenarians","volume":"299","author":"Longo","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.biocel.2004.08.002_bib41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0531-5565(00)00084-X","article-title":"Caloric restriction and ageing: an update","volume":"35","author":"Masoro","year":"2000","journal-title":"Experimental Gerontology"},{"key":"10.1016\/j.biocel.2004.08.002_bib42","doi-asserted-by":"crossref","unstructured":"Masoro, E.J. (2003). Subfield history: caloric restriction, slowing aging, and extending life. Science's SAGE KE, 2003. ns2 (26 February 2003). http:\/\/sageke.sciencemag.org\/cgi\/content\/full\/sageke;2003\/8\/re2.","DOI":"10.1126\/sageke.2003.8.re2"},{"key":"10.1016\/j.biocel.2004.08.002_bib43","first-page":"225","article-title":"Progress in the development of caloric restriction mimetic dietary supplements","volume":"4","author":"Mattson","year":"2001","journal-title":"Journal of Anti-Ageing Medicines"},{"key":"10.1016\/j.biocel.2004.08.002_bib44","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.mehy.2004.01.043","article-title":"Chron activation of AMP-activated kinase as a strategyforslowing aging","volume":"63","author":"McCarty","year":"2004","journal-title":"Medical Hypotheses"},{"key":"10.1016\/j.biocel.2004.08.002_bib45","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/01621459.1984.10478091","article-title":"Tests for differences in tumor incidence based on animal carcinogenesis experiments","volume":"80","author":"McKnight","year":"1984","journal-title":"Journal of American Statistical Association"},{"key":"10.1016\/j.biocel.2004.08.002_bib46","first-page":"15","article-title":"Synthesis and antioxidant activity N.N-substituted 3-amino-1H-1,2-diasaphenalenes","volume":"1","author":"Mezheritski","year":"1998","journal-title":"Chemical-Pharmaceutical Journal"},{"key":"10.1016\/j.biocel.2004.08.002_bib47","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0092-8674(04)00126-6","article-title":"Mammalian SIRT1 represses forkhead transcription factors","volume":"116","author":"Motta","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2004.08.002_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2337\/diacare.22.1.179","article-title":"Metformin and fatty acids","volume":"22","author":"Muntoni","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biocel.2004.08.002_bib49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0015-0282(01)02963-6","article-title":"Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome","volume":"77","author":"Nestler","year":"2002","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.biocel.2004.08.002_bib50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5694\/j.1326-5377.2004.tb05796.x","article-title":"Metformin and serious adverse effects","volume":"180","author":"Nisbet","year":"2004","journal-title":"Medical Journal of Australia"},{"key":"10.1016\/j.biocel.2004.08.002_bib51","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nature02583","article-title":"Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-\u03b3","volume":"429","author":"Picard","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2004.08.002_bib52","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc1387","article-title":"Insulin-like growth factors and neoplasia","volume":"4","author":"Pollak","year":"2004","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/j.biocel.2004.08.002_bib53","article-title":"Tumours of the intestines","volume":"vol. 1","author":"Pozharisski","year":"1990"},{"key":"10.1016\/j.biocel.2004.08.002_bib54","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0065-230X(08)60897-0","article-title":"Experimental intestinal cancer research with special reference to human pathology","volume":"30","author":"Pozharisski","year":"1979","journal-title":"Advances in Cancer Research"},{"key":"10.1016\/j.biocel.2004.08.002_bib55","first-page":"869","article-title":"Calorie restriction in primates: will it work and how will we know?","volume":"46","author":"Roth","year":"1999","journal-title":"Journal of American Geriatric Society"},{"key":"10.1016\/j.biocel.2004.08.002_bib56","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1053\/gast.2001.23258","article-title":"Prevention of pancreatic cancer induction in hamsters by metformin","volume":"120","author":"Schneider","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2004.08.002_bib57","first-page":"47","article-title":"Diabenol\u2014new antidiabetic compounds with haemobiological activity","volume":"2","author":"Spasov","year":"1997","journal-title":"Vestnik of Volgograd Medical Academy"},{"issue":"1","key":"10.1016\/j.biocel.2004.08.002_bib58","first-page":"38","article-title":"The effect of compounds with antioxidant properties on thrombocyte functional activity","volume":"62","author":"Spasov","year":"1999","journal-title":"Eksperimental\u2019nia i Klinicheskaia Farmakologiia"},{"key":"10.1016\/j.biocel.2004.08.002_bib59","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/CDLI.8.5.1003-1011.2001","article-title":"Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL\/6 mice","volume":"8","author":"Sun","year":"2001","journal-title":"Clinical and Diagnostic Laboratory Immunology"},{"key":"10.1016\/j.biocel.2004.08.002_bib60","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/biomet\/62.3.679","article-title":"Tests for trend in life table analysis","volume":"62","author":"Taron","year":"1975","journal-title":"Biometrika"},{"key":"10.1016\/j.biocel.2004.08.002_bib61","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.1081447","article-title":"The endocrine regulation of aging by insulin-like signals","volume":"299","author":"Tatar","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.biocel.2004.08.002_bib62","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/35065638","article-title":"Increased dosage of a sir-2 gene extendslifespanin Caenorhabditis elgans","volume":"410","author":"Tissenbaum","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2004.08.002_bib63","series-title":"Pathology of tumours in laboratory animals. Vol. 1. Tumours of the mouse","first-page":"111","year":"1994"},{"issue":"6","key":"10.1016\/j.biocel.2004.08.002_bib64","first-page":"45","article-title":"Effect of phenformin, L\u2013DOPA and para-chlorophenylalanine on the immunological reactivity and chemical carcinogenesis in BALB\/c mice","volume":"27","author":"Vinnitski","year":"1981","journal-title":"Voprosy Onkologii"},{"issue":"1","key":"10.1016\/j.biocel.2004.08.002_bib65","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/gerona\/56.suppl_1.20","article-title":"Caloric restriction mimetics: metabolic intervention.","volume":"56A","author":"Weindruch","year":"2001","journal-title":"Journal of Gerontology Biological Sciences"},{"key":"10.1016\/j.biocel.2004.08.002_bib66","unstructured":"Weindruch, R., & Walford, R. (1988). The retardation of aging and disease by dietary restriction. Springield, IL: C.C. Thomas."},{"key":"10.1016\/j.biocel.2004.08.002_bib67","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1055\/s-2007-978733","article-title":"Enhanced potential for oxidative stress in hyperinsulinemic rats: imbalance between hepatic peroxisomal hydrogen peroxide production and decomposition due to hyperinsulinemia","volume":"31","author":"Xu","year":"1999","journal-title":"Hormone and Metabolic Research"},{"key":"10.1016\/j.biocel.2004.08.002_bib68","first-page":"61","article-title":"Benzimidazole derivative inhibition of the mutagenic activity of 2-aminoanthracene","volume":"5","author":"Zinovieva","year":"2003","journal-title":"Gigiena i Sanitariia"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272504003127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272504003127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:19:37Z","timestamp":1761200377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272504003127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S1357272504003127"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2004.08.002","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insulin in aging and cancer: antidiabetic drug diabenol as geroprotector and anticarcinogen","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2004.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}