{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:10:25Z","timestamp":1766157025816,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.biocel.2004.12.006","type":"journal-article","created":{"date-parts":[[2005,1,11]],"date-time":"2005-01-11T07:38:59Z","timestamp":1105429139000},"page":"775-783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA \u03b1-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein"],"prefix":"10.1016","volume":"37","author":[{"given":"Marilyne","family":"Bescond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohra","family":"Rahmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2004.12.006_bib1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/hmg\/10.18.1915","article-title":"Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome","volume":"10","author":"Altafaj","year":"2001","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.biocel.2004.12.006_bib2","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1242\/jcs.00618","article-title":"DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly","volume":"116","author":"Alvarez","year":"2003","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2004.12.006_bib3","doi-asserted-by":"crossref","first-page":"25893","DOI":"10.1074\/jbc.273.40.25893","article-title":"Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases","volume":"273","author":"Becker","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2004.12.006_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0969-2126(00)00034-4","article-title":"Building proteins with fibronectin type III modules","volume":"2","author":"Campbell","year":"1994","journal-title":"Structure"},{"key":"10.1016\/j.biocel.2004.12.006_bib5","doi-asserted-by":"crossref","first-page":"17597","DOI":"10.1074\/jbc.M111101200","article-title":"Dynamin is a minibrain kinase\/ dual specificity Yak1-related kinase 1A substrate","volume":"277","author":"Chen-Hwang","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2004.12.006_bib6","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1074\/jbc.M310794200","article-title":"Characterization of cyclin L2, a novel cyclin with an arginine\/serine-rich (RS) domain: phosphorylation by DYRK1A and colocalization with splicing factors","volume":"279","author":"De Graaf","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2004.12.006_bib7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000472398","article-title":"Molecular mapping of twenty-four features of Down syndrome on chromosome 21","volume":"1","author":"Delabar","year":"1993","journal-title":"European Journal of Human Genetics"},{"key":"10.1016\/j.biocel.2004.12.006_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0968-0004(91)90096-E","article-title":"Arginyl-glycyl-aspartic acid (RGD): A cell adhesion motif","volume":"16","author":"D'Souza","year":"1991","journal-title":"Trends in Biochemical Sciences"},{"volume":"vol. 1","year":"2001","author":"Epstein","key":"10.1016\/j.biocel.2004.12.006_bib9"},{"key":"10.1016\/j.biocel.2004.12.006_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-3-7091-6721-2_12","article-title":"The MNB\/DYRK1A protein kinase: Genetic and biochemical properties","volume":"67","author":"Galceran","year":"2003","journal-title":"Journal of Neural Transmission Supplement"},{"key":"10.1016\/j.biocel.2004.12.006_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/geno.1999.5775","article-title":"Human minibrain homologue (MNBH\/DYRK1): Characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome","volume":"57","author":"Guimera","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.biocel.2004.12.006_bib12","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1093\/hmg\/5.9.1305","article-title":"A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region","volume":"5","author":"Guimera","year":"1996","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.biocel.2004.12.006_bib13","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1074\/jbc.275.4.2431","article-title":"Specificity determinants of substrate recognition by the protein kinase DYRK1A","volume":"275","author":"Himpel","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2004.12.006_bib14","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1074\/jbc.271.7.3488","article-title":"Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII","volume":"271","author":"Kentrup","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2004.12.006_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0169-328X(99)00304-6","article-title":"Identification of a brain specific protein that associates with a Refsum disease gene product, phytanoyl-CoA alpha-hydroxylase","volume":"75","author":"Lee","year":"2000","journal-title":"Molecular Brain Research"},{"key":"10.1016\/j.biocel.2004.12.006_bib16","doi-asserted-by":"crossref","first-page":"35156","DOI":"10.1074\/jbc.M206743200","article-title":"Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1","volume":"277","author":"Mao","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2004.12.006_bib17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0006-8993(02)04069-6","article-title":"Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system","volume":"964","author":"Marti","year":"2003","journal-title":"Brain Research"},{"key":"10.1016\/j.biocel.2004.12.006_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0022-1759(00)00313-6","article-title":"A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody","volume":"247","author":"Matsuo","year":"2001","journal-title":"Journal of Immunological Methods"},{"key":"10.1016\/j.biocel.2004.12.006_bib19","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1073\/pnas.93.20.10703","article-title":"Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module","volume":"93","author":"Plaxco","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2004.12.006_bib20","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1073\/pnas.86.15.5958","article-title":"Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome","volume":"86","author":"Rahmani","year":"1989","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2004.12.006_bib21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1006\/bbrc.1998.9803","article-title":"Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues","volume":"253","author":"Rahmani","year":"1998","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.biocel.2004.12.006_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/sj.ejhg.5200198","article-title":"Isolation of a novel human voltage-dependent anion channel gene","volume":"6","author":"Rahmani","year":"1998","journal-title":"European Journal of Human Genetics"},{"key":"10.1016\/j.biocel.2004.12.006_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/bbrc.1996.1135","article-title":"Cloning of a human homolog of the Drosophila minibrain\/rat Dyrk gene from the Down syndrome critical region of chromosome 21","volume":"225","author":"Shindoh","year":"1996","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.biocel.2004.12.006_bib24","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1128\/MCB.24.13.5821-5834.2004","article-title":"Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4","volume":"24","author":"Sitz","year":"2004","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.biocel.2004.12.006_bib25","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1074\/jbc.M301769200","article-title":"Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases","volume":"279","author":"Skurat","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2004.12.006_bib26","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1093\/hmg\/6.10.1729","article-title":"Functional screening and complex traits: Human 21q22.2 sequences affecting learning in mice","volume":"6","author":"Smith","year":"1997","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.biocel.2004.12.006_bib27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/ng0597-28","article-title":"Functional screening of 2Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome","volume":"16","author":"Smith","year":"1997","journal-title":"Nature Genetics"},{"key":"10.1016\/j.biocel.2004.12.006_bib28","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1006\/bbrc.1997.6154","article-title":"The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers","volume":"231","author":"Song","year":"1997","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.biocel.2004.12.006_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/geno.1996.0636","article-title":"Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome critical region","volume":"38","author":"Song","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.biocel.2004.12.006_bib30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1006\/jmbi.1996.0736","article-title":"Module-module interactions in the cell binding region of fibronectin: Stability, flexibility and specificity","volume":"265","author":"Spitzfaden","year":"1997","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.biocel.2004.12.006_bib31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0896-6273(95)90286-4","article-title":"Minibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila","volume":"14","author":"Tejedor","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.biocel.2004.12.006_bib32","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0006-291X(02)02914-5","article-title":"DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression","volume":"300","author":"von Groote-Bidlingmaier","year":"2003","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.biocel.2004.12.006_bib33","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/bj3550609","article-title":"The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: Potential role for DYRK as a glycogen synthase kinase 3-priming kinase","volume":"355","author":"Woods","year":"2001","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2004.12.006_bib34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj3550597","article-title":"The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site","volume":"355","author":"Woods","year":"2001","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2004.12.006_bib35","doi-asserted-by":"crossref","first-page":"39819","DOI":"10.1074\/jbc.M104091200","article-title":"Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells","volume":"276","author":"Yang","year":"2001","journal-title":"Journal of Biological Chemistry"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272504004273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272504004273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:16:51Z","timestamp":1761200211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272504004273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S1357272504004273"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2004.12.006","relation":{},"ISSN":["1357-2725"],"issn-type":[{"type":"print","value":"1357-2725"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA \u03b1-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2004.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}