{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:28:31Z","timestamp":1782484111624,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.biocel.2005.08.008","type":"journal-article","created":{"date-parts":[[2005,9,13]],"date-time":"2005-09-13T07:14:28Z","timestamp":1126595668000},"page":"102-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Induced thrombospondin expression in the mouse pancreas during pancreatic injury"],"prefix":"10.1016","volume":"38","author":[{"given":"Brent A.","family":"Neuschwander-Tetri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanita","family":"Talkad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Otis Stephen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2005.08.008_bib1","doi-asserted-by":"crossref","first-page":"17933","DOI":"10.1074\/jbc.275.24.17933","article-title":"Activation of platelet-transforming growth factor \u03b2-1 in the absence of thrombospondin-1","volume":"275","author":"Abdelouahed","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2005.08.008_bib2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.biocel.2004.01.004","article-title":"The thrombospondins","volume":"36","author":"Adams","year":"2004","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.biocel.2005.08.008_bib3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0002-9440(10)64243-5","article-title":"The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1\/TSP2-null mice","volume":"161","author":"Agah","year":"2002","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.biocel.2005.08.008_bib4","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: A new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.biocel.2005.08.008_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/gut.43.1.128","article-title":"Periacinar stellate shaped cells in rat pancreas: Identification, isolation, and culture","volume":"43","author":"Apte","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2005.08.008_bib6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0016-5085(98)70209-4","article-title":"Identification, culture, and characterization of pancreatic stellate cells in rats and humans","volume":"115","author":"Bachem","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2005.08.008_bib7","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI12749","article-title":"Thrombospondins as matricellular modulators of cell function","volume":"107","author":"Bornstein","year":"2001","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.biocel.2005.08.008_bib8","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1093\/emboj\/16.10.2621","article-title":"Expression of a dominant-negative mutant TGF-\u03b2 type II receptor in transgenic mice reveals essential roles for TGF-\u03b2 in regulation of growth and differentiation in the exocrine pancreas","volume":"16","author":"B\u00f6ttinger","year":"1997","journal-title":"EMBO Journal"},{"key":"10.1016\/j.biocel.2005.08.008_bib9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/gut.2004.042911","article-title":"Thrombospondin 1 acts as a strong promoter of transforming growth factor \u03b2 effects via two distinct mechanisms in hepatic stellate cells","volume":"54","author":"Breitkopf","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2005.08.008_bib10","doi-asserted-by":"crossref","first-page":"0206","DOI":"10.1371\/journal.pbio.0020007","article-title":"Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds","volume":"2","author":"Chang","year":"2004","journal-title":"PLoS Biology"},{"key":"10.1016\/j.biocel.2005.08.008_bib11","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0092-8674(00)81460-9","article-title":"Thrombospondin-1 is a major activator of TGF-\u03b21 in vivo","volume":"93","author":"Crawford","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2005.08.008_bib12","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0002-9440(10)63478-5","article-title":"Antisense oligonucleotides against thrombospondin-1 inhibit activation of TGF-\u03b2 in fibrotic renal disease in the rat in vivo","volume":"163","author":"Daniel","year":"2003","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.biocel.2005.08.008_bib13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1523-1755.2004.00395.x","article-title":"Thrombospondin-1 is a major activator of TGF-\u03b2 in fibrotic renal disease in the rat in vivo","volume":"65","author":"Daniel","year":"2004","journal-title":"Kidney International"},{"key":"10.1016\/j.biocel.2005.08.008_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jss.2004.05.015","article-title":"The role of thrombospondin-1 in human disease","volume":"122","author":"Esemuede","year":"2004","journal-title":"The Journal of Surgical Research"},{"key":"10.1016\/j.biocel.2005.08.008_bib15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00000658-199801000-00014","article-title":"Enhanced expression of TGF-\u03b2s and their receptors in human acute pancreatitis","volume":"227","author":"Friess","year":"1998","journal-title":"Annals of Surgery"},{"key":"10.1016\/j.biocel.2005.08.008_bib16","series-title":"The pancreas: biology, pathobiology, and disease","first-page":"501","article-title":"Cerulein-induced pancreatitis","author":"Gorelick","year":"1993"},{"key":"10.1016\/j.biocel.2005.08.008_bib17","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1159\/000007567","article-title":"Role of extracellular matrix in pancreatic diseases","volume":"59","author":"Gress","year":"1998","journal-title":"Digestion"},{"key":"10.1016\/j.biocel.2005.08.008_bib18","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1172\/JCI8337","article-title":"Loss of TGF-\u03b2 signaling contributes to autoimmune pancreatitis","volume":"105","author":"Hahm","year":"2000","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.biocel.2005.08.008_bib19","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1093\/emboj\/20.11.2631","article-title":"Thrombospondin-2 plays a protective role in multistep carcinogenesis: A novel host anti-tumor defense mechanism","volume":"20","author":"Hawighorst","year":"2001","journal-title":"EMBO Journal"},{"key":"10.1016\/j.biocel.2005.08.008_bib20","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00006676-199811000-00013","article-title":"Immunohistochemical study of transforming growth factor-\u03b21, matrix metalloproteinase-2,9, tissue inhibitors of metallproteinase-1,2, and basement membrane components at pancreatic ducts in chronic pancreatitis","volume":"17","author":"Ishihara","year":"1998","journal-title":"Pancreas"},{"key":"10.1016\/j.biocel.2005.08.008_bib21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1083\/jcb.140.2.419","article-title":"Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis","volume":"140","author":"Kyriakides","year":"1998","journal-title":"Journal of Cell Biology"},{"key":"10.1016\/j.biocel.2005.08.008_bib22","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1177\/002215549804600904","article-title":"The distribution of the matricellular protein thrombospondin 2 in tissues of embryonic and adult mice","volume":"46","author":"Kyriakides","year":"1998","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"10.1016\/j.biocel.2005.08.008_bib23","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1172\/JCI1684","article-title":"Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia","volume":"101","author":"Lawler","year":"1998","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.biocel.2005.08.008_bib24","first-page":"42","article-title":"Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-\u03b21","volume":"147","author":"Lee","year":"1995","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.biocel.2005.08.008_bib25","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0024-3205(03)00383-7","article-title":"The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells","volume":"73","author":"Li","year":"2003","journal-title":"Life Sciences"},{"key":"10.1016\/j.biocel.2005.08.008_bib26","first-page":"G364","article-title":"Transforming growth factor-\u03b2 (TGF-\u03b2 1) inhibits pancreatic acinar cell growth","volume":"262","author":"Logsdon","year":"1992","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.biocel.2005.08.008_bib27","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0016-5085(97)70107-0","article-title":"Extracellular matrix is reduced by inhibition of transforming growth factor \u03b21 in pancreatitis in the rat","volume":"113","author":"Menke","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2005.08.008_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1359-6101(99)00029-5","article-title":"Activation of latent TGF-\u03b2 by thrombospondin-1: Mechanisms and physiology","volume":"11","author":"Murphy-Ullrich","year":"2000","journal-title":"Cytokine and Growth Factor Reviews"},{"key":"10.1016\/j.biocel.2005.08.008_bib29","first-page":"278","article-title":"Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: A mechanism for activation of latent TGF-\u03b21","volume":"286","author":"Naito","year":"2004","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.biocel.2005.08.008_bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/labinvest.3780018","article-title":"Procollagen \u03b11(I) expression and the role of pancreatic stellate cells during and after repetitive acute pancreatic injury in the mouse","volume":"80","author":"Neuschwander-Tetri","year":"2000","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.biocel.2005.08.008_bib31","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1023\/A:1005423122127","article-title":"Repetitive self-limited acute pancreatitis induces pancreatic fibrogenesis in the mouse","volume":"45","author":"Neuschwander-Tetri","year":"2000","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.biocel.2005.08.008_bib32","first-page":"349","article-title":"Molecular mechanisms of transforming growth factor-\u03b2 signaling","volume":"19","author":"Pei-Chih Hu","year":"1998","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.biocel.2005.08.008_bib33","first-page":"185","article-title":"Negative regulation of cell growth by TGF\u03b2","volume":"1242","author":"Polyak","year":"1996","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2005.08.008_bib34","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1999.277.1.C1","article-title":"Myofibroblasts. I. Paracrine cells important in health and disease","volume":"277","author":"Powell","year":"1999","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.biocel.2005.08.008_bib35","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1074\/jbc.M212927200","article-title":"The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression","volume":"278","author":"Reif","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2005.08.008_bib36","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1074\/jbc.274.19.13586","volume":"274","author":"Ribeiro","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2005.08.008_bib37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/gut.40.1.73","article-title":"Increased expression of transforming growth factor \u03b2s after acute oedematous pancreatitis in rats suggests a role in pancreatic repair","volume":"40","author":"Riesle","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2005.08.008_bib38","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1073\/pnas.92.7.2572","article-title":"Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions","volume":"92","author":"Sanderson","year":"1995","journal-title":"Proceedings of the National Academy of Science of the United State of America"},{"key":"10.1016\/j.biocel.2005.08.008_bib39","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1242\/dev.120.12.3451","article-title":"TGF-\u03b2 1 influences the relative development of the exocrine and endocrine pancreas in vitro","volume":"120","author":"Sanvito","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.biocel.2005.08.008_bib40","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1006\/bbrc.1995.2906","article-title":"TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-\u03b1, triggers insulin-dependent diabetes","volume":"217","author":"Sanvito","year":"1995","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.biocel.2005.08.008_bib41","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1074\/jbc.270.13.7304","volume":"270","author":"Schultz-Cherry","year":"1995","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2005.08.008_bib42","doi-asserted-by":"crossref","first-page":"26775","DOI":"10.1016\/S0021-9258(18)47086-X","article-title":"Thrombospondin binds and activates the small and large forms of latent transforming growth factor-\u03b2 in a chemically defined system","volume":"269","author":"Schultz-Cherry","year":"1994","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2005.08.008_bib43","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-\u03b21 gene results in multifocal inflammatory disease","volume":"359","author":"Shull","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2005.08.008_bib44","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2144\/97223bm07","article-title":"Tissue homogenization as a key step in extracting RNA from human and rat pancreatic tissue","volume":"22","author":"Sparmann","year":"1997","journal-title":"Biotechniques"},{"key":"10.1016\/j.biocel.2005.08.008_bib45","first-page":"2060","article-title":"Pancreatic fibrosis in patients with chronic alcohol abuse: Correlation with alcoholic pancreatitis","volume":"89","author":"Suda","year":"1994","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.biocel.2005.08.008_bib46","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/0016-5085(95)90152-3","article-title":"Localization of transforming growth factor beta 1 and its latent binding protein in human chronic pancreatitis","volume":"108","author":"Van Laethem","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2005.08.008_bib47","first-page":"G164","article-title":"Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-\u03b21 transgenic mouse model","volume":"280","author":"Vogelmann","year":"2001","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.biocel.2005.08.008_bib48","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng1096-141","article-title":"Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene","volume":"14","author":"Whitcomb","year":"1996","journal-title":"Nature Genetics"},{"key":"10.1016\/j.biocel.2005.08.008_bib49","doi-asserted-by":"crossref","first-page":"38032","DOI":"10.1074\/jbc.M405658200","article-title":"Molecular interactions that confer latency to transforming growth factor-beta","volume":"279","author":"Young","year":"2004","journal-title":"The Journal of Biological Chemistry"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272505002621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272505002621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:19:27Z","timestamp":1761200367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272505002621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S1357272505002621"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2005.08.008","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Induced thrombospondin expression in the mouse pancreas during pancreatic injury","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2005.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}