{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T21:25:48Z","timestamp":1787261148440,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1016\/j.biocel.2006.01.009","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T07:49:44Z","timestamp":1140594584000},"page":"1450-1456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ovarian cancer: Homeobox genes, autocrine\/paracrine growth, and kinase signaling"],"prefix":"10.1016","volume":"38","author":[{"given":"B.T.","family":"Hennessy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.B.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2006.01.009_bib1","doi-asserted-by":"crossref","first-page":"7678","DOI":"10.1158\/0008-5472.CAN-04-2933","article-title":"Mutation of the PIK3CA gene in ovarian and breast cancer","volume":"64","author":"Campbell","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.biocel.2006.01.009_bib2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/nm1125","article-title":"The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers","volume":"10","author":"Cheng","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2006.01.009_bib3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nm1230","article-title":"Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract","volume":"11","author":"Cheng","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2006.01.009_bib4","first-page":"717","article-title":"Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis","volume":"71","author":"Cramer","year":"1983","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.biocel.2006.01.009_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nm1173","article-title":"Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer","volume":"11","author":"Dinulescu","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2006.01.009_bib6","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1128\/MCB.22.7.2099-2110.2002","article-title":"Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway","volume":"22","author":"Fang","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2006.01.009_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0140-6736(71)92335-X","article-title":"Incessant ovulation a factor in ovarian neoplasia?","volume":"17","author":"Fathalla","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.biocel.2006.01.009_bib8","first-page":"5","article-title":"Cancer statistics","volume":"53","author":"Jemal","year":"2003","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.biocel.2006.01.009_bib9","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/ijc.20971","article-title":"Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer","volume":"115","author":"Kamikihara","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biocel.2006.01.009_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mce.2004.02.020","article-title":"Estrogen and progesterone receptors in ovarian epithelial tumors","volume":"221","author":"Lindgren","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biocel.2006.01.009_bib11","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1158\/0008-5472.CAN-03-3380","article-title":"A genetically defined model for human ovarian","volume":"64","author":"Liu","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.biocel.2006.01.009_bib12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nrm1332","article-title":"Parsing the polarity code","volume":"5","author":"Macara","year":"2004","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2006.01.009_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/bj3590211","article-title":"Regulation of phospholipase D isoenzymes by transforming Ras and atypical protein kinase C-iota","volume":"359","author":"Mwanjewe","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.biocel.2006.01.009_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrc1611","article-title":"Ovarian cancer metastasis: Integrating insights from disparate model organisms","volume":"5","author":"Naora","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biocel.2006.01.009_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00001703-200202000-00004","article-title":"Current understanding of the epidemiology and clinical implications of BRCA1 and BRCA2 mutations for ovarian cancer","volume":"14","author":"Narod","year":"2002","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.biocel.2006.01.009_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1535-6108(01)00002-2","article-title":"Induction of ovarian cancer by defined multiple genetic changes in a mouse model system","volume":"1","author":"Orsulic","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.biocel.2006.01.009_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/5042","article-title":"PIK3CA is implicated as an oncogene in ovarian cancer","volume":"21","author":"Shayesteh","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biocel.2006.01.009_bib18","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0002-9440(10)63708-X","article-title":"Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis","volume":"164","author":"Shih","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biocel.2006.01.009_bib19","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1158\/0008-5472.CAN-03-3959","article-title":"Activated signal transducer and activator of transcription (STAT) 3: Localization in focal adhesions and function in ovarian cancer cell motility","volume":"64","author":"Silver","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.biocel.2006.01.009_bib20","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1200\/JCO.2004.04.070","article-title":"Gene expression signature with independent prognostic significance in epithelial ovarian cancer","volume":"22","author":"Spentzos","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.biocel.2006.01.009_bib21","first-page":"1073","article-title":"The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: Validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer","volume":"63","author":"Tanyi","year":"2003","journal-title":"Cancer Res."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272506000288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272506000288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T20:57:32Z","timestamp":1787259452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272506000288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006]]}},"alternative-id":["S1357272506000288"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2006.01.009","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ovarian cancer: Homeobox genes, autocrine\/paracrine growth, and kinase signaling","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2006.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}