{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:01:59Z","timestamp":1790838119115,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1016\/j.biocel.2006.05.009","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T17:11:45Z","timestamp":1149181905000},"page":"1946-1956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Mitochondria are a primary target of hypericin phototoxicity: Synergy of intracellular calcium mobilisation in cell killing"],"prefix":"10.1016","volume":"38","author":[{"given":"Theodossis A.","family":"Theodossiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Noronha-Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Hothersall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2006.05.009_bib1","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/0006-2952(95)00097-J","article-title":"Photosensitized inhibition of growth factor-regulated protein kinases by hypericin","volume":"49","author":"Agostinis","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biocel.2006.05.009_bib2","first-page":"601","article-title":"Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells","volume":"9","author":"Ali","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biocel.2006.05.009_bib3","first-page":"461","article-title":"Hypocrellins and hypericin induced apoptosis in human tumor cells: A possible role of hydrogen peroxide","volume":"9","author":"Ali","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biocel.2006.05.009_bib4","first-page":"531","article-title":"Bio-distribution and subcellular localization of hypericin and its role in PDT induced apoptosis in cancer cells","volume":"21","author":"Ali","year":"2002","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biocel.2006.05.009_bib5","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1021\/cr950040z","article-title":"Aconitase as iron\u2013sulfur protein, enzyme, and iron-regulatory protein","volume":"96","author":"Beinert","year":"1996","journal-title":"Chem. Rev."},{"key":"10.1016\/j.biocel.2006.05.009_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0887-2333(01)00108-4","article-title":"Effects of the ionophores valinomycin, ionomycin and gramicidin A on the element compartmentation in cultured rat hepatocytes","volume":"16","author":"Bolkent","year":"2002","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.biocel.2006.05.009_bib7","doi-asserted-by":"crossref","first-page":"14846","DOI":"10.1021\/bi0353979","article-title":"Redox-dependent modulation of aconitase activity in intact mitochondria","volume":"42","author":"Bulteau","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.biocel.2006.05.009_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0898-6568(98)00025-4","article-title":"Oxidant, mitochondria and calcium: An overview","volume":"11","author":"Chakraborti","year":"1999","journal-title":"Cell Signal."},{"key":"10.1016\/j.biocel.2006.05.009_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0005-2736(99)00016-4","article-title":"The effect of hypericin and hypocrellin-A on lipid membranes and membrane potential of 3T3 fibroblasts","volume":"1418","author":"Chaloupka","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biocel.2006.05.009_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0891-5849(93)90012-J","article-title":"Photosensitization with anticancer agents. 17. EPR studies of photodynamic action of hypericin: Formation of semiquinone radical and activated oxygen species on illumination","volume":"14","author":"Diwu","year":"1993","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biocel.2006.05.009_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1751-1097.1998.tb02479.x","article-title":"Kinetics and yield of singlet oxygen photosensitized by hypericin in organic and biological media","volume":"68","author":"Ehrenberg","year":"1998","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.biocel.2006.05.009_bib12","first-page":"301","article-title":"Subcellular distributions and excited-state processes of hypericin in neurons","volume":"69","author":"English","year":"1999","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.biocel.2006.05.009_bib13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0891-5849(95)02037-3","article-title":"Sod and catalase inactivation by singlet oxygen and peroxyl radicals","volume":"20","author":"Escobar","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biocel.2006.05.009_bib14","doi-asserted-by":"crossref","first-page":"22369","DOI":"10.1016\/S0021-9258(18)41538-4","article-title":"The inactivation of Fe\u2013S cluster containing hydrolyases by superoxide","volume":"268","author":"Flint","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2006.05.009_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0076-6879(02)49317-2","article-title":"Aconitase: Sensitive target and measure of superoxide 497","volume":"349","author":"Gardner","year":"2002","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.biocel.2006.05.009_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/1011-1344(94)07064-U","article-title":"Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5","volume":"27","author":"Hadjur","year":"1995","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.biocel.2006.05.009_bib17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1751-1097.1996.tb02474.x","article-title":"Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells","volume":"64","author":"Hadjur","year":"1996","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.biocel.2006.05.009_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0925-4439(95)00015-V","article-title":"Calcium ion-dependent signalling and mitochondrial dysfunction: Mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition","volume":"1271","author":"Hoek","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biocel.2006.05.009_bib19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/bj3220477","article-title":"Induction of nitric oxide synthesis in J774 cells lowers intracellular glutathione: Effect of modulated glutathione redox status on nitric oxide synthase induction","volume":"322","author":"Hothersall","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.biocel.2006.05.009_bib20","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0891-5849(97)00364-X","article-title":"Antioxidant enzyme response to hypericin in EMT6 mouse mammary carcinoma cells","volume":"24","author":"Johnson","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biocel.2006.05.009_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0300-9084(01)01258-5","article-title":"Inactivation of catalase and superoxide dismutase by singlet oxygen derived from photoactivated dye","volume":"83","author":"Kim","year":"2001","journal-title":"Biochimie"},{"key":"10.1016\/j.biocel.2006.05.009_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10863-005-6635-z","article-title":"Intracellular ca(2+) pools and fluxes in cardiac muscle-derived h9c2 cells","volume":"37","author":"Lax","year":"2005","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.biocel.2006.05.009_bib23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0022-1759(84)90477-0","article-title":"Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens","volume":"67","author":"Landegren","year":"1984","journal-title":"J. Immunol. Meth."},{"key":"10.1016\/j.biocel.2006.05.009_bib24","first-page":"5777","article-title":"Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria","volume":"58","author":"Miccoli","year":"1998","journal-title":"Cancer Res."},{"issue":"Pt 3","key":"10.1016\/j.biocel.2006.05.009_bib25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/bj3000665","article-title":"Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane","volume":"300","author":"Morgan","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.biocel.2006.05.009_bib26","doi-asserted-by":"crossref","first-page":"14864","DOI":"10.1074\/jbc.M510916200","article-title":"Simultaneous monitoring of ionophore- and inhibitor-mediated plasma and mitochondrial membrane potential changes in cultured neurons","volume":"281","author":"Nicholls","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2006.05.009_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0005-2728(98)00164-9","article-title":"Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia","volume":"1410","author":"Schapira","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biocel.2006.05.009_bib28","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1039\/b202884k","article-title":"The correlation between hydrophilicity of hypericins and helianthrone: Internalization mechanisms, subcellular distribution and photodynamic action in colon carcinoma cells","volume":"1","author":"Siboni","year":"2002","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.biocel.2006.05.009_bib29","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1021\/ja961783k","article-title":"Hypericin-induced cell photosensitization involves an intracellular pH decrease","volume":"118","author":"Sureau","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biocel.2006.05.009_bib30","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1751-1097.2004.tb00111.x","article-title":"Evidence for intracellular aggregation of hypericin and the impact on its photocytotoxicity in PAM 212 murine keratinocytes","volume":"80","author":"Theodossiou","year":"2004","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.biocel.2006.05.009_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1751-1097.1992.tb04208.x","article-title":"Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succinoxidase","volume":"55","author":"Thomas","year":"1992","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.biocel.2006.05.009_bib32","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1751-1097.1992.tb08531.x","article-title":"Oxygen dependence of hypericin-induced phototoxicity to EMT6 mouse mammary carcinoma cells","volume":"55","author":"Thomas","year":"1992","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.biocel.2006.05.009_bib33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/PL00011364","article-title":"Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines","volume":"16","author":"Uzdensky","year":"2001","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.biocel.2006.05.009_bib34","doi-asserted-by":"crossref","first-page":"14064","DOI":"10.1074\/jbc.275.19.14064","article-title":"Mitochondrial aconitase is a source of hydroxyl radical. An electron spin resonance investigation","volume":"275","author":"Vasquez-Vivar","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2006.05.009_bib35","doi-asserted-by":"crossref","first-page":"11168","DOI":"10.1073\/pnas.94.21.11168","article-title":"Oxidative damage during aging targets mitochondrial aconitase","volume":"94","author":"Yan","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272506001658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272506001658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:22:54Z","timestamp":1761200574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272506001658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006]]}},"alternative-id":["S1357272506001658"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2006.05.009","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondria are a primary target of hypericin phototoxicity: Synergy of intracellular calcium mobilisation in cell killing","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2006.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}