{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:45:05Z","timestamp":1791164705500,"version":"4.1.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2007]]},"DOI":"10.1016\/j.biocel.2006.06.007","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T10:43:11Z","timestamp":1152268991000},"page":"31-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"title":["Wnt4 action in gonadal development and sex determination"],"prefix":"10.1016","volume":"39","author":[{"given":"Pascal","family":"Bernard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent R.","family":"Harley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.biocel.2006.06.007_bib1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1101\/gad.1171104","article-title":"Interactions between Sox9 and beta-catenin control chondrocyte differentiation","volume":"18","author":"Akiyama","year":"2004","journal-title":"Genes Dev."},{"issue":"36","key":"10.1016\/j.biocel.2006.06.007_bib2","doi-asserted-by":"crossref","first-page":"33839","DOI":"10.1074\/jbc.M302078200","article-title":"A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia\/autosomal sex reversal","volume":"278","author":"Argentaro","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biocel.2006.06.007_bib3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/ng0894-497","article-title":"A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal","volume":"7","author":"Bardoni","year":"1994","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.biocel.2006.06.007_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1095\/biolreprod.105.045930","article-title":"Homozygous inactivation of Sox9 causes complete XY sex reversal in mice","volume":"74","author":"Barrionuevo","year":"2006","journal-title":"Biol. Reprod."},{"issue":"6271","key":"10.1016\/j.biocel.2006.06.007_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/345167a0","article-title":"Abnormal sexual development in transgenic mice chronically expressing mullerian inhibiting substance","volume":"345","author":"Behringer","year":"1990","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biocel.2006.06.007_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0092-8674(94)90251-8","article-title":"Mullerian-inhibiting substance function during mammalian sexual development","volume":"79","author":"Behringer","year":"1994","journal-title":"Cell"},{"issue":"6300","key":"10.1016\/j.biocel.2006.06.007_bib7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/348448a0","article-title":"Genetic evidence equating SRY and the testis-determining factor","volume":"348","author":"Berta","year":"1990","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.biocel.2006.06.007_bib8","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1056\/NEJMoa040533","article-title":"A WNT4 mutation associated with Mullerian-duct regression and virilization in a 46 XX woman","volume":"351","author":"Biason-Lauber","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"6772","key":"10.1016\/j.biocel.2006.06.007_bib9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/35002622","article-title":"The LIM homeobox gene Lhx9 is essential for mouse gonad formation","volume":"403","author":"Birk","year":"2000","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biocel.2006.06.007_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gde.2005.12.007","article-title":"Balancing cell adhesion and Wnt signaling, the key role of beta-catenin","volume":"16","author":"Brembeck","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"7","key":"10.1016\/j.biocel.2006.06.007_bib11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrg1381","article-title":"One tissue, two fates: Molecular genetic events that underlie testis versus ovary development","volume":"5","author":"Brennan","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/dbio.2002.0578","article-title":"Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad","volume":"244","author":"Brennan","year":"2002","journal-title":"Dev. Biol."},{"issue":"6","key":"10.1016\/j.biocel.2006.06.007_bib13","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1101\/gad.1052503","article-title":"Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad","volume":"17","author":"Brennan","year":"2003","journal-title":"Genes Dev."},{"issue":"24","key":"10.1016\/j.biocel.2006.06.007_bib14","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1101\/gad.11.24.3286","article-title":"Wnt signaling: A common theme in animal development","volume":"11","author":"Cadigan","year":"1997","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib15","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1074\/jbc.M109663200","article-title":"Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation","volume":"277","author":"Cai","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.devcel.2005.05.016","article-title":"Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system","volume":"9","author":"Carroll","year":"2005","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.biocel.2006.06.007_bib17","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1242\/dev.01087","article-title":"Functional analysis of Sox8 and Sox9 during sex determination in the mouse","volume":"131","author":"Chaboissier","year":"2004","journal-title":"Development"},{"issue":"6","key":"10.1016\/j.biocel.2006.06.007_bib18","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1095\/biolreprod63.6.1825","article-title":"Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules","volume":"63","author":"Clark","year":"2000","journal-title":"Biol. Reprod."},{"issue":"6","key":"10.1016\/j.biocel.2006.06.007_bib19","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0092-8674(01)00284-7","article-title":"Male-to-female sex reversal in mice lacking fibroblast growth factor 9","volume":"104","author":"Colvin","year":"2001","journal-title":"Cell"},{"issue":"5448","key":"10.1016\/j.biocel.2006.06.007_bib20","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1126\/science.286.5448.2328","article-title":"Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta","volume":"286","author":"Couse","year":"1999","journal-title":"Science"},{"issue":"Pt 4","key":"10.1016\/j.biocel.2006.06.007_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1469-1809.1981.tb00347.x","article-title":"Cytogenetic recognition of chromosomal duplication [dup(1)(p31.4 leads to p22.1)] and the detection of three different alleles at the PGM1 locus","volume":"45","author":"Cousineau","year":"1981","journal-title":"Ann. Hum. Genet."},{"issue":"6","key":"10.1016\/j.biocel.2006.06.007_bib22","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1083\/jcb.200302075","article-title":"A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation","volume":"161","author":"Dailey","year":"2003","journal-title":"J. Cell Biol."},{"issue":"12","key":"10.1016\/j.biocel.2006.06.007_bib23","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1101\/gad.341405","article-title":"p21WAF1\/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation","volume":"19","author":"Devgan","year":"2005","journal-title":"Genes Dev."},{"issue":"8","key":"10.1016\/j.biocel.2006.06.007_bib24","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1242\/dev.02303","article-title":"FGF9 promotes survival of germ cells in the fetal testis","volume":"133","author":"Dinapoli","year":"2006","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.biocel.2006.06.007_bib25","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1128\/MCB.15.5.2625","article-title":"Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos","volume":"15","author":"Du","year":"1995","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.biocel.2006.06.007_bib26","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/ajmg.1320170403","article-title":"Tandem dup (1p) within the short arm of chromosome 1 in a child with ambiguous genitalia and multiple congenital anomalies","volume":"17","author":"Elejalde","year":"1984","journal-title":"Am. J. Med. Genet."},{"issue":"6506","key":"10.1016\/j.biocel.2006.06.007_bib27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/372525a0","article-title":"Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene","volume":"372","author":"Foster","year":"1994","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.biocel.2006.06.007_bib28","doi-asserted-by":"crossref","first-page":"14879","DOI":"10.1074\/jbc.M306421200","article-title":"The human frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. Beta-catenin signaling cascade","volume":"279","author":"Golan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2006.06.007_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev.ge.27.120193.000443","article-title":"SRY and sex determination in mammals","volume":"27","author":"Goodfellow","year":"1993","journal-title":"Ann. Rev. Genet."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1083\/jcb.200402153","article-title":"Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes","volume":"167","author":"Gottardi","year":"2004","journal-title":"J. Cell Biol."},{"issue":"29","key":"10.1016\/j.biocel.2006.06.007_bib31","doi-asserted-by":"crossref","first-page":"26572","DOI":"10.1074\/jbc.M212677200","article-title":"Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene","volume":"278","author":"Gummow","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.biocel.2006.06.007_bib32","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1210\/en.2002-220275","article-title":"Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production","volume":"143","author":"Heikkila","year":"2002","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.biocel.2006.06.007_bib33","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1210\/en.2005-0463","article-title":"The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action","volume":"146","author":"Heikkila","year":"2005","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.biocel.2006.06.007_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0925-4773(95)00385-E","article-title":"Wnt expression patterns in chick embryo nervous system","volume":"52","author":"Hollyday","year":"1995","journal-title":"Mech. Dev."},{"issue":"29","key":"10.1016\/j.biocel.2006.06.007_bib35","doi-asserted-by":"crossref","first-page":"26511","DOI":"10.1074\/jbc.M300804200","article-title":"Synergistic cooperation between the beta-catenin signaling pathway and steroidogenic factor 1 in the activation of the Mullerian inhibiting substance type II receptor","volume":"278","author":"Hossain","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.biocel.2006.06.007_bib36","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1210\/me.2004-0259","article-title":"Canonical Wnt signaling is critical to estrogen-mediated uterine growth","volume":"18","author":"Hou","year":"2004","journal-title":"Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.biocel.2006.06.007_bib37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/(SICI)1096-8628(19991203)87:4<349::AID-AJMG13>3.0.CO;2-N","article-title":"Autosomal XX sex reversal caused by duplication of SOX9","volume":"87","author":"Huang","year":"1999","journal-title":"Am. J. Med. Genet."},{"issue":"9","key":"10.1016\/j.biocel.2006.06.007_bib38","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/hmg\/5.9.1269","article-title":"A 27 base-pair deletion of the anti-mullerian type II receptor gene is the most common cause of the persistent mullerian duct syndrome","volume":"5","author":"Imbeaud","year":"1996","journal-title":"Hum. Mol. Genet."},{"issue":"6738","key":"10.1016\/j.biocel.2006.06.007_bib39","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/21674","article-title":"The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF","volume":"399","author":"Ishitani","year":"1999","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib40","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ydbio.2004.08.049","article-title":"Wnt4 is required for proper male as well as female sexual development","volume":"276","author":"Jeays-Ward","year":"2004","journal-title":"Dev. Biol."},{"issue":"16","key":"10.1016\/j.biocel.2006.06.007_bib41","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1242\/dev.00591","article-title":"Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad","volume":"130","author":"Jeays-Ward","year":"2003","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.biocel.2006.06.007_bib42","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1086\/320125","article-title":"Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans","volume":"68","author":"Jordan","year":"2001","journal-title":"Am. J. Hum. Genet."},{"issue":"19","key":"10.1016\/j.biocel.2006.06.007_bib43","doi-asserted-by":"crossref","first-page":"10866","DOI":"10.1073\/pnas.1834480100","article-title":"Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1\/beta-catenin synergy","volume":"100","author":"Jordan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/toxsci\/kfj167","article-title":"Differential expression patterns of Wnt and {beta}-catenin\/TCF-target genes in the uterus of immature female rats exposed to 17{alpha}-ethynyl estradiol","volume":"91","author":"Katayama","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"6686","key":"10.1016\/j.biocel.2006.06.007_bib45","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/31482","article-title":"Male-to-female sex reversal in M33 mutant mice","volume":"393","author":"Katoh-Fukui","year":"1998","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.biocel.2006.06.007_bib46","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1242\/dev.122.9.2813","article-title":"A male-specific role for SOX9 in vertebrate sex determination","volume":"122","author":"Kent","year":"1996","journal-title":"Development"},{"issue":"6","key":"10.1016\/j.biocel.2006.06.007_bib47","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1371\/journal.pbio.0040187","article-title":"Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination","volume":"4","author":"Kim","year":"2006","journal-title":"PLoS Biol."},{"issue":"21","key":"10.1016\/j.biocel.2006.06.007_bib48","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1242\/dev.125.21.4225","article-title":"Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney","volume":"125","author":"Kispert","year":"1998","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.biocel.2006.06.007_bib49","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1242\/dev.00951","article-title":"Requirement of Lim1 for female reproductive tract development","volume":"131","author":"Kobayashi","year":"2004","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.biocel.2006.06.007_bib50","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1073\/pnas.0510813103","article-title":"Retinoic acid regulates sex-specific timing of meiotic initiation in mice","volume":"103","author":"Koubova","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"17","key":"10.1016\/j.biocel.2006.06.007_bib51","doi-asserted-by":"crossref","first-page":"12701","DOI":"10.1074\/jbc.275.17.12701","article-title":"Ca(2+)\/calmodulin-dependent protein kinase II is stimulated by Wnt and frizzled homologs and promotes ventral cell fates in Xenopus","volume":"275","author":"Kuhl","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.biocel.2006.06.007_bib52","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0168-9525(00)02028-X","article-title":"The Wnt\/Ca2+ pathway: A new vertebrate Wnt signaling pathway takes shape","volume":"16","author":"Kuhl","year":"2000","journal-title":"Trends Genet."},{"issue":"3","key":"10.1016\/j.biocel.2006.06.007_bib53","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tem.2004.02.002","article-title":"Sex determination: A \u2018window\u2019 of DAX1 activity","volume":"15","author":"Ludbrook","year":"2004","journal-title":"Trends Endocrinol. Metabol."},{"issue":"4","key":"10.1016\/j.biocel.2006.06.007_bib54","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0092-8674(94)90211-9","article-title":"A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation","volume":"77","author":"Luo","year":"1994","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.biocel.2006.06.007_bib55","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00432-003-0431-0","article-title":"The Wnt signaling pathway and its role in tumor development","volume":"129","author":"Lustig","year":"2003","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib56","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1095\/biolreprod52.2.444","article-title":"Ontogeny of reproductive abnormalities induced by deregulation of anti-mullerian hormone expression in transgenic mice","volume":"52","author":"Lyet","year":"1995","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib57","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.yexcr.2004.04.036","article-title":"Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds frizzled-6 CRD: Functional implications of Wnt\/beta-catenin activity in kidney epithelial cells","volume":"298","author":"Lyons","year":"2004","journal-title":"Exp. Cell Res."},{"issue":"12","key":"10.1016\/j.biocel.2006.06.007_bib58","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0960-9822(06)00415-5","article-title":"Male-specific cell migration into the developing gonad","volume":"7","author":"Martineau","year":"1997","journal-title":"Curr. Biol."},{"issue":"6","key":"10.1016\/j.biocel.2006.06.007_bib59","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/sj.emboj.7600603","article-title":"Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis","volume":"24","author":"Maurus","year":"2005","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.biocel.2006.06.007_bib60","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/ng1141","article-title":"Dax1 is required for testis determination","volume":"34","author":"Meeks","year":"2003","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.biocel.2006.06.007_bib61","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1242\/dev.124.9.1653","article-title":"Defects of urogenital development in mice lacking Emx2","volume":"124","author":"Miyamoto","year":"1997","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.biocel.2006.06.007_bib62","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1210\/me.2002-0362","article-title":"Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad","volume":"17","author":"Mizusaki","year":"2003","journal-title":"Mol. Endocrinol."},{"issue":"3","key":"10.1016\/j.biocel.2006.06.007_bib63","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ajmg.1320320316","article-title":"Direct duplication of chromosome 1, dir dup(1) (p21.2\u2013p32) in a Bedouin boy with multiple congenital anomalies","volume":"32","author":"Mohammed","year":"1989","journal-title":"Am. J. Med. Genet."},{"issue":"1","key":"10.1016\/j.biocel.2006.06.007_bib64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1242\/dev.119.1.97","article-title":"Xwnt-5A: A maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis","volume":"119","author":"Moon","year":"1993","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.biocel.2006.06.007_bib65","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng0996-62","article-title":"Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds","volume":"14","author":"Morais da Silva","year":"1996","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib66","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ydbio.2005.09.008","article-title":"Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development","volume":"287","author":"Nef","year":"2005","journal-title":"Dev. Biol."},{"issue":"6964","key":"10.1016\/j.biocel.2006.06.007_bib67","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nature02059","article-title":"Testis determination requires insulin receptor family function in mice","volume":"426","author":"Nef","year":"2003","journal-title":"Nature"},{"issue":"5663","key":"10.1016\/j.biocel.2006.06.007_bib68","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1126\/science.1094291","article-title":"Convergence of Wnt, beta-catenin, and cadherin pathways","volume":"303","author":"Nelson","year":"2004","journal-title":"Science"},{"issue":"25","key":"10.1016\/j.biocel.2006.06.007_bib69","doi-asserted-by":"crossref","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","article-title":"Receptor specificity of the fibroblast growth factor family","volume":"271","author":"Ornitz","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biocel.2006.06.007_bib70","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.bbrc.2005.11.118","article-title":"A novel response element confers p63- and p73-specific activation of the WNT4 promoter","volume":"339","author":"Osada","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biocel.2006.06.007_bib71","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1242\/dev.02174","article-title":"Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay","volume":"133","author":"Osafune","year":"2006","journal-title":"Development"},{"issue":"6703","key":"10.1016\/j.biocel.2006.06.007_bib72","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/27221","article-title":"Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a","volume":"395","author":"Parr","year":"1998","journal-title":"Nature"},{"issue":"6280","key":"10.1016\/j.biocel.2006.06.007_bib73","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/346194a0","article-title":"The candidate Wilms\u2019 tumour gene is involved in genitourinary development","volume":"346","author":"Pritchard-Jones","year":"1990","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.biocel.2006.06.007_bib74","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/hmg\/ddi133","article-title":"Sox9 is sufficient for functional testis development producing fertile male mice in the absence of Sry","volume":"14","author":"Qin","year":"2005","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"10.1016\/j.biocel.2006.06.007_bib75","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/hmg\/ddh141","article-title":"Long-range activation of Sox9 in odd sex (Ods) mice","volume":"13","author":"Qin","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib76","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0012-1606(03)00122-2","article-title":"Cell proliferation is necessary for the determination of male fate in the gonad","volume":"258","author":"Schmahl","year":"2003","journal-title":"Dev. Biol."},{"issue":"15","key":"10.1016\/j.biocel.2006.06.007_bib77","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1242\/dev.01239","article-title":"Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination","volume":"131","author":"Schmahl","year":"2004","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib78","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ydbio.2004.07.011","article-title":"SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors","volume":"274","author":"Sekido","year":"2004","journal-title":"Dev. Biol."},{"issue":"6281","key":"10.1016\/j.biocel.2006.06.007_bib79","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/346240a0","article-title":"A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif","volume":"346","author":"Sinclair","year":"1990","journal-title":"Nature"},{"issue":"6507","key":"10.1016\/j.biocel.2006.06.007_bib80","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/372679a0","article-title":"Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4","volume":"372","author":"Stark","year":"1994","journal-title":"Nature"},{"issue":"6669","key":"10.1016\/j.biocel.2006.06.007_bib81","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/35799","article-title":"Dax1 antagonizes Sry action in mammalian sex determination","volume":"391","author":"Swain","year":"1998","journal-title":"Nature"},{"issue":"36","key":"10.1016\/j.biocel.2006.06.007_bib82","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1038\/sj.onc.1206636","article-title":"Regulation of FGF receptor-2 expression by transcription factor E2F-1","volume":"22","author":"Tashiro","year":"2003","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.biocel.2006.06.007_bib83","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1097\/01.ASN.0000060577.94532.06","article-title":"Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats","volume":"14","author":"Terada","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"issue":"19","key":"10.1016\/j.biocel.2006.06.007_bib84","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1242\/dev.129.19.4627","article-title":"Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2","volume":"129","author":"Tevosian","year":"2002","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.biocel.2006.06.007_bib85","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1083\/jcb.200303158","article-title":"Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation","volume":"162","author":"Topol","year":"2003","journal-title":"J. Cell Biol."},{"issue":"18","key":"10.1016\/j.biocel.2006.06.007_bib86","doi-asserted-by":"crossref","first-page":"12705","DOI":"10.1074\/jbc.M513181200","article-title":"PAX2 activates Wnt4 expression during mammalian kidney development","volume":"281","author":"Torban","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.biocel.2006.06.007_bib87","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1242\/dev.121.12.4057","article-title":"Pax-2 controls multiple steps of urogenital development","volume":"121","author":"Torres","year":"1995","journal-title":"Development"},{"issue":"2\u20133","key":"10.1016\/j.biocel.2006.06.007_bib88","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0925-4773(95)00386-F","article-title":"Wnt4 affects morphogenesis when misexpressed in the zebrafish embryo","volume":"52","author":"Ungar","year":"1995","journal-title":"Mech. Dev."},{"issue":"6718","key":"10.1016\/j.biocel.2006.06.007_bib89","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/17068","article-title":"Female development in mammals is regulated by Wnt-4 signalling","volume":"397","author":"Vainio","year":"1999","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biocel.2006.06.007_bib90","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1534-5807(03)00266-1","article-title":"A second canon functions and mechanisms of beta-catenin-independent Wnt signaling","volume":"5","author":"Veeman","year":"2003","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.biocel.2006.06.007_bib91","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/90046","article-title":"Sox9 induces testis development in XX transgenic mice","volume":"28","author":"Vidal","year":"2001","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.biocel.2006.06.007_bib92","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0092-8674(94)90041-8","article-title":"Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9","volume":"79","author":"Wagner","year":"1994","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.biocel.2006.06.007_bib93","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1399-0004.1996.tb03786.x","article-title":"Sex reversal in a child with the karyotype 46, XY, dup (1) (p22.3p32. 3)","volume":"49","author":"Wieacker","year":"1996","journal-title":"Clin. Genet."},{"issue":"5","key":"10.1016\/j.biocel.2006.06.007_bib94","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1095\/biolreprod.105.050286","article-title":"Sexually dimorphic regulation of inhibin beta B in establishing gonadal vasculature in mice","volume":"74","author":"Yao","year":"2006","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.biocel.2006.06.007_bib95","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/dvdy.20042","article-title":"Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis","volume":"230","author":"Yao","year":"2004","journal-title":"Dev. Dyn."},{"issue":"4","key":"10.1016\/j.biocel.2006.06.007_bib96","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/3822","article-title":"Role of Ahch in gonadal development and gametogenesis","volume":"20","author":"Yu","year":"1998","journal-title":"Nat. Genet."}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272506001920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272506001920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:23:48Z","timestamp":1761200628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272506001920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007]]}},"alternative-id":["S1357272506001920"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2006.06.007","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2007]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wnt4 action in gonadal development and sex determination","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2006.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}