{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:30:23Z","timestamp":1761201023593,"version":"build-2065373602"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2008]]},"DOI":"10.1016\/j.biocel.2007.07.006","type":"journal-article","created":{"date-parts":[[2007,7,21]],"date-time":"2007-07-21T07:24:06Z","timestamp":1185002646000},"page":"135-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bone marrow transplantation into hemochromatotic mice decreases hepatic and duodenal iron overload"],"prefix":"10.1016","volume":"40","author":[{"given":"Mar\u00eda-Josefa","family":"Mor\u00e1n-Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Garc\u00eda-Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Guti\u00e9rrez-Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Grau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Navarro-Ordo\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Fontanellas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Enr\u00edquez-de-Salamanca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2007.07.006_bib1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s10534-006-9030-2","article-title":"Regulation of systemic iron homeostasis: How the body responds to changes in iron demand","volume":"20","author":"Anderson","year":"2007","journal-title":"Biometals"},{"key":"10.1016\/j.biocel.2007.07.006_bib2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ng1777","article-title":"Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression","volume":"38","author":"Babitt","year":"2006","journal-title":"Nature Genetics"},{"key":"10.1016\/j.biocel.2007.07.006_bib3","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1172\/JCI31342","article-title":"Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance","volume":"117","author":"Babitt","year":"2007","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.biocel.2007.07.006_bib4","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1073\/pnas.96.23.13312","article-title":"Experimental hemochromatosis due to MHC class I HFE deficiency: Immune status and iron metabolism","volume":"96","author":"Bahram","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2007.07.006_bib5","first-page":"1161","article-title":"Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload","volume":"90","author":"Bondi","year":"2005","journal-title":"Hematologica"},{"key":"10.1016\/j.biocel.2007.07.006_bib6","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/gut.50.6.752","article-title":"Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon","volume":"50","author":"Brittan","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2007.07.006_bib7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1055\/s-2005-923311","article-title":"Pathology of hepatic iron overload","volume":"25","author":"Brunt","year":"2005","journal-title":"Seminars in Liver Disease"},{"key":"10.1016\/j.biocel.2007.07.006_bib8","doi-asserted-by":"crossref","first-page":"G156","DOI":"10.1152\/ajpgi.00227.2005","article-title":"Comparative studies of duodenal and macrophages ferroportin proteins","volume":"290","author":"Canonne-Hergaux","year":"2006","journal-title":"American Journal of Physiology\u2014Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.biocel.2007.07.006_bib9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bcmd.2003.11.003","article-title":"Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice","volume":"32","author":"Courselaud","year":"2004","journal-title":"Blood Cells Molecular Diseases"},{"key":"10.1016\/j.biocel.2007.07.006_bib10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/gast.2002.31877","article-title":"Inactivation of hemochromatosis gene differentially regulates duodenal expression of iron related genes mRNAs between mouse strains","volume":"122","author":"Dupic","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2007.07.006_bib11","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1136\/gut.51.5.648","article-title":"Duodenal mRNA expression of iron related genes in response to iron loading and deficiency in four strains of mice","volume":"51","author":"Dupic","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2007.07.006_bib12","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/hep.20214","article-title":"Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells","volume":"6","author":"Fausto","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.biocel.2007.07.006_bib13","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1073\/pnas.051630898","article-title":"Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis","volume":"58","author":"Fleming","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2007.07.006_bib14","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1073\/pnas.96.6.3143","article-title":"Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1","volume":"96","author":"Fleming","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2007.07.006_bib15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood-2003-03-0672","article-title":"Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation","volume":"102","author":"Ganz","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.biocel.2007.07.006_bib16","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.bbamcr.2006.03.014","article-title":"Regulation of iron acquisition and iron distribution in mammals","volume":"1763","author":"Ganz","year":"2006","journal-title":"Biochimimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2007.07.006_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00109-003-0508-x","article-title":"Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1\/ferroportin","volume":"82","author":"Hermann","year":"2004","journal-title":"Journal of Molecular Medicine"},{"key":"10.1016\/j.biocel.2007.07.006_bib18","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/ncb1132","article-title":"Hematopoietic stem cells convert into liver cells within days without fusion","volume":"6","author":"Jang","year":"2004","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.biocel.2007.07.006_bib19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1182\/blood-2004-04-1416","article-title":"Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis","volume":"105","author":"Kawabata","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.biocel.2007.07.006_bib20","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jhep.2004.02.029","article-title":"Different expression pattern of hepcidin genes in the liver and pancreas of C57BL\/6N and DBA\/2N mice","volume":"40","author":"Krijt","year":"2004","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.biocel.2007.07.006_bib21","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1182\/blood-2003-03-0953","article-title":"Effect of hepcidin on intestinal iron absorption in mice","volume":"103","author":"Laftah","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.biocel.2007.07.006_bib22","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/81326","article-title":"Purified hematopoietic stem cells can differentiate into hepatocytes in vivo","volume":"6","author":"Lagasse","year":"2000","journal-title":"Nature Medicine"},{"key":"10.1016\/j.biocel.2007.07.006_bib23","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/sj.ejhg.5201490","article-title":"The molecular genetics of haemochromatosis","volume":"13","author":"Le Gac","year":"2005","journal-title":"European Journal of Human Genetics"},{"key":"10.1016\/j.biocel.2007.07.006_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood.V94.1.9.413a43_9_11","article-title":"The C282Y mutation causing hereditary hemochromatosis does not produce a null allele","volume":"94","author":"Levy","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.biocel.2007.07.006_bib25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00109-004-0542-3","article-title":"Duodenal HFE expression and hepcidin levels determine body iron homeostasis: Modulation by genetic diversity and dietary iron availability","volume":"82","author":"Ludwiczek","year":"2004","journal-title":"Journal of Molecular Medicine"},{"key":"10.1016\/j.biocel.2007.07.006_bib26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jcp.20315","article-title":"Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis","volume":"240","author":"Ludwiczek","year":"2005","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.biocel.2007.07.006_bib27","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1182\/blood-2005-02-0629","article-title":"Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading","volume":"106","author":"Makui","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.biocel.2007.07.006_bib28","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1634\/stemcells.22-6-897","article-title":"Potential of hematopoietic stem cell therapy in hepatology: A critical review","volume":"22","author":"Masson","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.biocel.2007.07.006_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/hep.21526","article-title":"The nexus of iron and inflammation in hepcidin regulation: SMADs, STATs, and ECSIT","volume":"45","author":"Milward","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.biocel.2007.07.006_bib30","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1182\/blood-2004-08-3042","article-title":"Hepcidin is decreased in TfR2-hemochormatosis","volume":"105","author":"Nemeth","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.biocel.2007.07.006_bib31","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biocel.2007.07.006_bib32","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbamcr.2006.05.013","article-title":"Hereditary hemochromatosis","volume":"1763","author":"Pietrangelo","year":"2006","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2007.07.006_bib33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.21005","article-title":"Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion","volume":"43","author":"Quintana-Bustamante","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.biocel.2007.07.006_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/00365520510011489","article-title":"Expression of iron absorption genes in mouse large intestine","volume":"40","author":"Takeuchi","year":"2005","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1016\/j.biocel.2007.07.006_bib35","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/jb\/mvg173","article-title":"An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes","volume":"134","author":"Terai","year":"2003","journal-title":"Journal of Biochemistry (Tokyo)"},{"key":"10.1016\/j.biocel.2007.07.006_bib36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jhep.2005.03.030","article-title":"Pathways for the regulation of body iron homeostasis in response to experimental iron overload","volume":"43","author":"Theurl","year":"2005","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.biocel.2007.07.006_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/hep.21015","article-title":"Hematopoietic cells as hepatocyte stem cells: A critical review of the evidence","volume":"43","author":"Thorgeirsson","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.biocel.2007.07.006_bib38","first-page":"10289","article-title":"Bone morphogenic proteins 2,4, and 9 stimulate murine hepcidin 12 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6","volume":"103","author":"Truska","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2007.07.006_bib39","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nature01539","article-title":"Transplanted bone marrow regenerates liver by cell fusion","volume":"422","author":"Vassilopoulos","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2007.07.006_bib40","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0092-8674(04)00208-9","article-title":"Plasticity of adult stem cells","volume":"116","author":"Wagers","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2007.07.006_bib41","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cmet.2005.10.010","article-title":"A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression","volume":"2","author":"Wang","year":"2005","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.biocel.2007.07.006_bib42","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nature01531","article-title":"Cell fusion is the principal source of bone marrow-derived hepatocytes","volume":"422","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2007.07.006_bib43","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nm1062","article-title":"Myelomonocytic cells are sufficient for therapeutic cell fusion in liver","volume":"10","author":"Willenbring","year":"2004","journal-title":"Nature Medicine"},{"key":"10.1016\/j.biocel.2007.07.006_bib44","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1073\/pnas.95.5.2492","article-title":"HFE gene knockout produces mouse model of hereditary hemochromatosis","volume":"95","author":"Zhou","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272507002269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272507002269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:27:09Z","timestamp":1761200829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272507002269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008]]}},"alternative-id":["S1357272507002269"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2007.07.006","relation":{},"ISSN":["1357-2725"],"issn-type":[{"type":"print","value":"1357-2725"}],"subject":[],"published":{"date-parts":[[2008]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone marrow transplantation into hemochromatotic mice decreases hepatic and duodenal iron overload","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2007.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}