{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:10:57Z","timestamp":1791054657501,"version":"4.1.0"},"reference-count":182,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016465","name":"Science Mission Directorate","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012166","name":"Gerald Kerkut Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2008]]},"DOI":"10.1016\/j.biocel.2008.02.020","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T11:23:48Z","timestamp":1205580228000},"page":"2023-2039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":250,"title":["Molecular regulation of cardiac hypertrophy"],"prefix":"10.1016","volume":"40","author":[{"given":"Sean P.","family":"Barry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2008.02.020_bib1","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1001\/jama.296.12.1465","article-title":"Risk of death associated with nesiritide in patients with acutely decompensated heart failure","volume":"296","author":"Aaronson","year":"2006","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.biocel.2008.02.020_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.tips.2005.01.005","article-title":"Endothelium-derived C-type natriuretic peptide: More than just a hyperpolarizing factor","volume":"26","author":"Ahluwalia","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biocel.2008.02.020_bib3","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1126\/science.280.5363.574","article-title":"Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy","volume":"280","author":"Akhter","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biocel.2008.02.020_bib4","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.RES.0000267723.65696.4a","article-title":"Sirt1 regulates aging and resistance to oxidative stress in the heart","volume":"100","author":"Alcendor","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib5","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/01.RES.0000147557.75257.ff","article-title":"Silent information regulator 2 alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes","volume":"95","author":"Alcendor","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1161\/CIRCULATIONAHA.105.560771","article-title":"Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice","volume":"113","author":"Arimoto","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib7","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1172\/JCI27438","article-title":"CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy","volume":"116","author":"Backs","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib8","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jtcvs.2004.06.046","article-title":"Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure","volume":"128","author":"Berry","year":"2004","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.biocel.2008.02.020_bib9","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0140-6736(64)91275-9","article-title":"A new adrenergic betareceptor antagonist","volume":"1","author":"Black","year":"1964","journal-title":"Lancet"},{"key":"10.1016\/j.biocel.2008.02.020_bib10","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"Diabetic cardiomyopathy revisited","volume":"115","author":"Boudina","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/cyto.2001.0951","article-title":"CT-1 mediated cardioprotection against ischaemic re-oxygenation injury is mediated by PI3 kinase, Akt and MEK1\/2 pathways","volume":"16","author":"Brar","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.biocel.2008.02.020_bib12","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.101.5.558","article-title":"beta-adrenergic receptor blockade in chronic heart failure","volume":"101","author":"Bristow","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib13","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1093\/emboj\/19.23.6341","article-title":"The MEK1-ERK1\/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice","volume":"19","author":"Bueno","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.biocel.2008.02.020_bib14","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.RES.0000038488.38975.1A","article-title":"Involvement of extracellular signal-regulated kinases 1\/2 in cardiac hypertrophy and cell death","volume":"91","author":"Bueno","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib15","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1172\/JCI119883","article-title":"Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts","volume":"101","author":"Calderone","year":"1998","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","article-title":"MicroRNA-133 controls cardiac hypertrophy","volume":"13","author":"Car\u00e8","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib17","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.bbrc.2005.01.001","article-title":"Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway","volume":"328","author":"Chanalaris","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biocel.2008.02.020_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10741-005-5252-6","article-title":"Sarcomeric protein mutations in dilated cardiomyopathy","volume":"10","author":"Chang","year":"2005","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.biocel.2008.02.020_bib19","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1128\/MCB.24.19.8467-8476.2004","article-title":"Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development","volume":"24","author":"Chang","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2008.02.020_bib20","doi-asserted-by":"crossref","first-page":"19369","DOI":"10.1074\/jbc.M601443200","article-title":"Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2 alpha","volume":"281","author":"Chen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng1725","article-title":"The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation","volume":"38","author":"Chen","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biocel.2008.02.020_bib22","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2353\/ajpath.2007.061170","article-title":"MicroRNAs are aberrantly expressed in hypertrophic heart: Do they play a role in cardiac hypertrophy?","volume":"170","author":"Cheng","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biocel.2008.02.020_bib23","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1074\/jbc.273.13.7228","article-title":"Stimulation of \u201cstress-regulated\u201d mitogen-activated protein kinases (stress-activated protein kinases\/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses","volume":"273","author":"Clerk","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib24","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1056\/NEJM200007273430403","article-title":"Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure. Nesiritide Study Group","volume":"343","author":"Colucci","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib25","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0092-8674(02)00699-2","article-title":"NFAT signaling: Choreographing the social lives of cells","volume":"109 Suppl.","author":"Crabtree","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2008.02.020_bib26","doi-asserted-by":"crossref","first-page":"37621","DOI":"10.1074\/jbc.M103276200","article-title":"The cytoprotective effects of the glycoprotein 130 receptor-coupled cytokine, cardiotrophin-1, require activation of NF-kappa B","volume":"276","author":"Craig","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1023\/A:1018613907574","article-title":"The in vitro motility activity of beta-cardiac myosin depends on the nature of the beta-myosin heavy chain gene mutation in hypertrophic cardiomyopathy","volume":"18","author":"Cuda","year":"1997","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.1016\/j.biocel.2008.02.020_bib28","doi-asserted-by":"crossref","first-page":"8121","DOI":"10.1073\/pnas.94.15.8121","article-title":"Transgenic Galphaq overexpression induces cardiac contractile failure in mice","volume":"94","author":"D\u2019Angelo","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/cbic.200400246","article-title":"The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin","volume":"6","author":"Davidson","year":"2005","journal-title":"ChemBioChem"},{"key":"10.1016\/j.biocel.2008.02.020_bib30","doi-asserted-by":"crossref","first-page":"H1477","DOI":"10.1152\/ajpheart.00789.2004","article-title":"Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: Implication for gain in cardiac muscle contractility","volume":"288","author":"Davis","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib31","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1378\/chest.125.2.652","article-title":"Brain natriuretic peptide in the management of heart failure: The versatile neurohormone","volume":"125","author":"de Denus","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.biocel.2008.02.020_bib32","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.ejheart.2004.12.009","article-title":"C-type natriuretic peptide plasma levels increase in patients with chronic heart failure as a function of clinical severity","volume":"7","author":"Del Ry","year":"2005","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biocel.2008.02.020_bib33","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1073\/pnas.031371998","article-title":"Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo","volume":"98","author":"De Windt","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib34","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1210\/en.2007-0081","article-title":"Differential regulation of membrane guanylyl cyclases in congestive heart failure: Natriuretic peptide receptor (NPR)-B, not NPR-A, is the predominant natriuretic peptide receptor in the failing heart","volume":"148","author":"Dickey","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2008.02.020_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/CIRCRESAHA.106.146670","article-title":"Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation","volume":"101","author":"Du","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib36","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0026-895X(24)12325-5","article-title":"Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure","volume":"61","author":"Eckhart","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.biocel.2008.02.020_bib37","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1365-2362.2001.00795.x","article-title":"Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure","volume":"31","author":"Eiken","year":"2001","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib38","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1073\/pnas.96.12.7059","article-title":"Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice","volume":"96","author":"Engelhardt","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/hc0102.101365","article-title":"Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress","volume":"105","author":"Esposito","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1046\/j.1440-1681.2003.03836.x","article-title":"Pressure-independent enhancement of cardiac hypertrophy in atrial natriuretic peptide-deficient mice","volume":"30","author":"Feng","year":"2003","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib41","doi-asserted-by":"crossref","first-page":"11363","DOI":"10.1073\/pnas.162100799","article-title":"Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes","volume":"99","author":"Fiedler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0008-6363(02)00694-6","article-title":"Sarcoplasmic reticulum Ca2+-ATPase modulates cardiac contraction and relaxation","volume":"57","author":"Frank","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib43","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","article-title":"Hypertrophy of the heart: A new therapeutic target?","volume":"109","author":"Frey","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib44","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.HYP.35.6.1191","article-title":"Cardiotrophin-1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3: An autocrine loop for hypertrophy","volume":"35","author":"Fukuzawa","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.biocel.2008.02.020_bib45","doi-asserted-by":"crossref","first-page":"10561","DOI":"10.1074\/jbc.275.14.10561","article-title":"Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes","volume":"275","author":"Funamoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib46","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1043-2760(03)00113-9","article-title":"Natriuretic peptides: Markers or modulators of cardiac hypertrophy?","volume":"14","author":"Gardner","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.biocel.2008.02.020_bib47","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1161\/01.HYP.0000258532.07418.fa","article-title":"Molecular biology of the natriuretic peptide system: Implications for physiology and hypertension","volume":"49","author":"Gardner","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.biocel.2008.02.020_bib48","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0092-8674(90)90274-I","article-title":"A molecular basis for familial hypertrophic cardiomyopathy: A beta cardiac myosin heavy chain gene missense mutation","volume":"62","author":"Geisterfer-Lowrance","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2008.02.020_bib49","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.yjmcc.2005.05.013","article-title":"A mutation in the N-terminus of troponin I that is associated with hypertrophic cardiomyopathy affects the Ca(2+)-sensitivity, phosphorylation kinetics and proteolytic susceptibility of troponin","volume":"39","author":"Gomes","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib50","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1097\/HJH.0b013e32828626e2","article-title":"Association of depressed cardiac gp130-mediated antiapoptotic pathways with stimulated cardiomyocyte apoptosis in hypertensive patients with heart failure","volume":"25","author":"Gonzalez","year":"2007","journal-title":"J. Hypertens."},{"key":"10.1016\/j.biocel.2008.02.020_bib51","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1074\/jbc.M211762200","article-title":"The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity","volume":"278","author":"Gusterson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib52","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1172\/JCI17892","article-title":"Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human","volume":"111","author":"Haghighi","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib53","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1161\/01.CIR.97.19.1952","article-title":"Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice","volume":"97","author":"Harada","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib54","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2008.02.020_bib55","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0092-8674(00)80729-1","article-title":"Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress","volume":"97","author":"Hirota","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2008.02.020_bib56","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1073\/pnas.92.11.4862","article-title":"Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice","volume":"92","author":"Hirota","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib57","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1172\/JCI17061","article-title":"Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A","volume":"111","author":"Holtwick","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib58","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm739","article-title":"Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery","volume":"8","author":"Hoshijima","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib59","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/01.HYP.0000126920.93207.53","article-title":"Characterization of a cGMP-response element in the guanylyl cyclase\/natriuretic peptide receptor A gene promoter","volume":"43","author":"Hum","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.biocel.2008.02.020_bib60","doi-asserted-by":"crossref","first-page":"23173","DOI":"10.1074\/jbc.270.39.23173","article-title":"Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice","volume":"270","author":"Hunter","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib61","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1006\/bbrc.1996.0241","article-title":"cDNA cloning of rat cardiotrophin-1 (CT-1): Augmented expression of CT-1 gene in ventricle of genetically hypertensive rats","volume":"219","author":"Ishikawa","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biocel.2008.02.020_bib62","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/01.RES.78.4.517","article-title":"Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression","volume":"78","author":"Iwase","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib63","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1172\/JCI112908","article-title":"Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals","volume":"79","author":"Izumo","year":"1987","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib64","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1006\/cyto.1996.0123","article-title":"In vivo effects of cardiotrophin-1","volume":"8","author":"Jin","year":"1996","journal-title":"Cytokine"},{"key":"10.1016\/j.biocel.2008.02.020_bib65","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/01.CIR.0000047280.15244.EB","article-title":"Myocardial production of C-type natriuretic peptide in chronic heart failure","volume":"107","author":"Kalra","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib66","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM200012073432304","article-title":"Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy","volume":"343","author":"Kamisago","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib67","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/07853890601145821","article-title":"Genetics of dilated cardiomyopathy","volume":"39","author":"Karkkainen","year":"2007","journal-title":"Ann. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib68","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/01.RES.87.10.937","article-title":"Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats","volume":"87","author":"Kato","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib69","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.HYP.0000035397.73223.CE","article-title":"Gq-coupled receptor agonists mediate cardiac hypertrophy via the vasculature","volume":"40","author":"Keys","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.biocel.2008.02.020_bib70","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/CIRCULATIONAHA.105.542209","article-title":"Enhanced activity of the myocardial Na+\/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice","volume":"112","author":"Kilic","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib71","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrm1644","article-title":"MicroRNA biogenesis: Coordinated cropping and dicing","volume":"6","author":"Kim","year":"2005","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2008.02.020_bib72","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1073\/pnas.051625598","article-title":"A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy","volume":"98","author":"Kishimoto","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib73","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1172\/JCI11273","article-title":"Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice","volume":"107","author":"Knowles","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib74","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.RES.81.5.656","article-title":"Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK\/STAT pathway in rat cardiomyocytes","volume":"81","author":"Kodama","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib75","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1161\/CIRCULATIONAHA.105.608828","article-title":"Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression","volume":"113","author":"K\u00f6gler","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib76","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/S0735-1097(01)01672-2","article-title":"Role of brain natriuretic peptide in risk stratification of patients with congestive heart failure","volume":"38","author":"Koglin","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib77","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0960-9822(00)80027-5","article-title":"MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium","volume":"9","author":"Kolodziejczyk","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.biocel.2008.02.020_bib78","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.cardiores.2004.07.004","article-title":"Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failure","volume":"64","author":"Kuhn","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib79","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1161\/01.CIR.94.10.2626","article-title":"Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes","volume":"94","author":"Kunisada","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib80","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1073\/pnas.97.1.315","article-title":"Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy","volume":"97","author":"Kunisada","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib81","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.CIR.98.4.346","article-title":"Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes","volume":"98","author":"Kunisada","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib82","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1074\/jbc.272.7.4500","article-title":"Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium","volume":"272","author":"Kuppuswamy","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib83","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1073\/pnas.0510019103","article-title":"Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B","volume":"103","author":"Langenickel","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib84","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib85","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10741-005-5254-4","article-title":"Functional consequences of sarcomeric protein abnormalities in failing myocardium","volume":"10","author":"LeWinter","year":"2005","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.biocel.2008.02.020_bib86","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1006\/jmcc.2002.2011","article-title":"Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression","volume":"34","author":"Liang","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib87","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.RES.0000102042.83024.CA","article-title":"What is the role of beta-adrenergic signaling in heart failure?","volume":"93","author":"Lohse","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib88","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2006.07.002","article-title":"Sirtuins in aging and age-related disease","volume":"126","author":"Longo","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2008.02.020_bib89","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/01.hjh.0000160221.09468.d3","article-title":"Is plasma cardiotrophin-1 a marker of hypertensive heart disease?","volume":"23","author":"Lopez","year":"2005","journal-title":"J. Hypertens."},{"key":"10.1016\/j.biocel.2008.02.020_bib90","doi-asserted-by":"crossref","first-page":"23064","DOI":"10.1074\/jbc.272.37.23064","article-title":"The guanylyl cyclase-deficient mouse defines differential pathways of natriuretic peptide signaling","volume":"272","author":"Lopez","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib91","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1056\/NEJMoa012630","article-title":"Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents","volume":"346","author":"Lowes","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib92","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1172\/JCI119770","article-title":"Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium","volume":"100","author":"Lowes","year":"1997","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib93","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S1050-1738(02)00181-0","article-title":"Functional consequences of mutations in the myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy","volume":"12","author":"Lowey","year":"2002","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib94","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1161\/CIRCULATIONAHA.106.642330","article-title":"Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice","volume":"114","author":"Lu","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib95","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1073\/pnas.080064097","article-title":"Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases","volume":"97","author":"Lu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"Suppl. F","key":"10.1016\/j.biocel.2008.02.020_bib96","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/eurheartj\/5.suppl_F.181","article-title":"Cardiac myosin heavy chain isozymic transitions during development and under pathological conditions are regulated at the level of mRNA availability","volume":"5","author":"Mahdavi","year":"1984","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biocel.2008.02.020_bib97","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yjmcc.2006.04.001","article-title":"Beta-adrenergic receptors signaling and heart failure in mice, rabbits and humans","volume":"41","author":"Marian","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib98","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.yjmcc.2004.08.002","article-title":"Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways","volume":"37","author":"Markou","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib99","doi-asserted-by":"crossref","first-page":"12670","DOI":"10.1074\/jbc.274.18.12670","article-title":"A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor","volume":"274","author":"Mason","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"39","key":"10.1016\/j.biocel.2008.02.020_bib100","doi-asserted-by":"crossref","first-page":"41018","DOI":"10.1074\/jbc.M403578200","article-title":"A ternary complex of transcription factors, Nish\u00e9d and NFATc4, and co-activator p300 bound to an intronic sequence, intronic regulatory element, is pivotal for the up-regulation of myosin light chain-2v gene in cardiac hypertrophy","volume":"279","author":"Mathew","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib101","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.CIR.0000025242.79963.4C","article-title":"B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: Analysis from Breathing Not Properly (BNP) Multinational Study","volume":"106","author":"McCullough","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib102","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.tig.2004.02.002","article-title":"Cardiac histone acetylation\u2014Therapeutic opportunities abound","volume":"20","author":"McKinsey","year":"2004","journal-title":"Trends Genet."},{"key":"10.1016\/j.biocel.2008.02.020_bib103","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/0470862637.ch9","article-title":"Dual roles of histone deacetylases in the control of cardiac growth","volume":"259","author":"McKinsey","year":"2004","journal-title":"Novartis. Found. Symp."},{"key":"10.1016\/j.biocel.2008.02.020_bib104","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jacc.2006.10.048","article-title":"Effects of perioperative nesiritide in patients with left ventricular dysfunction undergoing cardiac surgery: The NAPA Trial","volume":"49","author":"Mentzer","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib105","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1172\/JCI114429","article-title":"Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure","volume":"85","author":"Mercadier","year":"1990","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib106","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/01.RES.0000110083.17024.60","article-title":"Covalent and noncovalent modification of thin filament action: The essential role of troponin in cardiac muscle regulation","volume":"94","author":"Metzger","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib107","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/01.CIR.92.4.778","article-title":"Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy","volume":"92","author":"Meyer","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib108","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0092-8674(00)81662-1","article-title":"Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy","volume":"99","author":"Minamisawa","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2008.02.020_bib109","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1093\/emboj\/18.18.5099","article-title":"HDAC4 deacetylase associates with and represses the MEF2 transcription factor","volume":"18","author":"Miska","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.biocel.2008.02.020_bib110","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/CIRCULATIONAHA.105.585182","article-title":"Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo","volume":"113","author":"Miyamoto","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib111","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/01.hco.0000221582.71619.84","article-title":"B-type natriuretic peptide in heart failure","volume":"21","author":"Moe","year":"2006","journal-title":"Curr. Opin. Cardiol."},{"issue":"7","key":"10.1016\/j.biocel.2008.02.020_bib112","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1128\/MCB.24.7.2944-2957.2004","article-title":"A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300","volume":"24","author":"Molinari","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2008.02.020_bib113","first-page":"3833","article-title":"GATA4: A novel transcriptional regulator of cardiac hypertrophy?","volume":"96","author":"Molkentin","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib114","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cardiores.2003.12.005","article-title":"Volume overload results in exaggerated cardiac hypertrophy in the atrial natriuretic peptide knockout mouse","volume":"61","author":"Mori","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib115","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0140-6736(04)15468-8","article-title":"Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy","volume":"363","author":"Murphy","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.biocel.2008.02.020_bib116","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/01.HYP.0000173420.31354.ef","article-title":"Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice","volume":"46","author":"Nakanishi","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.biocel.2008.02.020_bib117","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.genom.1.1.179","article-title":"From the sarcomere to the nucleus: Role of genetics and signaling in structural heart disease","volume":"1","author":"Nicol","year":"2000","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"10.1016\/j.biocel.2008.02.020_bib118","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/emboj\/20.11.2757","article-title":"Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy","volume":"20","author":"Nicol","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.biocel.2008.02.020_bib119","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cardiores.2005.10.001","article-title":"The role of natriuretic peptides in cardioprotection","volume":"69","author":"Nishikimi","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib120","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/sj.embor.7400755","article-title":"MAPK signalling: ERK5 versus ERK1\/2","volume":"7","author":"Nishimoto","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biocel.2008.02.020_bib121","doi-asserted-by":"crossref","first-page":"14730","DOI":"10.1073\/pnas.94.26.14730","article-title":"Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A","volume":"94","author":"Oliver","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib122","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1023\/A:1005678905119","article-title":"R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level","volume":"21","author":"Palmiter","year":"2000","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.1016\/j.biocel.2008.02.020_bib123","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF01745045","article-title":"Involvement of gp130-mediated signaling in pressure overload-induced activation of the JAK\/STAT pathway in rodent heart","volume":"13","author":"Pan","year":"1998","journal-title":"Heart Vessels"},{"key":"10.1016\/j.biocel.2008.02.020_bib124","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/ng2073","article-title":"Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy","volume":"39","author":"Pandit","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biocel.2008.02.020_bib125","doi-asserted-by":"crossref","first-page":"16864","DOI":"10.1073\/pnas.0607700103","article-title":"Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo","volume":"103","author":"Pandya","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib126","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1073\/pnas.97.2.931","article-title":"Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling","volume":"97","author":"Paradis","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib127","doi-asserted-by":"crossref","first-page":"10915","DOI":"10.1074\/jbc.270.18.10915","article-title":"Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor\/gp130 signaling complex","volume":"270","author":"Pennica","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.biocel.2008.02.020_bib128","doi-asserted-by":"crossref","first-page":"H1388","DOI":"10.1152\/ajpheart.01339.2007","article-title":"Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding mediated induction of the \u03b1-myosin heavy chain expression","volume":"294","author":"Pillai","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib129","doi-asserted-by":"crossref","first-page":"C2269","DOI":"10.1152\/ajpcell.00441.2006","article-title":"Phenylephrine hypertrophy, Ca2+-ATPase (SERCA2), and Ca2+ signaling in neonatal rat cardiac myocytes","volume":"292","author":"Prasad","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib130","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1073\/pnas.0610906104","article-title":"Genetic inhibition of cardiac ERK1\/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo","volume":"104","author":"Purcell","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib131","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10741-007-9034-1","article-title":"Return to the fetal gene program protects the stressed heart: A strong hypothesis","volume":"12","author":"Rajabi","year":"2007","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.biocel.2008.02.020_bib132","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/01.CIR.0000066323.15244.54","article-title":"Hypertrophic cardiomyopathy: Distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy","volume":"107","author":"Richard","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib133","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/HYPERTENSIONAHA.106.069153","article-title":"Natriuretic peptides: Update on peptide release, bioactivity, and clinical use","volume":"50","author":"Richards","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.biocel.2008.02.020_bib134","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1073\/pnas.95.12.7000","article-title":"Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice","volume":"95","author":"Rockman","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib135","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0008-6363(02)00667-3","article-title":"Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: Importance of cyclic GMP","volume":"57","author":"Rosenkranz","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib136","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jacc.2005.12.081","article-title":"Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension","volume":"48","author":"Rubattu","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib137","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0008-6363(00)00076-6","article-title":"Mechanical stress-induced cardiac hypertrophy: Mechanisms and signal transduction pathways","volume":"47","author":"Ruwhof","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib138","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/B:HREV.0000046363.59374.23","article-title":"Biologic rationale for the use of beta-blockers in the treatment of heart failure","volume":"9","author":"Sabbah","year":"2004","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.biocel.2008.02.020_bib139","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI6842","article-title":"Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure","volume":"103","author":"Sah","year":"1999","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib140","doi-asserted-by":"crossref","first-page":"29717","DOI":"10.1074\/jbc.M003128200","article-title":"Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes","volume":"275","author":"Sano","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib141","doi-asserted-by":"crossref","first-page":"9392","DOI":"10.1074\/jbc.M006889200","article-title":"Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation","volume":"276","author":"Sato","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib142","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.RES.0000257913.42552.23","article-title":"MicroRNAs play an essential role in the development of cardiac hypertrophy","volume":"100","author":"Sayed","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib143","doi-asserted-by":"crossref","first-page":"H1146","DOI":"10.1152\/ajpheart.00720.2003","article-title":"Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity","volume":"286","author":"Schultz","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib144","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1015882302796","article-title":"Expression of atrial natriuretic peptide receptor-A antagonizes the mitogen-activated protein kinases (Erk2 and P38MAPK) in cultured human vascular smooth muscle cells","volume":"233","author":"Sharma","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.biocel.2008.02.020_bib145","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1074\/jbc.272.9.5783","article-title":"Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy","volume":"272","author":"Sheng","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib146","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1242\/dev.122.2.419","article-title":"Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival","volume":"122","author":"Sheng","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.biocel.2008.02.020_bib147","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jacc.2004.10.067","article-title":"C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction","volume":"45","author":"Soeki","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib148","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1172\/JCI8497","article-title":"Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1","volume":"105","author":"Sussman","year":"2000","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib149","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/01.RES.0000126405.38858.BC","article-title":"Leukemia inhibitory factor activates cardiac l-type Ca2+ channels via phosphorylation of serine 1829 in the rabbit Cav1.2 subunit","volume":"94","author":"Takahashi","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib150","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/01.RES.86.12.1218","article-title":"Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy","volume":"86","author":"Takeishi","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2008.02.020_bib151","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nm1175","article-title":"Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy","volume":"11","author":"Takimoto","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib152","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1136\/heart.84.4.421","article-title":"Plasma N terminal pro-brain natriuretic peptide and cardiotrophin 1 are raised in unstable angina","volume":"84","author":"Talwar","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.biocel.2008.02.020_bib153","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1042\/cs0990083","article-title":"Elevated circulating cardiotrophin-1 in heart failure: Relationship with parameters of left ventricular systolic dysfunction","volume":"99","author":"Talwar","year":"2000","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.biocel.2008.02.020_bib154","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/cs1020009","article-title":"Plasma cardiotrophin-1 following acute myocardial infarction: Relationship with left ventricular systolic dysfunction","volume":"102","author":"Talwar","year":"2002","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.biocel.2008.02.020_bib155","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1073\/pnas.070371497","article-title":"Cardiac fibrosis in mice lacking brain natriuretic peptide","volume":"97","author":"Tamura","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib156","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.yjmcc.2007.04.004","article-title":"Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy","volume":"42","author":"Tatsuguchi","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib157","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCULATIONAHA.107.687947","article-title":"MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure","volume":"116","author":"Thum","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib158","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1210\/en.2003-1260","article-title":"Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: Interference between CNP and endothelin-1 signaling pathways","volume":"145","author":"Tokudome","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2008.02.020_bib159","isbn-type":"print","first-page":"693","article-title":"The bicyclic depsipeptide family of histone deacetylase inhibitors","volume":"Vol. 1","author":"Townsend","year":"2007","ISBN":"https:\/\/id.crossref.org\/isbn\/3527311505"},{"key":"10.1016\/j.biocel.2008.02.020_bib160","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.ejheart.2007.07.015","article-title":"Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure","volume":"9","author":"Tsutamoto","year":"2007","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biocel.2008.02.020_bib161","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0735-1097(01)01576-5","article-title":"Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy","volume":"38","author":"Tsutamoto","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib162","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/HJH.0b013e3282f293c8","article-title":"Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat","volume":"26","author":"Vahtola","year":"2008","journal-title":"J. Hypertens."},{"key":"10.1016\/j.biocel.2008.02.020_bib163","doi-asserted-by":"crossref","first-page":"18255","DOI":"10.1073\/pnas.0608791103","article-title":"A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure","volume":"103","author":"van Rooij","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2008.02.020_bib164","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1126\/science.1139089","article-title":"Control of stress-dependent cardiac growth and gene expression by a microRNA","volume":"316","author":"van Rooij","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.biocel.2008.02.020_bib165","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1128\/MCB.24.19.8374-8385.2004","article-title":"Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5","volume":"24","author":"Vega","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2008.02.020_bib166","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s003950050007","article-title":"Leukemia Inhibitory Factor and Interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytes","volume":"95","author":"Villegas","year":"2000","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib167","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s003950050007","article-title":"Leukemia inhibitory factor and interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytes","volume":"95","author":"Villegas","year":"2000","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.biocel.2008.02.020_bib168","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tibs.2004.09.002","article-title":"The biochemical response of the heart to hypertension and exercise","volume":"29","author":"Wakatsuki","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.biocel.2008.02.020_bib169","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/01.HYP.0000074905.22908.A6","article-title":"Effects of pressure overload on extracellular matrix expression in the heart of the atrial natriuretic peptide-null mouse","volume":"42","author":"Wang","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.biocel.2008.02.020_bib170","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ejheart.2007.02.006","article-title":"Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice","volume":"9","author":"Wang","year":"2007","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biocel.2008.02.020_bib171","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nm1101-1236","article-title":"Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq\/Galpha11 in cardiomyocytes","volume":"7","author":"Wettschureck","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2008.02.020_bib172","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbrc.2004.07.121","article-title":"Calcium-calcineurin signaling in the regulation of cardiac hypertrophy","volume":"322","author":"Wilkins","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biocel.2008.02.020_bib173","doi-asserted-by":"crossref","first-page":"9535","DOI":"10.1074\/jbc.271.16.9535","article-title":"Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130\/leukemia inhibitory factor receptor-dependent pathways","volume":"271","author":"Wollert","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib174","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1172\/JCI200420317","article-title":"Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis","volume":"114","author":"Yamaguchi","year":"2004","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib175","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1128\/MCB.23.10.3593-3606.2003","article-title":"Cardiac p300 is involved in myocyte growth with decompensated heart failure","volume":"23","author":"Yanazume","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2008.02.020_bib176","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/A:1024132217870","article-title":"Biological role of p300 in cardiac myocytes","volume":"248","author":"Yanazume","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.biocel.2008.02.020_bib177","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1172\/JCI13939","article-title":"Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways","volume":"108","author":"Yasukawa","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2008.02.020_bib178","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1021\/jm0703800","article-title":"The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor","volume":"50","author":"Yurek-George","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biocel.2008.02.020_bib179","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.4161\/cc.6.17.4632","article-title":"Role of beta-catenin in adult cardiac remodeling","volume":"6","author":"Zelarayan","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biocel.2008.02.020_bib180","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(02)00861-9","article-title":"Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy","volume":"110","author":"Zhang","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2008.02.020_bib181","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1161\/01.CIR.0000033117.39335.DF","article-title":"Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance","volume":"106","author":"Zolk","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2008.02.020_bib182","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/01.CIR.0000081773.76337.44","article-title":"Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction","volume":"108","author":"Zou","year":"2003","journal-title":"Circulation"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272508001027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272508001027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T20:58:49Z","timestamp":1787259529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272508001027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":182,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008]]}},"alternative-id":["S1357272508001027"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2008.02.020","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular regulation of cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2008.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}