{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:55:12Z","timestamp":1778050512913,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2008]]},"DOI":"10.1016\/j.biocel.2008.04.023","type":"journal-article","created":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T12:41:18Z","timestamp":1212583278000},"page":"2442-2451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Polyamine depletion down-regulates expression of the Trichomonas vaginalis cytotoxic CP65, a 65-kDa cysteine proteinase involved in cellular damage"],"prefix":"10.1016","volume":"40","author":[{"given":"Mar\u00eda Elizbeth","family":"Alvarez-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertha Isabel","family":"Carvajal-Gamez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Solano-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ximo","family":"Mart\u00ednez-Benitez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana F.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Alderete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Arroyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2008.04.023_bib1","first-page":"99","article-title":"Pathogenic Trichomonas vaginalis cytotoxicity to cell culture monolayers","volume":"60","author":"Alderete","year":"1984","journal-title":"British Journal of Venereal Diseases"},{"key":"10.1016\/j.biocel.2008.04.023_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/mpat.1999.0336","article-title":"A novel cysteine proteinase (CP65) of Trichomonas vaginalis involved in cytotoxicity","volume":"28","author":"Alvarez-S\u00e1nchez","year":"2000","journal-title":"Microbial Pathogenesis"},{"key":"10.1016\/j.biocel.2008.04.023_bib3","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.micinf.2007.09.011","article-title":"Negative iron regulation of the CP65 cysteine proteinase cytotoxicity in Trichomonas vaginalis","volume":"9","author":"Alvarez-S\u00e1nchez","year":"2007","journal-title":"Microbes and Infection"},{"key":"10.1016\/j.biocel.2008.04.023_bib4","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1128\/iai.57.10.2991-2997.1989","article-title":"Trichomonas vaginalis surface proteinase activity is necessary for parasite adherence to epithelial cells","volume":"57","author":"Arroyo","year":"1989","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.biocel.2008.04.023_bib5","first-page":"279","article-title":"Two Trichomonas vaginalis surface proteinases bind to host epithelial cells and are related to levels of cytoadherence and cytotoxicity","volume":"26","author":"Arroyo","year":"1995","journal-title":"Archives of Medical Research"},{"key":"10.1016\/j.biocel.2008.04.023_bib6","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1365-2958.1992.tb01536.x","article-title":"Molecular basis of host epithelial cell recognition by Trichomonas vaginalis","volume":"6","author":"Arroyo","year":"1992","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2958.1993.tb01121.x","article-title":"Signalling of Trichomonas vaginalis for amoeboid transformation and adhesion synthesis follows cytoadherence","volume":"7","author":"Arroyo","year":"1993","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib8","first-page":"106","article-title":"Polyamines: new cues in cellular signal transduction","volume":"16","author":"Bachrach","year":"2001","journal-title":"News for Physiological Science"},{"key":"10.1016\/j.biocel.2008.04.023_bib9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/jac\/20.3.405","article-title":"Antitrichomonal activity of alpha-difluoromethylornithine","volume":"20","author":"Bremner","year":"1987","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.biocel.2008.04.023_bib10","doi-asserted-by":"crossref","first-page":"G568","DOI":"10.1152\/ajpgi.00201.2007","article-title":"Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity","volume":"293","author":"Chen","year":"2007","journal-title":"American Journal of Physiology and Gastrointestinal Liver Physiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib11","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1007\/s00018-003-2332-4","article-title":"Polyamine-dependent gene expression","volume":"60","author":"Childs","year":"2003","journal-title":"Cellular and Molecular Life Science"},{"key":"10.1016\/j.biocel.2008.04.023_bib12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00007435-199707000-00008","article-title":"Trichomonas vaginalis associated with low-birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group","volume":"24","author":"Cotch","year":"1997","journal-title":"Sexually Transmitted Diseases"},{"key":"10.1016\/j.biocel.2008.04.023_bib13","first-page":"545","article-title":"A study on Trichomoniasis vaginalis and female infertility","volume":"31","author":"El-Shazly","year":"2001","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"10.1016\/j.biocel.2008.04.023_bib14","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1046\/j.1365-2958.2003.03366.x","article-title":"Iron and contact with host cells induce expression of adhesins on surface of Trichomonas vaginalis","volume":"47","author":"Garc\u00eda","year":"2003","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib15","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1128\/IAI.73.5.2602-2610.2005","article-title":"Trichomonas vaginalis polyamines metabolism is linked to host cell adherence and cytotoxicity","volume":"73","author":"Garc\u00eda","year":"2005","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.biocel.2008.04.023_bib16","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1128\/IAI.73.7.4155-4160.2005","article-title":"Trichomonas vaginalis-induced epithelial monolayer disruption and human immunodeficiency virus type 1 (HIV-1) replication: implications for the sexual transmission of HIV-1","volume":"73","author":"Guenthner","year":"2005","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.biocel.2008.04.023_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.0141-9838.2004.00690.x","article-title":"Monoclonal antibodies against a 62kDa proteinase of Trichomonas vaginalis decrease parasites cytoadherence to epithelial cells and confer protection to mice","volume":"26","author":"Hernandez","year":"2004","journal-title":"Parasite Immunology"},{"issue":"Suppl.","key":"10.1016\/j.biocel.2008.04.023_bib18","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1550-7408.2003.tb00692.x","article-title":"A 39-kDa cysteine proteinase CP39 from Trichomonas vaginalis, which is negatively affected by iron, may be involved in trichomonal cytotoxicity","volume":"50","author":"Hern\u00e1ndez-Guti\u00e9rrez","year":"2003","journal-title":"Journal of Eukaryotic Microbiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.exppara.2004.05.004","article-title":"Trichomonas vaginalis: characterization of a 39-kDa cysteine proteinase found in patient vaginal secretions","volume":"107","author":"Hern\u00e1ndez-Guti\u00e9rrez","year":"2004","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.biocel.2008.04.023_bib20","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/iai.50.3.778-786.1985","article-title":"Contact-dependent cytopathogenic mechanisms of Trichomonas vaginalis","volume":"50","author":"Krieger","year":"1985","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.biocel.2008.04.023_bib21","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1462-5822.2005.00522.x","article-title":"Trichomonas vaginalis adherence mediates differential gene expression in human vaginal epithelial cells","volume":"7","author":"Kucknoor","year":"2005","journal-title":"Cellular Microbiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib22","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1128\/IAI.73.10.6472-6478.2005","article-title":"Adherence to human vaginal epithelial cells signals for increased expression of Trichomonas vaginalis genes","volume":"73","author":"Kucknoor","year":"2005","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.biocel.2008.04.023_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/sti.75.4.231","article-title":"Trichomonad invasion of the mucous layer requires adhesins, mucinases, and motility","volume":"75","author":"Lehker","year":"1999","journal-title":"Sexually Transmitted Infections"},{"key":"10.1016\/j.biocel.2008.04.023_bib24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1084\/jem.174.2.311","article-title":"The regulation by iron of the synthesis of adhesins and cytoadherence levels in the protozoan Trichomonas vaginalis","volume":"174","author":"Lehker","year":"1991","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.biocel.2008.04.023_bib25","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1099\/mic.0.26927-0","article-title":"tvcp12: a novel Trichomonas vaginalis cathepsin L-like cysteine proteinase-encoding gene","volume":"150","author":"Le\u00f3n-Sicairos","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1017\/S0950268804003127","article-title":"Seroepidemiology of Trichomonas vaginalis in rural women in Zimbabwe and patterns of association with HIV infection","volume":"133","author":"Mason","year":"2005","journal-title":"Epidemiology and Infection"},{"key":"10.1016\/j.biocel.2008.04.023_bib27","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1128\/IAI.68.9.4907-4912.2000","article-title":"CP30, a cysteine proteinase involved in Trichomonas vaginalis cytoadherence","volume":"68","author":"Mendoza-L\u00f3pez","year":"2000","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.biocel.2008.04.023_bib28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1086\/338399","article-title":"Trichomonas vaginalis is associated with pelvic inflammatory disease in women infected with human immunodeficiency virus","volume":"34","author":"Moodley","year":"2002","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.biocel.2008.04.023_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1462-5822.2004.00455.x","article-title":"A Trichomonas vaginalis 120kDa protein with identity to hydrogenosome pyruvate:ferredoxin oxidoreductase is a surface adhesin induced by iron","volume":"7","author":"Moreno-Brito","year":"2005","journal-title":"Cellular Microbiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib30","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0300-9084(02)01439-6","article-title":"Polyamine-mediated post-transcriptional regulation of COX-2","volume":"84","author":"Parker","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.biocel.2008.04.023_bib31","doi-asserted-by":"crossref","first-page":"C1020","DOI":"10.1152\/ajpcell.1997.273.3.C1020","article-title":"Polyamines modulate transcription but not posttranscription of c-myc and c-jun in IEC-6 cells","volume":"273","author":"Patel","year":"1997","journal-title":"American Journal of Physiology and Cellular Physiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib32","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jcb.240590817","article-title":"Ornithine decarboxylase as a target for chemoprevention","volume":"22","author":"Pegg","year":"1995","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/j.biocel.2008.04.023_bib33","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.160.5.1261","article-title":"Trichomonas vaginalis is dependent on uptake and degradation of human low density lipoproteins","volume":"160","author":"Peterson","year":"1984","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.biocel.2008.04.023_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0166-6851(84)90042-2","article-title":"Selective acquisition of plasma proteins by Trichomonas vaginalis and human lipoproteins as a growth requirement for this species","volume":"12","author":"Peterson","year":"1984","journal-title":"Molecular Biochemical Parasitology"},{"key":"10.1016\/j.biocel.2008.04.023_bib35","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1152\/ajpcell.2000.279.4.C1034","article-title":"Expression of the TGF-beta receptor gene and sensitivity to growth inhibition following polyamine depletion","volume":"279","author":"Rao","year":"2000","journal-title":"American Journal of Physiology and Cellular Physiology"},{"key":"10.1016\/j.biocel.2008.04.023_bib36","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1128\/AAC.43.8.1919","article-title":"Inhibition of polyamine synthesis arrests trichomonad growth and induces destruction of hydrogenosomes","volume":"43","author":"Reis","year":"1999","journal-title":"Antimicrobial Agents Chemotherapy"},{"key":"10.1016\/j.biocel.2008.04.023_bib37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/09674845.2005.11732710","article-title":"Trichomonas vaginalis: paradigm of a successful sexually transmitted organism","volume":"62","author":"Rughooputh","year":"2005","journal-title":"British Journal of Biomedical Science"},{"key":"10.1016\/j.biocel.2008.04.023_bib38","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1016\/j.biocel.2006.06.003","article-title":"Location of the cell-binding domain of CP65, a 65kDa cysteine proteinase involved in Trichomonas vaginalis cytotoxicity","volume":"38","author":"Solano-Gonz\u00e1lez","year":"2006","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.biocel.2008.04.023_bib39","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.febslet.2007.05.056","article-title":"The trichomonad cysteine proteinase TVCP4 transcript contains an iron-responsive element","volume":"581","author":"Solano-Gonz\u00e1lez","year":"2007","journal-title":"FEBS Letters"},{"key":"10.1016\/j.biocel.2008.04.023_bib40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4269\/ajtmh.1998.58.495","article-title":"Risk factors for trichomoniasis among women with human immunodeficiency virus (HIV) infection at a public clinic in Los Angeles County, California: implications for HIV prevention","volume":"58","author":"Sorvillo","year":"1998","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.biocel.2008.04.023_bib41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/bj3550199","article-title":"Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells","volume":"355","author":"Stefanelli","year":"2001","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2008.04.023_bib42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0014-5793(02)03242-8","article-title":"Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion","volume":"527","author":"Stefanelli","year":"2002","journal-title":"FEBS Letters"},{"key":"10.1016\/j.biocel.2008.04.023_bib43","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1158\/1055-9965.EPI-05-0781","article-title":"Plasma antibodies against Trichomonas vaginalis and subsequent risk of prostate cancer","volume":"15","author":"Sutcliffe","year":"2006","journal-title":"Cancer Epidemiological Biomarkers Prevention"},{"key":"10.1016\/j.biocel.2008.04.023_bib44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/PL00000852","article-title":"Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications","volume":"58","author":"Thomas","year":"2001","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.biocel.2008.04.023_bib45","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1074\/jbc.M110234200","article-title":"Characterization of an iron-responsive promoter in the protozoan pathogen Trichomonas vaginalis","volume":"277","author":"Tsai","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.04.023_bib46","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1086\/498217","article-title":"Prevalence, incidence, natural history, and response to treatment of Trichomonas vaginalis infection among adolescent women","volume":"192","author":"Van Der Pol","year":"2005","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/j.biocel.2008.04.023_bib47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/028418600431003","article-title":"Gynaecological infections as risk determinants of subsequent cervical neoplasia","volume":"39","author":"Viikki","year":"2000","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.biocel.2008.04.023_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20031327","article-title":"A perspective of polyamine metabolism","volume":"376","author":"Wallace","year":"2003","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2008.04.023_bib49","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1163\/156856005774423890","article-title":"Polyamines regulate expression of E-cadherin and play an important role in control of intestinal epithelial barrier function","volume":"13","author":"Wang","year":"2005","journal-title":"Inflamopharmacology"},{"key":"10.1016\/j.biocel.2008.04.023_bib50","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00726-007-0518-z","article-title":"Polyamines and mRNA stability in regulation of intestinal mucosal growth","volume":"33","author":"Wang","year":"2007","journal-title":"Amino Acid"},{"key":"10.1016\/j.biocel.2008.04.023_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-6851(88)90139-9","article-title":"Effect of dl-alpha-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium","volume":"31","author":"Yarlett","year":"1988","journal-title":"Molecular Biochemistry Parasitology"},{"key":"10.1016\/j.biocel.2008.04.023_bib52","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1042\/bst0220875","article-title":"Parasite polyamine metabolism targets for chemotherapy","volume":"22","author":"Yarlett","year":"1994","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.biocel.2008.04.023_bib53","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0166-6851(96)02616-3","article-title":"The contribution of arginine dihydrolase pathway to energy metabolism by Trichomonas vaginalis","volume":"78","author":"Yarlett","year":"1996","journal-title":"Molecular Biochemical Parasitology"},{"key":"10.1016\/j.biocel.2008.04.023_bib54","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1099\/00221287-146-10-2715","article-title":"Dependence of Trichomonas vaginalis upon polyamine backconversion","volume":"146","author":"Yarlett","year":"2000","journal-title":"Microbiology"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272508001581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272508001581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:29:49Z","timestamp":1761200989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272508001581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008]]}},"alternative-id":["S1357272508001581"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2008.04.023","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polyamine depletion down-regulates expression of the Trichomonas vaginalis cytotoxic CP65, a 65-kDa cysteine proteinase involved in cellular damage","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2008.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}