{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:33:06Z","timestamp":1790886786006,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.biocel.2008.04.027","type":"journal-article","created":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T10:20:24Z","timestamp":1217845224000},"page":"733-735","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Interleukin-23: Immunological roles and clinical implications"],"prefix":"10.1016","volume":"41","author":[{"given":"Zi Yan","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Bealgey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Ming","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shisan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biocel.2008.04.027_bib1","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1074\/jbc.M207577200","article-title":"Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17","volume":"278","author":"Aggarwal","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.biocel.2008.04.027_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00005-006-0002-6","article-title":"Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27","volume":"54","author":"Beadling","year":"2006","journal-title":"Arch Immunol Ther Exp"},{"issue":"42","key":"10.1016\/j.biocel.2008.04.027_bib3","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.3748\/wjg.v13.i42.5547","article-title":"Emerging role of IL-23\/17 axis in H pylori-associated pathology","volume":"13","author":"Caruso","year":"2007","journal-title":"World J Gastroenterol"},{"issue":"4","key":"10.1016\/j.biocel.2008.04.027_bib4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1053\/j.gastro.2007.08.032","article-title":"The genetics of inflammatory bowel disease","volume":"133","author":"Cho","year":"2007","journal-title":"Gastroenterology"},{"issue":"5368","key":"10.1016\/j.biocel.2008.04.027_bib5","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.280.5368.1435","article-title":"Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients","volume":"280","author":"de Jong","year":"1998","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.biocel.2008.04.027_bib6","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.4049\/jimmunol.172.5.2827","article-title":"Compromised humoral and delayed-type hypersensitivity responses in IL-23 deficient mice","volume":"172","author":"Ghiladri","year":"2004","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.biocel.2008.04.027_bib7","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1084\/jem.20061099","article-title":"Interleukin-23 drives innate and T cell-mediated intestinal inflammation","volume":"203","author":"Hue","year":"2006","journal-title":"J Exp Med"},{"issue":"5","key":"10.1016\/j.biocel.2008.04.027_bib8","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1172\/JCI28508","article-title":"The IL-23\/IL-17 axis in inflammation","volume":"116","author":"Iwakura","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biocel.2008.04.027_bib9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.immunol.22.012703.104758","article-title":"Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation","volume":"25","author":"Kastelein","year":"2007","journal-title":"Annu Rev Immunol"},{"issue":"6","key":"10.1016\/j.biocel.2008.04.027_bib10","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.coi.2006.09.008","article-title":"The IL-23\/Th(17) axis: therapeutic targets for autoimmune inflammation","volume":"18","author":"Kikly","year":"2006","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"10.1016\/j.biocel.2008.04.027_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.biocel.2008.04.027_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.0105-2896.2004.00214.x","article-title":"IL-12 and IL-23: master regulators of innate and adaptive immunity","volume":"202","author":"Langrish","year":"2004","journal-title":"Immunnol Rev"},{"issue":"1","key":"10.1016\/j.biocel.2008.04.027_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1189\/jlb.0602326","article-title":"A unique role for IL-23 in promoting cellular immunity","volume":"73","author":"Lankford","year":"2003","journal-title":"J Leukoc Biol"},{"issue":"3","key":"10.1016\/j.biocel.2008.04.027_bib14","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.4049\/jimmunol.173.3.1887","article-title":"IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12","volume":"173","author":"Lieberman","year":"2004","journal-title":"J Immunol"},{"issue":"10","key":"10.1016\/j.biocel.2008.04.027_bib15","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1136\/gut.2006.115402","article-title":"The IL23 axis plays a key role in the pathogenesis of IBD","volume":"56","author":"McGovern","year":"2007","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.biocel.2008.04.027_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.it.2005.10.003","article-title":"Understanding the IL-23-IL-17 immune pathway","volume":"27","author":"McKenzie","year":"2006","journal-title":"Trends Immunol"},{"issue":"5","key":"10.1016\/j.biocel.2008.04.027_bib17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","article-title":"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12","volume":"13","author":"Oppmann","year":"2000","journal-title":"Immunity"},{"issue":"40","key":"10.1016\/j.biocel.2008.04.027_bib18","doi-asserted-by":"crossref","first-page":"37692","DOI":"10.1074\/jbc.M105927200","article-title":"Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells","volume":"276","author":"Re","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2008.04.027_bib19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.immuni.2006.05.017","article-title":"Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology","volume":"25","author":"Uhlig","year":"2006","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.biocel.2008.04.027_bib20","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00251-002-0534-9","article-title":"Genetic variations in the interleukin-12\/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function","volume":"54","author":"van de Vosse","year":"2003","journal-title":"Immunogenetics"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272508001945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272508001945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:35:09Z","timestamp":1761201309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272508001945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S1357272508001945"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2008.04.027","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-23: Immunological roles and clinical implications","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2008.04.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2008 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}