{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:52:17Z","timestamp":1791237137624,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2008]]},"DOI":"10.1016\/j.biocel.2008.05.021","type":"journal-article","created":{"date-parts":[[2008,6,9]],"date-time":"2008-06-09T04:04:48Z","timestamp":1212984288000},"page":"2781-2792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The critical interaction of the metallopeptidase PHEX with heparan sulfate proteoglycans"],"prefix":"10.1016","volume":"40","author":[{"given":"Nilana M.T.","family":"Barros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio D.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida","family":"Juliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Juliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Loisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena B.","family":"Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Boileau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivarne L.S.","family":"Tersariol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana K.","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2008.05.021_bib1","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1074\/jbc.M003820200","article-title":"Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation","volume":"276","author":"Almeida","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib2","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/j.1432-1033.2004.04035.x","article-title":"Antimicrobial activities of heparin-binding peptides","volume":"271","author":"Andersson","year":"2004","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-2797(84)90015-2","article-title":"Interaction between human leukocyte elastase and chondroitin sulfate","volume":"51","author":"Baici","year":"1984","journal-title":"Chemical\u2013Biological Interactions"},{"key":"10.1016\/j.biocel.2008.05.021_bib4","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1172\/JCI119276","article-title":"Pex\/PEX tissue distribution and evidence for a deletion in the 3\u2019 region of the Pex gene in X-linked hypophosphatemic mice","volume":"99","author":"Beck","year":"1997","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.biocel.2008.05.021_bib5","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1146\/annurev.biochem.68.1.729","article-title":"Functions of cell surface heparan sulfate proteoglycans","volume":"68","author":"Bernfield","year":"1999","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s004670050669","article-title":"PHEX expression in parathyroid gland and parathyroid hormone dysregulation in X-linked hypophosphatemia","volume":"13","author":"Blydt-Hansen","year":"1999","journal-title":"Pediatric Nephrology"},{"key":"10.1016\/j.biocel.2008.05.021_bib7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj3550707","article-title":"Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitors","volume":"355","author":"Boileau","year":"2001","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2008.05.021_bib8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s002239900339","article-title":"Effects of bone CS-proteoglycans, DS-decorin, and DS-biglycan on hydroxyapatite formation in a gelatin gel","volume":"61","author":"Boskey","year":"1997","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.biocel.2008.05.021_bib9","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1074\/jbc.273.8.4350","article-title":"Structural modification of fibroblast growth factor-binding heparan sulfate at a determinative stage of neural development","volume":"273","author":"Brickman","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/bj20030287","article-title":"Human recombinant endopeptidase PHEX has a strict S1\u2019 specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein","volume":"373","author":"Campos","year":"2003","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2008.05.021_bib11","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/1521-3773(20020201)41:3<390::AID-ANIE390>3.0.CO;2-B","article-title":"Heparin\u2013protein interactions","volume":"41","author":"Capila","year":"2002","journal-title":"Angewandte Chemie (International ed. in English)"},{"key":"10.1016\/j.biocel.2008.05.021_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/01.ATV.9.1.21","article-title":"Molecular modeling of protein\u2013glycosaminoglycan interactions","volume":"9","author":"Cardin","year":"1989","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.biocel.2008.05.021_bib13","series-title":"Heparin-binding proteins","author":"Conrad","year":"1998"},{"key":"10.1016\/j.biocel.2008.05.021_bib14","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.biocel.2005.03.006","article-title":"The osteoblast\u2013heparan sulfate axis: control of the bone cell lineage","volume":"37","author":"Cool","year":"2005","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.biocel.2008.05.021_bib15","series-title":"Endopeptidase 24:11: cell-surface peptidases in health and disease","author":"Crine","year":"1997"},{"key":"10.1016\/j.biocel.2008.05.021_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/A:1006848730927","article-title":"Association of myeloperoxidase with heparin: oxidative inactivation of proteins on the surface of endothelial cells by the bound enzyme","volume":"183","author":"Daphna","year":"1998","journal-title":"Molecular Cellular Biochemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib17","first-page":"417","article-title":"Structure of heparan sulfate: identification of variable and constant oligosaccharide domains in eight heparan sulfates of different origins","volume":"44","author":"Dietrich","year":"1998","journal-title":"Cellular and Molecular Biology"},{"key":"10.1016\/j.biocel.2008.05.021_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1006\/geno.1996.0421","article-title":"cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone","volume":"36","author":"Du","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.biocel.2008.05.021_bib19","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1210\/endo.140.3.6593","article-title":"1,25-(OH)2D3 down-regulates expression of Phex, a marker of the mature osteoblast","volume":"140","author":"Ecarot","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2008.05.021_bib20","first-page":"F489","article-title":"Positional cloning of the PEX gene: new insights into the pathophysiology of X-linked hypophosphatemic rickets","volume":"273","author":"Econs","year":"1997","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.biocel.2008.05.021_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI200113530","article-title":"Molecular diversity of heparan sulfate","volume":"108","author":"Esko","year":"2001","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.biocel.2008.05.021_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.matbio.2005.07.008","article-title":"Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation","volume":"25","author":"Fisher","year":"2006","journal-title":"Matrix Biology"},{"key":"10.1016\/j.biocel.2008.05.021_bib23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00223-005-0026-7","article-title":"Targeted disruption of two small leucine-rich proteoglycans, biglycan and decorin, excerpts divergent effects on enamel and dentin formation","volume":"77","author":"Goldberg","year":"2005","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.biocel.2008.05.021_bib24","doi-asserted-by":"crossref","first-page":"42774","DOI":"10.1074\/jbc.M105531200","article-title":"Structural requirements and mechanism for heparin-induced activation of a recombinant mouse mast cell tryptase, mouse mast cell protease-6: formation of active tryptase monomers in the presence of low molecular weight heparin","volume":"276","author":"Hallgren","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.biochem.72.121801.161747","article-title":"Regulation of protein function by glycosaminoglycans\u2014as exemplified by chemokines","volume":"74","author":"Handel","year":"2005","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/glycob\/cwg013","article-title":"(Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization","volume":"13","author":"Hardt","year":"2003","journal-title":"Glycobiology"},{"key":"10.1016\/j.biocel.2008.05.021_bib27","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1083\/jcb.119.3.513","article-title":"SED5 encodes a 39-kDa integral membrane protein required for vesicular transport between the ER and the Golgi complex","volume":"119","author":"Hardwick","year":"1992","journal-title":"Journal of Cell Biology"},{"key":"10.1016\/j.biocel.2008.05.021_bib28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/(SICI)1521-1878(199802)20:2<156::AID-BIES8>3.0.CO;2-R","article-title":"Glycosaminoglycan\u2013protein interactions: definition of consensus sites in glycosaminoglycan binding proteins","volume":"20","author":"Hileman","year":"1998","journal-title":"Bioessays"},{"key":"10.1016\/j.biocel.2008.05.021_bib29","series-title":"Protein identification and analysis tools on the ExPASy server: the proteomics protocols handbook","author":"Gasteiger","year":"2005"},{"key":"10.1016\/j.biocel.2008.05.021_bib30","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0006-291X(03)01500-6","article-title":"Heparan sulfate is required for bone morphogenetic protein-7 signaling","volume":"308","author":"Irie","year":"2003","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.biocel.2008.05.021_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0968-0004(90)90014-3","article-title":"Why are proteins O-glycosylated?","volume":"15","author":"Jentoft","year":"1990","journal-title":"Trends in Biochemical Sciences"},{"key":"10.1016\/j.biocel.2008.05.021_bib32","doi-asserted-by":"crossref","first-page":"42061","DOI":"10.1074\/jbc.M412280200","article-title":"Kinetics and template nucleation of self-assembled hydroxyapatite nanocrystallites by chondroitin sulfate","volume":"280","author":"Jiang","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib33","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1074\/jbc.M513414200","article-title":"Heparan sulfate proteoglycans (HSPGs) modulate BMP2 osteogenic bioactivity in C2C12 cells","volume":"282","author":"Jiao","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib34","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1056\/NEJMoa020881","article-title":"Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia","volume":"348","author":"Jonsson","year":"2003","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.biocel.2008.05.021_bib35","doi-asserted-by":"crossref","first-page":"18370","DOI":"10.1074\/jbc.M602469200","article-title":"Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosilation","volume":"281","author":"Kato","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib36","first-page":"191","article-title":"Proteoglycans in haemopoietic cells","volume":"1032","author":"Kolset","year":"1990","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2008.05.021_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/bj20031230","article-title":"Intracellular proteoglycans","volume":"379","author":"Kolset","year":"2004","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2008.05.021_bib38","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1242\/jcs.112.11.1797","article-title":"Apical secretion of chondroitin sulphate in polarized Madin\u2013Darby canine kidney (MDCK) cells","volume":"112","author":"Kolset","year":"1999","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2008.05.021_bib39","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1021\/bi992251u","article-title":"Collagenolytic activity of cathepsin K is specifically modulated by cartilage-resident chondroitin sulfates","volume":"39","author":"Li","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0049-3848(94)90136-8","article-title":"More to \u201cheparin\u201d than anticoagulation","volume":"75","author":"Lindahl","year":"1994","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.biocel.2008.05.021_bib41","doi-asserted-by":"crossref","first-page":"13729","DOI":"10.1074\/jbc.273.22.13729","article-title":"Cloning of human PEX cDNA. Expression, subcellular localization, and endopeptidase activity","volume":"273","author":"Lipman","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib42","doi-asserted-by":"crossref","first-page":"37419","DOI":"10.1074\/jbc.M304544200","article-title":"Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX","volume":"278","author":"Liu","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib43","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1681\/ASN.2005111185","article-title":"Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D","volume":"17","author":"Liu","year":"2006","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.biocel.2008.05.021_bib44","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1634\/stemcells.2007-0065","article-title":"Disruption of heparan and chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein signaling pathways","volume":"25","author":"Manton","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.biocel.2008.05.021_bib45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1046\/j.1537-2995.1992.32292180158.x","article-title":"Molecular biology of blood groups: cloning the Kell gene","volume":"32","author":"Marsh","year":"1992","journal-title":"Transfusion"},{"key":"10.1016\/j.biocel.2008.05.021_bib46","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1210\/en.2007-1205","article-title":"Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP","volume":"149","author":"Martin","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2008.05.021_bib47","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1146\/annurev.bi.55.070186.003311","article-title":"Acidification of the endocytic and exocytic pathways","volume":"55","author":"Mellman","year":"1986","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib48","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1083\/jcb.132.3.487","article-title":"Heparan sulfate expression in polarized epithelial cells: the apical sorting of glypican (GPI-anchored proteoglycan) is inversely related to its heparan sulfate content","volume":"132","author":"Mertens","year":"1996","journal-title":"Journal of Cell Biology"},{"key":"10.1016\/j.biocel.2008.05.021_bib49","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1210\/endo.142.2.7976","article-title":"Osteomalacia in hyp mice is associated with abnormal PHEX expression and with altered bone matrix protein expression and deposition","volume":"142","author":"Miao","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2008.05.021_bib50","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s004410051258","article-title":"Alterations of matrix- and cell-associated proteoglycans inhibit osteogenesis and growth response to fibroblast growth factor-2 in cultured rat mandibular condyle and calvaria","volume":"295","author":"Molteni","year":"1999","journal-title":"Cell and Tissue Research"},{"key":"10.1016\/j.biocel.2008.05.021_bib51","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.abb.2005.01.013","article-title":"Cathepsin X binds to cell surface heparan sulfate proteoglycans","volume":"436","author":"Nascimento","year":"2005","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.biocel.2008.05.021_bib52","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<108::AID-BIES2>3.0.CO;2-M","article-title":"FGFs, heparan sulfate and FGFRs: complex interactions essential for development","volume":"22","author":"Ornitz","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.biocel.2008.05.021_bib53","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1042\/bj3200897","article-title":"Lactoferrin regulates the activity of heparin proteoglycan-bound mast cell chymase: characterization of the binding of heparin to lactoferrin","volume":"320","author":"Pejler","year":"1996","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2008.05.021_bib54","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1046\/j.1432-1033.2003.03785.x","article-title":"Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans","volume":"270","author":"Pejler","year":"2003","journal-title":"European Journal Biochemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib55","doi-asserted-by":"crossref","first-page":"49523","DOI":"10.1074\/jbc.M209607200","article-title":"Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin","volume":"277","author":"Raja","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib56","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1210\/jc.2002-021809","article-title":"Structure and function of disease-causing missense mutations in the PHEX gene","volume":"88","author":"Sabbagh","year":"2003","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.biocel.2008.05.021_bib57","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1016\/S0021-9258(18)48317-2","article-title":"Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans","volume":"262","author":"Sayama","year":"1987","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib58","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1073\/pnas.101545198","article-title":"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia","volume":"98","author":"Shimada","year":"2001","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1016\/j.biocel.2008.05.021_bib59","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1210\/endo.143.8.8795","article-title":"Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo","volume":"143","author":"Shimada","year":"2002","journal-title":"Endocrinolology"},{"key":"10.1016\/j.biocel.2008.05.021_bib60","doi-asserted-by":"crossref","first-page":"8857","DOI":"10.1016\/S0021-9258(19)50359-3","article-title":"Localization and characterization of a heparin binding domain peptide of human von Willebrand factor","volume":"267","author":"Sobel","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2008.05.021_bib61","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.cellbio.12.1.27","article-title":"Signal-mediated sorting of membrane proteins between the endoplasmic reticulum and the Golgi apparatus","volume":"12","author":"Teasdale","year":"1996","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"10.1016\/j.biocel.2008.05.021_bib62","series-title":"Disease-causing missense mutations in the PHEX gene interfere with membrane targeting of the recombinant protein. Mendelian hypophosphatemias: the metabolic and molecular basis of inherited disease","author":"Tenenhouse","year":"2001"},{"key":"10.1016\/j.biocel.2008.05.021_bib63","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jsbmb.2006.12.090","article-title":"Phosphate transport: molecular basis, regulation and pathophysiology","volume":"103","author":"Tenenhouse","year":"2007","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"key":"10.1016\/j.biocel.2008.05.021_bib64","doi-asserted-by":"crossref","unstructured":"The ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nature Genetics 26 (2000) 345\u201348.","DOI":"10.1038\/81664"},{"key":"10.1016\/j.biocel.2008.05.021_bib65","doi-asserted-by":"crossref","unstructured":"The HYP Consortium. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. Nature Genetics 11 (1995) 130\u201336.","DOI":"10.1038\/ng1095-130"},{"key":"10.1016\/j.biocel.2008.05.021_bib66","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1359\/jbmr.2002.17.2.311","article-title":"Ontogeny of Phex\/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts","volume":"17","author":"Thompson","year":"2002","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.biocel.2008.05.021_bib67","series-title":"Endothelin-converting enzymes: cell-surface peptidases in health and disease","author":"Turner","year":"1997"},{"key":"10.1016\/j.biocel.2008.05.021_bib68","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1210\/en.2003-0253","article-title":"Parathyroid hormone-related protein(1-34) regulates Phex expression in osteoblasts through the protein kinase A pathway","volume":"144","author":"Vargas","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2008.05.021_bib69","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0955-0674(99)80063-5","article-title":"Mechanisms of vesicle formation: insights from the COP system","volume":"11","author":"Wieland","year":"1999","journal-title":"Current Opinion in Cell Biology"},{"key":"10.1016\/j.biocel.2008.05.021_bib70","first-page":"700","article-title":"Intrinsic mineralization defect in Hyp mouse osteoblasts","volume":"275","author":"Xiao","year":"1998","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.biocel.2008.05.021_bib71","first-page":"722","article-title":"Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia","volume":"118","author":"Yuan","year":"2008","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.biocel.2008.05.021_bib72","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1742-4658.2005.05085.x","article-title":"Secretion of proteases in serglycin transfected Madin\u2013Darby canine kidney cells","volume":"273","author":"Zernichow","year":"2006","journal-title":"FEBS Journal"}],"updated-by":[{"DOI":"10.1016\/j.biocel.2026.107022","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000}},{"DOI":"10.1016\/j.biocel.2026.107022","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000}}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272508002197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272508002197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:31:19Z","timestamp":1761201079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272508002197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":72,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008]]}},"alternative-id":["S1357272508002197"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2008.05.021","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1116403.572422","asserted-by":"object"}]},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The critical interaction of the metallopeptidase PHEX with heparan sulfate proteoglycans","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2008.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}