{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:11:25Z","timestamp":1791259885556,"version":"4.1.0"},"reference-count":173,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,4,18]],"date-time":"2010-04-18T00:00:00Z","timestamp":1271548800000},"content-version":"vor","delay-in-days":199,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.biocel.2009.04.007","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T04:46:46Z","timestamp":1240202806000},"page":"2069-2080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida)"],"prefix":"10.1016","volume":"41","author":[{"given":"Wanderley","family":"de Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia","family":"Attias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliany C.F.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2009.04.007_bib1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.1094786","article-title":"Complete genome sequence of the apicomplexan, Cryptosporidium parvum","volume":"304","author":"Abrahamsen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biocel.2009.04.007_bib2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4269\/ajtmh.1966.15.449","article-title":"The fine structure of the erythrocytic stages of three avian malaria parasites, Plasmodium fallax, P. lophurae, and P. cathemerium","volume":"15","author":"Aikawa","year":"1966","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.biocel.2009.04.007_bib3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/25023","volume":"396","author":"Akhmanova","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2009.04.007_bib4","series-title":"Molecular biology of the cell","author":"Alberts","year":"2007"},{"key":"10.1016\/j.biocel.2009.04.007_bib5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1242\/jcs.4.3.611","article-title":"Division and DNA synthesis in the kinetoplast of Crithidia fasciculata","volume":"4","author":"Anderson","year":"1969","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2009.04.007_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1383-5769(01)00093-9","article-title":"Mitochondrial-type Hsp 70 genes of the amitochondrial protists Giardia intestinalis, Entamoeba histolytica and two microsporidians","volume":"51","author":"Arisue","year":"2002","journal-title":"Parasitol Int"},{"key":"10.1016\/j.biocel.2009.04.007_bib7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1550-7408.1988.tb04108.x","article-title":"Comparative analisys of the fine structure of four isolates of (the genus) Phytomonas","volume":"35","author":"Attias","year":"1988","journal-title":"J Protozool"},{"key":"10.1016\/j.biocel.2009.04.007_bib8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1247\/csf.21.297","article-title":"Computer aided three-dimensional reconstruction of the free-living protozoa Bodo sp. (Kinetoplastida: Bodonidae)","volume":"21","author":"Attias","year":"1996","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.biocel.2009.04.007_bib9","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1089\/ars.2007.2000","article-title":"Ultrastructure of the mitochondrion and its bearing on function and bioenergetics","volume":"10","author":"Benard","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.biocel.2009.04.007_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0248-4900(99)80039-2","article-title":"Hydrogenosome autophagy: an ultrastructural and cytochemical study","volume":"91","author":"Benchimol","year":"1999","journal-title":"Biol Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib11","series-title":"Hydrogenosomes and mitosomes: mitochondria of anaerobic eukaryotes","first-page":"75","article-title":"Structure of the hydrogenosome","author":"Benchimol","year":"2008"},{"key":"10.1016\/j.biocel.2009.04.007_bib12","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1073\/pnas.92.9.3726","article-title":"Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania","volume":"92","author":"Bodley","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biocel.2009.04.007_bib13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1550-7408.1974.tb03731.x","article-title":"Quantitative ultrastructural differences between strains of the Trypanosoma brucei subgroup during transformation in blood","volume":"21","author":"B\u00f6hringer","year":"1974","journal-title":"J Protozool"},{"key":"10.1016\/j.biocel.2009.04.007_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1550-7408.1975.tb05210.x","article-title":"Quantitative ultrastructural investigations of the life cycle of Trypanosoma brucei: a morphometric analysis","volume":"22","author":"B\u00f6hringer","year":"1975","journal-title":"J Protozool"},{"key":"10.1016\/j.biocel.2009.04.007_bib15","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1038\/cdd.2008.85","article-title":"The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFEN-1 and LdTatD as a DNA \u2018degradosome\u2019","volume":"15","author":"BoseDasgupta","year":"2008","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.biocel.2009.04.007_bib16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nature03343","article-title":"An anaerobic mitochondrion that produces hydrogen","volume":"434","author":"Boxma","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2009.04.007_bib17","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1093\/emboj\/16.12.3484","article-title":"Targeting and translocation of proteins into the hydrogenosome of the protist Trichomonas: similarities with mitochondrial protein import","volume":"16","author":"Bradley","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.biocel.2009.04.007_bib18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijantimicag.2003.12.009","article-title":"Effects of squalene synthase inhibitors on the growth and ultrastructure of Trypanosoma cruzi","volume":"24","author":"Braga","year":"2004","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.biocel.2009.04.007_bib19","first-page":"509","article-title":"Die kerne der Ty-panosomen und ihr Verhalten zur Nuclealreaktion","volume":"48","author":"Bresslau","year":"1924","journal-title":"Arch Protist"},{"key":"10.1016\/j.biocel.2009.04.007_bib20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1550-7408.1976.tb03824.x","article-title":"Quantitative ultrastructural investigations of mitochondrial development in Leishmania donovani during transformation","volume":"23","author":"Brun","year":"1976","journal-title":"J Protozool"},{"key":"10.1016\/j.biocel.2009.04.007_bib21","doi-asserted-by":"crossref","first-page":"9651","DOI":"10.1073\/pnas.93.18.9651","article-title":"A common evolutionary origin of mitochondria and hydrogenosomes","volume":"93","author":"Bui","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biocel.2009.04.007_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00380544","article-title":"Effect of 2-deoxy-d-glucose on Herpetomonas samuelpessoai","volume":"52","author":"Bunn","year":"1977","journal-title":"Z Parasitenkd"},{"key":"10.1016\/j.biocel.2009.04.007_bib23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ijpara.2006.12.004","article-title":"Protein targeting in parasites with cryptic mitochondria","volume":"37","author":"Burri","year":"2007","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib24","doi-asserted-by":"crossref","first-page":"15916","DOI":"10.1073\/pnas.0604109103","article-title":"Microsporidian mitosomes retain elements of the general mitochondrial targeting system","volume":"103","author":"Burri","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biocel.2009.04.007_bib25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1083\/jcb.39.2.318","article-title":"Fine structure and replication of the kinetoplast of Trypanosoma lewisi","volume":"39","author":"Burton","year":"1968","journal-title":"J Cell Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib26","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00436-004-1223-4","article-title":"The effect of topoisomerase II inhibitors on the kinetoplast ultrastructure","volume":"94","author":"Cavalcanti","year":"2004","journal-title":"Parasitol Res"},{"key":"10.1016\/j.biocel.2009.04.007_bib27","first-page":"65","article-title":"The respiratory chain and oxidative phosphorylation","volume":"17","author":"Chance","year":"1956","journal-title":"Adv Enzymol"},{"key":"10.1016\/j.biocel.2009.04.007_bib28","doi-asserted-by":"crossref","first-page":"17770","DOI":"10.1016\/S0021-9258(19)84639-2","article-title":"Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase","volume":"264","author":"Clarkson","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1126\/science.986688","article-title":"Trypanosomiasis: and approach to chemotherapy by the inhibition of carbohydrate catabolism","volume":"194","author":"Clarkson","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.biocel.2009.04.007_bib30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0006-2952(96)00903-3","article-title":"Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schyzotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors","volume":"53","author":"Contreras","year":"1997","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biocel.2009.04.007_bib31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1383-5742(02)00070-4","article-title":"Roles of DNA topoisomerases in chromosome segregation and mitosis","volume":"543","author":"Cortes","year":"2003","journal-title":"Mutant Res"},{"key":"10.1016\/j.biocel.2009.04.007_bib32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/00034983.1982.11687502","article-title":"Effect of pentamidine isethionate on the ultrastructure and morphology of Leishmania Mexicana amazonensis in vitro","volume":"76","author":"Croft","year":"1982","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijantimicag.2004.08.016","article-title":"Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii","volume":"25","author":"Dantas-Leite","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.biocel.2009.04.007_bib35","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ijantimicag.2003.11.005","article-title":"Selective anti-Toxoplasma gondii activities of azasterols","volume":"23","author":"Dantas-Leite","year":"2004","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.biocel.2009.04.007_bib36","first-page":"81","article-title":"Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani","volume":"565","author":"Das","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biocel.2009.04.007_bib37","first-page":"355","article-title":"Cytochemical detection of cytochrome oxidase on the mitochondrion-kinetoplast complexo f Herpetomonas samuelpessoai. Influence of the growth medium","volume":"9","author":"de Souza","year":"1977","journal-title":"J Submicr Cytol"},{"key":"10.1016\/j.biocel.2009.04.007_bib38","first-page":"619","article-title":"Electron spectroscopic imaging of calcium in the hydrogenosome of Tritrichomonas foetus","volume":"20","author":"de Souza","year":"1988","journal-title":"J Submicrosc Cytol Pathol"},{"key":"10.1016\/j.biocel.2009.04.007_bib39","first-page":"89","article-title":"DNA containing organelles in pathogenic protozoa","volume":"2","author":"de Souza","year":"2008","journal-title":"Trends Cell Mol Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0074-7696(08)60180-1","article-title":"Cell biology of Trypanosoma cruzi","volume":"86","author":"de Souza","year":"1984","journal-title":"Int Rev Cytol"},{"key":"10.1016\/j.biocel.2009.04.007_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-9292-1-3","article-title":"From the cell biology to the development of new chemotherapeutic approaches against trypanosomatids: dreams and reality","volume":"1","author":"de Souza","year":"2002","journal-title":"Kinetoplastid Biol Dis"},{"key":"10.1016\/j.biocel.2009.04.007_bib42","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1083\/jcb.144.5.891","article-title":"Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis","volume":"144","author":"Desagher","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib43","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1128\/EC.00027-07","article-title":"Frataxin, a conserved mitochondrial protein in hydrogenosomes of Trichomonas vaginalis","volume":"6","author":"Dolezal","year":"2007","journal-title":"Euk Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib44","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S1369-5274(00)00112-0","article-title":"Origins of hydrogenosomes and mitochondria: evolution and organelle biogenesis","volume":"3","author":"Dyall","year":"2000","journal-title":"Curr Op Microbiol"},{"key":"10.1016\/j.biocel.2009.04.007_bib45","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/15216540310001592834","article-title":"hydrogenosomes, mitochondria and eukaryotic evolution","volume":"55","author":"Embley","year":"2003","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biocel.2009.04.007_bib46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/34112","article-title":"A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD","volume":"391","author":"Enari","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2009.04.007_bib47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0248-4900(00)88762-6","article-title":"Biochemical and ultrastructural changes in Herpetomonas roitmani related to the energy metabolism","volume":"92","author":"Faria-e-Silva","year":"2000","journal-title":"Biol Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib48","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0166-6851(01)00356-5","article-title":"Alpha and beta subunits of pyruvate dehydrogenase E1 from the microsporidian Nosema locustae: mitochondrion-derived carbon metabolism in microsporidia","volume":"117","author":"Fast","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib49","doi-asserted-by":"crossref","first-page":"E255","DOI":"10.1038\/ncb1101-e255","article-title":"Organelle-specific initiation of cell death pathways","volume":"3","author":"Ferri","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib50","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/0006-2952(92)90213-3","article-title":"Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4\u2032-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566C80)","volume":"43","author":"Fry","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biocel.2009.04.007_bib51","first-page":"159","article-title":"Evidence for loss of mitochondria in microsporida from amitochondrial-type HSP70 in Nosema locustae","volume":"87","author":"Germont","year":"1997","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib52","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.vetpar.2006.12.022","article-title":"Alterations on the growth and ultrastructure of Leishmania chagasi induced by squalene synthase inhibitors","volume":"146","author":"Granthon","year":"2007","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib53","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cell.2005.05.019","article-title":"Apoptotic pathways: ten minutes to dead","volume":"121","author":"Green","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib54","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1242\/jcs.02949","article-title":"A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus","volume":"119","author":"Gubbels","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2009.04.007_bib55","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00294-006-0088-8","article-title":"Mitochondria, hydrogenosomes and mitosomes: products of evolutionary tinkering","volume":"50","author":"Hackstein","year":"2006","journal-title":"Curr Genet"},{"key":"10.1016\/j.biocel.2009.04.007_bib56","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.1073\/pnas.95.12.6860","article-title":"Secondary absence of mitochondria in Giardia lamblia and Trichomonas vaginalis revealed by valyl-tRNA synthetase","volume":"95","author":"Hashimoto","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biocel.2009.04.007_bib57","first-page":"240","article-title":"Conservation of mitochondrial targeting sequence function in mitochondrial and hydrogenosomal proteins from the early-branching eukaryotes Crithidia, Trypanosoma and Trichomonas","volume":"73","author":"Hausler","year":"1997","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib58","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbrc.2007.11.107","article-title":"Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm","volume":"366","author":"Haze","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biocel.2009.04.007_bib59","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pt.2004.11.010","article-title":"The unusual mitochondrial compartment of Cryptosporidium parvum","volume":"21","author":"Henriquez","year":"2005","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib60","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/00034983.1977.11687174","article-title":"The ultrastructural changes of Leishmania tropica after treatment with pentamidine","volume":"71","author":"Hentzer","year":"1977","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib61","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0960-9822(06)00420-9","article-title":"A mitochondrial Hsp70 ortologue in Vairimorpha necatrix: molecular evidence that microsporidia once contained mitochondria","volume":"7","author":"Hirst","year":"1997","journal-title":"Curr Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib62","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1073\/pnas.87.16.6097","article-title":"Molecular analysis of the hydrogenosomal ferrodoxin of the anaerobic protist Trichomonas vaginalis","volume":"87","author":"Johnson","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biocel.2009.04.007_bib63","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11010-007-9520-8","article-title":"Mitochondria: a hub of redox activities and cellular distress control","volume":"305","author":"Kakkar","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.biocel.2009.04.007_bib64","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1128\/AAC.44.1.14-18.2000","article-title":"Effects of atovaquone and siospyrin-based drugs on ubiquinone biosynthesis in Pneumocystis carinii","volume":"44","author":"Kaneshiro","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib65","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0304-4165(94)00158-T","article-title":"Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite","volume":"1243","author":"Krungkrai","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biocel.2009.04.007_bib66","doi-asserted-by":"crossref","first-page":"6822","DOI":"10.1128\/jb.174.21.6822-6830.1992","article-title":"Beta-succinyl-coenzyme A-synthetase from Trichomonas vaginalis is a soluble hydrogenosomal protein with an amino-terminal sequence that resembles mitochondrial presequences","volume":"174","author":"Lahti","year":"1992","journal-title":"J Bacteriol"},{"key":"10.1016\/j.biocel.2009.04.007_bib67","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1128\/AAC.34.11.2097","article-title":"Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes of Trypanosoma (Schizotrypanum) cruzi","volume":"34","author":"Lazardi","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib68","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1128\/AAC.35.4.736","article-title":"Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivate with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi","volume":"35","author":"Lazardi","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib69","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.cell.2006.06.045","article-title":"Fatty acid synthesis by elongases in trypanosomes","volume":"126","author":"Lee","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib70","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1099\/mic.0.26923-0","article-title":"Mitosomes of Entamoeba histolytica are abundant mitochondrion-related remnant organlelles that lack a detectable organellar genome","volume":"150","author":"Le\u00f3n-Avila","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.biocel.2009.04.007_bib71","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1371\/journal.pgen.0010036","article-title":"Yeast model uncorvers dual roles of mitochondria in action of artemisinin","volume":"1","author":"Li","year":"2005","journal-title":"PLoS Genet"},{"key":"10.1016\/j.biocel.2009.04.007_bib72","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0968-0004(00)01589-9","article-title":"Maturation of cellular Fe\u2013S proteins: an essential function of mitochondria","volume":"25","author":"Lill","year":"2000","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.biocel.2009.04.007_bib73","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pt.2005.06.008","article-title":"Fellowship of the rings: the replication of kinetoplast DNA","volume":"21","author":"Liu","year":"2005","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib74","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0092-8674(00)80197-X","article-title":"DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis","volume":"89","author":"Liu","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib75","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1365-2958.2007.05686.x","article-title":"The rotational dynamics of kinetoplast DNA replication","volume":"64","author":"Liu","year":"2007","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.biocel.2009.04.007_bib76","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1099\/00221287-148-5-1349","article-title":"The \u201cprimitive\u201d microaerophile Giardia intestinalis (syn. lamblia, duodenalis) has specialized membranes with electron transport and membrane-potential-generating functions","volume":"148","author":"Lloyd","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.biocel.2009.04.007_bib77","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nature03291","article-title":"The genome of the protist parasite Entamoeba histolytica","volume":"433","author":"Loftus","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2009.04.007_bib78","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1128\/AAC.48.8.2937-2950.2004","article-title":"Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis","volume":"48","author":"Lorente","year":"2004","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib79","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/EC.1.4.495-502.2002","article-title":"Kinetoplast DNA network: evolution of an improbable structure","volume":"1","author":"Lukes","year":"2002","journal-title":"Euk Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib80","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1021\/jm021114j","article-title":"Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi","volume":"46","author":"Magaraci","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib81","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1128\/MCB.19.3.2198","article-title":"Hsp60 is targeted to a cryptic mitochondrion-derived organelle (\u201cCrypton\u201d) in the microaerophilic protozoan parasite Entamoeba histolytica","volume":"19","author":"Mai","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib82","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tim.2005.08.005","article-title":"The missing link between hydrogenosomes and mitochondria","volume":"13","author":"Martin","year":"2005","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.biocel.2009.04.007_bib83","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1574-6968.2008.01130.x","article-title":"Itraconazole affects Toxoplasma gondii endodyogeny","volume":"282","author":"Martins-Duarte","year":"2008","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.biocel.2009.04.007_bib84","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jac\/dkl180","article-title":"Antiproliferative activities of two novel quinuclidine inhibitors against Toxoplasma gondii tachyzoites in vitro","volume":"58","author":"Martins-Duarte","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib85","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0020-7519(01)00111-4","article-title":"Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I","volume":"31","author":"McLeod","year":"2001","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib86","doi-asserted-by":"crossref","first-page":"11798","DOI":"10.1074\/jbc.M309341200","article-title":"Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: complex II inhibition results in increase pentamidine cytotoxicity","volume":"279","author":"Mehta","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib87","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/jsbi.2000.4228","article-title":"The single mitochondrion of tachyzoites of Toxoplasma gondii","volume":"130","author":"Melo","year":"2000","journal-title":"J Struct Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib88","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.micron.2008.08.003","article-title":"Different cell death pathways induced by drugs in Trypanosoma cruzi: an ultrastructural study","volume":"40","author":"Menna-Barreto","year":"2008","journal-title":"Micron"},{"key":"10.1016\/j.biocel.2009.04.007_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182000021028","article-title":"Electron microscopic study of Trypanosoma cruzi in thin sections of infected tissue cultures and of blood agar forms","volume":"48","author":"Meyer","year":"1958","journal-title":"Parasitology"},{"key":"10.1016\/j.biocel.2009.04.007_bib90","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1550-7408.1968.tb02181.x","article-title":"The fine structure of the flagellum and the kinetoplast-chondriome of Trypanosoma (Schyzotrypanum) cruzi in tissue culture","volume":"15","author":"Meyer","year":"1968","journal-title":"J Protozool"},{"key":"10.1016\/j.biocel.2009.04.007_bib91","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1016\/j.bmc.2008.04.006","article-title":"Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents","volume":"16","author":"Mishra","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib92","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/BF03401792","article-title":"Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis","volume":"6","author":"Mittra","year":"2000","journal-title":"Mol Med"},{"key":"10.1016\/j.biocel.2009.04.007_bib93","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1073\/pnas.0237315100","article-title":"Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase)","volume":"100","author":"Miyadera","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biocel.2009.04.007_bib94","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1126\/science.288.5463.140","article-title":"Specialized fatty acid synthesis in African trypanosomes: myristate for GPI anchors","volume":"288","author":"Morita","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.biocel.2009.04.007_bib95","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/oxfordjournals.molbev.a003832","article-title":"Giardia lamblia expresses a proteobacterial-like DNA K homolog","volume":"18","author":"Morrison","year":"2001","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.biocel.2009.04.007_bib96","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2174\/138161208784041051","article-title":"Kinetoplast as a potential chemotherapeutic target of trypanosomatids","volume":"14","author":"Motta","year":"2008","journal-title":"Cur Pharm Des"},{"key":"10.1016\/j.biocel.2009.04.007_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2005.08.016","article-title":"Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani","volume":"145","author":"Mukherjee","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib98","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mimet.2004.03.008","article-title":"Isolation and characterization of the mitochondrion-like organelle from Blastocystis hominis","volume":"58","author":"Nasirudeen","year":"2004","journal-title":"J Microbiol Meth"},{"key":"10.1016\/j.biocel.2009.04.007_bib99","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2307\/3282922","article-title":"Reconstruction of the chondriome of the amastigote form of Trypanosoma cruzi","volume":"75","author":"Newberry","year":"1989","journal-title":"J Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib100","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1242\/jcs.021089","article-title":"Organellar dynamics during the cell cycle of Toxoplasma gondii","volume":"121","author":"Nishi","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2009.04.007_bib101","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature05572","article-title":"Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum","volume":"446","author":"Painter","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2009.04.007_bib102","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1574-6968.2005.00056.x","article-title":"Effects of sterol biosynthesis inhibitors on endosymbiont-bearing trypanosomatids","volume":"255","author":"Palmie-Peixoto","year":"2006","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.biocel.2009.04.007_bib103","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s10495-007-0052-1","article-title":"Lysosomal and mitochondrial pathways in miltefosine-induced apoptosis in U937 cells","volume":"12","author":"Paris","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.biocel.2009.04.007_bib104","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/AAC.48.3.852-859.2004","article-title":"Miltefosine induces apoptosis-like death in Leishmania donovani","volume":"48","author":"Paris","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib105","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/EC.3.4.855-861.2004","article-title":"Multiple triclosan targets in Trypanosoma brucei","volume":"3","author":"Paul","year":"2004","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib106","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1083\/jcb.66.2.404","article-title":"The chondriome of selected trypanosomatids. A three-dimensional study based on serial thick sections and high voltage electron microscopy","volume":"66","author":"Paulin","year":"1975","journal-title":"J Cell Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib107","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2307\/3281310","article-title":"Conformation of a single mitochondrion in the trypomastigote stage of Trypanosoma cruzi","volume":"69","author":"Paulin","year":"1983","journal-title":"J Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib108","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0014-4894(77)90101-1","article-title":"Crithidia fasciculata: reconstruction of the mitochondrion based on serial thick sections and high-voltage electron microscopy","volume":"41","author":"Paulin","year":"1977","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib109","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/oxfordjournals.molbev.a025971","article-title":"Microsporidia, amitochondrial protists, possess a 70kDa heat shock protein gene of mitochondrial evolutionary origin","volume":"15","author":"Peyretailade","year":"1998","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.biocel.2009.04.007_bib110","doi-asserted-by":"crossref","first-page":"30577","DOI":"10.1074\/jbc.M500787200","article-title":"Protein import, replication and inheritance of a vestigial mitochondrion","volume":"280","author":"Regoes","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib111","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1073\/pnas.62.1.210","article-title":"Electron microscopy of the circular kinetoplastic DNA from Trypanosoma cruzi: occurrence of concatenated forms","volume":"62","author":"Riou","year":"1969","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.biocel.2009.04.007_bib112","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0022-2836(67)80017-2","article-title":"Preparation and properties of nuclear and satellite deoxyribonucleic acid of Trypanosoma cruzi","volume":"28","author":"Riou","year":"1967","journal-title":"J Mol Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib113","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ijpara.2003.11.002","article-title":"Evidence for mitochondrial-derived alternative oxidase in the apicomplexan parasite Cryptosporidium parvum: a potential anti-microbial agent target","volume":"34","author":"Roberts","year":"2004","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib114","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1550-7408.2001.tb00195.x","article-title":"The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin permeabilization","volume":"48","author":"Rodrigues","year":"2001","journal-title":"J Eukaryot Microbiol"},{"key":"10.1016\/j.biocel.2009.04.007_bib115","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1128\/AAC.46.2.487-499.2002","article-title":"Ultrastructural and biochemical alterations induced by 22,26-azasterol, a \u039424(25)-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis","volume":"46","author":"Rodrigues","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib116","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.protis.2007.05.004","article-title":"Sterol methenyl transferase inhibitors alter the ultrastructure and function of the Leishmania amazonensis mitochondrion leading to potent growth inhibition","volume":"158","author":"Rodrigues","year":"2007","journal-title":"Protist"},{"key":"10.1016\/j.biocel.2009.04.007_bib117","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1128\/AAC.01616-07","article-title":"In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical and ultrastructural effects","volume":"52","author":"Rodrigues","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib118","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2174\/138161208784041033","article-title":"Ultrastructural alterations in organelles of parasitic protozoa induced by different classes metabolic inhibitors","volume":"14","author":"Rodrigues","year":"2008","journal-title":"Cur Pharm Des"},{"key":"10.1016\/j.biocel.2009.04.007_bib119","first-page":"87","article-title":"Apoptosis-like death in parasitic protozoa","volume":"23","author":"Rodrigues","year":"2006","journal-title":"Braz J Morphol Sci"},{"key":"10.1016\/j.biocel.2009.04.007_bib120","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.exppara.2005.08.006","article-title":"Antiproliferative and ultrastructural effects of BPQ-OH, a specific inhibitors of squalene synthase, on Leishmania amazonensis","volume":"111","author":"Rodrigues","year":"2005","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib121","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1073\/pnas.95.1.229","article-title":"A mitochondrion-like chaperonin 60 gene in Giardia lamblia: evidence that diplomonads once harbored an endosymbiont related to the progenitor of mitochondria","volume":"95","author":"Roger","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biocel.2009.04.007_bib122","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1128\/EC.5.4.784-787.2006","article-title":"Cardiolipin in hydrogenosomes: evidence of symbiotic origin","volume":"5","author":"Rosa","year":"2006","journal-title":"Euk Cell"},{"key":"10.1016\/j.biocel.2009.04.007_bib123","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1124\/mol.108.050161","article-title":"Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3\u2032-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani","volume":"74","author":"Roy","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biocel.2009.04.007_bib124","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0074-7696(08)60203-X","article-title":"The fine structure of malaria parasites","volume":"25","author":"Rudzinska","year":"1969","journal-title":"Int Rev Cytol"},{"key":"10.1016\/j.biocel.2009.04.007_bib125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-5521(00)00057-0","article-title":"Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase","volume":"8","author":"Salomon","year":"2001","journal-title":"Chem Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib126","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/clinids\/7.5.625","article-title":"Pentamidine: a review","volume":"7","author":"Sands","year":"1985","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.biocel.2009.04.007_bib127","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0001-706X(00)00052-8","article-title":"Effect of the alkyl-lysophospholipid on the proliferation and differentiation of Trypanosoma cruzi","volume":"75","author":"Santa-Rita","year":"2000","journal-title":"Acta Trop"},{"key":"10.1016\/j.biocel.2009.04.007_bib128","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/jac\/dkh380","article-title":"Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis","volume":"54","author":"Santa-Rita","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib129","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/jac\/dki087","article-title":"Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis","volume":"55","author":"Santa-Rita","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/15216540152845911","article-title":"Respiratory chain complexes","volume":"52","author":"Schagger","year":"2001","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biocel.2009.04.007_bib131","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tcb.2007.09.009","article-title":"The direct route: a simplified pathway for protein import into the mitochondria of trypanosomes","volume":"18","author":"Schneider","year":"2007","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib132","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.pt.2008.07.004","article-title":"Apicomplexan mitochondrial metabolism: a story of gains, losses and retentions","volume":"24","author":"Seeber","year":"2008","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib133","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.exppara.2006.08.005","article-title":"Leishmania donovani: dyskinetoplastid cells survive and proliferate in the presence of pyruvate and uridine but do not undergo apoptosis after treatment with camptothecin","volume":"115","author":"Sen","year":"2007","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib134","doi-asserted-by":"crossref","first-page":"52366","DOI":"10.1074\/jbc.M406705200","article-title":"Camptothecin-induced imbalance in intracellular cation homeostasis regulates programmed cell death in unicellular hemoflagellate Leishmania donovani","volume":"279","author":"Sen","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib135","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/sj.cdd.4401435","article-title":"Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani","volume":"11","author":"Sen","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.biocel.2009.04.007_bib136","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2174\/138161208784041024","article-title":"Mitochondrion of protozoan parasite emerges as potent therapeutic target: exciting drugs are on the horizon","volume":"14","author":"Sen","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.biocel.2009.04.007_bib137","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1128\/AAC.45.7.2064-2069.2001","article-title":"Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes","volume":"45","author":"Sereno","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib138","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0001-706X(93)90097-U","article-title":"Inhibition of topoisomerases in African trypanosomes","volume":"54","author":"Shapiro","year":"1993","journal-title":"Acta Trop"},{"key":"10.1016\/j.biocel.2009.04.007_bib139","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1073\/pnas.87.3.950","article-title":"Selective cleavage of kinetoplast DNA minicircles promoted by anti-trypanosomal drugs","volume":"87","author":"Shapiro","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biocel.2009.04.007_bib140","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.mi.49.100195.001001","article-title":"The structure and replication of the kinetoplast DNA","volume":"49","author":"Shapiro","year":"1995","journal-title":"Ann Rev Microbiol"},{"key":"10.1016\/j.biocel.2009.04.007_bib141","first-page":"349","article-title":"Cytoplasmic organelles of trypanosomatids: a cytochemical and stereological study","volume":"20","author":"Soares","year":"1988","journal-title":"J Submicrosc Cytol Pathol"},{"key":"10.1016\/j.biocel.2009.04.007_bib142","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00927859","article-title":"An electron microscopic and cytochemical study of Leptomonas samueli","volume":"62","author":"Souto-Padr\u00f3n","year":"1980","journal-title":"Z Parasitenkd"},{"key":"10.1016\/j.biocel.2009.04.007_bib143","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1074\/jbc.272.7.3961","article-title":"Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite","volume":"272","author":"Srivastava","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib144","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1128\/AAC.43.6.1334","article-title":"A mechanism for the synergistic antimalarial action of atovaquone and proguanil","volume":"43","author":"Srivastava","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biocel.2009.04.007_bib145","first-page":"64","article-title":"On the ultrastructure of Trypanosoma (Trypanozoon) brucei in the course of its life cycle and some related aspects","volume":"30","author":"Steiger","year":"1973","journal-title":"Acta Trop"},{"key":"10.1016\/j.biocel.2009.04.007_bib146","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/0014-4827(58)90117-4","article-title":"Synthesis of deoxyribonucleic acid in the parabasal body of Trypanosoma mega","volume":"15","author":"Steinert","year":"1958","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.biocel.2009.04.007_bib147","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1074\/jbc.M609037200","article-title":"Mitochondrial fatty acid synthesis in Trypanosoma brucei","volume":"282","author":"Stephens","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib148","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1365-2958.2002.03028.x","article-title":"RNA editing: complexity and complications","volume":"45","author":"Stuart","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.biocel.2009.04.007_bib149","doi-asserted-by":"crossref","first-page":"25120","DOI":"10.1074\/jbc.M301975200","article-title":"Antimonial-induced increase in intracellular Ca2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani amastigotes","volume":"278","author":"Sudhandiran","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib150","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/84612","article-title":"Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium","volume":"7","author":"Surolia","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.biocel.2009.04.007_bib151","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1093\/oxfordjournals.molbev.a003732","article-title":"Mitochondrial-type iron\u2013sulfur cluster assembly in the amitochondriated eukaryotes Trichomonas vaginalis and Giardia intestinalis, as indicated by the phylogeny of IscS","volume":"18","author":"Tachezy","year":"2001","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.biocel.2009.04.007_bib152","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1046\/j.1365-2958.1999.01414.x","article-title":"The mitosome, a novel organelle related to mitochondria in the amitochondrial parasite Entamoeba histolytica","volume":"32","author":"Tovar","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.biocel.2009.04.007_bib153","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nature01945","article-title":"Mitochondrial remnnant organelles of Giardia function in the iron\u2013sulfur protein maturation","volume":"426","author":"Tovar","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2009.04.007_bib154","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.trstmh.2006.03.010","article-title":"Mechanisms of action of lysophospholipid analogues against trypanosomatid parasites","volume":"1","author":"Urbina","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.biocel.2009.04.007_bib155","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1074\/jbc.M307264200","article-title":"Oxidative phosphorylation and rotenone-sensitive malate- and NADH-quinone oxidoreductase in Plasmodium yoelii yoelii mitochondria in situ","volume":"279","author":"Uyemura","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2009.04.007_bib156","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2958.2005.04699.x","article-title":"Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum","volume":"57","author":"van Dooren","year":"2005","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.biocel.2009.04.007_bib157","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1574-6976.2006.00027.x","article-title":"Metabolic maps and functions of the Plasmodium mitochondrion","volume":"30","author":"van Dooren","year":"2006","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.biocel.2009.04.007_bib158","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1550-7408.1995.tb01591.x","article-title":"Alterations induced by the antifungal compounds ketoconazole and terbinafine in Leishmania","volume":"42","author":"Vannier-Santos","year":"1995","journal-title":"J Euk Microbiol"},{"key":"10.1016\/j.biocel.2009.04.007_bib159","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/bj2840463","article-title":"Ca2+ transport by digitonin-permeabilized Leishmania donovani. Effects of Ca2+, pentamidine and WR-6026 on mitochondrial membrane potential in situ","volume":"284","author":"Vercesi","year":"1992","journal-title":"Biochem J"},{"key":"10.1016\/j.biocel.2009.04.007_bib160","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1242\/jcs.112.17.2797","article-title":"Protozoan paradigms for cell biology","volume":"112","author":"Vickerman","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2009.04.007_bib161","series-title":"Biology of kinetoplastida","first-page":"35","article-title":"Comparative cell biology of the kinetoplastid flagellates","author":"Vickerman","year":"1976"},{"key":"10.1016\/j.biocel.2009.04.007_bib162","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/208762a0","article-title":"Polymorphism and mitochondrial activity in sleeping sickness trypanosomes","volume":"208","author":"Vickerman","year":"1965","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2009.04.007_bib163","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1550-7408.1973.tb00909.x","article-title":"The mode of attachment of Trypanosoma vivax in the proboscis of the tsetse fly Glossina fuscipes: an ultrastructural study of the epimastigote stage of the trypanosome","volume":"20","author":"Vickerman","year":"1973","journal-title":"J Protozool"},{"key":"10.1016\/j.biocel.2009.04.007_bib164","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0924-8579(96)00325-1","article-title":"Ultrastructural alterations in Trypanosoma (Schizotrypanum) cruzi induced by \u039424(25)-sterol methyltransferase inhibitors and their combinations with ketoconazole","volume":"7","author":"Vivas","year":"1996","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.biocel.2009.04.007_bib165","first-page":"199","article-title":"Donn\u00e9s ultrastructurales compl\u00e9mentaries, morphologiques et cytochimiques, sur Toxoplasma gondii","volume":"VIII","author":"Vivier","year":"1972","journal-title":"Protistologica"},{"key":"10.1016\/j.biocel.2009.04.007_bib166","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrm831","article-title":"Cellular roles of DNA topoisomerases: a molecular perspective","volume":"3","author":"Wang","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.biocel.2009.04.007_bib167","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.ijpara.2008.06.001","article-title":"Complete circular DNA in the mitochondria-like organelles of Blastocystis hominis","volume":"38","author":"Wawrzyniak","year":"2008","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biocel.2009.04.007_bib168","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nature00949","article-title":"A mitochondrial remnant in the microsopridian Trachipleistophora hominis","volume":"418","author":"Williams","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2009.04.007_bib169","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0163-7258(79)90040-8","article-title":"Effects of trypanocides on the fine structure of target organisms","volume":"7","author":"Williamson","year":"1979","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.biocel.2009.04.007_bib170","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0006-2952(75)90328-7","article-title":"Drug-induced lesions in trypanosome fine structure: a guide to modes of trypanocidal action","volume":"24","author":"Williamson","year":"1975","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biocel.2009.04.007_bib171","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/nature02977","article-title":"The genome of Cryptosporidium hominis","volume":"431","author":"Xu","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2009.04.007_bib172","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.parint.2005.09.003","article-title":"Chemotherapeutic efficacy of ascofuranone in Trypanosoma vivax-infected mice without glycerol","volume":"55","author":"Yabu","year":"2006","journal-title":"Parasitol Int"},{"key":"10.1016\/j.biocel.2009.04.007_bib173","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/sj.bjp.0703397","article-title":"Inhibition of mitochondrial proton F0F1-ATPase\/ATP synthase by polyphenolic phytochemicals","volume":"130","author":"Zheng","year":"2000","journal-title":"Br J Pharmacol"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272509001290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272509001290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:37:33Z","timestamp":1761201453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272509001290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":173,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S1357272509001290"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2009.04.007","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida)","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2009.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}