{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:18:41Z","timestamp":1772770721177,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.biocel.2009.12.022","type":"journal-article","created":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T05:01:04Z","timestamp":1263272464000},"page":"1059-1064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exacerbation of tobacco smoke mediated apoptosis by resveratrol: An unexpected consequence of its antioxidant action"],"prefix":"10.1016","volume":"43","author":[{"given":"Hongqiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Rinna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry Jay","family":"Forman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2009.12.022_bib1","first-page":"1466","article-title":"Resveratrol causes WAF-1\/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells","volume":"7","author":"Ahmad","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biocel.2009.12.022_bib2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jss.2005.01.024","article-title":"Protective effect of resveratrol against oxidative stress in cholestasis","volume":"127","author":"Ara","year":"2005","journal-title":"J Surg Res"},{"key":"10.1016\/j.biocel.2009.12.022_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2164\/jandrol.106.000968","article-title":"Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines","volume":"28","author":"Benitez","year":"2007","journal-title":"J Androl"},{"key":"10.1016\/j.biocel.2009.12.022_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0014-5793(01)02593-5","article-title":"Caspases are reversibly inactivated by hydrogen peroxide","volume":"500","author":"Borutaite","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biocel.2009.12.022_bib5","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0891-5849(99)00019-2","article-title":"Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3","volume":"26","author":"Cadenas","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.biocel.2009.12.022_bib6","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbrc.2005.03.237","article-title":"Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells","volume":"331","author":"Chen","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biocel.2009.12.022_bib7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/carcin\/22.3.375","article-title":"Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats","volume":"22","author":"D\u2019Agostini","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.biocel.2009.12.022_bib8","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1080\/10715760600833085","article-title":"Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkappaB","volume":"40","author":"Das","year":"2006","journal-title":"Free Radic Res"},{"key":"10.1016\/j.biocel.2009.12.022_bib9","article-title":"Protective effects of resveratrol on hydrogen peroxide induced toxicity in primary cortical astrocyte cultures","author":"de Almeida","year":"2007","journal-title":"Neurochem Res"},{"key":"10.1016\/j.biocel.2009.12.022_bib10","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1038\/sj.onc.1208086","article-title":"Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells","volume":"23","author":"Delmas","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.biocel.2009.12.022_bib11","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0891-5849(02)00991-7","article-title":"4-Hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells","volume":"33","author":"Dickinson","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.biocel.2009.12.022_bib12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(04)78023-4","article-title":"Analysis of transcription factor remodeling in phase II gene expression with curcumin","volume":"378","author":"Dickinson","year":"2004","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.biocel.2009.12.022_bib13","first-page":"384","article-title":"Diverse resveratrol sensitization to apoptosis induced by anticancer drugs in sensitive and resistant leukemia cells","volume":"53","author":"Duraj","year":"2006","journal-title":"Neoplasma"},{"key":"10.1016\/j.biocel.2009.12.022_bib14","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/carcin\/23.8.1327","article-title":"Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells","volume":"23","author":"Ferry-Dumazet","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.biocel.2009.12.022_bib15","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1038\/sj.onc.1207630","article-title":"Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol","volume":"23","author":"Fulda","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.biocel.2009.12.022_bib16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0014-5793(97)01068-5","article-title":"Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis","volume":"414","author":"Hampton","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biocel.2009.12.022_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1165\/ajrcmb.25.2.4471","article-title":"Activation of nuclear factor-kappa b transcriptional activity in airway epithelial cells by thioredoxin but not by N-acetyl-cysteine and glutathione","volume":"25","author":"Harper","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.biocel.2009.12.022_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/excr.1999.4471","article-title":"Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines","volume":"249","author":"Hsieh","year":"1999","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.biocel.2009.12.022_bib19","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1016\/j.lfs.2006.06.019","article-title":"Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray","volume":"79","author":"Hu","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.biocel.2009.12.022_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1515\/BC.2007.023","article-title":"Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells","volume":"388","author":"Hu","year":"2007","journal-title":"Biol Chem."},{"key":"10.1016\/j.biocel.2009.12.022_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1158\/1535-7163.71.3.1","article-title":"Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis","volume":"3","author":"Jazirehi","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.biocel.2009.12.022_bib22","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1021\/jf035012t","article-title":"Modulations of the Bcl-2\/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell","volume":"52","author":"Jo","year":"2004","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.biocel.2009.12.022_bib23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bcp.2004.09.015","article-title":"Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells","volume":"69","author":"Juan","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biocel.2009.12.022_bib24","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.lfs.2006.11.044","article-title":"Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver","volume":"80","author":"Kasdallah-Grissa","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.biocel.2009.12.022_bib25","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/thx.2004.037473","article-title":"Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases","volume":"60","author":"Kinnula","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.biocel.2009.12.022_bib26","doi-asserted-by":"crossref","first-page":"L921","DOI":"10.1152\/ajplung.00250.2007","article-title":"TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells","volume":"294","author":"Lee","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.biocel.2009.12.022_bib27","doi-asserted-by":"crossref","DOI":"10.1378\/chest.117.5_suppl_1.303S-a","article-title":"Oxidants\/antioxidants and COPD","volume":"117","author":"MacNee","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.biocel.2009.12.022_bib28","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.bcp.2003.12.024","article-title":"Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats","volume":"67","author":"Martin","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biocel.2009.12.022_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1440-1681.2001.03415.x","article-title":"Protective effect of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats","volume":"28","author":"Mizutani","year":"2001","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.biocel.2009.12.022_bib30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/bbrc.1997.7304","article-title":"Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide","volume":"238","author":"Mohr","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biocel.2009.12.022_bib31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0009-8981(95)06045-1","article-title":"The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease","volume":"235","author":"Pace-Asciak","year":"1995","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.biocel.2009.12.022_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1749-6632.1993.tb39148.x","article-title":"Oxidants in cigarette smoke, radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite","volume":"686","author":"Pryor","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biocel.2009.12.022_bib33","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000073766","article-title":"Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity","volume":"49","author":"Savaskan","year":"2003","journal-title":"Gerontology"},{"key":"10.1016\/j.biocel.2009.12.022_bib34","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.2741\/2432","article-title":"Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential","volume":"12","author":"Shankar","year":"2007","journal-title":"Front Biosci"},{"key":"10.1016\/j.biocel.2009.12.022_bib35","doi-asserted-by":"crossref","first-page":"L1572","DOI":"10.1152\/ajplung.00325.2006","article-title":"Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis","volume":"292","author":"Stringer","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.biocel.2009.12.022_bib36","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1161\/01.CIR.0000060819.46705.EE","article-title":"Upregulation and activation of eNOS by resveratrol","volume":"107","author":"Taubert","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2009.12.022_bib37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0272-5231(05)70016-2","article-title":"Tobacco-related diseases. Is there a role for antioxidant micronutrient supplementation?","volume":"21","author":"Traber","year":"2000","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.biocel.2009.12.022_bib38","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10571-007-9152-2","article-title":"Resveratrol increases glutamate uptake, glutathione content, and S100B secretion in cortical astrocyte cultures","volume":"27","author":"Vieira de Almeida","year":"2007","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.biocel.2009.12.022_bib39","doi-asserted-by":"crossref","first-page":"L726","DOI":"10.1152\/ajplung.00025.2002","article-title":"A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile","volume":"283","author":"Watanabe","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.biocel.2009.12.022_bib40","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1158\/1535-7163.MCT-05-0497","article-title":"Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2","volume":"5","author":"Xu","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.biocel.2009.12.022_bib41","doi-asserted-by":"crossref","first-page":"C1219","DOI":"10.1152\/ajpcell.1993.264.5.C1219","article-title":"Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype","volume":"264","author":"Yankaskas","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.biocel.2009.12.022_bib42","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.freeradbiomed.2004.10.031","article-title":"4-Hydroxynonenal increases gamma-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways","volume":"38","author":"Zhang","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.biocel.2009.12.022_bib43","article-title":"4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through MAPK mediated EpRE\/Nrf2 signaling","author":"Zhang","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.biocel.2009.12.022_bib44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0163-7258(01)00159-0","article-title":"The machinery of programmed cell death","volume":"92","author":"Zimmermann","year":"2001","journal-title":"Pharmacol Ther"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272510000026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272510000026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:44:09Z","timestamp":1761201849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272510000026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S1357272510000026"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2009.12.022","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exacerbation of tobacco smoke mediated apoptosis by resveratrol: An unexpected consequence of its antioxidant action","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2009.12.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}