{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:37:55Z","timestamp":1791095875864,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.biocel.2011.01.001","type":"journal-article","created":{"date-parts":[[2011,1,8]],"date-time":"2011-01-08T04:23:46Z","timestamp":1294460626000},"page":"622-631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Matrigel improves functional properties of human submandibular salivary gland cell line"],"prefix":"10.1016","volume":"43","author":[{"given":"Ola M.","family":"Maria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana V.","family":"Komarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon D.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2011.01.001_bib0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/10763270050044380","article-title":"The growth and morphological behavior of salivary epithelial cells on matrix protein-coated biodegradable substrata","volume":"6","author":"Aframian","year":"2000","journal-title":"Tissue Eng"},{"key":"10.1016\/j.biocel.2011.01.001_bib0010","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/10763270260424231","article-title":"Absence of tight junction formation in an allogeneic graft cell line used for developing an engineered artificial salivary gland","volume":"8","author":"Aframian","year":"2002","journal-title":"Tissue Eng"},{"key":"10.1016\/j.biocel.2011.01.001_bib0015","first-page":"770","article-title":"Emergence of differentiated subclones from a human salivary adenocarcinoma cell clone in culture after treatment with sodium butyrate","volume":"46","author":"Azuma","year":"1986","journal-title":"Cancer Res"},{"key":"10.1016\/j.biocel.2011.01.001_bib0020","first-page":"7219","article-title":"Effects of retinoic acid on morphological features and biological markers of a neoplastic human salivary intercalated duct cell line in culture","volume":"48","author":"Azuma","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/j.biocel.2011.01.001_bib0025","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0030-4220(80)90053-5","article-title":"Salivary gland neoplasia: an outcome of modified morphogenesis and cytodifferentiation","volume":"49","author":"Batsakis","year":"1980","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.14219\/jada.archive.1995.0143","article-title":"The impact of gene therapy on dentistry","volume":"126","author":"Baum","year":"1995","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.biocel.2011.01.001_bib0035","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.1993.tb18338.x","article-title":"Principles of saliva secretion","volume":"694","author":"Baum","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.biocel.2011.01.001_bib0040","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1600-0757.2006.00160.x","article-title":"Synergy between genetic and tissue engineering: creating an artificial salivary gland","volume":"41","author":"Baum","year":"2006","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.biocel.2011.01.001_bib0045","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/S0140-6736(01)06900-8","article-title":"Subcellular distribution of aquaporin 5 in salivary glands in primary Sjogren's syndrome","volume":"358","author":"Beroukas","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.biocel.2011.01.001_bib0050","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1126\/science.7531366","article-title":"Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix","volume":"267","author":"Boudreau","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.biocel.2011.01.001_bib0055","series-title":"Physiology of the gastrointestinal tract","first-page":"1061","article-title":"Secretion by the major salivary glands","author":"Cook","year":"1994"},{"key":"10.1016\/j.biocel.2011.01.001_bib0060","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/10454411970080010301","article-title":"Salivary glands: a paradigm for diversity of gland development","volume":"8","author":"Denny","year":"1997","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.biocel.2011.01.001_bib0065","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1210\/endo.136.10.7664664","article-title":"Evidence that basement membrane prevents apoptosis of sertoli cells in vitro in the absence of known regulators of sertoli cell function","volume":"136","author":"Dirami","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2011.01.001_bib0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF02624152","article-title":"Mouse submandibular salivary epithelial cell growth and differentiation in long term culture: influence of the extracellular matrix","volume":"26","author":"Durban","year":"1990","journal-title":"In Vitro Cell Dev Biol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0075","first-page":"433","article-title":"Histogenic classification of salivary tumors","volume":"92","author":"Eversole","year":"1971","journal-title":"Arch Pathol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0080","doi-asserted-by":"crossref","first-page":"719","DOI":"10.14219\/jada.archive.1998.0313","article-title":"Sjogren's syndrome: a model for dental care in the 21st century","volume":"129","author":"Fox","year":"1998","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.biocel.2011.01.001_bib0085","doi-asserted-by":"crossref","first-page":"519","DOI":"10.14219\/jada.archive.1985.0384","article-title":"Xerostomia: evaluation of a symptom with increasing significance","volume":"110","author":"Fox","year":"1985","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.biocel.2011.01.001_bib0090","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/00002281-199709000-00004","article-title":"Pathogenesis and treatment of Sj\u00f6gren's syndrome","volume":"9","author":"Fox","year":"1997","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0095","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0738-081X(00)00135-8","article-title":"Sjogren's syndrome","volume":"18","author":"Fox","year":"2000","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0100","doi-asserted-by":"crossref","first-page":"G247","DOI":"10.1152\/ajpgi.2001.281.1.G247","article-title":"Identification and localization of aquaporin water channels in human salivary glands","volume":"281","author":"Gresz","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0105","first-page":"1","article-title":"Induction of cells with a myoepithelial cell phenotype by treatment with dibutyryl cyclic AMP in human salivary adenocarcinoma cells grown in athymic nude mice","volume":"50","author":"Hayashi","year":"1985","journal-title":"Virchows Arch Zellpathol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0110","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1242\/jcs.109.8.2013","article-title":"Role of laminin-1 and TGF-b3 in acinar differentiation of a human submandibular gland cell line (HSG)","volume":"109","author":"Hoffman","year":"1996","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2011.01.001_bib0115","doi-asserted-by":"crossref","first-page":"28633","DOI":"10.1074\/jbc.273.44.28633","article-title":"Laminin-1 and laminin-2 Gdomain synthetic peptides bind syndecan-1 and are involved in acinar formation of a human submandibular gland cell line","volume":"273","author":"Hoffman","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2011.01.001_bib0120","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/(SICI)1097-0185(19991101)256:3<252::AID-AR5>3.0.CO;2-6","article-title":"Submandibular gland morphogenesis: stage-specific expression of TGF-alpha\/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations","volume":"256","author":"Jaskoll","year":"1999","journal-title":"Anat Rec"},{"key":"10.1016\/j.biocel.2011.01.001_bib0125","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1432-0436.2006.00138.x","article-title":"In-vitro reconstitution of three dimensional human salivary gland tissue structures","volume":"75","author":"Joraku","year":"2007","journal-title":"Differentiation"},{"key":"10.1016\/j.biocel.2011.01.001_bib0130","first-page":"271","article-title":"Post-irradiation sialadenitis. A study of the clinical features, histopathologic changes and serum enzyme variations following irradiation of human salivary glands","volume":"94","author":"Kashima","year":"1965","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"10.1016\/j.biocel.2011.01.001_bib0135","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.semcancer.2005.05.004","article-title":"Matrigel: basement membrane matrix with biological activity","volume":"15","author":"Kleinman","year":"2005","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0140","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/jcp.20247","article-title":"HSG cells differentiated by culture on extracellular matrix involves induction of s-adenosylmethione decarboxylase and ornithine decarboxylase","volume":"203","author":"Lam","year":"2005","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0145","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1369\/jhc.2008.951780","article-title":"Distribution of tight junction proteins in adult human salivary glands","volume":"56","author":"Maria","year":"2008","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.biocel.2011.01.001_bib0150","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/labinvest.3700234","article-title":"Expression of aquaporin-5 in and fluid secretion from immortalized human salivary gland ductal cells by treatment with 5-aza-2\u2032-deoxycytidine: a possibility for improvement of xerostomia in patients with Sjogren's syndrome","volume":"85","author":"Motegi","year":"2005","journal-title":"Lab Invest"},{"key":"10.1016\/j.biocel.2011.01.001_bib0155","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0079-6336(03)80001-3","article-title":"Immunocytochemistry of myoepithelial cells in the salivary glands","volume":"38","author":"Ogawa","year":"2003","journal-title":"Prog Histochem Cytochem"},{"key":"10.1016\/j.biocel.2011.01.001_bib0160","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF02628416","article-title":"Growth of exocrine acinar cells on a reconstituted basement membrane gel","volume":"23","author":"Oliver","year":"1987","journal-title":"In Vitro Cell Dev Biol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0165","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.0021-8782.2004.00332.x","article-title":"Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands","volume":"205","author":"Peppi","year":"2004","journal-title":"J Anat"},{"key":"10.1016\/j.biocel.2011.01.001_bib0170","first-page":"103","article-title":"Neoplasms, differentiations and mutations","volume":"77","author":"Pierce","year":"1974","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0175","series-title":"Biology of the Salivary Glands","first-page":"285","article-title":"Isolation and maintenance of submandibular gland cells","author":"Redman","year":"1993"},{"key":"10.1016\/j.biocel.2011.01.001_bib0180","series-title":"Peptide growth factors and their receptors. Part 1","first-page":"419","article-title":"The transforming growth factor-bs","author":"Roberts","year":"1990"},{"key":"10.1016\/j.biocel.2011.01.001_bib0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1432-0436.1993.tb00637.x","article-title":"Human neoplastic submandibular intercalated duct cells express an acinar phenotype when cultured on a basement membrane matrix","volume":"52","author":"Royce","year":"1993","journal-title":"Differentiation"},{"key":"10.1016\/j.biocel.2011.01.001_bib0190","first-page":"4453","article-title":"5-Azacytidine induction of stable myoepithelial and acinar cells from a human salivary intercalated duct cell clone","volume":"47","author":"Sato","year":"1987","journal-title":"Cancer Res"},{"key":"10.1016\/j.biocel.2011.01.001_bib0195","first-page":"3878","article-title":"Intermediate-sized filaments and specific markers in a human salivary gland adenocarcinoma cell line and its nude mouse tumors","volume":"45","author":"Sato","year":"1985","journal-title":"Cancer Res"},{"key":"10.1016\/j.biocel.2011.01.001_bib0200","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/1097-0142(19810801)48:3<745::AID-CNCR2820480314>3.0.CO;2-7","article-title":"A neoplastic epithelial duct cell line established from an irradiated human salivary gland","volume":"48","author":"Shirasuna","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.biocel.2011.01.001_bib0205","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/jcb.21404","article-title":"Matrigel-induced acinar differentiation is followed by apoptosis in HSG cells","volume":"103","author":"Szl\u00e1vik","year":"2008","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.biocel.2011.01.001_bib0210","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ar.1092300303","article-title":"Differential distribution of salivary agglutinin and amylase in the golgi apparatus and secretory granules of the human salivary gland acinar cells","volume":"230","author":"Takano","year":"1991","journal-title":"Anat Rec"},{"key":"10.1016\/j.biocel.2011.01.001_bib0215","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1089\/ten.2005.11.172","article-title":"Primary culture of polarized human salivary epithelial cells for use in developing an artificial salivary gland","volume":"11","author":"Tran","year":"2005","journal-title":"Tissue Eng"},{"key":"10.1016\/j.biocel.2011.01.001_bib0220","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1089\/ten.2006.12.2939","article-title":"Re-engineering primary epithelial cells from rhesus monkey parotid glands for use in developing an artificial salivary gland","volume":"12","author":"Tran","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1016\/j.biocel.2011.01.001_bib0225","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/jcp.21035","article-title":"Morphological and functional differentiation of HSG cells: role of extracellular matrix and trpc 1","volume":"212","author":"Vag","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.biocel.2011.01.001_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4827(92)90397-Q","article-title":"Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components","volume":"202","author":"Vukicevic","year":"1992","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.biocel.2011.01.001_bib0235","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1089\/ten.2006.0123","article-title":"Self-organization and branching morphogenesis of primary salivary epithelial cells","volume":"13","author":"Wei","year":"2007","journal-title":"Tissue Eng"},{"key":"10.1016\/j.biocel.2011.01.001_bib0240","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/1097-0142(19860301)57:5<1011::AID-CNCR2820570524>3.0.CO;2-X","article-title":"Effect of dibutyryl cyclic AMP on morphologic features and biologic markers of a human salivary gland adenocarcinoma cell line in culture","volume":"57","author":"Yoshida","year":"1986","journal-title":"Cancer"},{"key":"10.1016\/j.biocel.2011.01.001_bib0245","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/(SICI)1097-4652(199812)177:4<628::AID-JCP13>3.0.CO;2-L","article-title":"Growth factor regulation of the amylase promoter in a differentiating salivary acinar cell line","volume":"177","author":"Zheng","year":"1998","journal-title":"J Cell Physiol"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272511000021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272511000021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:42:57Z","timestamp":1761201777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272511000021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S1357272511000021"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2011.01.001","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Matrigel improves functional properties of human submandibular salivary gland cell line","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2011.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}