{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:41:05Z","timestamp":1789951265519,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.biocel.2011.06.001","type":"journal-article","created":{"date-parts":[[2011,6,20]],"date-time":"2011-06-20T05:56:07Z","timestamp":1308549367000},"page":"1373-1382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Reactive oxygen species participate in the p38-mediated apoptosis induced by potassium deprivation and staurosporine in cerebellar granule neurons"],"prefix":"10.1016","volume":"43","author":[{"given":"Yazm\u00edn","family":"Ramiro-Cort\u00e9s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Guemez-Gamboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Mor\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2011.06.001_bib0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.biocel.2011.06.001_bib0010","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/jnr.10493","article-title":"Caspase activation pathways induced by staurosporine and low potassium: role of caspase-2","volume":"71","author":"Caballero-Benitez","year":"2003","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.biocel.2011.06.001_bib0015","doi-asserted-by":"crossref","first-page":"35903","DOI":"10.1074\/jbc.M402353200","article-title":"Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death","volume":"279","author":"Cao","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0020","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.biocel.2008.10.029","article-title":"Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway","volume":"41","author":"Chen","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.biocel.2011.06.001_bib0025","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.freeradbiomed.2008.06.027","article-title":"Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons","volume":"45","author":"Coyoy","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.biocel.2011.06.001_bib0030","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neulet.2007.02.061","article-title":"Staurosporine-induced apoptosis in astrocytes is prevented by A1 adenosine receptor activation","volume":"418","author":"D\u2019Alimonte","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biocel.2011.06.001_bib0035","doi-asserted-by":"crossref","first-page":"10989","DOI":"10.1073\/pnas.90.23.10989","article-title":"Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP","volume":"90","author":"D\u2019Mello","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biocel.2011.06.001_bib0040","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1172\/JCI27544","article-title":"A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites","volume":"116","author":"Dang","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biocel.2011.06.001_bib0045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.biocel.2011.06.001_bib0050","doi-asserted-by":"crossref","first-page":"23431","DOI":"10.1016\/S0021-9258(17)31534-X","article-title":"The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases","volume":"269","author":"el Benna","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0055","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1023\/B:NEUR.0000021909.84327.e8","article-title":"Vitamin E affects cell death in adult rat dentate gyrus","volume":"32","author":"Ferri","year":"2003","journal-title":"J Neurocytol"},{"key":"10.1016\/j.biocel.2011.06.001_bib0060","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1111\/j.1471-4159.2007.04921.x","article-title":"Monoamine oxidase-A modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells","volume":"103","author":"Fitzgerald","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0065","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1523\/JNEUROSCI.07-07-02203.1987","article-title":"The role of depolarization in the survival and differentiation of cerebellar granule cells in culture","volume":"7","author":"Gallo","year":"1987","journal-title":"J Neurosci"},{"key":"10.1016\/j.biocel.2011.06.001_bib0070","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1126\/science.1067289","article-title":"MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha","volume":"295","author":"Ge","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.biocel.2011.06.001_bib0075","doi-asserted-by":"crossref","first-page":"15434","DOI":"10.1073\/pnas.2535024100","article-title":"An efficient proteomics method to identify the cellular targets of protein kinase inhibitors","volume":"100","author":"Godl","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biocel.2011.06.001_bib0080","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1124\/mol.106.030718","article-title":"Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate","volume":"71","author":"Gomez-Lazaro","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biocel.2011.06.001_bib0085","doi-asserted-by":"crossref","first-page":"17477","DOI":"10.1074\/jbc.273.28.17477","article-title":"Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction","volume":"273","author":"Gotoh","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0090","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0896-6273(95)90287-2","article-title":"Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death","volume":"14","author":"Greenlund","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.biocel.2011.06.001_bib0095","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1002\/jnr.22079","article-title":"NOX2 mediates apoptotic death induced by staurosporine but not by potassium deprivation in cerebellar granule neurons","volume":"87","author":"Guemez-Gamboa","year":"2009","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.biocel.2011.06.001_bib0100","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1254\/jjp.79.369","article-title":"An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons","volume":"79","author":"Harada","year":"1999","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.biocel.2011.06.001_bib0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.taap.2009.02.014","article-title":"Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells","volume":"237","author":"Hong","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.biocel.2011.06.001_bib0110","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1046\/j.1471-4159.2002.01023.x","article-title":"Inhibition of oxidative stress produced by plasma membrane NADH oxidase delays low-potassium-induced apoptosis of cerebellar granule cells","volume":"82","author":"Martin-Romero","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0115","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0165-3806(89)90146-6","article-title":"Effect of potassium depolarization on phosphate-activated glutaminase activity in primary cultures of cerebellar granule neurons and astroglial cells during development","volume":"46","author":"Moran","year":"1989","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.biocel.2011.06.001_bib0120","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1046\/j.1471-4159.1999.0730568.x","article-title":"Caspase-3 expression by cerebellar granule neurons is regulated by calcium and cyclic AMP","volume":"73","author":"Moran","year":"1999","journal-title":"J Neurochem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.febslet.2004.07.031","article-title":"Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2","volume":"572","author":"Morton","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biocel.2011.06.001_bib0130","first-page":"173","article-title":"Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons","volume":"6","author":"Nath","year":"2001","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.biocel.2011.06.001_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0898-6568(99)00071-6","article-title":"The p38 signal transduction pathway: activation and function","volume":"12","author":"Ono","year":"2000","journal-title":"Cell Signal"},{"key":"10.1016\/j.biocel.2011.06.001_bib0140","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1091\/mbc.e03-08-0592","article-title":"P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli","volume":"15","author":"Porras","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.biocel.2011.06.001_bib0145","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/bj20031587","article-title":"Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1","volume":"378","author":"Qadri","year":"2004","journal-title":"Biochem J"},{"key":"10.1016\/j.biocel.2011.06.001_bib0150","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/sj.onc.1210392","article-title":"Differential regulation and properties of MAPKs","volume":"26","author":"Raman","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.biocel.2011.06.001_bib0155","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1038\/sj.emboj.7601668","article-title":"TAO kinases mediate activation of p38 in response to DNA damage","volume":"26","author":"Raman","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.biocel.2011.06.001_bib0160","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.neuint.2009.05.015","article-title":"Role of oxidative stress and JNK pathway in apoptotic death induced by potassium deprivation and staurosporine in cerebellar granule neurons","volume":"55","author":"Ramiro-Cortes","year":"2009","journal-title":"Neurochem Int"},{"key":"10.1016\/j.biocel.2011.06.001_bib0165","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-5793(00)01588-X","article-title":"Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1","volume":"474","author":"Sakurai","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biocel.2011.06.001_bib0170","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ni1177","article-title":"Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases","volume":"6","author":"Salvador","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.biocel.2011.06.001_bib0175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.freeradbiomed.2004.04.002","article-title":"Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis","volume":"37","author":"Samhan-Arias","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.biocel.2011.06.001_bib0180","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1523\/JNEUROSCI.16-15-04696.1996","article-title":"Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species","volume":"16","author":"Schulz","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.biocel.2011.06.001_bib0185","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1046\/j.1365-2443.2002.00591.x","article-title":"Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system","volume":"7","author":"Takeda","year":"2002","journal-title":"Genes Cells"},{"key":"10.1016\/j.biocel.2011.06.001_bib0190","doi-asserted-by":"crossref","first-page":"RC53","DOI":"10.1523\/JNEUROSCI.20-01-j0006.2000","article-title":"NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons","volume":"20","author":"Tammariello","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.biocel.2011.06.001_bib0195","doi-asserted-by":"crossref","first-page":"17907","DOI":"10.1074\/jbc.272.29.17907","article-title":"A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis","volume":"272","author":"Thornberry","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0200","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/embo-reports\/kve046","article-title":"ASK1 is required for sustained activations of JNK\/p38 MAP kinases and apoptosis","volume":"2","author":"Tobiume","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.biocel.2011.06.001_bib0205","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/jnr.1077","article-title":"Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule neurons","volume":"64","author":"Valencia","year":"2001","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.biocel.2011.06.001_bib0210","doi-asserted-by":"crossref","first-page":"5676","DOI":"10.1074\/jbc.M008787200","article-title":"The kinetic mechanism of the dual phosphorylation of the ATF2 transcription factor by p38 mitogen-activated protein (MAP) kinase alpha. Implications for signal\/response profiles of MAP kinase pathways","volume":"276","author":"Waas","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0215","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/jnr.10597","article-title":"Oxidative neurotoxicity in rat cerebral cortex neurons: synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3","volume":"72","author":"Wang","year":"2003","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.biocel.2011.06.001_bib0220","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1074\/jbc.M007258200","article-title":"p38 mitogen-activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons","volume":"276","author":"Yamagishi","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0230","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.cr.7290257","article-title":"Activation and signaling of the p38 MAP kinase pathway","volume":"15","author":"Zarubin","year":"2005","journal-title":"Cell Res"},{"key":"10.1016\/j.biocel.2011.06.001_bib0235","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1111\/j.1471-4159.2007.04906.x","article-title":"Superoxide dismutase\/catalase mimetics but not MAP kinase inhibitors are neuroprotective against oxygen\/glucose deprivation-induced neuronal death in hippocampus","volume":"103","author":"Zhou","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.biocel.2011.06.001_bib0240","doi-asserted-by":"crossref","first-page":"25939","DOI":"10.1074\/jbc.M001185200","article-title":"p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide","volume":"275","author":"Zhuang","year":"2000","journal-title":"J Biol Chem"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272511001646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272511001646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:43:36Z","timestamp":1761201816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272511001646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S1357272511001646"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2011.06.001","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reactive oxygen species participate in the p38-mediated apoptosis induced by potassium deprivation and staurosporine in cerebellar granule neurons","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2011.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}