{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:27:56Z","timestamp":1791278876604,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.biocel.2012.03.006","type":"journal-article","created":{"date-parts":[[2012,3,17]],"date-time":"2012-03-17T11:01:13Z","timestamp":1331982073000},"page":"980-988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function"],"prefix":"10.1016","volume":"44","author":[{"given":"Arnaud","family":"Chevrollier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Cassereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ferr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Alban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Desquiret-Dumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00efg","family":"Gueguen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Amati-Bonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Procaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Bonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Reynier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2012.03.006_bib0005","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/ana.20681","article-title":"Opa1 R445H mutation in optic atrophy associated with sensorineural deafness","volume":"58","author":"Amati-Bonneau","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0010","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/brain\/awm298","article-title":"Opa1 mutations induce mitochondrial dna instability and optic atrophy \u2018Plus\u2019 phenotypes","volume":"131","author":"Amati-Bonneau","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.biocel.2012.03.006_bib0015","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.biocel.2009.04.012","article-title":"Opa1-associated disorders: phenotypes and pathophysiology","volume":"41","author":"Amati-Bonneau","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.expneurol.2008.01.010","article-title":"Mitochondrial fusion and function in Charcot-Marie-Tooth Type 2a patient fibroblasts with mitofusin 2 mutations","volume":"211","author":"Amiott","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0025","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1242\/jcs.03381","article-title":"Mitochondrial bioenergetics and structural network organization","volume":"120","author":"Benard","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2012.03.006_bib0030","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1089\/ars.2007.2000","article-title":"Ultrastructure of the mitochondrion and its bearing on function and bioenergetics","volume":"10","author":"Benard","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.biocel.2012.03.006_bib0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.expneurol.2010.09.006","article-title":"Mitochondrial dysfunction and pathophysiology of Charcot-Marie-Tooth disease involving Gdap1 mutations","volume":"227","author":"Cassereau","year":"2011","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0040","first-page":"97","article-title":"Une Forme Particuli\u00e8re D\u2018atrophie Musculaire Progressive, Souvent Familiale D\u00e9butant Par Les Pieds Et Les Jambes Et Atteignant Plus Tard Les Mains","volume":"6","author":"Charcot","year":"1886","journal-title":"Rev Med"},{"key":"10.1016\/j.biocel.2012.03.006_bib0045","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","article-title":"Mitochondrial dynamics \u2013 fusion, fission, movement, and mitophagy \u2013 in neurodegenerative diseases","volume":"18","author":"Chen","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biocel.2012.03.006_bib0050","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-Nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.biocel.2012.03.006_bib0055","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/jmg.2004.022178","article-title":"Genetics of Charcot-Marie-Tooth disease type 4a: mutations, inheritance, phenotypic variability, and founder effect","volume":"42","author":"Claramunt","year":"2005","journal-title":"J Med Genet"},{"key":"10.1016\/j.biocel.2012.03.006_bib0060","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/emboj\/21.7.1616","article-title":"Mitochondria are morphologically and functionally heterogeneous within cells","volume":"21","author":"Collins","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.biocel.2012.03.006_bib0065","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nrm2275","article-title":"Functions and dysfunctions of mitochondrial dynamics","volume":"8","author":"Detmer","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0070","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1101\/gr.108696.110","article-title":"Opa1 links human mitochondrial genome maintenance to mtDNA replication and distribution","volume":"21","author":"Elachouri","year":"2011","journal-title":"Genome Res"},{"key":"10.1016\/j.biocel.2012.03.006_bib0075","doi-asserted-by":"crossref","first-page":"E692","DOI":"10.1002\/humu.21025","article-title":"Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations","volume":"30","author":"Ferr\u00e9","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1016\/j.biocel.2012.03.006_bib0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2337\/diab.45.2.113","article-title":"Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit","volume":"45","author":"Gerbitz","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.biocel.2012.03.006_bib0085","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cell.2008.01.007","article-title":"Mitochondria \u2013 a Nexus for aging, calorie restriction, and sirtuins","volume":"132","author":"Guarente","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2012.03.006_bib0090","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/bj20040095","article-title":"Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts","volume":"380","author":"Hutter","year":"2004","journal-title":"Biochem J"},{"key":"10.1016\/j.biocel.2012.03.006_bib0095","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1242\/jcs.114.2.281","article-title":"Opposite effects of microtubule-stabilizing and microtubule-destabilizing drugs on biogenesis of mitochondria in mammalian cells","volume":"114","author":"Karbowski","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2012.03.006_bib0100","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.200309082","article-title":"Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the bax activation phase of apoptosis","volume":"164","author":"Karbowski","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.a.20198","article-title":"Simultaneous quantitative measurement and automated analysis of mitochondrial morphology, mass, potential, and motility in living human skin fibroblasts","volume":"69","author":"Koopman","year":"2006","journal-title":"Cytometry A"},{"key":"10.1016\/j.biocel.2012.03.006_bib0110","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrn2417","article-title":"Mitochondrial fragmentation in neurodegeneration","volume":"9","author":"Knott","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biocel.2012.03.006_bib0115","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.biocel.2009.03.007","article-title":"The Cell-type specificity of mitochondrial dynamics","volume":"41","author":"Kuznetsov","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0120","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/ana.21086","article-title":"Mitochondrial coupling defect in Charcot-Marie-Tooth Type 2a disease","volume":"61","author":"Loiseau","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0125","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1242\/jcs.03443","article-title":"A cell biological perspective on mitochondrial dysfunction in parkinson disease and other neurodegenerative diseases","volume":"120","author":"Mandemakers","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2012.03.006_bib0130","first-page":"21","article-title":"Analysis of mitochondrial dynamics and functions using imaging approaches","volume":"25","author":"Mitra","year":"2010","journal-title":"Curr Protoc Cell Biol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0135","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1073\/pnas.0904875106","article-title":"A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase","volume":"106","author":"Mitra","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biocel.2012.03.006_bib0140","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ophtha.2005.10.054","article-title":"Novel mutations in the OPA1 gene and associated clinical features in japanese patients with optic atrophy","volume":"113","author":"Nakamura","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.biocel.2012.03.006_bib0145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1757-5036-3-4","article-title":"Two-color sted microscopy reveals different degrees of colocalization between hexokinase-I and the three human VDAC isoforms","volume":"3","author":"Neumann","year":"2010","journal-title":"PMC Biophys"},{"key":"10.1016\/j.biocel.2012.03.006_bib0150","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1468-1331.2006.01688.x","article-title":"Mitofusin 2 gene mutation (R94q) causing severe early-onset axonal polyneuropathy (CMT2A)","volume":"14","author":"Neusch","year":"2007","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0155","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nbd.2009.09.011","article-title":"Gdap1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance","volume":"36","author":"Niemann","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.biocel.2012.03.006_bib0160","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/jcp.20950","article-title":"Effects of OPA1 mutations on mitochondrial morphology and apoptosis: relevance to Adoa pathogenesis","volume":"211","author":"Olichon","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0165","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.bbabio.2008.04.002","article-title":"Mitochondrial oxidative phosphorylation and energetic status are reflected by morphology of mitochondrial network in Ins-1e and Hep-G2 cells viewed by 4pi microscopy","volume":"1777","author":"Plecita-Hlavata","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biocel.2012.03.006_bib0170","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1242\/jcs.115.8.1663","article-title":"Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane Gtpase Fzo","volume":"115","author":"Rojo","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2012.03.006_bib0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/brain\/awr323","article-title":"The Mfn2 gene is responsible for mitochondrial dna instability and optic atrophy \u2018Plus\u2019 phenotype","volume":"135","author":"Rouzier","year":"2012","journal-title":"Brain J Neurol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0180","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cell.2007.12.033","article-title":"Visualizing spatiotemporal dynamics of multicellular cell-cycle progression","volume":"132","author":"Sakaue-Sawano","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2012.03.006_bib0185","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/jcs.114.5.867","article-title":"Control of mitochondrial morphology by a human mitofusin","volume":"114","author":"Santel","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biocel.2012.03.006_bib0190","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.semcdb.2009.12.006","article-title":"Energetic requirements and bioenergetic modulation of mitochondrial morphology and dynamics","volume":"21","author":"Sauvanet","year":"2010","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0195","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(06)68970-8","article-title":"Mitochondrial disease","volume":"368","author":"Schapira","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.biocel.2012.03.006_bib0200","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nmeth.1462","article-title":"Probabilistic density maps to study global endomembrane organization","volume":"7","author":"Schauer","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.biocel.2012.03.006_bib0205","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.cub.2009.05.065","article-title":"Par3 and Dynein associate to regulate local microtubule dynamics and centrosome orientation during migration","volume":"19","author":"Schmoranzer","year":"2009","journal-title":"Curr Biol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0210","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nm.2313","article-title":"Mutant huntingtin binds the mitochondrial fission gtpase dynamin-related protein-1 and increases its enzymatic activity","volume":"17","author":"Song","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.biocel.2012.03.006_bib0215","doi-asserted-by":"crossref","first-page":"19771","DOI":"10.1073\/pnas.0609267103","article-title":"Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity","volume":"103","author":"Thery","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biocel.2012.03.006_bib0220","doi-asserted-by":"crossref","first-page":"C477","DOI":"10.1152\/ajpcell.00427.2009","article-title":"Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity","volume":"299","author":"Twig","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0225","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1093\/brain\/awl126","article-title":"Mfn2 mutation distribution and genotype\/phenotype correlation in Charcot-Marie-Tooth Type 2","volume":"129","author":"Verhoeven","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.biocel.2012.03.006_bib0230","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/archopht.116.3.351","article-title":"Clinical features in affected individuals from 21 pedigrees with dominant optic atrophy","volume":"116","author":"Votruba","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0235","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1056\/NEJMoa064436","article-title":"A lethal defect of mitochondrial and peroxisomal fission","volume":"356","author":"Waterham","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biocel.2012.03.006_bib0240","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrm3013","article-title":"Mitochondrial fusion and fission in cell life and death","volume":"11","author":"Westermann","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.biocel.2012.03.006_bib0245","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1073\/pnas.0913485107","article-title":"Drosophila Parkin requires Pink1 for mitochondrial translocation and ubiquitinates mitofusin","volume":"107","author":"Ziviani","year":"2010","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512000970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512000970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:46:30Z","timestamp":1761201990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272512000970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S1357272512000970"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2012.03.006","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2012.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}