{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:57:36Z","timestamp":1777510656307,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["RO2495\/1-3"],"award-info":[{"award-number":["RO2495\/1-3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.biocel.2012.04.018","type":"journal-article","created":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T15:24:42Z","timestamp":1335626682000},"page":"1254-1265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP\/PKA\/CREB pathway via regulation of Rab11b expression"],"prefix":"10.1016","volume":"44","author":[{"given":"Oliver","family":"Oehlke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius","family":"Schlosshardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Feuerstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Roussa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2012.04.018_bib0005","doi-asserted-by":"crossref","first-page":"24676","DOI":"10.1074\/jbc.M110.106278","article-title":"Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase","volume":"285","author":"Alzamora","year":"2010","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.04.018_bib0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ceb.2007.02.011","article-title":"A-kinase anchoring proteins take shape","volume":"19","author":"Beene","year":"2007","journal-title":"Current Opinion in Cell Biology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0020","first-page":"R2400","article-title":"Adaptive redistribution of NBCe1-A and NBCe1-B in rat kidney proximal tubule and striated ducts of salivary glands during acid\u2013base disturbances","volume":"293","author":"Brandes","year":"2007","journal-title":"American Journal of Physiology: Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0025","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nm0496-470","article-title":"Acidification of the male reproductive tract by a proton pumping H+ ATPase","volume":"2","author":"Breton","year":"1996","journal-title":"Nature Medicine"},{"key":"10.1016\/j.biocel.2012.04.018_bib0030","doi-asserted-by":"crossref","first-page":"24965","DOI":"10.1074\/jbc.M109.037135","article-title":"cAMP stimulates apical exocytosis of the renal Na+\/K+\/2Cl\u2212 cotransporter NKCC2 in the thick ascending limb","volume":"284","author":"Caceres","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.04.018_bib0035","doi-asserted-by":"crossref","first-page":"28011","DOI":"10.1074\/jbc.M605865200","article-title":"c-Src control of chloride channel transport for osteoclast HCl transport and bone resorption","volume":"281","author":"Edwards","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.04.018_bib0040","doi-asserted-by":"crossref","first-page":"9042","DOI":"10.1074\/jbc.M607041200","article-title":"Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+\/HCO3\u2212 cotransporter","volume":"282","author":"Gawenis","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.04.018_bib0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0002-9440(10)62969-0","article-title":"c-Fos-dependent induction of the small Ras-related GTPase Rab11a in skin carcinogenesis","volume":"167","author":"Gebhardt","year":"2005","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0050","doi-asserted-by":"crossref","first-page":"F1162","DOI":"10.1152\/ajprenal.00645.2009","article-title":"Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase","volume":"298","author":"Gong","year":"2010","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0055","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(89)90013-5","article-title":"Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133","volume":"59","author":"Gonzalez","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2012.04.018_bib0060","doi-asserted-by":"crossref","first-page":"C672","DOI":"10.1152\/ajpcell.00004.2009","article-title":"AMP-activated protein kinase inhibits alkaline pH and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells","volume":"296","author":"Hallows","year":"2009","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0065","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1681\/ASN.2004080667","article-title":"Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities","volume":"16","author":"Horita","year":"2005","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0070","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/70563","article-title":"Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification","volume":"23","author":"Li","year":"1999","journal-title":"Nature Genetics"},{"key":"10.1016\/j.biocel.2012.04.018_bib0075","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1111\/j.1462-5822.2007.00925.x","article-title":"The JNK\/AP-1 pathway regulates expression of the recycling endosome rab11a gene in B cells transformed with Theileria","volume":"9","author":"Lizundia","year":"2007","journal-title":"Cellular Microbiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0080","doi-asserted-by":"crossref","first-page":"F223","DOI":"10.1152\/ajprenal.00179.2003","article-title":"Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2","volume":"286","author":"Lu","year":"2004","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0085","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","article-title":"Transcriptional regulation of the phosphorylation-dependent factor CREB","volume":"2","author":"Mayr","year":"2001","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0090","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nrm729","article-title":"The vacuolar [H+]-ATPases: nature's most versatile proton pumps","volume":"3","author":"Nishi","year":"2002","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0095","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/jcp.22388","article-title":"Rab11b and its effector Rip11 mediate the acidosis-induced V-ATPase trafficking in salivary ducts","volume":"226","author":"Oehlke","year":"2011","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0100","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1242\/jcs.01009","article-title":"Ganglioside GM1 levels are a determinant of the extent of caveolae\/raft-dependent endocytosis of cholera toxin to the Golgi apparatus","volume":"117","author":"Pang","year":"2004","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2012.04.018_bib0105","doi-asserted-by":"crossref","first-page":"C488","DOI":"10.1152\/ajpcell.00537.2007","article-title":"Alkaline pH and c-AMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells","volume":"294","author":"Pastor-Soler","year":"2008","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0110","doi-asserted-by":"crossref","first-page":"F643","DOI":"10.1152\/ajprenal.00584.2009","article-title":"cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells","volume":"298","author":"Paunescu","year":"2010","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0115","doi-asserted-by":"crossref","first-page":"C1409","DOI":"10.1152\/ajpcell.00028.2009","article-title":"Grichtchenko II. PKC \u03b1, \u03b2, \u03b3 and PKC\u03b4-dependent endocytosis of NBCe1-A and NBCe1-B in salivary parotid acinar cells","volume":"297","author":"Perry","year":"2009","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0120","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1172\/JCI113750","article-title":"Chronic metabolic acidosis causes an adaptation in the apical membrane Na\/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule","volume":"82","author":"Preisig","year":"1988","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.biocel.2012.04.018_bib0125","doi-asserted-by":"crossref","first-page":"e322445","DOI":"10.1371\/journal.pone.0022445","article-title":"Acidic environment leads to ROS-induced MAPK signaling in cancer cells","volume":"6","author":"Riemann","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biocel.2012.04.018_bib0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/002215549804600112","article-title":"Immunolocalization of vacuolar type H+-ATPase in rat submandibular gland and adaptive changes induced by acid\u2013base disturbances","volume":"46","author":"Roussa","year":"1998","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"10.1016\/j.biocel.2012.04.018_bib0135","doi-asserted-by":"crossref","first-page":"F580","DOI":"10.1152\/ajprenal.1999.277.4.F580","article-title":"Regulation of the renal Na-HCO3- cotransporter. XI Signal transduction underlying CO2 stimulation","volume":"277","author":"Ruiz","year":"1999","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0140","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/ki.1997.16","article-title":"Regulation of AE1 anion exchanger and H+-ATPase in rat cortex by acute metabolic acidosis and alkalosis","volume":"51","author":"Sabolic","year":"1997","journal-title":"Kidney International"},{"key":"10.1016\/j.biocel.2012.04.018_bib0145","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/MCB.25.2.575-589.2005","article-title":"Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells","volume":"25","author":"Sautin","year":"2005","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0150","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/1097-0142(19810801)48:3<745::AID-CNCR2820480314>3.0.CO;2-7","article-title":"A neoplastic epithelial duct cell line established from an irradiated human salivary gland","volume":"48","author":"Shirasuna","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.biocel.2012.04.018_bib0155","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/1471-2474-11-250","article-title":"Screening of protein kinase inhibitors of osteoclastic acid secretion and bone resorption","volume":"11","author":"Sorensen","year":"2010","journal-title":"BMC Musculoskeletal Disorders"},{"key":"10.1016\/j.biocel.2012.04.018_bib0160","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.biocel.2012.04.018_bib0165","doi-asserted-by":"crossref","first-page":"C130","DOI":"10.1152\/ajpcell.1992.263.1.C130","article-title":"Protein kinase C affects microfilaments, bone resorption, and [Ca2+]o sensing in cultured osteoclasts","volume":"263","author":"Teti","year":"1992","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0170","doi-asserted-by":"crossref","first-page":"22023","DOI":"10.1074\/jbc.M302436200","article-title":"From lysosomes to the plasma membrane: localization of vacuolar-type H+-ATPase with the a3 isoform during osteoclast differentiation","volume":"278","author":"Toyomura","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.04.018_bib0175","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1523-1755.2002.00418.x","article-title":"Role of c-SRC and ERK in acid-induced activation of NHE3","volume":"62","author":"Tsuganezawa","year":"2002","journal-title":"Kidney International"},{"key":"10.1016\/j.biocel.2012.04.018_bib0180","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1152\/physrev.00045.2003","article-title":"Renal vacuolar H+-ATPase","volume":"84","author":"Wagner","year":"2004","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.biocel.2012.04.018_bib0185","doi-asserted-by":"crossref","first-page":"32749","DOI":"10.1074\/jbc.271.51.32749","article-title":"Role of NHE3 in mediating renal brush border Na+\u2013H+ exchange. Adaptation to metabolic acidosis","volume":"271","author":"Wu","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.04.018_bib0190","doi-asserted-by":"crossref","first-page":"6274","DOI":"10.1073\/pnas.92.14.6274","article-title":"Overexpression of csk inhibits acid-induced activation of NHE3","volume":"92","author":"Yamaji","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States"},{"key":"10.1016\/j.biocel.2012.04.018_bib0195","doi-asserted-by":"crossref","first-page":"C886","DOI":"10.1152\/ajpcell.1997.272.3.C886","article-title":"Intracellular acidosis activates c-Src","volume":"272","author":"Yamaji","year":"1997","journal-title":"American Journal of Physiology: Cell Physiology"},{"key":"10.1016\/j.biocel.2012.04.018_bib0200","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1073\/pnas.0501076102","article-title":"Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues","volume":"102","author":"Zhang","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United"},{"key":"10.1016\/j.biocel.2012.04.018_bib0205","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1267\/ahc.07002","article-title":"Quantitative co-localization analysis of multicolor immunofluorescence microscopic images: pushing pixels to explore biological phenomena","volume":"40","author":"Zinchuk","year":"2007","journal-title":"Acta Histochemistry and Cytochemistry"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512001434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512001434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:45:33Z","timestamp":1761201933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272512001434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1357272512001434"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2012.04.018","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP\/PKA\/CREB pathway via regulation of Rab11b expression","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2012.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}