{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:18:33Z","timestamp":1790965113001,"version":"4.1.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.biocel.2012.06.013","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T11:13:45Z","timestamp":1340018025000},"page":"1519-1530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Neuromyelitis optica: Aquaporin-4 based pathogenesis mechanisms and new therapies"],"prefix":"10.1016","volume":"44","author":[{"given":"Julien","family":"Ratelade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Verkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2012.06.013_bib0005","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1212\/01.WNL.0000115168.73299.88","article-title":"Devic disease and thymoma with anti-central nervous system and antithymus antibodies","volume":"62","author":"Antoine","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0010","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1096\/fj.06-6848com","article-title":"Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury","volume":"21","author":"Auguste","year":"2007","journal-title":"FASEB Journal"},{"key":"10.1016\/j.biocel.2012.06.013_bib0015","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1007\/s00415-010-5706-1","article-title":"The clinical spectrum of late-onset Alexander disease: a systematic literature review","volume":"257","author":"Balbi","year":"2010","journal-title":"Journal of Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0020","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/ana.21802","article-title":"Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica","volume":"66","author":"Bennett","year":"2009","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0025","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/glia.20318","article-title":"Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels","volume":"53","author":"Binder","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.biocel.2012.06.013_bib0030","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/sj.jcbfm.9600306","article-title":"Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice","volume":"26","author":"Bloch","year":"2006","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.biocel.2012.06.013_bib0035","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1471-4159.2005.03362.x","article-title":"Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess","volume":"95","author":"Bloch","year":"2005","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0040","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ana.21837","article-title":"Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo","volume":"66","author":"Bradl","year":"2009","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/immu.1994.1004","article-title":"Heterogeneity of human IgG Fc receptors","volume":"4","author":"Capel","year":"1994","journal-title":"Immunomethods"},{"key":"10.1016\/j.biocel.2012.06.013_bib0050","doi-asserted-by":"crossref","first-page":"35850","DOI":"10.1074\/jbc.M109.071670","article-title":"Live cell analysis of aquaporin-4 M1\/M23 interactions and regulated orthogonal array assembly in glial cells","volume":"284","author":"Crane","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0055","doi-asserted-by":"crossref","first-page":"16516","DOI":"10.1074\/jbc.M111.227298","article-title":"Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1\/M23 isoforms and orthogonal arrays","volume":"286","author":"Crane","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jneuroim.2011.05.001","article-title":"Orthogonal array formation by human aquaporin-4: Examination of neuromyelitis optica-associated aquaporin-4 polymorphisms","volume":"236","author":"Crane","year":"2011","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0065","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1091\/mbc.e08-03-0322","article-title":"Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking","volume":"19","author":"Crane","year":"2008","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.biocel.2012.06.013_bib0070","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1242\/jcs.042341","article-title":"Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging","volume":"122","author":"Crane","year":"2009","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2012.06.013_bib0075","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1016\/j.bpj.2009.09.017","article-title":"Reversible, temperature-dependent supramolecular assembly of aquaporin-4 orthogonal arrays in live cell membranes","volume":"97","author":"Crane","year":"2009","journal-title":"Biophysical Journal"},{"key":"10.1016\/j.biocel.2012.06.013_bib0080","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/jnnp.2006.097972","article-title":"Devic's syndrome-like phenotype associated with thymoma and anti-CV2\/CRMP5 antibodies","volume":"78","author":"Ducray","year":"2007","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0085","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jneuroim.2010.10.012","article-title":"Neuromyelitis optica: concepts in evolution","volume":"231","author":"Fazio","year":"2011","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0090","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1073\/pnas.92.10.4328","article-title":"Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes","volume":"92","author":"Frigeri","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.06.013_bib0095","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1242\/jcs.108.9.2993","article-title":"Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues","volume":"108","author":"Frigeri","year":"1995","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2012.06.013_bib0100","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0959-440X(02)00355-X","article-title":"Structure and function of water channels","volume":"12","author":"Fujiyoshi","year":"2002","journal-title":"Current Opinion in Structural Biology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0105","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1038\/jid.2008.70","article-title":"Roles of aquaporin-3 in the epidermis","volume":"128","author":"Hara-Chikuma","year":"2008","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0110","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1016\/S0021-9258(17)37486-0","article-title":"Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues","volume":"269","author":"Hasegawa","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0115","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1001\/archneurol.2009.188","article-title":"Prediction of neuromyelitis optica attack severity by quantitation of complement-mediated injury to aquaporin-4-expressing cells","volume":"66","author":"Hinson","year":"2009","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0120","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1212\/01.WNL.0000289761.64862.ce","article-title":"Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica","volume":"69","author":"Hinson","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0125","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1084\/jem.20081241","article-title":"Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2","volume":"205","author":"Hinson","year":"2008","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.biocel.2012.06.013_bib0130","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1073\/pnas.1109980108","article-title":"Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes","volume":"109","author":"Hinson","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.06.013_bib0135","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1073\/pnas.0902725106","article-title":"Crystal structure of human aquaporin 4 at 1.8A and its mechanism of conductance","volume":"106","author":"Ho","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.06.013_bib0140","unstructured":"Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, et al. Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica. Multiple Sclerosis, in press."},{"key":"10.1016\/j.biocel.2012.06.013_bib0145","first-page":"383","article-title":"AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance","volume":"6","author":"Jarius","year":"2010","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.biocel.2012.06.013_bib0150","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1016\/j.bpj.2011.05.012","article-title":"Model of aquaporin-4 supramolecular assembly in orthogonal arrays based on heterotetrameric association of M1\u2013M23 isoforms","volume":"100","author":"Jin","year":"2011","journal-title":"Biophysical Journal"},{"key":"10.1016\/j.biocel.2012.06.013_bib0155","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1001\/archneurol.2010.269","article-title":"Quantification and functional characterization of antibodies to native aquaporin 4 in neuromyelitis optica","volume":"67","author":"Kalluri","year":"2010","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0160","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbrc.2009.06.085","article-title":"Neuromyelitis optica: passive transfer to rats by human immunoglobulin","volume":"386","author":"Kinoshita","year":"2009","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.biocel.2012.06.013_bib0165","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbrc.2010.02.157","article-title":"Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells","volume":"394","author":"Kinoshita","year":"2010","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.biocel.2012.06.013_bib0170","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1083\/jcb.60.1.316","article-title":"Arrays of particles in freeze-fractured astrocytic membranes","volume":"60","author":"Landis","year":"1974","journal-title":"Journal of Cell Biology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0175","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1084\/jem.20050304","article-title":"IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel","volume":"202","author":"Lennon","year":"2005","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.biocel.2012.06.013_bib0180","first-page":"573","article-title":"Mildly abnormal retinal function in transgenic mice without Muller cell aquaporin-4 water channels","volume":"43","author":"Li","year":"2002","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1016\/j.biocel.2012.06.013_bib0185","doi-asserted-by":"crossref","first-page":"31233","DOI":"10.1074\/jbc.M104368200","article-title":"Impaired hearing in mice lacking aquaporin-4 water channels","volume":"276","author":"Li","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0190","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1096\/fj.10-177279","article-title":"Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation","volume":"25","author":"Li","year":"2011","journal-title":"FASEB Journal"},{"key":"10.1016\/j.biocel.2012.06.013_bib0195","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1096\/fj.07-104836","article-title":"Impaired olfaction in mice lacking aquaporin-4 water channels","volume":"22","author":"Lu","year":"2008","journal-title":"FASEB Journal"},{"key":"10.1016\/j.biocel.2012.06.013_bib0200","doi-asserted-by":"crossref","first-page":"10908","DOI":"10.1073\/pnas.93.20.10908","article-title":"The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain","volume":"93","author":"Lu","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.06.013_bib0205","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/72256","article-title":"Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke","volume":"6","author":"Manley","year":"2000","journal-title":"Nature Medicine"},{"key":"10.1016\/j.biocel.2012.06.013_bib0210","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1093\/brain\/awq177","article-title":"Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury","volume":"133","author":"Marignier","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.biocel.2012.06.013_bib0215","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1212\/WNL.0b013e3181ea9f15","article-title":"Familial neuromyelitis optica","volume":"75","author":"Matiello","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0220","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1212\/WNL.0b013e31822f045b","article-title":"Genetic analysis of aquaporin-4 in neuromyelitis optica","volume":"77","author":"Matiello","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0225","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/jnr.22822","article-title":"Neuromyelitis optica immunoglobulin G present in sera from neuromyelitis optica patients affects aquaporin-4 expression and water permeability of the astrocyte plasma membrane","volume":"90","author":"Melamud","year":"2012","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.biocel.2012.06.013_bib0230","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/brain\/awm047","article-title":"Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis","volume":"130","author":"Misu","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.biocel.2012.06.013_bib0235","doi-asserted-by":"crossref","first-page":"11156","DOI":"10.1021\/bi990941s","article-title":"Heterotetrameric composition of aquaporin-4 water channels","volume":"38","author":"Neely","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0240","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/glia.20855","article-title":"Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies","volume":"57","author":"Nicchia","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.biocel.2012.06.013_bib0245","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1523\/JNEUROSCI.17-01-00171.1997","article-title":"Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain","volume":"17","author":"Nielsen","year":"1997","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.biocel.2012.06.013_bib0250","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.tins.2006.08.004","article-title":"Astrocytic complexity distinguishes the human brain","volume":"29","author":"Oberheim","year":"2006","journal-title":"Trends in Neuroscience"},{"key":"10.1016\/j.biocel.2012.06.013_bib0255","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1096\/fj.04-1723fje","article-title":"Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema","volume":"18","author":"Papadopoulos","year":"2004","journal-title":"FASEB Journal"},{"key":"10.1016\/j.biocel.2012.06.013_bib0260","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1074\/jbc.M112.344325","article-title":"Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 assembly in orthogonal arrays","volume":"287","author":"Phuan","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0265","doi-asserted-by":"crossref","first-page":"9216","DOI":"10.1074\/jbc.M110.123000","article-title":"Identification of two major conformational aquaporin-4 epitopes for neuromyelitis optica autoantibody binding","volume":"286","author":"Pisani","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0270","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/archneur.65.5.629","article-title":"Aquaporin-4 autoantibodies in a paraneoplastic context","volume":"65","author":"Pittock","year":"2008","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0275","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-4827(74)90670-3","article-title":"Rectangular arrays of particles on freeze-cleaved plasma membranes are not gap junctions","volume":"86","author":"Rash","year":"1974","journal-title":"Experimental Cell Research"},{"key":"10.1016\/j.biocel.2012.06.013_bib0280","doi-asserted-by":"crossref","first-page":"11981","DOI":"10.1073\/pnas.95.20.11981","article-title":"Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord","volume":"95","author":"Rash","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.06.013_bib0285","doi-asserted-by":"crossref","first-page":"45156","DOI":"10.1074\/jbc.M111.297275","article-title":"Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica","volume":"286","author":"Ratelade","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0290","doi-asserted-by":"crossref","first-page":"e27412","DOI":"10.1371\/journal.pone.0027412","article-title":"Intravenous neuromyelitis optica autoantibody in mice targets aquaporin-4 in peripheral organs and area postrema","volume":"6","author":"Ratelade","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biocel.2012.06.013_bib0295","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00401-012-0986-4","article-title":"Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss","volume":"123","author":"Ratelade","year":"2012","journal-title":"Acta Neuropathologica"},{"key":"10.1016\/j.biocel.2012.06.013_bib0300","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.physiol.70.113006.100452","article-title":"A current view of the mammalian aquaglyceroporins","volume":"70","author":"Rojek","year":"2008","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0305","unstructured":"Rossi A, Moritz TJ, Ratelade J, Verkman AS. Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes. Journal of Cell Science, in press."},{"key":"10.1016\/j.biocel.2012.06.013_bib0425","first-page":"E1511","article-title":"Consequences of NMO-IgG binding to aquaporin-4 in neuromyelitis optica","volume":"109","author":"Rossi","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.06.013_bib0320","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature03180","article-title":"Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression","volume":"433","author":"Rothstein","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2012.06.013_bib0325","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1242\/jcs.02680","article-title":"Involvement of aquaporin-4 in astroglial cell migration and glial scar formation","volume":"118","author":"Saadoun","year":"2005","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2012.06.013_bib0330","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/brain\/awp309","article-title":"Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice","volume":"133","author":"Saadoun","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.biocel.2012.06.013_bib0335","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ana.22686","article-title":"Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain","volume":"71","author":"Saadoun","year":"2012","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0340","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1126\/science.276.5319.1699","article-title":"Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1","volume":"276","author":"Tanaka","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.biocel.2012.06.013_bib0345","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1096\/fj.11-201608","article-title":"Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica","volume":"26","author":"Tradtrantip","year":"2012","journal-title":"FASEB Journal"},{"key":"10.1016\/j.biocel.2012.06.013_bib0350","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/ana.22657","article-title":"Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica","volume":"71","author":"Tradtrantip","year":"2012","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0355","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1242\/jcs.110.22.2855","article-title":"Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4","volume":"110","author":"Verbavatz","year":"1997","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2012.06.013_bib0360","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1242\/jcs.079467","article-title":"Aquaporins at a glance","volume":"124","author":"Verkman","year":"2011","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2012.06.013_bib0365","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-med-043010-193843","article-title":"Aquaporins in clinical medicine","volume":"63","author":"Verkman","year":"2012","journal-title":"Annual Review of Medicine"},{"key":"10.1016\/j.biocel.2012.06.013_bib0370","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.4049\/jimmunol.181.8.5730","article-title":"Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood\u2013brain barrier permeability and granulocyte recruitment","volume":"181","author":"Vincent","year":"2008","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0375","first-page":"31","article-title":"The AQP structure and functional implications","author":"Walz","year":"2009","journal-title":"Handbook of Experimental Pharmacology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0380","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jneuroim.2010.11.004","article-title":"HLA-DPB1 0501 is associated with susceptibility to anti-aquaporin-4 antibodies positive neuromyelitis optica in southern Han Chinese","volume":"233","author":"Wang","year":"2011","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0385","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk","year":"2007","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-386043-9.00001-3","article-title":"Structure and functions of aquaporin-4-based orthogonal arrays of particles","volume":"287","author":"Wolburg","year":"2011","journal-title":"International Review of Cell and Molecular Biology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0395","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1074\/jbc.271.9.4577","article-title":"The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells","volume":"271","author":"Yang","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0400","doi-asserted-by":"crossref","first-page":"22907","DOI":"10.1074\/jbc.270.39.22907","article-title":"cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units","volume":"270","author":"Yang","year":"1995","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.06.013_bib0405","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jneuroim.2011.04.007","article-title":"Identification of peptide targets in neuromyelitis optica","volume":"236","author":"Yu","year":"2011","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0410","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/1352458508102085","article-title":"Is neuromyelitis optica associated with human leukocyte antigen","volume":"15","author":"Zephir","year":"2009","journal-title":"Multiple Sclerosis"},{"key":"10.1016\/j.biocel.2012.06.013_bib0415","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/ana.22551","article-title":"Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms","volume":"70","author":"Zhang","year":"2011","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.biocel.2012.06.013_bib0420","unstructured":"Zhang H, Ratelade J, Verkman AS. Eosinophil pathogenicity in neuromyelitis optica by ADCC and CDCC mechanisms: potential therapeutic efficacy of over-the counter eosinophil stabilizing drugs. ECTRIMS, in press."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512002129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512002129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T23:11:42Z","timestamp":1750288302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272512002129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":83,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S1357272512002129"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2012.06.013","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuromyelitis optica: Aquaporin-4 based pathogenesis mechanisms and new therapies","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2012.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}