{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:51:09Z","timestamp":1768017069874,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Spanish Government"},{"name":"Ministerio de Educaci\u00f3n y Ciencia","award":["AGL2009-11277\/ALI"],"award-info":[{"award-number":["AGL2009-11277\/ALI"]}]},{"name":"\u2018Direcci\u00f3 General d\u2019Universitats, Recerca i Transfer\u00e8ncia del Coneixement\u2019 of Regional Government (CAIB)"},{"name":"FEDER funds (EU)"},{"name":"Government of the CAIB"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.biocel.2012.07.026","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T11:32:27Z","timestamp":1343734347000},"page":"2019-2027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells"],"prefix":"10.1016","volume":"44","author":[{"given":"Jaume","family":"Amengual","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petar","family":"Petrov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Luisa","family":"Bonet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Ribot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreu","family":"Palou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biocel.2012.07.026_bib0005","doi-asserted-by":"crossref","first-page":"e20644","DOI":"10.1371\/journal.pone.0020644","article-title":"Beta-carotene reduces body adiposity of mice via BCMO1","volume":"6","author":"Amengual","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.biocel.2012.07.026_bib0010","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/oby.2007.104","article-title":"Retinoic acid treatment increases lipid oxidation capacity in skeletal muscle of mice","volume":"16","author":"Amengual","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.biocel.2012.07.026_bib0015","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1159\/000315085","article-title":"Retinoic acid treatment enhances lipid oxidation and inhibits lipid biosynthesis capacities in the liver of mice","volume":"25","author":"Amengual","year":"2010","journal-title":"Cellular Physiology and Biochemistry"},{"key":"10.1016\/j.biocel.2012.07.026_bib0020","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1152\/physrev.2001.81.3.1269","article-title":"Nuclear hormone receptors gene expression","volume":"81","author":"Aranda","year":"2001","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.biocel.2012.07.026_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2003.12.005","article-title":"Nuclear retinoid receptors and the transcription of retinoid-target genes","volume":"328","author":"Bastien","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.biocel.2012.07.026_bib0030","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1128\/MCB.01742-08","article-title":"All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta\/delta and retinoic acid receptor","volume":"29","author":"Berry","year":"2009","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0035","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1677\/joe.0.1660511","article-title":"Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression","volume":"166","author":"Bonet","year":"2000","journal-title":"Journal of Endocrinology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbalip.2011.06.001","article-title":"Lipid metabolism in mammalian tissues and its control by retinoic acid","volume":"1821","author":"Bonet","year":"2012","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2012.07.026_bib0045","doi-asserted-by":"crossref","first-page":"882","DOI":"10.2337\/diabetes.53.4.882","article-title":"Modulation of resistin expression by retinoic acid and vitamin A status","volume":"53","author":"Felipe","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.biocel.2012.07.026_bib0050","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbadis.2004.11.014","article-title":"Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: lack of correlation with changes of adipose tissue mass and food intake","volume":"1740","author":"Felipe","year":"2005","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2012.07.026_bib0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000100426","article-title":"SREBP-1c transcription factor and lipid homeostasis: clinical perspective","volume":"68","author":"Ferre","year":"2007","journal-title":"Hormone Research"},{"key":"10.1016\/j.biocel.2012.07.026_bib0060","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0190-9622(82)80047-9","article-title":"Changes in lipid metabolism during retinoid administration","volume":"6","author":"Gerber","year":"1982","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0065","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1073\/pnas.92.13.6157","article-title":"Activation of mammalian retinoid X receptors by the insect growth regulator methoprene","volume":"92","author":"Harmon","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.07.026_bib0070","doi-asserted-by":"crossref","first-page":"33553","DOI":"10.1074\/jbc.M706763200","article-title":"CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice","volume":"282","author":"Hessel","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.07.026_bib0075","doi-asserted-by":"crossref","first-page":"27950","DOI":"10.1074\/jbc.M100258200","article-title":"Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells","volume":"276","author":"Hsu","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.07.026_bib0080","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1038\/sj.emboj.7600209","article-title":"In vivo activation of PPAR target genes by RXR homodimers","volume":"23","author":"IJpenberg","year":"2004","journal-title":"EMBO Journal"},{"key":"10.1016\/j.biocel.2012.07.026_bib0085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mce.2007.03.002","article-title":"Altered lipid catabolism in the vitamin A deficient liver","volume":"271","author":"Kang","year":"2007","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/ATVBAHA.107.147538","article-title":"Fatty liver: a novel component of the metabolic syndrome","volume":"28","author":"Kotronen","year":"2008","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0095","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1161\/ATVBAHA.109.189506","article-title":"Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR\/LXR heterodimer in the liver","volume":"29","author":"Lalloyer","year":"2009","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0100","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1432-1033.1997.00596.x","article-title":"Differences in metabolism and isomerization of all-trans-retinoic acid and 9-cis-retinoic acid between human endothelial cells and hepatocytes","volume":"247","author":"Lansink","year":"1997","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.biocel.2012.07.026_bib0105","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1042\/bst0290310","article-title":"Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids","volume":"29","author":"Louet","year":"2001","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.biocel.2012.07.026_bib0110","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00018-003-3216-3","article-title":"Peroxisome proliferator-activated receptor alpha target genes","volume":"61","author":"Mandard","year":"2004","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.biocel.2012.07.026_bib0115","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1101\/gad.6.3.329","article-title":"Characterization of three RXR genes that mediate the action of 9-cis retinoic acid","volume":"6","author":"Mangelsdorf","year":"1992","journal-title":"Genes and Development"},{"key":"10.1016\/j.biocel.2012.07.026_bib0120","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3945\/jn.109.115147","article-title":"All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases insulin sensitivity in diabetic mice","volume":"140","author":"Manolescu","year":"2010","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.biocel.2012.07.026_bib0125","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/ncb1404","article-title":"APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function","volume":"8","author":"Mao","year":"2006","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0130","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jnutbio.2005.08.006","article-title":"Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism","volume":"17","author":"McClintick","year":"2006","journal-title":"Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.biocel.2012.07.026_bib0135","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000149815","article-title":"All-trans retinoic acid decreases murine adipose retinol binding protein 4 production","volume":"22","author":"Mercader","year":"2008","journal-title":"Cellular Physiology and Biochemistry"},{"key":"10.1016\/j.biocel.2012.07.026_bib0140","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1159\/000110717","article-title":"All-trans retinoic acid increases oxidative metabolism in mature adipocytes","volume":"20","author":"Mercader","year":"2007","journal-title":"Cellular Physiology and Biochemistry"},{"key":"10.1016\/j.biocel.2012.07.026_bib0145","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1210\/en.2006-0760","article-title":"Remodeling of white adipose tissue after retinoic acid administration in mice","volume":"147","author":"Mercader","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0150","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/386407a0","article-title":"Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists","volume":"386","author":"Mukherjee","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2012.07.026_bib0155","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jmb.2005.09.097","article-title":"An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A","volume":"354","author":"Napal","year":"2005","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0160","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1439-0396.2007.00752.x","article-title":"Liver lipid metabolism","volume":"92","author":"Nguyen","year":"2008","journal-title":"Journal of Animal Physiology and Animal Nutrition (Berlin)"},{"key":"10.1016\/j.biocel.2012.07.026_bib0165","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1017\/S0007114507182659","article-title":"Vitamin A deficiency modifies lipid metabolism in rat liver","volume":"97","author":"Oliveros","year":"2007","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.biocel.2012.07.026_bib0170","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.biocel.2012.07.026_bib0175","doi-asserted-by":"crossref","first-page":"94156","DOI":"10.1155\/2007\/94156","article-title":"Therapeutic potential of retinoid x receptor modulators for the treatment of the metabolic syndrome","volume":"2007","author":"Pinaire","year":"2007","journal-title":"PPAR Research"},{"key":"10.1016\/j.biocel.2012.07.026_bib0180","first-page":"208","article-title":"Effect of excess and deficiency of vitamin A on the utilization of FFA by liver and skeletal muscle","volume":"5","author":"Ramachandran","year":"1975","journal-title":"Environmental Physiology and Biochemistry"},{"key":"10.1016\/j.biocel.2012.07.026_bib0185","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/oby.2001.65","article-title":"Changes of adiposity in response to vitamin A status correlate with changes of PPAR gamma 2 expression","volume":"9","author":"Ribot","year":"2001","journal-title":"Obesity Research"},{"key":"10.1016\/j.biocel.2012.07.026_bib0190","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1042\/BST0351211","article-title":"Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation","volume":"35","author":"Roder","year":"2007","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.biocel.2012.07.026_bib0195","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.febslet.2007.05.022","article-title":"SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2","volume":"581","author":"Roder","year":"2007","journal-title":"FEBS Letters"},{"key":"10.1016\/j.biocel.2012.07.026_bib0200","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1096\/fj.08-120923","article-title":"Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL","volume":"23","author":"Strom","year":"2009","journal-title":"FASEB Journal"},{"key":"10.1016\/j.biocel.2012.07.026_bib0205","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.dld.2010.01.016","article-title":"From the metabolic syndrome to NAFLD or vice versa?","volume":"42","author":"Vanni","year":"2010","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.biocel.2012.07.026_bib0210","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1101\/gad.9.9.1033","article-title":"LXR, a nuclear receptor that defines a distinct retinoid response pathway","volume":"9","author":"Willy","year":"1995","journal-title":"Genes and Development"},{"key":"10.1016\/j.biocel.2012.07.026_bib0215","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/hep.20335","article-title":"Retinoic acid receptor alpha dominant negative form causes steatohepatitis and liver tumors in transgenic mice","volume":"40","author":"Yanagitani","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.biocel.2012.07.026_bib0220","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/iub.78","article-title":"Carnitine palmitoyltransferase 1: central to cell function","volume":"60","author":"Zammit","year":"2008","journal-title":"IUBMB Life"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512002762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512002762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:47:04Z","timestamp":1761202024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272512002762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1357272512002762"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2012.07.026","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2012.07.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}