{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:00:49Z","timestamp":1792724449821,"version":"4.5.0"},"reference-count":141,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT083620"],"award-info":[{"award-number":["WT083620"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["\u2013 WT094757"],"award-info":[{"award-number":["\u2013 WT094757"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.biocel.2012.10.011","type":"journal-article","created":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T03:30:33Z","timestamp":1351308633000},"page":"364-374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["A new role for mucins in immunity: Insights from gastrointestinal nematode infection"],"prefix":"10.1016","volume":"45","author":[{"given":"Sumaira Z.","family":"Hasnain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Grencis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2012.10.011_bib0005","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1073\/pnas.1120269109","article-title":"Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin","volume":"109","author":"Ambort","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.10.011_bib0010","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/BJ20102066","article-title":"Function of the CysD domain of the gel-forming MUC2 mucin","volume":"436","author":"Ambort","year":"2011","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2012.10.011_bib0015","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/expr.1999.4407","article-title":"Trichuris muris: host intestinal epithelial cell hyperproliferation during chronic infection is regulated by interferon-gamma","volume":"92","author":"Artis","year":"1999","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0020","doi-asserted-by":"crossref","first-page":"13596","DOI":"10.1073\/pnas.0404034101","article-title":"RELMbeta\/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract","volume":"101","author":"Artis","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.10.011_bib0025","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1074\/jbc.M111.332593","article-title":"The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine","volume":"287","author":"Asada","year":"2012","journal-title":"Journal of Biological Chemistry"},{"issue":"Pt 3","key":"10.1016\/j.biocel.2012.10.011_bib0030","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1042\/bj3080873","article-title":"The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the \u2018insoluble\u2019 mucin of rat small intestine","volume":"308","author":"Asker","year":"1995","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2012.10.011_bib0035","doi-asserted-by":"crossref","first-page":"18857","DOI":"10.1074\/jbc.273.30.18857","article-title":"Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus","volume":"273","author":"Asker","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.10.011_bib0040","first-page":"G922","article-title":"The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo","volume":"280","author":"Atuma","year":"2001","journal-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0045","doi-asserted-by":"crossref","first-page":"18864","DOI":"10.1074\/jbc.273.30.18864","article-title":"O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds","volume":"273","author":"Axelsson","year":"1998","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.biocel.2012.10.011_bib0050","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jaci.2009.08.006","article-title":"Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial","volume":"125","author":"Bager","year":"2010","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0055","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1002\/eji.1830241230","article-title":"Low-level infection with Trichuris muris significantly affects the polarization of the CD4 response","volume":"24","author":"Bancroft","year":"1994","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0060","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1128\/iai.45.1.267-272.1984","article-title":"Intestinal mucus trapping in the rapid expulsion of Trichinella spiralis by rats: induction and expression analyzed by quantitative worm recovery","volume":"45","author":"Bell","year":"1984","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.biocel.2012.10.011_bib0065","doi-asserted-by":"crossref","first-page":"20563","DOI":"10.1016\/S0021-9258(20)80762-5","article-title":"Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7)","volume":"268","author":"Bobek","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.10.011_bib0070","doi-asserted-by":"crossref","first-page":"60ra88","DOI":"10.1126\/scitranslmed.3001500","article-title":"IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient","volume":"2","author":"Broadhurst","year":"2010","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.biocel.2012.10.011_bib0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbamcr.2005.08.007","article-title":"Two-hybrid analysis of human salivary mucin MUC7 interactions","volume":"1746","author":"Bruno","year":"2005","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2012.10.011_bib0080","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1017\/S0022149X00026535","article-title":"The life cycle of Nematospiroides dubius, Baylis, 1926 (Nematoda: Heligmosomidae)","volume":"47","author":"Bryant","year":"1973","journal-title":"Journal of Helminthology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0085","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1136\/gut.43.4.519","article-title":"Mucin gene expression in human embryonic and fetal intestine","volume":"43","author":"Buisine","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2012.10.011_bib0090","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1165\/ajrcmb.20.2.3259","article-title":"Developmental mucin gene expression in the human respiratory tract","volume":"20","author":"Buisine","year":"1999","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0095","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1165\/rcmb.2003-0103OC","article-title":"Genome-wide search and identification of a novel gel-forming mucin MUC19\/Muc19 in glandular tissues","volume":"30","author":"Chen","year":"2004","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0100","first-page":"L542","article-title":"A new role for bicarbonate in mucus formation","volume":"299","author":"Chen","year":"2010","journal-title":"American Journal of Physiology: Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0105","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0065-308X(04)57004-5","article-title":"The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection","volume":"57","author":"Cliffe","year":"2004","journal-title":"Advances in Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0110","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1126\/science.1108661","article-title":"Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion","volume":"308","author":"Cliffe","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biocel.2012.10.011_bib0115","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/BF00702345","article-title":"Colonic mucins in ulcerative colitis: evidence for loss of sulfation","volume":"13","author":"Corfield","year":"1996","journal-title":"Glycoconjugate Journal"},{"key":"10.1016\/j.biocel.2012.10.011_bib0120","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0020-7519(76)90031-X","article-title":"The location of parasites within their hosts: the influence of host feeding and diet on the dispersion of adults of Nippostrongylus brasiliensis in the intestine of the rat","volume":"6","author":"Croll","year":"1976","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0125","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/1471-2164-10-492","article-title":"Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell","volume":"10","author":"D\u2019Elia","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.biocel.2012.10.011_bib0130","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.physiol.70.113006.100638","article-title":"Regulated airway goblet cell mucin secretion","volume":"70","author":"Davis","year":"2008","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0135","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1136\/gut.2007.147595","article-title":"Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse","volume":"58","author":"Dawson","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2012.10.011_bib0140","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0016-5085(95)90379-8","article-title":"MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach","volume":"109","author":"De Bolos","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0145","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.parint.2006.05.002","article-title":"Effects of Trichinella spiralis infection on intestinal pathology in mice lacking interleukin-4 (IL-4) or intestinal trefoil factor (ITF\/TFF3)","volume":"55","author":"Dehlawi","year":"2006","journal-title":"Parasitology International"},{"key":"10.1016\/j.biocel.2012.10.011_bib0150","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0014-4894(75)90058-2","article-title":"Trichinella spiralis: growth of the intracellular (muscle) larva","volume":"37","author":"Despommier","year":"1975","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0155","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0169-4758(98)01287-3","article-title":"How does Trichinella spiralis make itself at home?","volume":"14","author":"Despommier","year":"1998","journal-title":"Parasitology Today"},{"key":"10.1016\/j.biocel.2012.10.011_bib0160","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0020-7519(83)90014-0","article-title":"In vitro bioassay of sheep gastrointestinal mucus for nematode paralysing activity mediated by substances with some properties characteristic of SRS-A","volume":"13","author":"Douch","year":"1983","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0165","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0169-4758(91)90268-S","article-title":"Helper T-cell subsets in mouse trichuriasis","volume":"7","author":"Else","year":"1991","journal-title":"Parasitology Today"},{"key":"10.1016\/j.biocel.2012.10.011_bib0170","first-page":"508","article-title":"Cellular immune responses to the murine nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection","volume":"72","author":"Else","year":"1991","journal-title":"Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0175","first-page":"232","article-title":"Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice","volume":"75","author":"Else","year":"1992","journal-title":"Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0180","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/pim.1993.15.10.595","article-title":"Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with Trichuris muris","volume":"15","author":"Else","year":"1993","journal-title":"Parasite Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0185","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbaexp.2004.01.001","article-title":"The mouse secreted gel-forming mucin gene cluster","volume":"1676","author":"Escande","year":"2004","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2012.10.011_bib0190","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev.immunol.15.1.505","article-title":"Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models","volume":"15","author":"Finkelman","year":"1997","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00192.x","article-title":"Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites","volume":"201","author":"Finkelman","year":"2004","journal-title":"Immunological Reviews"},{"key":"10.1016\/j.biocel.2012.10.011_bib0200","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/ijc.22865","article-title":"Abnormal expression of M1\/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer","volume":"121","author":"Forgue-Lafitte","year":"2007","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.biocel.2012.10.011_bib0205","doi-asserted-by":"crossref","first-page":"e42248","DOI":"10.1371\/journal.pone.0042248","article-title":"The goblet cell is the cellular source of the anti-microbial angiogenin 4 in the large intestine post Trichuris muris infection","volume":"7","author":"Forman","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biocel.2012.10.011_bib0210","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ni0303-213","article-title":"Angiogenin: an antimicrobial ribonuclease","volume":"4","author":"Ganz","year":"2003","journal-title":"Nature Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0215","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1471-4906(03)00101-7","article-title":"The immune response to parasitic helminths: insights from murine models","volume":"24","author":"Gause","year":"2003","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0220","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/10454411930040030201","article-title":"Biophysical approaches to salivary mucin structure, conformation and dynamics","volume":"4","author":"Gerken","year":"1993","journal-title":"Critical Reviews in Oral Biology and Medicine"},{"key":"10.1016\/j.biocel.2012.10.011_bib0225","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-61779-513-8_5","article-title":"O-glycoprotein biosynthesis: site localization by Edman degradation and site prediction based on random peptide substrates","volume":"842","author":"Gerken","year":"2012","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4615-5359-5_32","article-title":"Cellular origin of mucins of the ocular surface tear film","volume":"438","author":"Gipson","year":"1998","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0235","first-page":"329","article-title":"Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes","volume":"74","author":"Grencis","year":"1991","journal-title":"Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0240","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/00034983.1993.11812823","article-title":"Cytokine-mediated regulation of intestinal helminth infections: the Trichuris muris model","volume":"87","author":"Grencis","year":"1993","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0245","doi-asserted-by":"crossref","first-page":"20547","DOI":"10.1074\/jbc.M110.121319","article-title":"Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen","volume":"285","author":"Guang","year":"2010","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.10.011_bib0250","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0167-4838(99)00034-5","article-title":"Candidacidal activity prompted by N-terminus histatin-like domain of human salivary mucin (MUC7)1","volume":"1431","author":"Gururaja","year":"1999","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2012.10.011_bib0255","first-page":"G430","article-title":"An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants","volume":"302","author":"Gustafsson","year":"2012","journal-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0260","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1084\/jem.20120562","article-title":"Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype","volume":"209","author":"Gustafsson","year":"2012","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.biocel.2012.10.011_bib0265","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-3024.2009.01123.x","article-title":"Depleted intestinal goblet cells and severe pathological changes in SCID mice infected with Heligmosomoides polygyrus","volume":"31","author":"Hashimoto","year":"2009","journal-title":"Parasite Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0270","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1053\/j.gastro.2010.01.045","article-title":"Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection","volume":"138","author":"Hasnain","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0275","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1084\/jem.20102057","article-title":"Muc5ac: a critical component mediating the rejection of enteric nematodes","volume":"208","author":"Hasnain","year":"2011","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.biocel.2012.10.011_bib0280","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-3024.2010.01258.x","article-title":"Changes in the mucosal barrier during acute and chronic Trichuris muris infection","volume":"33","author":"Hasnain","year":"2011","journal-title":"Parasite Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0285","doi-asserted-by":"crossref","first-page":"e1856","DOI":"10.1371\/journal.pntd.0001856","article-title":"Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier","volume":"6","author":"Hasnain","year":"2012","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"10.1016\/j.biocel.2012.10.011_bib0290","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1371\/journal.pmed.0050054","article-title":"Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis","volume":"5","author":"Heazlewood","year":"2008","journal-title":"PLoS Medicine"},{"key":"10.1016\/j.biocel.2012.10.011_bib0295","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1128\/IAI.01252-10","article-title":"Serine proteases degrade airway mucins in cystic fibrosis","volume":"79","author":"Henke","year":"2011","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.biocel.2012.10.011_bib0300","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1084\/jem.20091268","article-title":"Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection","volume":"206","author":"Herbert","year":"2009","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.biocel.2012.10.011_bib0305","doi-asserted-by":"crossref","first-page":"15828","DOI":"10.1074\/jbc.274.22.15828","article-title":"Studies on the \u201cinsoluble\u201d glycoprotein complex from human colon Identification of reduction-insensitive MUC2 oligomers and C-terminal cleavage","volume":"274","author":"Herrmann","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.10.011_bib0310","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0016-5085(95)90380-1","article-title":"Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression","volume":"109","author":"Ho","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0315","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrc1251","article-title":"Mucins in cancer: protection and control of the cell surface","volume":"4","author":"Hollingsworth","year":"2004","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/j.biocel.2012.10.011_bib0320","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4049\/jimmunol.169.1.443","article-title":"New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25","volume":"169","author":"Hurst","year":"2002","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0325","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1164\/rccm.200807-1056OC","article-title":"Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma","volume":"180","author":"Innes","year":"2009","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.biocel.2012.10.011_bib0330","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1177\/00220345970760030501","article-title":"Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins","volume":"76","author":"Iontcheva","year":"1997","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.biocel.2012.10.011_bib0335","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1365-3024.1995.tb01001.x","article-title":"Reserpine-induced sulphomucin production by goblet cells in the jejunum of rats and its significance in the establishment of intestinal helminths","volume":"17","author":"Ishikawa","year":"1995","journal-title":"Parasite Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0340","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1053\/gast.1997.v113.pm9247474","article-title":"Role of T helper 2 cells in intestinal goblet cell hyperplasia in mice infected with Trichinella spiralis","volume":"113","author":"Ishikawa","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0345","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1073\/pnas.0803124105","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria","volume":"105","author":"Johansson","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.10.011_bib0350","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1021\/pr9002504","article-title":"Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein","volume":"8","author":"Johansson","year":"2009","journal-title":"Journal of Proteome Research"},{"key":"10.1016\/j.biocel.2012.10.011_bib0355","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00003226-200301000-00010","article-title":"MUC7 expression in the human lacrimal gland and conjunctiva","volume":"22","author":"Jumblatt","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.biocel.2012.10.011_bib0360","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-0463.2007.apm_510.x","article-title":"T cell-dependent and -independent expression of intestinal epithelial cell-related molecules in rats infected with the nematode Nippostrongylus brasiliensis","volume":"115","author":"Kawai","year":"2007","journal-title":"Acta Pathologica, Microbiologica et Immunologica Scandinavica"},{"key":"10.1016\/j.biocel.2012.10.011_bib0365","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1126\/science.1099250","article-title":"Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection","volume":"305","author":"Kawakubo","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biocel.2012.10.011_bib0370","first-page":"L92","article-title":"Tracheobronchial air\u2013liquid interface cell culture: a model for innate mucosal defense of the upper airways?","volume":"296","author":"Kesimer","year":"2009","journal-title":"American Journal of Physiology: Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0375","first-page":"L15","article-title":"Unpacking a gel-forming mucin: a view of MUC5B organization after granular release","volume":"298","author":"Kesimer","year":"2010","journal-title":"American Journal of Physiology: Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0380","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1365-3024.2001.00353.x","article-title":"Stat6 dependent goblet cell hyperplasia during intestinal nematode infection","volume":"23","author":"Khan","year":"2001","journal-title":"Parasite Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0385","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1128\/IAI.71.5.2430-2438.2003","article-title":"Modulation of intestinal muscle contraction by interleukin-9 (IL-9) or IL-9 neutralization: correlation with worm expulsion in murine nematode infections","volume":"71","author":"Khan","year":"2003","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.biocel.2012.10.011_bib0390","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/bj3610537","article-title":"Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B","volume":"361","author":"Kirkham","year":"2002","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2012.10.011_bib0395","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/glycob\/cwp004","article-title":"Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection","volume":"19","author":"Kobayashi","year":"2009","journal-title":"Glycobiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0400","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1165\/rcmb.4682","article-title":"Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epithelium","volume":"27","author":"Kondo","year":"2002","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0405","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1002\/ibd.21625","article-title":"Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation","volume":"17","author":"Larsson","year":"2011","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.biocel.2012.10.011_bib0410","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/ibd.21326","article-title":"Colonic transcriptional profiling in resistance and susceptibility to trichuriasis: phenotyping a chronic colitis and lessons for iatrogenic helminthosis","volume":"16","author":"Levison","year":"2010","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.biocel.2012.10.011_bib0415","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1021\/bm3001292","article-title":"Mucin biopolymers as broad-spectrum antiviral agents","volume":"13","author":"Lieleg","year":"2012","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biocel.2012.10.011_bib0420","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1053\/gast.2002.37076","article-title":"Strain- and blood group-dependent binding of Helicobacter pylori to human gastric MUC5AC glycoforms","volume":"123","author":"Linden","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0425","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1369\/jhc.5A6904.2006","article-title":"Alterations in the composition of the supramucosal defense barrier in relation to disease severity of ulcerative colitis","volume":"54","author":"Longman","year":"2006","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"10.1016\/j.biocel.2012.10.011_bib0430","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/gut.40.6.782","article-title":"Histochemistry of the surface mucous gel layer of the human colon","volume":"40","author":"Matsuo","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2012.10.011_bib0435","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.4049\/jimmunol.175.5.3207","article-title":"Intraepithelial NK cell-derived IL-13 induces intestinal pathology associated with nematode infection","volume":"175","author":"McDermott","year":"2005","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0440","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature10863","article-title":"Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine","volume":"483","author":"McDole","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2012.10.011_bib0445","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/ibd.20539","article-title":"Intestinal barrier dysfunction in inflammatory bowel diseases","volume":"15","author":"McGuckin","year":"2009","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.biocel.2012.10.011_bib0450","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrmicro2538","article-title":"Mucin dynamics and enteric pathogens","volume":"9","author":"McGuckin","year":"2011","journal-title":"Nature Reviews Microbiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0455","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1074-7613(00)80625-1","article-title":"Impaired development of Th2 cells in IL-13-deficient mice","volume":"9","author":"McKenzie","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.biocel.2012.10.011_bib0460","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1038\/onc.2009.467","article-title":"Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors","volume":"29","author":"Mejias-Luque","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.biocel.2012.10.011_bib0465","first-page":"419","article-title":"Immune exclusion and mucus trapping during the rapid expulsion of Nippostrongylus brasiliensis from primed rats","volume":"44","author":"Miller","year":"1981","journal-title":"Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0470","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1017\/S0031182000085838","article-title":"Gastrointestinal mucus, a medium for survival and for elimination of parasitic nematodes and protozoa","volume":"94 Suppl.","author":"Miller","year":"1987","journal-title":"Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0475","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2012.10.011_bib0480","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.2307\/3276966","article-title":"Effects of immunity of Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction, and morphology","volume":"54","author":"Ogilvie","year":"1968","journal-title":"Journal of Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0485","first-page":"147","article-title":"Co-operation between antibodies and cells in immunity to a nematode parasite","volume":"19","author":"Ogilvie","year":"1974","journal-title":"Transplantation Reviews"},{"key":"10.1016\/j.biocel.2012.10.011_bib0490","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0020-7519(80)90006-5","article-title":"The location of parasites within their hosts: site selection by Trichuris muris in the laboratory mouse","volume":"10","author":"Panesar","year":"1980","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0495","doi-asserted-by":"crossref","first-page":"6950","DOI":"10.1073\/pnas.0808722106","article-title":"The protein disulfide isomerase AGR2 is essential for production of intestinal mucus","volume":"106","author":"Park","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.10.011_bib0500","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijpara.2008.08.003","article-title":"Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites","volume":"39","author":"Patel","year":"2009","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0505","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/glycob\/cwh041","article-title":"C-mannosylation of MUC5AC and MUC5B Cys subdomains","volume":"14","author":"Perez-Vilar","year":"2004","journal-title":"Glycobiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0510","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1074-7613(02)00341-2","article-title":"Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo","volume":"17","author":"Phalipon","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.biocel.2012.10.011_bib0515","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/geno.1996.0637","article-title":"Human mucin genes assigned to 11p15.5: identification and organization of a cluster of genes","volume":"38","author":"Pigny","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.biocel.2012.10.011_bib0520","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.gastro.2009.03.007","article-title":"Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency","volume":"137","author":"Podolsky","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0525","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"Price","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.biocel.2012.10.011_bib0530","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1756-3305-5-81","article-title":"The global limits and population at risk of soil-transmitted helminth infections in 2010","volume":"5","author":"Pullan","year":"2012","journal-title":"Parasites & Vectors"},{"key":"10.1016\/j.biocel.2012.10.011_bib0535","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0140-6736(08)61162-9","article-title":"Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis","volume":"372","author":"Quinton","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.biocel.2012.10.011_bib0540","doi-asserted-by":"crossref","first-page":"C1222","DOI":"10.1152\/ajpcell.00362.2010","article-title":"Role of epithelial HCO3(\u2212) transport in mucin secretion: lessons from cystic fibrosis","volume":"299","author":"Quinton","year":"2010","journal-title":"American Journal of Physiology \u2013 Cell Physiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0545","first-page":"L13","article-title":"Birth of mucus","volume":"298","author":"Quinton","year":"2010","journal-title":"American Journal of Physiology: Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0550","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/biof.64","article-title":"Current status of mucins in the diagnosis and therapy of cancer","volume":"35","author":"Rachagani","year":"2009","journal-title":"Biofactors"},{"key":"10.1016\/j.biocel.2012.10.011_bib0555","doi-asserted-by":"crossref","first-page":"28703","DOI":"10.1074\/jbc.M304632200","article-title":"Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus","volume":"278","author":"Raynal","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.10.011_bib0560","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/nature08901","article-title":"IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses","volume":"464","author":"Saenz","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2012.10.011_bib0565","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.proghi.2007.02.001","article-title":"Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: physiological distribution and pathological significance","volume":"42","author":"Sasaki","year":"2007","journal-title":"Progress in Histochemistry and Cytochemistry"},{"key":"10.1016\/j.biocel.2012.10.011_bib0570","doi-asserted-by":"crossref","first-page":"15698","DOI":"10.1074\/jbc.M313241200","article-title":"Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin","volume":"279","author":"Sheehan","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.10.011_bib0575","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/bj2390147","article-title":"Electron microscopy of cervical, gastric and bronchial mucus glycoproteins","volume":"239","author":"Sheehan","year":"1986","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.biocel.2012.10.011_bib0580","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1440-1746.2011.06909.x","article-title":"Mucins in inflammatory bowel diseases and colorectal cancer","volume":"27","author":"Sheng","year":"2012","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0585","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro2384","article-title":"The role of secretory antibodies in infection immunity","volume":"8","author":"Strugnell","year":"2010","journal-title":"Nature Reviews Microbiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0590","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1017\/S0022149X00027991","article-title":"The site selected by the larvae of Heligmosomoides polygyrus","volume":"58","author":"Sukhdeo","year":"1984","journal-title":"Journal of Helminthology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0595","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1111\/j.1572-0241.2003.07660.x","article-title":"Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease","volume":"98","author":"Summers","year":"2003","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0600","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/gut.2004.041749","article-title":"Trichuris suis therapy in Crohn's disease","volume":"54","author":"Summers","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2012.10.011_bib0605","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1053\/j.gastro.2005.01.005","article-title":"Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial","volume":"128","author":"Summers","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0610","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.5858\/2006-130-1753a-TCWTS","article-title":"Therapeutic colonization with Trichuris suis","volume":"130","author":"Summers","year":"2006","journal-title":"Archives of Pathology and Laboratory Medicine"},{"key":"10.1016\/j.biocel.2012.10.011_bib0615","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jaci.2009.12.937","article-title":"Trichuris suis might be effective in treating allergic rhinitis","volume":"125","author":"Summers","year":"2010","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0620","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1046\/j.1365-2362.2002.01014.x","article-title":"Effect of trefoil factors on the viscoelastic properties of mucus gels","volume":"32","author":"Thim","year":"2002","journal-title":"European Journal of Clinical Investigation"},{"key":"10.1016\/j.biocel.2012.10.011_bib0625","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/glycob\/cws083","article-title":"Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2","volume":"22","author":"Thomsson","year":"2012","journal-title":"Glycobiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0630","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/glycob\/9.3.293","article-title":"Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product","volume":"9","author":"Thornton","year":"1999","journal-title":"Glycobiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0635","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1513\/pats.2306016","article-title":"From mucins to mucus: toward a more coherent understanding of this essential barrier","volume":"1","author":"Thornton","year":"2004","journal-title":"Proceedings of the American Thoracic Society"},{"key":"10.1016\/j.biocel.2012.10.011_bib0640","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.physiol.70.113006.100702","article-title":"Structure and function of the polymeric mucins in airways mucus","volume":"70","author":"Thornton","year":"2008","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0645","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1074\/jbc.M109.067082","article-title":"Sulfation of colonic mucins by N-acetylglucosamine 6-O-sulfotransferase-2 and its protective function in experimental colitis in mice","volume":"285","author":"Tobisawa","year":"2010","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2012.10.011_bib0650","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/glycob\/7.7.965","article-title":"Molecular characterization of a major high molecular weight mucin from human sublingual gland","volume":"7","author":"Troxler","year":"1997","journal-title":"Glycobiology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0655","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.exppara.2012.01.002","article-title":"Rapid and specific alterations of goblet cell mucin in rat airway and small intestine associated with resistance against Nippostrongylus brasiliensis reinfection","volume":"130","author":"Tsubokawa","year":"2012","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0660","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1209791","article-title":"The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine","volume":"334","author":"Vaishnava","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.biocel.2012.10.011_bib0665","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/00220345870660022001","article-title":"Molecular mechanism of mucin secretion. I. The role of intragranular charge shielding","volume":"66","author":"Verdugo","year":"1987","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.biocel.2012.10.011_bib0670","first-page":"625","article-title":"Molecular mechanism of product storage and release in mucin secretion. II. The role of extracellular Ca++","volume":"24","author":"Verdugo","year":"1987","journal-title":"Biorheology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0675","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1017\/S0031182000072395","article-title":"Acquired immunity to Trichuris muris in the albino laboratory mouse","volume":"57","author":"Wakelin","year":"1967","journal-title":"Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0680","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chom.2011.12.006","article-title":"Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2","volume":"11","author":"Wei","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.biocel.2012.10.011_bib0685","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2307\/3276476","article-title":"Adaptation of Nippostrongylus brasiliensis to the mouse","volume":"52","author":"Wescott","year":"1966","journal-title":"The Journal of Parasitology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0690","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1165\/rcmb.4838","article-title":"Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9","volume":"27","author":"Whittaker","year":"2002","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.biocel.2012.10.011_bib0695","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1084\/jem.20110079","article-title":"Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection","volume":"209","author":"Wills-Karp","year":"2012","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.biocel.2012.10.011_bib0700","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1600-0463.2006.apm_353.x","article-title":"Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat","volume":"114","author":"Yamauchi","year":"2006","journal-title":"Acta Pathologica, Microbiologica et Immunologica Scandinavica"},{"key":"10.1016\/j.biocel.2012.10.011_bib0705","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1165\/rcmb.2010-0312OC","article-title":"Cloning and characterization of human MUC19 gene","volume":"45","author":"Zhu","year":"2011","journal-title":"American Journal of Respiratory Cell and Molecular Biology"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512003573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272512003573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:30:26Z","timestamp":1788157826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272512003573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":141,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S1357272512003573"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2012.10.011","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new role for mucins in immunity: Insights from gastrointestinal nematode infection","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2012.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}