{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:09:16Z","timestamp":1791320956139,"version":"4.3.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.biocel.2013.04.005","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T11:46:14Z","timestamp":1365594374000},"page":"1318-1326","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability"],"prefix":"10.1016","volume":"45","author":[{"given":"M.J.","family":"Rodr\u00edguez-Lagunas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Storniolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2013.04.005_bib0005","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.2741\/3413","article-title":"Mechanism of cytokine modulation of epithelial tight junction barrier","volume":"14","author":"Al-Sadi","year":"2009","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.biocel.2013.04.005_bib0010","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.4049\/jimmunol.180.8.5653","article-title":"Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability","volume":"180","author":"Al-Sadi","year":"2008","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0015","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1748-1716.2010.02148.x","article-title":"Claudins of intestine and nephron \u2013 a correlation of molecular tight junction structure and barrier function","volume":"201","author":"Amasheh","year":"2011","journal-title":"Acta Physiologica (Oxford)"},{"key":"10.1016\/j.biocel.2013.04.005_bib0020","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/ajg2006242","article-title":"Mucosal barrier defects in irritable bowel syndrome. Who left the door open?","volume":"101","author":"Barbara","year":"2006","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0025","doi-asserted-by":"crossref","first-page":"46129","DOI":"10.1074\/jbc.M407057200","article-title":"Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice","volume":"279","author":"Beller","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2013.04.005_bib0030","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/labinvest.3700373","article-title":"Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease","volume":"86","author":"Blair","year":"2006","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.biocel.2013.04.005_bib0035","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1136\/gut.24.12.1176","article-title":"Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa","volume":"24","author":"Boughton-Smith","year":"1983","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2013.04.005_bib0040","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.4049\/jimmunol.171.11.6164","article-title":"Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms","volume":"171","author":"Bruewer","year":"2003","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0045","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1196\/annals.1326.017","article-title":"Inflammatory bowel disease and the apical junctional complex","volume":"1072","author":"Bruewer","year":"2006","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.biocel.2013.04.005_bib0050","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/labinvest.3700050","article-title":"A porous defense: the leaky epithelial barrier in intestinal disease","volume":"84","author":"Clayburgh","year":"2004","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.biocel.2013.04.005_bib0055","doi-asserted-by":"crossref","first-page":"G719","DOI":"10.1152\/ajpgi.00117.2007","article-title":"HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts","volume":"293","author":"Di Mari","year":"2007","journal-title":"American Journal of Physiology \u2013 Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0060","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/j.1939-4640.1995.tb01728.x","article-title":"Characterization of two second messenger pathways and their interactions in eliciting the human sperm acrosome reaction","volume":"16","author":"Doherty","year":"1995","journal-title":"Journal of Andrology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0065","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0016-5085(95)90296-1","article-title":"Eicosanoids and the gastrointestinal tract","volume":"109","author":"Eberhart","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0070","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1572-0241.2006.00384.x","article-title":"The gastrointestinal safety and effect on disease activity of etoricoxib, a selective cox-2 inhibitor in inflammatory bowel diseases","volume":"101","author":"El Miedany","year":"2006","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0075","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bcp.2010.04.033","article-title":"Role of eicosanoids on intestinal epithelial homeostasis","volume":"80","author":"Ferrer","year":"2010","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0080","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0022-3565(25)21132-6","article-title":"LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist","volume":"233","author":"Fleisch","year":"1985","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.biocel.2013.04.005_bib0085","doi-asserted-by":"crossref","first-page":"18352","DOI":"10.1074\/jbc.M109.077602","article-title":"Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB\u2013IkappaB complex","volume":"285","author":"Gambaryan","year":"2010","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2013.04.005_bib0090","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.bbamem.2007.08.018","article-title":"Crosstalk of tight junction components with signaling pathways","volume":"1778","author":"Gonzalez-Mariscal","year":"2008","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2013.04.005_bib0095","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2013.04.005_bib0100","doi-asserted-by":"crossref","first-page":"50639","DOI":"10.1074\/jbc.R400027200","article-title":"Leukotriene A4 hydrolase\/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis","volume":"279","author":"Haeggstrom","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2013.04.005_bib0105","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.biocel.2003.08.007","article-title":"Regulation of tight junctions and loss of barrier function in pathophysiology","volume":"36","author":"Harhaj","year":"2004","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0110","first-page":"125","article-title":"Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives","volume":"5","author":"Harris","year":"1979","journal-title":"Journal of Cyclic Nucleotide Research"},{"key":"10.1016\/j.biocel.2013.04.005_bib0115","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/labinvest.2010.180","article-title":"Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29\/B6 cell monolayers","volume":"91","author":"Hering","year":"2011","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.biocel.2013.04.005_bib0120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbamcr.2004.03.005","article-title":"Regulation of actin-based cell migration by cAMP\/PKA","volume":"1692","author":"Howe","year":"2004","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.biocel.2013.04.005_bib0125","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1254\/jphs.FP0060651","article-title":"Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer","volume":"103","author":"Ihara","year":"2007","journal-title":"Journal of Pharmacological Sciences"},{"key":"10.1016\/j.biocel.2013.04.005_bib0130","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00228-009-0719-3","article-title":"Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality?","volume":"65","author":"Kefalakes","year":"2009","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0135","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.yjmcc.2010.01.007","article-title":"cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes","volume":"48","author":"Kohr","year":"2010","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0140","doi-asserted-by":"crossref","first-page":"G586","DOI":"10.1152\/ajpgi.00463.2002","article-title":"Amelioration of TNBS-induced colon inflammation in rats by phospholipase A2 inhibitor","volume":"285","author":"Krimsky","year":"2003","journal-title":"American Journal of Physiology \u2013 Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/01.mog.0000203864.48255.4f","article-title":"Regulation of the intestinal epithelial barrier by the apical junctional complex","volume":"22","author":"Laukoetter","year":"2006","journal-title":"Current Opinion in Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0150","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ajpath.2011.05.001","article-title":"Prostaglandin E2 produced by entamoeba histolytica signals via EP4 receptor and alters claudin-4 to increase ion permeability of tight junctions","volume":"179","author":"Lejeune","year":"2011","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0155","first-page":"G965","article-title":"Ethanol modulation of intestinal epithelial tight junction barrier","volume":"276","author":"Ma","year":"1999","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0160","doi-asserted-by":"crossref","first-page":"9190","DOI":"10.1158\/0008-5472.CAN-07-0771","article-title":"An increased expression of cysteinyl leukotriene 2 receptor in colorectal adenocarcinomas correlates with high differentiation","volume":"67","author":"Magnusson","year":"2007","journal-title":"Cancer Research"},{"key":"10.1016\/j.biocel.2013.04.005_bib0165","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/MOG.0b013e32816aa392","article-title":"Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications","volume":"23","author":"Mankertz","year":"2007","journal-title":"Current Opinion in Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0170","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0006-2952(01)00774-2","article-title":"Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors","volume":"62","author":"Martin","year":"2001","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0175","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1194\/jlr.M500564-JLR200","article-title":"Arachidonic acid cascade and epithelial barrier function during Caco-2 cell differentiation","volume":"47","author":"Martin-Venegas","year":"2006","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.biocel.2013.04.005_bib0180","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00054725-200407000-00005","article-title":"The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease","volume":"10","author":"Matuk","year":"2004","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.biocel.2013.04.005_bib0185","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev.physiol.60.1.121","article-title":"Molecular architecture of tight junctions","volume":"60","author":"Mitic","year":"1998","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0190","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1158\/0008-5472.732.65.3","article-title":"A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells","volume":"65","author":"Nielsen","year":"2005","journal-title":"Cancer Research"},{"key":"10.1016\/j.biocel.2013.04.005_bib0195","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/S0960-9822(01)00530-9","article-title":"Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation","volume":"11","author":"Niu","year":"2001","journal-title":"Current Biology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0200","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1124\/mol.58.6.1601","article-title":"Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist","volume":"58","author":"Nothacker","year":"2000","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0205","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0016-5085(98)70661-4","article-title":"Gastrointestinal permeability in celiac disease","volume":"114","author":"Oberhuber","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0210","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.nut.2004.12.004","article-title":"Short-chain fatty acids alter tight junction permeability in intestinal monolayer cells via lipoxygenase activation","volume":"21","author":"Ohata","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.biocel.2013.04.005_bib0215","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1053\/gast.2000.18141","article-title":"Leukotrienes induce cell-survival signaling in intestinal epithelial cells","volume":"119","author":"Ohd","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0220","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1053\/gast.2000.18141","article-title":"Leukotrienes induce cell-survival signaling in intestinal epithelial cells","volume":"119","author":"Ohd","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0225","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/sj.ijir.3900911","article-title":"Role of rho-kinase activity in angiotensin II-induced contraction of rabbit clitoral cavernosum smooth muscle","volume":"14","author":"Park","year":"2002","journal-title":"International Journal of Impotence Research"},{"key":"10.1016\/j.biocel.2013.04.005_bib0230","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1038\/sj.onc.1209666","article-title":"Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells","volume":"25","author":"Paruchuri","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.biocel.2013.04.005_bib0235","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/labinvest.3700316","article-title":"Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells","volume":"85","author":"Prasad","year":"2005","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.biocel.2013.04.005_bib0240","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.3748\/wjg.v11.i16.2371","article-title":"Radical induction theory of ulcerative colitis","volume":"11","author":"Pravda","year":"2005","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0245","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1124\/jpet.107.131649","article-title":"Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion","volume":"325","author":"Profita","year":"2008","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.biocel.2013.04.005_bib0250","doi-asserted-by":"crossref","first-page":"7210","DOI":"10.2741\/3223","article-title":"Oxidative stress-induced disruption of epithelial and endothelial tight junctions","volume":"13","author":"Rao","year":"2008","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.biocel.2013.04.005_bib0255","doi-asserted-by":"crossref","first-page":"C324","DOI":"10.1152\/ajpcell.00397.2009","article-title":"PGE2 promotes Ca2+-mediated epithelial barrier disruption through EP1 and EP4 receptors in Caco-2 cell monolayers","volume":"299","author":"Rodriguez-Lagunas","year":"2010","journal-title":"American Journal of Physiology \u2013 Cell Physiology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0260","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-2999(99)00108-9","article-title":"Ketoprofen S(+) enantiomer inhibits prostaglandin production and cell growth in 3T6 fibroblast cultures","volume":"370","author":"Sanchez","year":"1999","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0265","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbrc.2003.10.115","article-title":"Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs","volume":"312","author":"Schroder","year":"2003","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.biocel.2013.04.005_bib0270","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1053\/j.gastro.2007.02.052","article-title":"LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms","volume":"132","author":"Schwarz","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0275","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1242\/jcs.02915","article-title":"Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure","volume":"119","author":"Shen","year":"2006","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.biocel.2013.04.005_bib0280","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev.cellbio.22.010305.104219","article-title":"Tight junctions and cell polarity","volume":"22","author":"Shin","year":"2006","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0285","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000312669","article-title":"Cysteinyl leukotrienes and their receptors: molecular and functional characteristics","volume":"85","author":"Singh","year":"2010","journal-title":"Pharmacology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0290","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0022-3565(25)13034-6","article-title":"Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness","volume":"253","author":"Smith","year":"1990","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.biocel.2013.04.005_bib0295","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000112866","article-title":"Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells","volume":"81","author":"Suzuki","year":"2008","journal-title":"Pharmacology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0300","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3945\/jn.108.100867","article-title":"Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells","volume":"139","author":"Suzuki","year":"2009","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.biocel.2013.04.005_bib0305","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.2353\/ajpath.2006.060681","article-title":"Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application","volume":"169","author":"Turner","year":"2006","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0310","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.959824","article-title":"Calcium release from skeletal muscle sarcoplasmic reticulum: site of action of dantrolene sodium","volume":"193","author":"Van Winkle","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.biocel.2013.04.005_bib0315","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/jsfa.4598","article-title":"Apple extract induces increased epithelial resistance and claudin 4 expression in Caco-2 cells","volume":"92","author":"Vreeburg","year":"2012","journal-title":"Journal of the Science of Food and Agriculture"},{"key":"10.1016\/j.biocel.2013.04.005_bib0320","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0076-6879(07)33002-4","article-title":"Measurement of eicosanoids in cancer tissues","volume":"433","author":"Wang","year":"2007","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0325","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1136\/gut.34.4.503","article-title":"Inter-relationships between inflammatory mediators released from colonic mucosa in ulcerative colitis and their effects on colonic secretion","volume":"34","author":"Wardle","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2013.04.005_bib0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2007.09.013","article-title":"Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor","volume":"121","author":"Woszczek","year":"2008","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0335","doi-asserted-by":"crossref","first-page":"G496","DOI":"10.1152\/ajpgi.00318.2005","article-title":"Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier","volume":"290","author":"Ye","year":"2006","journal-title":"American Journal of Physiology \u2013 Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.biocel.2013.04.005_bib0340","doi-asserted-by":"crossref","first-page":"12454","DOI":"10.1074\/jbc.M011361200","article-title":"Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2","volume":"276","author":"Yokomizo","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biocel.2013.04.005_bib0345","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1084\/jem.192.3.421","article-title":"A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders","volume":"192","author":"Yokomizo","year":"2000","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.biocel.2013.04.005_bib0350","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-11","article-title":"Leukotriene B4 receptor. Cloning and intracellular signaling","volume":"161","author":"Yokomizo","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.biocel.2013.04.005_bib0355","doi-asserted-by":"crossref","DOI":"10.1007\/BF01991027","article-title":"Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue","author":"Zijlstra","year":"1992","journal-title":"Agents and Actions"},{"key":"10.1016\/j.biocel.2013.04.005_bib0360","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0952-3278(91)90133-P","article-title":"15-HETE is the main eicosanoid present in mucus of ulcerative proctocolitis","volume":"43","author":"Zijlstra","year":"1991","journal-title":"Prostaglandins Leukotrienes and Essential Fatty Acids"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272513001027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272513001027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:49:42Z","timestamp":1761202182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272513001027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":72,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S1357272513001027"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2013.04.005","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2013.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}