{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:35:41Z","timestamp":1789659341238,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Department of Health's NIHR Biomedical Research Centres"},{"name":"Great Ormond Street Hospital Children's Charity"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.biocel.2014.02.003","type":"journal-article","created":{"date-parts":[[2014,2,15]],"date-time":"2014-02-15T05:31:05Z","timestamp":1392442265000},"page":"60-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"special_numbering":"C","title":["Effect of Coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in Coenzyme Q10 deficient human neuronal cells"],"prefix":"10.1016","volume":"50","author":[{"given":"K.E.","family":"Duberley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.R.","family":"Heales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.Y.","family":"Abramov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chalasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Land","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.P.","family":"Hargreaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2014.02.003_bib0005","first-page":"797","article-title":"Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations","volume":"133","author":"Abramov","year":"2010","journal-title":"J Neurology"},{"key":"10.1016\/j.biocel.2014.02.003_bib0010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0003-9861(75)90022-3","article-title":"4-Hydroxybenzoate: polyprenyl transferase and the prenylation of 4-aminobenzoate in mammalian tissues.","volume":"171","author":"Alam","year":"1975","journal-title":"Arch biochem biophys"},{"key":"10.1016\/j.biocel.2014.02.003_bib0015","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0891-5849(02)01357-6","article-title":"Distribution and breakdown of labelled coenzyme Q10 in rat","volume":"34","author":"Bentinger","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.biocel.2014.02.003_bib0020","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.mito.2007.02.006","article-title":"The antioxidant role of coenzyme Q10","volume":"7S","author":"Bentinger","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.biocel.2014.02.003_bib0025","first-page":"3751","article-title":"Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones","volume":"38","author":"Biedler","year":"1978","journal-title":"Cancer Res"},{"key":"10.1016\/j.biocel.2014.02.003_bib0030","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/10715760600617843","article-title":"Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics","volume":"40","author":"Bhagavan","year":"2006","journal-title":"Free radical res"},{"key":"10.1016\/j.biocel.2014.02.003_bib0035","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1074\/jbc.273.21.12753","article-title":"Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration","volume":"273","author":"Davey","year":"1998","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.biocel.2014.02.003_bib0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10545-012-9511-0","article-title":"Human neuronal coenzyme Q10 deficiency results in a global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and a reversal of ATP synthase activity: Implications for the pathogenesis and treatment","volume":"36","author":"Duberley","year":"2013","journal-title":"Inherit Metab Dis"},{"key":"10.1016\/j.biocel.2014.02.003_bib0045","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1373\/clinchem.2005.054643","article-title":"Determination of Coenzyme Q10 in blood mononuclear cells, skeletal muscle and plasma by HPLC using di-propoxy-Coenzyme Q10 as an internal standard","volume":"51","author":"Duncan","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.biocel.2014.02.003_bib0050","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1001\/archneurol.2012.206","article-title":"Heterogeneity of coenzyme Q10 deficiency: patient study and literature review","volume":"69","author":"Emmanuele","year":"2012","journal-title":"Arc neurol"},{"key":"10.1016\/j.biocel.2014.02.003_bib0055","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0891-5849(98)00216-0","article-title":"Mitochondrial damage induced by conditions of oxidative stress","volume":"26","author":"Kowaltowski","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.biocel.2014.02.003_bib0060","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/hmg\/ddm058","article-title":"Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis","volume":"16","author":"L\u00f3pez-Mart\u00edn","year":"2007","journal-title":"Hum mol genet"},{"key":"10.1016\/j.biocel.2014.02.003_bib0065","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"issue":"Suppl.","key":"10.1016\/j.biocel.2014.02.003_bib0070","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1016\/j.mito.2007.02.012","article-title":"The uptake and distribution of coenzyme Q10","volume":"7","author":"Miles","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.biocel.2014.02.003_bib0075","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.clinbiochem.2008.03.007","article-title":"Analysis of coenzyme Q10 in muscle and fibroblasts for the diagnosis of CoQ10 deficiency syndromes","volume":"41","author":"Montero","year":"2008","journal-title":"Clin Biochem"},{"key":"10.1016\/j.biocel.2014.02.003_bib0080","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nmd.2011.05.001","article-title":"176th ENMC International Workshop: diagnosis and treatment of coenzyme Q(10) deficiency","volume":"22","author":"Rahman","year":"2012","journal-title":"Neuromuscul disord"},{"key":"10.1016\/j.biocel.2014.02.003_bib0085","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0887-8994(00)00145-4","article-title":"Mitochondrial activity in Pompe's disease","volume":"23","author":"Selak","year":"2000","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.biocel.2014.02.003_bib0090","doi-asserted-by":"crossref","first-page":"L1005","DOI":"10.1152\/ajplung.2000.279.6.L1005","article-title":"Reactive oxygen species in cell signaling","volume":"279","author":"Thannickal","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514000466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514000466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:53:19Z","timestamp":1761202399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272514000466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":18,"alternative-id":["S1357272514000466"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2014.02.003","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in Coenzyme Q10 deficient human neuronal cells","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2014.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}