{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:52:13Z","timestamp":1783407133257,"version":"3.54.6"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Hong Kong Research Grant Council GRF","award":["HKU7740\/11M"],"award-info":[{"award-number":["HKU7740\/11M"]}]},{"DOI":"10.13039\/501100002409","name":"University of Hong Kong Seed Funding Programme for Basic Research","doi-asserted-by":"publisher","award":["200811159088"],"award-info":[{"award-number":["200811159088"]}],"id":[{"id":"10.13039\/501100002409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.biocel.2014.04.013","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T09:15:23Z","timestamp":1398762923000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-7040","authenticated-orcid":false,"given":"Joe Jiang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy KaMan","family":"Kam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Merc\u00e8","family":"Garcia-Barcel\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Kwong Hang","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Chi Hang","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2014.04.013_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2007.053959","article-title":"Hirschsprung disease, associated syndromes and genetics: a review","volume":"45","author":"Amiel","year":"2008","journal-title":"J Med Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0010","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ng0893-351","article-title":"A gene for Hirschsprung disease (megacolon) in the pericentromeric region of human chromosome 10","volume":"4","author":"Angrist","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0015","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1086\/429589","article-title":"Identifying candidate Hirschsprung disease-associated RET variants","volume":"76","author":"Burzynski","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0020","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ajhg.2010.06.007","article-title":"Differential contributions of rare and common, coding and noncoding Ret mutations to multifactorial Hirschsprung disease liability","volume":"87","author":"Emison","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0025","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nature03467","article-title":"A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk","volume":"434","author":"Emison","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2014.04.013_bib0030","first-page":"173","article-title":"The neural crest: basic biology and clinical relationships in the craniofacial and enteric nervous systems. Birth defects research Part C","volume":"72","author":"Farlie","year":"2004","journal-title":"Embryo Today: Rev"},{"key":"10.1016\/j.biocel.2014.04.013_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/dvdy.10350","article-title":"HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts","volume":"228","author":"Fu","year":"2003","journal-title":"Dev Dyn"},{"key":"10.1016\/j.biocel.2014.04.013_bib0040","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/hmg\/ddi015","article-title":"TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease","volume":"14","author":"Garcia-Barcelo","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0045","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1469-1809.2007.00347.x","article-title":"Correlation between genetic variations in Hox clusters and Hirschsprung's disease","volume":"71","author":"Garcia-Barcelo","year":"2007","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0050","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1093\/hmg\/ddi408","article-title":"Evaluation of the RET regulatory landscape reveals the biological relevance of a HSCR-implicated enhancer","volume":"14","author":"Grice","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0055","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1086\/342774","article-title":"A rare haplotype of the RET proto-oncogene is a risk-modifying allele in hirschsprung disease","volume":"71","author":"Griseri","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0060","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ng1966","article-title":"Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome","volume":"39","author":"Heintzman","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0065","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1172\/JCI10828","article-title":"Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret","volume":"106","author":"Lang","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biocel.2014.04.013_bib0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jcb.22250","article-title":"Stability of histone modifications across mammalian genomes: implications for \u2018epigenetic\u2019 marking","volume":"108","author":"Lee","year":"2009","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.biocel.2014.04.013_bib0075","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.jpedsurg.2008.11.055","article-title":"Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3","volume":"44","author":"Leon","year":"2009","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.biocel.2014.04.013_bib0080","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1053\/j.gastro.2008.01.028","article-title":"Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice","volume":"134","author":"Lui","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2014.04.013_bib0085","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/ng0893-346","article-title":"A gene for Hirschsprung disease maps to the proximal long arm of chromosome 10","volume":"4","author":"Lyonnet","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0090","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1002\/j.1460-2075.1994.tb06610.x","article-title":"TATA-binding protein-associated factor(s) in TFIID function through the initiator to direct basal transcription from a TATA-less class II promoter","volume":"13","author":"Martinez","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.biocel.2014.04.013_bib0095","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/hmg\/ddq020","article-title":"Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease","volume":"19","author":"Miao","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biocel.2014.04.013_bib0100","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1242\/dev.129.22.5151","article-title":"Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis","volume":"129","author":"Natarajan","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.biocel.2014.04.013_bib0105","doi-asserted-by":"crossref","first-page":"20222","DOI":"10.1073\/pnas.0902454106","article-title":"Transcription factors mediate long-range enhancer-promoter interactions","volume":"106","author":"Nolis","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biocel.2014.04.013_bib0110","first-page":"G183","article-title":"Role of the RET signal transduction pathway in development of the mammalian enteric nervous system","volume":"275","author":"Pachnis","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.biocel.2014.04.013_bib0115","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/dev.119.4.1005","article-title":"Expression of the c-ret proto-oncogene during mouse embryogenesis","volume":"119","author":"Pachnis","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.biocel.2014.04.013_bib0120","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1093\/emboj\/17.6.1788","article-title":"Selectivity, sharing and competitive interactions in the regulation of Hoxb genes","volume":"17","author":"Sharpe","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.biocel.2014.04.013_bib0125","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4161\/nucl.19232","article-title":"Chromatin signatures of active enhancers","volume":"3","author":"Spicuglia","year":"2012","journal-title":"Nucleus"},{"key":"10.1016\/j.biocel.2014.04.013_bib0130","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1053\/j.gastro.2010.10.044","article-title":"Variants in RET associated with Hirschsprung's disease affect binding of transcription factors and gene expression","volume":"140","author":"Sribudiani","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2014.04.013_bib0135","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00383-009-2402-2","article-title":"Genetic basis of Hirschsprung's disease","volume":"25","author":"Tam","year":"2009","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.biocel.2014.04.013_bib0140","doi-asserted-by":"crossref","first-page":"e20815","DOI":"10.1371\/journal.pone.0020815","article-title":"HOXB5 cooperates with NKX2-1 in the transcription of human RET","volume":"6","author":"Zhu","year":"2011","journal-title":"PLoS ONE"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514001289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514001289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:54:25Z","timestamp":1761202465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272514001289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":28,"alternative-id":["S1357272514001289"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2014.04.013","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2014.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}