{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:08:00Z","timestamp":1790165280026,"version":"4.1.0"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000297","name":"FRAXA Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"J\u00e9r\u00f4me Lejeune Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["#BFU2012-33500"],"award-info":[{"award-number":["#BFU2012-33500"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["#SAF2011-29864"],"award-info":[{"award-number":["#SAF2011-29864"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Instituto de Salud Carlos","award":["RD06\/0001\/0001"],"award-info":[{"award-number":["RD06\/0001\/0001"]}]},{"name":"PLAN E (Plan Espa\u00f1ol para el Est\u00edmulo de la Econom\u00eda y el Empleo)"},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SGR-2009-00731"],"award-info":[{"award-number":["SGR-2009-00731"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ICREA (Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.biocel.2014.05.004","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T07:47:07Z","timestamp":1400053627000},"page":"121-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model"],"prefix":"10.1016","volume":"53","author":[{"given":"Arnau","family":"Busquets-Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Ozaita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"August (2)","key":"10.1016\/j.biocel.2014.05.004_bib0005","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/jn.00449.2010","article-title":"Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis","volume":"104","author":"Auerbach","year":"2010","journal-title":"J Neurophysiol"},{"issue":"August (16)","key":"10.1016\/j.biocel.2014.05.004_bib0010","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/ajmg.a.32439","article-title":"Co-occurring conditions associated with FMR1 gene variations: findings from a national parent survey","volume":"146A","author":"Bailey","year":"2008","journal-title":"Am J Med Genet A"},{"issue":"July (1)","key":"10.1016\/j.biocel.2014.05.004_bib0015","first-page":"23","article-title":"Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium","volume":"78","author":"Baker","year":"1994","journal-title":"Cell"},{"issue":"August (6)","key":"10.1016\/j.biocel.2014.05.004_bib0020","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1601-183X.2010.00585.x","article-title":"Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments","volume":"9","author":"Baker","year":"2010","journal-title":"Genes Brain Behav"},{"issue":"May (3)","key":"10.1016\/j.biocel.2014.05.004_bib0025","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.neuron.2013.03.017","article-title":"Excitatory\/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis","volume":"78","author":"Bateup","year":"2013","journal-title":"Neuron"},{"issue":"July (7)","key":"10.1016\/j.biocel.2014.05.004_bib0030","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","article-title":"The mGluR theory of fragile X mental retardation","volume":"27","author":"Bear","year":"2004","journal-title":"Trends Neurosci"},{"issue":"January (1)","key":"10.1016\/j.biocel.2014.05.004_bib0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1503\/jpn.110011","article-title":"A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health","volume":"37","author":"Beaulieu","year":"2012","journal-title":"J Psychiatry Neurosci"},{"issue":"November (6)","key":"10.1016\/j.biocel.2014.05.004_bib0040","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1352\/1944-7558-115.6.461","article-title":"Seizures in fragile X syndrome: characteristics and comorbid diagnoses","volume":"115","author":"Berry-Kravis","year":"2010","journal-title":"Am J Intellect Dev Disabil"},{"issue":"October (2)","key":"10.1016\/j.biocel.2014.05.004_bib0045","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuron.2012.07.022","article-title":"Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice","volume":"76","author":"Bhattacharya","year":"2012","journal-title":"Neuron"},{"issue":"February (2)","key":"10.1016\/j.biocel.2014.05.004_bib0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/jmg.2008.061796","article-title":"Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model","volume":"46","author":"Bilousova","year":"2009","journal-title":"J Med Genet"},{"issue":"May (5)","key":"10.1016\/j.biocel.2014.05.004_bib0055","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nm.3127","article-title":"Targeting the endocannabinoid system in the treatment of fragile X syndrome","volume":"19","author":"Busquets-Garcia","year":"2013","journal-title":"Nat Med"},{"issue":"October (1)","key":"10.1016\/j.biocel.2014.05.004_bib0060","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuron.2012.09.020","article-title":"Endocannabinoid signaling and synaptic function","volume":"76","author":"Castillo","year":"2012","journal-title":"Neuron"},{"issue":"August (35)","key":"10.1016\/j.biocel.2014.05.004_bib0065","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1523\/JNEUROSCI.1777-05.2005","article-title":"Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model","volume":"25","author":"Chuang","year":"2005","journal-title":"J Neurosci"},{"issue":"June (6)","key":"10.1016\/j.biocel.2014.05.004_bib0070","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0022-3476(87)80392-X","article-title":"Fragile X syndrome","volume":"110","author":"Chudley","year":"1987","journal-title":"J Pediatr"},{"issue":"June (Pt 6)","key":"10.1016\/j.biocel.2014.05.004_bib0075","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2788.2008.01056.x","article-title":"The fragile X continuum: new advances and perspectives","volume":"52","author":"Cornish","year":"2008","journal-title":"J Intellect Disabil Res"},{"issue":"January (2)","key":"10.1016\/j.biocel.2014.05.004_bib0080","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0306-4522(96)00224-2","article-title":"Mildly impaired water maze performance in male Fmr1 knockout mice","volume":"76","author":"D\u2019Hooge","year":"1997","journal-title":"Neuroscience"},{"issue":"August (8)","key":"10.1016\/j.biocel.2014.05.004_bib0085","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.tins.2007.06.003","article-title":"The GABAA receptor: a novel target for treatment of fragile X?","volume":"30","author":"D\u2019Hulst","year":"2007","journal-title":"Trends Neurosci"},{"issue":"July (2)","key":"10.1016\/j.biocel.2014.05.004_bib0090","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2011.06.013","article-title":"FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism","volume":"146","author":"Darnell","year":"2011","journal-title":"Cell"},{"issue":"April (14)","key":"10.1016\/j.biocel.2014.05.004_bib0095","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1073\/pnas.1219383110","article-title":"Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486","volume":"110","author":"Dolan","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.biocel.2014.05.004_bib0100","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0306-4522(00)00292-X","article-title":"Fmr1 knockout mouse has a distinctive strain-specific learning impairment","volume":"100","author":"Dobkin","year":"2000","journal-title":"Neuroscience"},{"issue":"December (12)","key":"10.1016\/j.biocel.2014.05.004_bib0105","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2004.10.001","article-title":"Neuroprotection by tetracyclines","volume":"25","author":"Domercq","year":"2004","journal-title":"Trends Pharmacol Sci"},{"issue":"March","key":"10.1016\/j.biocel.2014.05.004_bib0110","first-page":"2","article-title":"E-I balance and human diseases - from molecules to networking","volume":"1","author":"Eichler","year":"2008","journal-title":"Front Mol Neurosci"},{"issue":"July (1)","key":"10.1016\/j.biocel.2014.05.004_bib0115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00213-013-3022-z","article-title":"Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome","volume":"228","author":"Erickson","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"issue":"April (2)","key":"10.1016\/j.biocel.2014.05.004_bib0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1014888505185","article-title":"Longitudinal changes in cognitive and adaptive behavior scores in children and adolescents with the fragile X mutation or autism","volume":"32","author":"Fisch","year":"2002","journal-title":"J Autism Dev Disord"},{"issue":"February (3)","key":"10.1016\/j.biocel.2014.05.004_bib0125","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biopsych.2013.08.003","article-title":"Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice","volume":"75","author":"Franklin","year":"2014","journal-title":"Biol Psychiatry"},{"issue":"December (6)","key":"10.1016\/j.biocel.2014.05.004_bib0130","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2174\/156800705774933069","article-title":"Endocannabinoids in the central nervous system: from neuronal networks to behavior","volume":"4","author":"Fride","year":"2005","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"issue":"November (5)","key":"10.1016\/j.biocel.2014.05.004_bib0135","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1152\/jn.90752.2008","article-title":"Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome","volume":"100","author":"Gibson","year":"2008","journal-title":"J Neurophysiol"},{"issue":"August (2)","key":"10.1016\/j.biocel.2014.05.004_bib0140","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/(SICI)1096-8628(19960809)64:2<246::AID-AJMG2>3.0.CO;2-S","article-title":"Long-term potentiation in the hippocampus of fragile X knockout mice","volume":"64","author":"Godfraind","year":"1996","journal-title":"Am J Med Genet"},{"issue":"January (1)","key":"10.1016\/j.biocel.2014.05.004_bib0145","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1517\/13543784.2014.857400","article-title":"Development of mavoglurant and its potential for the treatment of fragile X syndrome","volume":"23","author":"Gomez-Mancilla","year":"2014","journal-title":"Expert Opin Investig Drugs"},{"issue":"July (7)","key":"10.1016\/j.biocel.2014.05.004_bib0150","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nn.3415","article-title":"Circuit level defects in the developing neocortex of Fragile X mice","volume":"16","author":"Gon\u00e7alves","year":"2013","journal-title":"Nat Neurosci"},{"issue":"August (32)","key":"10.1016\/j.biocel.2014.05.004_bib0155","doi-asserted-by":"crossref","first-page":"10624","DOI":"10.1523\/JNEUROSCI.0402-10.2010","article-title":"Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome","volume":"30","author":"Gross","year":"2010","journal-title":"J Neurosci"},{"issue":"April (1)","key":"10.1016\/j.biocel.2014.05.004_bib0160","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.brainres.2006.02.044","article-title":"Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines","volume":"1084","author":"Grossman","year":"2006","journal-title":"Brain Res"},{"issue":"April (67)","key":"10.1016\/j.biocel.2014.05.004_bib0165","first-page":"pe24","article-title":"The pharmacology of mTOR inhibition","volume":"2","author":"Guertin","year":"2009","journal-title":"Sci Signal"},{"issue":"February (1)","key":"10.1016\/j.biocel.2014.05.004_bib0170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00004703-200602000-00012","article-title":"Lessons from fragile X regarding neurobiology, autism, and neurodegeneration","volume":"27","author":"Hagerman","year":"2006","journal-title":"J Dev Behav Pediatr"},{"key":"10.1016\/j.biocel.2014.05.004_bib0175","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/978-3-642-21649-7_17","article-title":"Fragile X syndrome and targeted treatment trials","volume":"54","author":"Hagerman","year":"2012","journal-title":"Results Probl Cell Differ"},{"issue":"July (27)","key":"10.1016\/j.biocel.2014.05.004_bib0180","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.0705003104","article-title":"Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice","volume":"104","author":"Hayashi","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"October (40)","key":"10.1016\/j.biocel.2014.05.004_bib0185","doi-asserted-by":"crossref","first-page":"14223","DOI":"10.1523\/JNEUROSCI.3157-11.2011","article-title":"Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry","volume":"31","author":"Hays","year":"2011","journal-title":"J Neurosci"},{"issue":"October","key":"10.1016\/j.biocel.2014.05.004_bib0190","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuroscience.2012.03.049","article-title":"The trouble with spines in fragile X syndrome: density, maturity and plasticity","volume":"251","author":"He","year":"2013","journal-title":"Neuroscience"},{"issue":"September (152)","key":"10.1016\/j.biocel.2014.05.004_bib0195","first-page":"152ra128","article-title":"Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen","volume":"4","author":"Henderson","year":"2012","journal-title":"Sci Transl Med"},{"issue":"December (3)","key":"10.1016\/j.biocel.2014.05.004_bib0200","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ajmg.1320410306","article-title":"Analysis of neocortex in three males with the fragile X syndrome","volume":"41","author":"Hinton","year":"1991","journal-title":"Am J Med Genet"},{"issue":"April (3)","key":"10.1016\/j.biocel.2014.05.004_bib0205","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1601-183X.2012.00768.x","article-title":"Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome","volume":"11","author":"Hoeffer","year":"2012","journal-title":"Genes Brain Behav"},{"issue":"July (28)","key":"10.1016\/j.biocel.2014.05.004_bib0210","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1523\/JNEUROSCI.0995-04.2004","article-title":"Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression","volume":"24","author":"Hou","year":"2004","journal-title":"J Neurosci"},{"issue":"July (31)","key":"10.1016\/j.biocel.2014.05.004_bib0215","doi-asserted-by":"crossref","first-page":"7847","DOI":"10.1523\/JNEUROSCI.1496-08.2008","article-title":"Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome","volume":"28","author":"Hu","year":"2008","journal-title":"J Neurosci"},{"issue":"May (11)","key":"10.1016\/j.biocel.2014.05.004_bib0220","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1073\/pnas.122205699","article-title":"Altered synaptic plasticity in a mouse model of fragile X mental retardation","volume":"99","author":"Huber","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"October","key":"10.1016\/j.biocel.2014.05.004_bib0225","article-title":"The challenges of clinical trials in fragile X syndrome","author":"Jacquemont","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"issue":"November (46)","key":"10.1016\/j.biocel.2014.05.004_bib0230","doi-asserted-by":"crossref","first-page":"18234","DOI":"10.1523\/JNEUROSCI.2207-13.2013","article-title":"The Fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses","volume":"33","author":"Janusz","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.biocel.2014.05.004_bib0235","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/ncomms2045","article-title":"Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome","volume":"3","author":"Jung","year":"2012","journal-title":"Nat Commun"},{"issue":"January (1)","key":"10.1016\/j.biocel.2014.05.004_bib0240","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1152\/physrev.00019.2008","article-title":"Endocannabinoid-mediated control of synaptic transmission","volume":"89","author":"Kano","year":"2009","journal-title":"Physiol Rev"},{"issue":"March (3)","key":"10.1016\/j.biocel.2014.05.004_bib0245","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0168-9525(03)00017-9","article-title":"Of mice and the fragile X syndrome","volume":"19","author":"Kooy","year":"2003","journal-title":"Trends Genet"},{"key":"10.1016\/j.biocel.2014.05.004_bib0250","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-med-061109-134644","article-title":"Toward fulfilling the promise of molecular medicine in fragile X syndrome","volume":"62","author":"Krueger","year":"2011","journal-title":"Annu Rev Med"},{"issue":"October (40)","key":"10.1016\/j.biocel.2014.05.004_bib0255","doi-asserted-by":"crossref","first-page":"10685","DOI":"10.1523\/JNEUROSCI.2624-07.2007","article-title":"Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome","volume":"27","author":"Lauterborn","year":"2007","journal-title":"J Neurosci"},{"issue":"November (4)","key":"10.1016\/j.biocel.2014.05.004_bib0260","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.neuron.2011.09.033","article-title":"Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein","volume":"72","author":"Lee","year":"2011","journal-title":"Neuron"},{"issue":"November (11)","key":"10.1016\/j.biocel.2014.05.004_bib0265","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.molmed.2010.08.005","article-title":"Potential therapeutic interventions for fragile X syndrome","volume":"16","author":"Levenga","year":"2010","journal-title":"Trends Mol Med"},{"issue":"February (3)","key":"10.1016\/j.biocel.2014.05.004_bib0270","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1101\/gad.232470.113","article-title":"Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model","volume":"28","author":"Lim","year":"2014","journal-title":"Genes Dev"},{"issue":"April (1)","key":"10.1016\/j.biocel.2014.05.004_bib0275","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2009.02.066","article-title":"Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome","volume":"454","author":"Liu","year":"2009","journal-title":"Neurosci Lett"},{"issue":"January (1)","key":"10.1016\/j.biocel.2014.05.004_bib0280","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nchembio.129","article-title":"Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects","volume":"5","author":"Long","year":"2009","journal-title":"Nat Chem Biol"},{"issue":"January (1)","key":"10.1016\/j.biocel.2014.05.004_bib0285","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1152\/physrev.00014.2003","article-title":"Long-term potentiation and memory","volume":"84","author":"Lynch","year":"2004","journal-title":"Physiol Rev"},{"issue":"June (7)","key":"10.1016\/j.biocel.2014.05.004_bib0290","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/npp.2010.19","article-title":"Abnormal mGlu 5 receptor\/endocannabinoid coupling in mice lacking FMRP and BC1 RNA","volume":"35","author":"Maccarrone","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"July (7)","key":"10.1016\/j.biocel.2014.05.004_bib0295","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1530-0277.2008.00690.x","article-title":"Acamprosate: recent findings and future research directions","volume":"32","author":"Mann","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"issue":"December","key":"10.1016\/j.biocel.2014.05.004_bib0300","first-page":"224","article-title":"The intense world theory - a unifying theory of the neurobiology of autism","volume":"4","author":"Markram","year":"2010","journal-title":"Front Hum Neurosci"},{"issue":"December (12)","key":"10.1016\/j.biocel.2014.05.004_bib0305","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1046\/j.1460-9568.1999.00847.x","article-title":"Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain","volume":"11","author":"Marsicano","year":"1999","journal-title":"Eur J Neurosci"},{"issue":"April (4)","key":"10.1016\/j.biocel.2014.05.004_bib0310","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tins.2007.02.005","article-title":"Long-term depression: multiple forms and implications for brain function","volume":"30","author":"Massey","year":"2007","journal-title":"Trends Neurosci"},{"issue":"April (1)","key":"10.1016\/j.biocel.2014.05.004_bib0315","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuron.2012.03.009","article-title":"Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice","volume":"74","author":"Michalon","year":"2012","journal-title":"Neuron"},{"issue":"February (3)","key":"10.1016\/j.biocel.2014.05.004_bib0320","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.biopsych.2013.05.038","article-title":"Chronic metabotropic glutamate receptor 5 inhibition corrects local alterations of brain activity and improves cognitive performance in fragile X mice","volume":"75","author":"Michalon","year":"2014","journal-title":"Biol Psychiatry"},{"issue":"April (4)","key":"10.1016\/j.biocel.2014.05.004_bib0325","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/(SICI)1096-8628(19990402)83:4<268::AID-AJMG7>3.0.CO;2-K","article-title":"Electrodermal responses to sensory stimuli in individuals with fragile X syndrome: a preliminary report","volume":"83","author":"Miller","year":"1999","journal-title":"Am J Med Genet"},{"issue":"February (2)","key":"10.1016\/j.biocel.2014.05.004_bib0330","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.neuropharm.2008.09.017","article-title":"Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential","volume":"56","author":"Min","year":"2009","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.biocel.2014.05.004_bib0335","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/hipo.10005","article-title":"Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse","volume":"12","author":"Mineur","year":"2002","journal-title":"Hippocampus"},{"issue":"January (1)","key":"10.1016\/j.biocel.2014.05.004_bib0340","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1528-1157.2000.tb01499.x","article-title":"Audiogenic seizures susceptibility in transgenic mice with fragile X syndrome","volume":"41","author":"Musumeci","year":"2000","journal-title":"Epilepsia"},{"issue":"July (1)","key":"10.1016\/j.biocel.2014.05.004_bib0345","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1124\/mol.109.056127","article-title":"Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures","volume":"76","author":"Pacey","year":"2009","journal-title":"Mol Pharmacol"},{"issue":"November (5)","key":"10.1016\/j.biocel.2014.05.004_bib0350","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1152\/jn.00421.2011","article-title":"Impaired inhibitory control of cortical synchronization in fragile X syndrome","volume":"106","author":"Paluszkiewicz","year":"2011","journal-title":"J Neurophysiol"},{"issue":"1","key":"10.1016\/j.biocel.2014.05.004_bib0355","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0306-4522(99)00285-7","article-title":"mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function","volume":"94","author":"Paradee","year":"1999","journal-title":"Neuroscience"},{"issue":"May (5)","key":"10.1016\/j.biocel.2014.05.004_bib0360","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2788.2011.01484.x","article-title":"Self-injurious behaviour in intellectual disability syndromes: evidence for aberrant pain signalling as a contributing factor","volume":"56","author":"Peebles","year":"2012","journal-title":"J Intellect Disabil Res"},{"key":"10.1016\/j.biocel.2014.05.004_bib0365","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev.genom.8.080706.092249","article-title":"The pathophysiology of fragile X syndrome","volume":"8","author":"Penagarikano","year":"2007","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"March (3)","key":"10.1016\/j.biocel.2014.05.004_bib0370","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nn.2741","article-title":"Dendritic spine pathology in neuropsychiatric disorders","volume":"14","author":"Penzes","year":"2011","journal-title":"Nat Neurosci"},{"issue":"October (5)","key":"10.1016\/j.biocel.2014.05.004_bib0375","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1177\/1073858409333075","article-title":"The state of synapses in fragile X syndrome","volume":"15","author":"Pfeiffer","year":"2009","journal-title":"Neuroscientist"},{"issue":"December (51)","key":"10.1016\/j.biocel.2014.05.004_bib0380","doi-asserted-by":"crossref","first-page":"13958","DOI":"10.1523\/JNEUROSCI.4383-07.2007","article-title":"Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1\/5 and mTOR","volume":"27","author":"Price","year":"2007","journal-title":"J Neurosci"},{"issue":"December (1607)","key":"10.1016\/j.biocel.2014.05.004_bib0385","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1098\/rstb.2011.0384","article-title":"Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids","volume":"367","author":"Puighermanal","year":"2012","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"Fall (3)","key":"10.1016\/j.biocel.2014.05.004_bib0390","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1527-3458.2003.tb00254.x","article-title":"The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease","volume":"9","author":"Rogawski","year":"2003","journal-title":"CNS Drug Rev"},{"issue":"April (4)","key":"10.1016\/j.biocel.2014.05.004_bib0395","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrd1346","article-title":"Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia","volume":"3","author":"Roth","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biocel.2014.05.004_bib0400","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-pathol-011811-132457","article-title":"Molecular mechanisms of fragile X syndrome: a twenty-year perspective","volume":"7","author":"Santoro","year":"2012","journal-title":"Annu Rev Pathol"},{"issue":"November (3)","key":"10.1016\/j.biocel.2014.05.004_bib0405","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1471-4159.2009.06314.x","article-title":"mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice","volume":"111","author":"Shang","year":"2009","journal-title":"J Neurochem"},{"issue":"January (2)","key":"10.1016\/j.biocel.2014.05.004_bib0410","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1523\/JNEUROSCI.3696-09.2010","article-title":"Dysregulation of mTOR signaling in fragile X syndrome","volume":"30","author":"Sharma","year":"2010","journal-title":"J Neurosci"},{"issue":"February (1)","key":"10.1016\/j.biocel.2014.05.004_bib0415","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/aur.168","article-title":"Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses","volume":"4","author":"Spencer","year":"2011","journal-title":"Autism Res"},{"issue":"December (12)","key":"10.1016\/j.biocel.2014.05.004_bib0420","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tips.2012.09.004","article-title":"Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders","volume":"33","author":"Spooren","year":"2012","journal-title":"Trends Pharmacol Sci"},{"issue":"February (1)","key":"10.1016\/j.biocel.2014.05.004_bib0425","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/1073858410365562","article-title":"Ras and Rap signaling in synaptic plasticity and mental disorders","volume":"17","author":"Stornetta","year":"2011","journal-title":"Neuroscientist"},{"issue":"3","key":"10.1016\/j.biocel.2014.05.004_bib0430","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/mrdd.20031","article-title":"Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis","volume":"10","author":"Symons","year":"2004","journal-title":"Ment Retard Dev Disabil Res Rev"},{"issue":"November (6)","key":"10.1016\/j.biocel.2014.05.004_bib0435","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1352\/1944-7558-115.6.473","article-title":"Self-injurious behavior and fragile X syndrome: findings from the national fragile X survey","volume":"115","author":"Symons","year":"2010","journal-title":"Am J Intellect Dev Disabil"},{"issue":"April (1420)","key":"10.1016\/j.biocel.2014.05.004_bib0440","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1098\/rstb.2001.0887","article-title":"Protein synthesis in the dendrite","volume":"357","author":"Tang","year":"2002","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"October (2)","key":"10.1016\/j.biocel.2014.05.004_bib0445","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbr.2011.04.049","article-title":"Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome","volume":"223","author":"Thomas","year":"2011","journal-title":"Behav Brain Res"},{"issue":"5","key":"10.1016\/j.biocel.2014.05.004_bib0450","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000329421","article-title":"The psychiatric presentation of fragile x: evolution of the diagnosis and treatment of the psychiatric comorbidities of fragile X syndrome","volume":"33","author":"Tranfaglia","year":"2011","journal-title":"Dev Neurosci"},{"issue":"February (2)","key":"10.1016\/j.biocel.2014.05.004_bib0455","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.pneurobio.2012.01.005","article-title":"Deregulated mTOR-mediated translation in intellectual disability","volume":"96","author":"Troca-Mar\u00edn","year":"2012","journal-title":"Prog Neurobiol"},{"issue":"1\u20132","key":"10.1016\/j.biocel.2014.05.004_bib0460","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0166-4328(00)00296-5","article-title":"Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice","volume":"117","author":"Van Dam","year":"2000","journal-title":"Behav Brain Res"},{"issue":"December (24)","key":"10.1016\/j.biocel.2014.05.004_bib0465","doi-asserted-by":"crossref","first-page":"RC188","DOI":"10.1523\/JNEUROSCI.21-24-j0003.2001","article-title":"Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus","volume":"21","author":"Varma","year":"2001","journal-title":"J Neurosci"},{"issue":"September (5\u20136)","key":"10.1016\/j.biocel.2014.05.004_bib0470","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/00008877-200409000-00018","article-title":"Object recognition impairment in Fmr1 knockout mice is reversed by amphetamine: involvement of dopamine in the medial prefrontal cortex","volume":"15","author":"Ventura","year":"2004","journal-title":"Behav Pharmacol"},{"issue":"June (3)","key":"10.1016\/j.biocel.2014.05.004_bib0475","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.gde.2012.02.002","article-title":"New perspectives on the biology of fragile X syndrome","volume":"22","author":"Wang","year":"2012","journal-title":"Curr Opin Genet Dev"},{"issue":"July (1)","key":"10.1016\/j.biocel.2014.05.004_bib0480","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuron.2008.05.014","article-title":"Rapid translation of Arc\/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate","volume":"59","author":"Waung","year":"2008","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.biocel.2014.05.004_bib0485","doi-asserted-by":"crossref","first-page":"e36981","DOI":"10.1371\/journal.pone.0036981","article-title":"The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome","volume":"7","author":"Wei","year":"2012","journal-title":"PLoS One"},{"issue":"April (5568)","key":"10.1016\/j.biocel.2014.05.004_bib0490","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1063545","article-title":"Endocannabinoid signaling in the brain","volume":"296","author":"Wilson","year":"2002","journal-title":"Science"},{"issue":"November","key":"10.1016\/j.biocel.2014.05.004_bib0495","first-page":"223","article-title":"Emerging links between homeostatic synaptic plasticity and neurological disease","volume":"7","author":"Wondolowski","year":"2013","journal-title":"Front Cell Neurosci"},{"issue":"May (5)","key":"10.1016\/j.biocel.2014.05.004_bib0500","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1152\/jn.90558.2008","article-title":"Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models","volume":"101","author":"Zhang","year":"2009","journal-title":"J Neurophysiol"},{"issue":"April (16)","key":"10.1016\/j.biocel.2014.05.004_bib0505","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1523\/JNEUROSCI.0795-10.2010","article-title":"Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome","volume":"30","author":"Zhang","year":"2010","journal-title":"J Neurosci"},{"issue":"October (5646)","key":"10.1016\/j.biocel.2014.05.004_bib0510","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1089071","article-title":"Postnatal neurodevelopmental disorders: meeting at the synapse?","volume":"302","author":"Zoghbi","year":"2003","journal-title":"Science"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514001484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514001484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:58:01Z","timestamp":1761202681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272514001484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":102,"alternative-id":["S1357272514001484"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2014.05.004","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2014.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}