{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:27:20Z","timestamp":1791199640674,"version":"4.2.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Medical University of Graz, Austria"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.biocel.2014.06.020","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T01:46:03Z","timestamp":1404956763000},"page":"137-148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent"],"prefix":"10.1016","volume":"54","author":[{"given":"Valentina","family":"Biasin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Chwalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Best","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh M.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahil","family":"Ghanim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Klepetko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph T.","family":"Schermuly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Weissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Olschewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazyna","family":"Kwapiszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biocel.2014.06.020_bib0005","doi-asserted-by":"crossref","first-page":"L580","DOI":"10.1152\/ajplung.00281.2007","article-title":"Rodent models of PAH: are we there yet?","volume":"293","author":"Bauer","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"10.1016\/j.biocel.2014.06.020_bib0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/path.4303","article-title":"Meprin beta, a novel mediator of vascular remodeling underlying pulmonary hypertension","volume":"233","author":"Biasin","year":"2014","journal-title":"J Pathol"},{"issue":"4","key":"10.1016\/j.biocel.2014.06.020_bib0015","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10985-007-9065-x","article-title":"Generalized linear mixed models: a review and some extensions","volume":"13","author":"Dean","year":"2007","journal-title":"Lifetime Data Anal"},{"issue":"7088","key":"10.1016\/j.biocel.2014.06.020_bib0020","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nature04695","article-title":"Lysyl oxidase is essential for hypoxia-induced metastasis","volume":"440","author":"Erler","year":"2006","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib0025","doi-asserted-by":"crossref","first-page":"L1233","DOI":"10.1152\/ajplung.00445.2002","article-title":"Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells","volume":"285","author":"Fantozzi","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"7","key":"10.1016\/j.biocel.2014.06.020_bib0030","first-page":"1531","article-title":"Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase","volume":"13","author":"Fuchs","year":"1996","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib0035","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.biocel.2012.03.003","article-title":"Intracellular redox equilibrium is essential for the constitutive expression of AP-1 dependent genes in resting cells: studies on TGF-beta1 regulation","volume":"44","author":"Gonzalez-Ramos","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"issue":"4","key":"10.1016\/j.biocel.2014.06.020_bib0040","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1183\/09031936.00167010","article-title":"Endothelin receptor expression in idiopathic pulmonary arterial hypertension: effect of bosentan and epoprostenol treatment","volume":"38","author":"Hall","year":"2011","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.biocel.2014.06.020_bib0045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pharmthera.2012.09.001","article-title":"Immediate early response genes and cell transformation","volume":"137","author":"Healy","year":"2013","journal-title":"Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib0050","doi-asserted-by":"crossref","first-page":"F1223","DOI":"10.1152\/ajprenal.00245.2004","article-title":"Hypoxic induction of Ctgf is directly mediated by Hif-1","volume":"287","author":"Higgins","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"10.1016\/j.biocel.2014.06.020_bib0055","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1006\/bbrc.1998.8543","article-title":"Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand","volume":"245","author":"Hu","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"issue":"2 Pt 2","key":"10.1016\/j.biocel.2014.06.020_bib0060","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0002-8703(93)90208-Q","article-title":"Manidipine inhibits endothelin-1-induced [Ca2+]i signaling but potentiates endothelin's effect on c-fos and c-jun induction in vascular smooth muscle and glomerular mesangial cells","volume":"125","author":"Huang","year":"1993","journal-title":"Am Heart J"},{"issue":"2 Pt 1","key":"10.1016\/j.biocel.2014.06.020_bib0065","first-page":"L123","article-title":"Cytokine signaling in lung: transforming growth factor-beta secretion by lung fibroblasts","volume":"260","author":"Kelley","year":"1991","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.biocel.2014.06.020_bib0070","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1172\/JCI115367","article-title":"Hypoxia induces endothelin gene expression and secretion in cultured human endothelium","volume":"88","author":"Kourembanas","year":"1991","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.biocel.2014.06.020_bib0075","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1164\/rccm.200312-1668OC","article-title":"Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes","volume":"170","author":"Kunichika","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib0080","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.ajpath.2012.08.028","article-title":"BDNF\/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension","volume":"181","author":"Kwapiszewska","year":"2012","journal-title":"Am J Pathol"},{"issue":"9","key":"10.1016\/j.biocel.2014.06.020_bib0085","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1161\/CIRCRESAHA.111.257568","article-title":"PAR-2 inhibition reverses experimental pulmonary hypertension","volume":"110","author":"Kwapiszewska","year":"2012","journal-title":"Circ Res"},{"issue":"8","key":"10.1016\/j.biocel.2014.06.020_bib0090","doi-asserted-by":"crossref","first-page":"e73399","DOI":"10.1371\/journal.pone.0073399","article-title":"The interaction of endothelin-1 and TGF-beta1 mediates vascular cell remodeling","volume":"8","author":"Lambers","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biocel.2014.06.020_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/emm.2004.1","article-title":"Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions","volume":"36","author":"Lee","year":"2004","journal-title":"Exp Mol Med"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib0105","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/jcp.22489","article-title":"Peptidoglycan induces interleukin-6 expression through the TLR2 receptor, JNK, c-Jun, and AP-1 pathways in microglia","volume":"226","author":"Lin","year":"2011","journal-title":"J Cell Physiol"},{"issue":"5","key":"10.1016\/j.biocel.2014.06.020_bib0110","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00001721-200207000-00006","article-title":"Plasminogen activation by blood monocytes and alveolar macrophages in primary pulmonary hypertension","volume":"13","author":"Martin","year":"2002","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib0115","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/01.RES.0000182425.49768.8a","article-title":"Increased fibulin-5 and elastin in S100A4\/Mts1 mice with pulmonary hypertension","volume":"97","author":"Merklinger","year":"2005","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.biocel.2014.06.020_bib0120","first-page":"205","article-title":"Interaction of AP-1 and the ctgf gene: a possible driver of chondrocyte hypertrophy in growth cartilage","volume":"21","author":"Moritani","year":"2003","journal-title":"J Bone Miner Metab"},{"issue":"1 Suppl","key":"10.1016\/j.biocel.2014.06.020_bib0125","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.jacc.2009.04.018","article-title":"Cellular and molecular basis of pulmonary arterial hypertension","volume":"54","author":"Morrell","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib1234","first-page":"659","article-title":"The avian cellular homolog of the oncogene jun","volume":"3","author":"Nishimura","year":"1988","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.biocel.2014.06.020_bib0130","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/0735-1097(95)00399-1","article-title":"Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: relation to hemodynamic variables and endothelin levels","volume":"26","author":"Nootens","year":"1995","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"10.1016\/j.biocel.2014.06.020_bib0135","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1002\/j.1460-2075.1995.tb00187.x","article-title":"The Mos\/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells","volume":"14","author":"Okazaki","year":"1995","journal-title":"EMBO J"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib0140","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1067\/mlc.2001.119285","article-title":"Cellular pathophysiology and therapy of pulmonary hypertension","volume":"138","author":"Olschewski","year":"2001","journal-title":"J Lab Clin Med"},{"issue":"2","key":"10.1016\/j.biocel.2014.06.020_bib0145","first-page":"153","article-title":"Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions","volume":"22","author":"Pearson","year":"2001","journal-title":"Endocr Rev"},{"issue":"1","key":"10.1016\/j.biocel.2014.06.020_bib0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1164\/rccm.200707-1037OC","article-title":"Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension","volume":"178","author":"Perros","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.biocel.2014.06.020_bib0155","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1056\/NEJMoa012212","article-title":"Bosentan therapy for pulmonary arterial hypertension","volume":"346","author":"Rubin","year":"2002","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.biocel.2014.06.020_bib0160","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.molcel.2006.08.005","article-title":"Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role","volume":"24","author":"Sasaki","year":"2006","journal-title":"Mol Cell"},{"issue":"10","key":"10.1016\/j.biocel.2014.06.020_bib0165","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1172\/JCI24838","article-title":"Reversal of experimental pulmonary hypertension by PDGF inhibition","volume":"115","author":"Schermuly","year":"2005","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.biocel.2014.06.020_bib0170","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrcardio.2011.87","article-title":"Mechanisms of disease: pulmonary arterial hypertension","volume":"8","author":"Schermuly","year":"2011","journal-title":"Nat Rev Cardiol"},{"issue":"19","key":"10.1016\/j.biocel.2014.06.020_bib0175","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/sj.onc.1204383","article-title":"AP-1 in cell proliferation and survival","volume":"20","author":"Shaulian","year":"2001","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.biocel.2014.06.020_bib0180","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/BF02555240","article-title":"In vitro induction of osteosarcomalike lesion by transformation of differentiating skeletal precursor cells with FBR murine osteosarcoma virus","volume":"41","author":"Silbermann","year":"1987","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.biocel.2014.06.020_bib0185","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1046-2023(03)00155-5","article-title":"Normalization of cDNA microarray data","volume":"31","author":"Smyth","year":"2003","journal-title":"Methods"},{"issue":"7","key":"10.1016\/j.biocel.2014.06.020_bib0190","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/01.RES.0000243584.45145.3f","article-title":"Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms","volume":"99","author":"Stenmark","year":"2006","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib0195","doi-asserted-by":"crossref","first-page":"L1013","DOI":"10.1152\/ajplung.00217.2009","article-title":"Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure","volume":"297","author":"Stenmark","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"19","key":"10.1016\/j.biocel.2014.06.020_bib0200","doi-asserted-by":"crossref","first-page":"18842","DOI":"10.1074\/jbc.M500620200","article-title":"Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light","volume":"280","author":"Tanos","year":"2005","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.biocel.2014.06.020_bib0205","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1164\/rccm.200911-1663OC","article-title":"Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases","volume":"183","author":"ten Freyhaus","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.biocel.2014.06.020_bib0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/bmb\/ldq012","article-title":"Pulmonary hypertension: advances in pathogenesis and treatment","volume":"94","author":"Toshner","year":"2010","journal-title":"Br Med Bull"},{"issue":"3","key":"10.1016\/j.biocel.2014.06.020_bib0215","first-page":"195","article-title":"Secretory functions of the vascular endothelium","volume":"43","author":"Vane","year":"1992","journal-title":"J Physiol Pharmacol"},{"issue":"1","key":"10.1016\/j.biocel.2014.06.020_bib0220","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/pmic.201200206","article-title":"Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension","volume":"13","author":"Veith","year":"2013","journal-title":"Proteomics"},{"issue":"23","key":"10.1016\/j.biocel.2014.06.020_bib0225","doi-asserted-by":"crossref","first-page":"16066","DOI":"10.1016\/S0021-9258(18)41966-7","article-title":"Polar secretion of endothelin-1 by cultured endothelial cells","volume":"267","author":"Wagner","year":"1992","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.biocel.2014.06.020_bib0230","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1165\/ajrcmb.25.5.4461","article-title":"Rho-kinase activation is involved in hypoxia-induced pulmonary vasoconstriction","volume":"25","author":"Wang","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"14","key":"10.1016\/j.biocel.2014.06.020_bib0235","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/CIRCULATIONAHA.113.006402","article-title":"Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling","volume":"129","author":"Weisel","year":"2014","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.biocel.2014.06.020_bib0240","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1152\/physiolgenomics.00249.2010","article-title":"Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH","volume":"43","author":"White","year":"2011","journal-title":"Physiol Genomics"},{"issue":"16","key":"10.1016\/j.biocel.2014.06.020_bib0245","doi-asserted-by":"crossref","first-page":"12645","DOI":"10.1074\/jbc.M011344200","article-title":"Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300\/CBP","volume":"276","author":"Yamashita","year":"2001","journal-title":"J Biol Chem"},{"issue":"13","key":"10.1016\/j.biocel.2014.06.020_bib0250","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/hc3801.095662","article-title":"c-Jun decreases voltage-gated K(+)channel activity in pulmonary artery smooth muscle cells","volume":"104","author":"Yu","year":"2001","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.biocel.2014.06.020_bib0255","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/01.CIR.0000156326.48823.55","article-title":"Pathogenesis of pulmonary arterial hypertension: the need for multiple hits","volume":"111","author":"Yuan","year":"2005","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.biocel.2014.06.020_bib0260","doi-asserted-by":"crossref","first-page":"L574","DOI":"10.1152\/ajplung.00327.2013","article-title":"Transgelin as a therapeutic target to prevent hypoxic pulmonary hypertension","volume":"306","author":"Zhang","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514002192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514002192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:54:50Z","timestamp":1761202490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272514002192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":52,"alternative-id":["S1357272514002192"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2014.06.020","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2014.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}