{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:34:15Z","timestamp":1770348855799,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.biocel.2014.10.008","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T04:33:21Z","timestamp":1413261201000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Transient receptor potential vanilloid 1 is expressed in human cytotrophoblasts: Induction of cell apoptosis and impairment of syncytialization"],"prefix":"10.1016","volume":"57","author":[{"given":"M.A.","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.M.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Keating","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.A.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5787-9018","authenticated-orcid":false,"given":"G.","family":"Correia-da-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2014.10.008_bib0005","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/carcin\/bgp138","article-title":"Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas\/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner","volume":"30","author":"Amantini","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.biocel.2014.10.008_bib0010","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/sj.cdd.4401506","article-title":"Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death","volume":"11","author":"Amantini","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.biocel.2014.10.008_bib0015","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1471-4159.2007.04582.x","article-title":"Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation","volume":"102","author":"Amantini","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.biocel.2014.10.008_bib0020","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ceca.2010.12.003","article-title":"Calcium signaling in placenta","volume":"49","author":"Baczyk","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.biocel.2014.10.008_bib0025","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.placenta.2005.12.007","article-title":"Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane","volume":"27","author":"Bernucci","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.biocel.2014.10.008_bib0030","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2014.10.008_bib0035","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.placenta.2008.05.003","article-title":"Dual effect of anandamide on rat placenta nitric oxide synthesis","volume":"29","author":"Cella","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.biocel.2014.10.008_bib0040","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.juro.2006.11.046","article-title":"Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis","volume":"177","author":"Charrua","year":"2007","journal-title":"J U"},{"key":"10.1016\/j.biocel.2014.10.008_bib0045","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1093\/jnen\/63.9.956","article-title":"Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1","volume":"63","author":"Contassot","year":"2004","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0050","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0143-4004(03)00183-8","article-title":"Altered placental oxidative stress status in gestational diabetes mellitus","volume":"25","author":"Coughlan","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.biocel.2014.10.008_bib0055","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0002-9440(10)63857-6","article-title":"Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction","volume":"162","author":"Crocker","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0060","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1189\/jlb.0312123","article-title":"Transient receptor potential vanilloid 1 activation induces autophagy in thymocytes through ROS-regulated AMPK and Atg4C pathways","volume":"92","author":"Farfariello","year":"2012","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0065","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.4049\/jimmunol.1102147","article-title":"TRPV1 deletion enhances local inflammation and accelerates the onset of systemic inflammatory response syndrome","volume":"188","author":"Fernandes","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0070","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.reprotox.2012.05.036","article-title":"Characterisation of the endocannabinoid system in rat haemochorial placenta","volume":"34","author":"Fonseca","year":"2012","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.prostaglandins.2013.02.002","article-title":"Endogenous cannabinoids revisited: a biochemistry perspective","volume":"102\u2013103","author":"Fonseca","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.biocel.2014.10.008_bib0080","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1210\/en.2007-1799","article-title":"Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation","volume":"149","author":"Habayeb","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2014.10.008_bib0085","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1582-4934.2010.01039.x","article-title":"Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta","volume":"15","author":"Hache","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.biocel.2014.10.008_bib0090","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbrc.2012.06.115","article-title":"Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-kappaB translocation and ROS production in synoviocytes","volume":"424","author":"Hu","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biocel.2014.10.008_bib0095","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.bone.2010.01.368","article-title":"The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo","volume":"46","author":"Idris","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.biocel.2014.10.008_bib0100","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1203\/PDR.0b013e3181b9b4a3","article-title":"Comparison of the transport characteristics of bioactive substances in IUGR and normal placentas","volume":"66","author":"Keating","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.biocel.2014.10.008_bib0105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00232-007-9057-5","article-title":"Progesterone inhibits folic acid transport in human trophoblasts","volume":"216","author":"Keating","year":"2007","journal-title":"J Membr Biol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0110","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/mrd.20729","article-title":"Impaired cytotrophoblast cell-cell fusion is associated with reduced Syncytin and increased apoptosis in patients with placental dysfunction","volume":"75","author":"Langbein","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.biocel.2014.10.008_bib0115","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1067\/mob.2001.112906","article-title":"Increased placental apoptosis in pregnancies complicated by preeclampsia","volume":"184","author":"Leung","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0120","doi-asserted-by":"crossref","first-page":"e1182","DOI":"10.1038\/cddis.2014.146","article-title":"TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells","volume":"5","author":"Li","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.biocel.2014.10.008_bib0125","first-page":"1809","article-title":"Human cytotrophoblast differentiation\/invasion is abnormal in pre-eclampsia","volume":"151","author":"Lim","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0130","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1472-6882-13-46","article-title":"Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells","volume":"13","author":"Lin","year":"2013","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.biocel.2014.10.008_bib0135","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.placenta.2012.01.017","article-title":"Villous trophoblast apoptosis is elevated and restricted to cytotrophoblasts in pregnancies complicated by preeclampsia, IUGR, or preeclampsia with IUGR","volume":"33","author":"Longtine","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.biocel.2014.10.008_bib0140","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1523\/JNEUROSCI.4465-07.2008","article-title":"Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus","volume":"28","author":"Ludanyi","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.biocel.2014.10.008_bib0145","doi-asserted-by":"crossref","first-page":"31938","DOI":"10.1074\/jbc.M005722200","article-title":"Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors","volume":"275","author":"Maccarrone","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biocel.2014.10.008_bib0150","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ab.2009.12.025","article-title":"Anandamide levels in human female reproductive tissues: solid-phase extraction and measurement by ultraperformance liquid chromatography tandem mass spectrometry","volume":"400","author":"Marczylo","year":"2010","journal-title":"Anal Biochem"},{"key":"10.1016\/j.biocel.2014.10.008_bib0155","first-page":"G348","article-title":"Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon","volume":"297","author":"Matsumoto","year":"2009","journal-title":"Am J Physiol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0160","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1447-0756.2011.01771.x","article-title":"Role of oxidative stress in preeclampsia and intrauterine growth restriction","volume":"38","author":"Mert","year":"2012","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.biocel.2014.10.008_bib0165","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1095\/biolreprod.102.005397","article-title":"Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta","volume":"67","author":"Moreau","year":"2002","journal-title":"Biol Reprod"},{"key":"10.1016\/j.biocel.2014.10.008_bib0170","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ejphar.2013.05.009","article-title":"Nitric oxide induces apoptosis associated with TRPV1 channel-mediated Ca(2+) entry via S-nitrosylation in osteoblasts","volume":"715","author":"Pan","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0175","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3109\/14767058.2010.526158","article-title":"Trophoblast apoptosis in human term placentas from pregnancies complicated with idiopathic intrauterine growth retardation","volume":"24","author":"Roje","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.biocel.2014.10.008_bib0180","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00109-010-0656-8","article-title":"Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes","volume":"88","author":"Ruebner","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.biocel.2014.10.008_bib0185","first-page":"3874","article-title":"Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner","volume":"85","author":"Schaiff","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.biocel.2014.10.008_bib0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijgo.2006.03.025","article-title":"Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia","volume":"94","author":"Sharma","year":"2006","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.biocel.2014.10.008_bib0195","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ejphar.2007.05.017","article-title":"Role of capsaicin-sensitive sensory nerves in protease-activated receptor-2-mediated contraction of rat urinary bladder","volume":"569","author":"Shimizu","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0200","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.bbrc.2008.10.152","article-title":"TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons","volume":"377","author":"Shirakawa","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biocel.2014.10.008_bib0205","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cellsig.2013.09.014","article-title":"Capsaicin induces cytotoxicity in pancreatic neuroendocrine tumor cells via mitochondrial action","volume":"26","author":"Skrzypski","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.biocel.2014.10.008_bib0210","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0002-9378(97)70081-4","article-title":"Increased placental apoptosis in intrauterine growth restriction","volume":"177","author":"Smith","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0215","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5607\/en.2013.22.1.51","article-title":"TRPV1 Activation in Primary Cortical Neurons Induces Calcium-Dependent Programmed Cell Death","volume":"22","author":"Song","year":"2013","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0220","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000320289","article-title":"Trophoblast apoptosis in placentas from pregnancies complicated by preeclampsia","volume":"71","author":"Tomas","year":"2011","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.biocel.2014.10.008_bib0225","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.febslet.2009.04.031","article-title":"Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells","volume":"583","author":"Toth","year":"2009","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biocel.2014.10.008_bib0230","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1124\/jpet.103.064162","article-title":"Ethanol causes inflammation in the airways by a neurogenic and TRPV1-dependent mechanism","volume":"309","author":"Trevisani","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.biocel.2014.10.008_bib0235","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/MPA.0b013e318214c8df","article-title":"Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats","volume":"40","author":"Vigna","year":"2011","journal-title":"Pancreas"},{"key":"10.1016\/j.biocel.2014.10.008_bib0240","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1124\/mol.109.055624","article-title":"Pharmacology of vanilloid transient receptor potential cation channels","volume":"75","author":"Vriens","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0245","first-page":"R1204","article-title":"K+ channel inhibition modulates the biochemical and morphological differentiation of human placental cytotrophoblast cells in vitro","volume":"295","author":"Williams","year":"2008","journal-title":"Am J Physiol"},{"key":"10.1016\/j.biocel.2014.10.008_bib0250","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1055\/s-0037-1613475","article-title":"Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications","volume":"89","author":"Yamaji","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.biocel.2014.10.008_bib0255","doi-asserted-by":"crossref","first-page":"e77300","DOI":"10.1371\/journal.pone.0077300","article-title":"TRPV1 potentiates TGFbeta-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514003197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272514003197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:57:12Z","timestamp":1761202632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272514003197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":51,"alternative-id":["S1357272514003197"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2014.10.008","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transient receptor potential vanilloid 1 is expressed in human cytotrophoblasts: Induction of cell apoptosis and impairment of syncytialization","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2014.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}