{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:14:27Z","timestamp":1784546067008,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"DST and DBT","award":["SR\/SO\/AS-55\/2009"],"award-info":[{"award-number":["SR\/SO\/AS-55\/2009"]}]},{"name":"DST and DBT","award":["BT\/PR11490\/BRB\/10\/675\/2008"],"award-info":[{"award-number":["BT\/PR11490\/BRB\/10\/675\/2008"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.biocel.2015.08.002","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T23:23:30Z","timestamp":1438817010000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-\u03b1"],"prefix":"10.1016","volume":"67","author":[{"given":"Sumit Kumar","family":"Hira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrani","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasis","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-0818","authenticated-orcid":false,"given":"Partha Pratim","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2015.08.002_bib0005","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrc2256","article-title":"Models, mechanisms and clinical evidence for cancer dormancy","volume":"7","author":"Aguirre-Ghiso","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biocel.2015.08.002_bib0010","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1084\/jem.20070991","article-title":"Development and function of murine B220+ CD11c+ NK1.1+ cells identify them as a subset of NK cells","volume":"204","author":"Blasius","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.biocel.2015.08.002_bib0015","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.coi.2008.04.006","article-title":"Killer dendritic cells: IKDC and the others","volume":"20","author":"Bonmort","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0020","first-page":"945","article-title":"Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention","volume":"8","author":"Buettner","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biocel.2015.08.002_bib0025","first-page":"3833","article-title":"TNF-\u03b1 is critical for antitumor but not antiviral T cell immunity in mice","volume":"117","author":"Calzascia","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biocel.2015.08.002_bib0030","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1084\/jem.20071351","article-title":"Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells","volume":"204","author":"Caminschi","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.biocel.2015.08.002_bib0035","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1056\/NEJM199808273390904","article-title":"Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia","volume":"339","author":"Cav\u00e9","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biocel.2015.08.002_bib0040","first-page":"23","article-title":"IL-15: targeting CD8+T cells for immunotherapy","volume":"7","author":"Diab","year":"2005","journal-title":"Chemotherapy"},{"key":"10.1016\/j.biocel.2015.08.002_bib0045","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1182\/blood-2002-06-1841","article-title":"Dendritic cells from CML patients have altered actin organization, reduced antigen processing, and impaired migration","volume":"101","author":"Dong","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.biocel.2015.08.002_bib0050","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/cimm.1997.1132","article-title":"IL-15 mediates anti-tumor effects after cyclophosphamide injection of tumor-bearing mice and enhances adoptive immunotherapy: the potential role of NK cell subpopulations","volume":"179","author":"Evans","year":"1997","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0055","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1470-2045(03)01022-2","article-title":"Study of suboptimum treatment response: lessons from breast cancer","volume":"4","author":"Eystein L\u00f8nning","year":"2003","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0060","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1200\/JCO.1989.7.3.291","article-title":"Tumor necrosis factor: still a promising agent","volume":"7","author":"Frei","year":"1989","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0065","first-page":"73","article-title":"Growth characteristics of free tumor cells transferred serially in the peritoneal fluid of the mouse","volume":"11","author":"Goldie","year":"1951","journal-title":"Cancer Res."},{"key":"10.1016\/j.biocel.2015.08.002_bib0070","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.med.53.082901.103929","article-title":"Mechanisms of cancer drug resistance","volume":"53","author":"Gottesman","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.biocel.2015.08.002_bib0075","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/nm0909-1010","article-title":"Cancer stem cells: mirage or reality?","volume":"15","author":"Gupta","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2015.08.002_bib0080","doi-asserted-by":"crossref","first-page":"e94309","DOI":"10.1371\/journal.pone.0094309","article-title":"Targeted delivery of doxorubicin-loaded poly (epsilon-caprolactone)-b-poly (n-vinylpyrrolidone) micelles enhances antitumor effect in lymphoma","volume":"9","author":"Hira","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.biocel.2015.08.002_bib0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.yexcr.2014.08.012","article-title":"Downregulation of endogenous STAT3 augments tumoricidal activity of interleukin 15 activated dendritic cell against lymphoma and leukemia via TRAIL","volume":"327","author":"Hira","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biocel.2015.08.002_bib0090","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-4939-0345-0_6","article-title":"Tumor antigen-\/cytokine-pulsed dendritic cells in therapy against lymphoma","volume":"1139","author":"Hira","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0095","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1101\/gad.1815309","article-title":"The combined status of ATM and p53 link tumor development with therapeutic response","volume":"23","author":"Jiang","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.biocel.2015.08.002_bib0100","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bcp.2009.09.008","article-title":"Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines","volume":"79","author":"Kim","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0105","first-page":"139","article-title":"Differential survival of solid tumor cells after inoculation into established ascites tumors","volume":"14","author":"Klein","year":"1954","journal-title":"Cancer Res."},{"key":"10.1016\/j.biocel.2015.08.002_bib0110","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1182\/blood-2003-12-4187","article-title":"Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance","volume":"105","author":"Kobayashi","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.biocel.2015.08.002_bib0115","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.coi.2008.03.010","article-title":"Role of Stat3 in suppressing anti-tumor immunity","volume":"20","author":"Kortylewski","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0120","first-page":"1703","article-title":"Doxorubicin gradients in human breast cancer","volume":"5","author":"Lankelma","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biocel.2015.08.002_bib0125","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1677\/erc.0.0100043","article-title":"ATP binding cassette transporters and drug resistance in breast cancer","volume":"10","author":"Leonessa","year":"2003","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.biocel.2015.08.002_bib0130","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.4049\/jimmunol.166.9.5407","article-title":"The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells","volume":"166","author":"Liu","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0135","doi-asserted-by":"crossref","first-page":"e24786","DOI":"10.4161\/onci.24786","article-title":"Tumor necrosis factor is dispensable for the success of immunogenic anticancer chemotherapy","volume":"2","author":"Ma","year":"2013","journal-title":"OncoImmunology"},{"key":"10.1016\/j.biocel.2015.08.002_bib0140","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.fct.2010.05.013","article-title":"Antitumor properties of a heteroglucan isolated from Astraeus hygrometricus on Dalton's lymphoma bearing mouse","volume":"48","author":"Mallick","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0145","doi-asserted-by":"crossref","first-page":"29637","DOI":"10.1074\/jbc.M500922200","article-title":"CD47 augments Fas\/CD95-mediated apoptosis","volume":"280","author":"Manna","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2015.08.002_bib0150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cyto.2012.09.004","article-title":"IL-15 activated human peripheral blood dendritic cell kill allogeneic and xenogeneic endothelial cells via apoptosis","volume":"61","author":"Manna","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.biocel.2015.08.002_bib0155","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1189\/jlb.72.2.312","article-title":"Human dendritic cell mediated cytotoxicity against breast carcinoma cells in vitro","volume":"72","author":"Manna","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0160","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.4049\/jimmunol.180.10.6477","article-title":"The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2","volume":"180","author":"Mignot","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0165","series-title":"Handbook of Cancer Chemotherapy","author":"Skeel","year":"2011"},{"key":"10.1016\/j.biocel.2015.08.002_bib0170","first-page":"3467","article-title":"An overview on the use of TNF-alpha: our experience with regional administration and developments towards new opportunities for systemic application","volume":"20","author":"van Der Veen","year":"2000","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biocel.2015.08.002_bib0175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nm976","article-title":"Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells","volume":"10","author":"Wang","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2015.08.002_bib0180","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1128\/MCB.15.10.5339","article-title":"N-and C-terminal sequences control degradation of MAD3\/I kappa B alpha in response to inducers of NF-kappa B activity","volume":"15","author":"Whiteside","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0185","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.clim.2004.09.007","article-title":"Impaired function of circulating dendritic cells in patients with pancreatic cancer","volume":"114","author":"Yanagimoto","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.biocel.2015.08.002_bib0190","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1084\/jem.20041057","article-title":"Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function","volume":"201","author":"Zeng","year":"2005","journal-title":"J. Exp. Med."}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272515002034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272515002034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:03:30Z","timestamp":1761203010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272515002034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":38,"alternative-id":["S1357272515002034"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2015.08.002","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-\u03b1","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2015.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}