{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:23:52Z","timestamp":1771457032563,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Natural Scientific Foundation","award":["81130010"],"award-info":[{"award-number":["81130010"]}]},{"name":"National Natural Scientific Foundation","award":["81470997"],"award-info":[{"award-number":["81470997"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.biocel.2015.10.014","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T04:22:39Z","timestamp":1445574159000},"page":"114-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["TLR2\u2013MyD88\u2013NF-\u03baB pathway is involved in tubulointerstitial inflammation caused by proteinuria"],"prefix":"10.1016","volume":"69","author":[{"given":"Li-Hong","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ri-Ning","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun-Ling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2015.10.014_bib0005","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2015.10.014_bib0010","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/sj.ki.5002436","article-title":"Innate pathogen recognition in the kidney: toll-like receptors, NOD-like receptors, and RIG-like helicases","volume":"72","author":"Anders","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.biocel.2015.10.014_bib0015","doi-asserted-by":"crossref","first-page":"15028","DOI":"10.1074\/jbc.M200497200","article-title":"Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4","volume":"277","author":"Asea","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2015.10.014_bib0020","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ki.2010.381","article-title":"Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury","volume":"79","author":"Chen","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.biocel.2015.10.014_bib0025","doi-asserted-by":"crossref","first-page":"F676","DOI":"10.1152\/ajprenal.00507.2012","article-title":"Pirfenidone inhibits macrophage infiltration in 5\/6 nephrectomized rats","volume":"304","author":"Chen","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0030","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/bcp.12104","article-title":"Pathophysiology of proteinuria and its value as an outcome measure in chronic kidney disease","volume":"76","author":"Cravedi","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0035","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1523-1755.2003.00840.x","article-title":"Pathophysiology of proteinuria","volume":"63","author":"D\u2019Amico","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.biocel.2015.10.014_bib0040","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.micinf.2006.02.024","article-title":"Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4","volume":"8","author":"de Graaf","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.biocel.2015.10.014_bib0045","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/aps.2014.66","article-title":"Enalapril inhibits tubulointerstitial inflammation and NLRP3 inflammasome expression in BSA-overload nephropathy of rats","volume":"35","author":"Ding","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biocel.2015.10.014_bib0050","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/cs0980295","article-title":"Albumin stimulates p44\/p42 extracellular-signal-regulated mitogen-activated protein kinase in opossum kidney proximal tubular cells","volume":"98","author":"Dixon","year":"2000","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.biocel.2015.10.014_bib0055","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1097\/01.ASN.0000089564.55411.7F","article-title":"Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappaB- and p38 mitogen-activated protein kinase-dependent pathways","volume":"14","author":"Donadelli","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0060","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ncpneph0300","article-title":"Renal Toll-like receptors: recent advances and implications for disease","volume":"2","author":"El-Achkar","year":"2006","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0065","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0070","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1681\/ASN.2010111210","article-title":"Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy","volume":"23","author":"Lin","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000110019","article-title":"Inhibition of integrin-linked kinase via a siRNA expression plasmid attenuates connective tissue growth factor-induced human proximal tubular epithelial cells to mesenchymal transition","volume":"28","author":"Liu","year":"2008","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.biocel.2014.09.018","article-title":"Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: a novel mechanism of albumin-induced tubulointerstitial inflammation","volume":"57C","author":"Liu","year":"2014","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0085","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1159\/000112850","article-title":"Norcantharidin ameliorates proteinuria, associated tubulointerstitial inflammation and fibrosis in protein overload nephropathy","volume":"28","author":"Liu","year":"2008","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0090","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biocel.2015.01.011","article-title":"Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease","volume":"61C","author":"Liu","year":"2015","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0095","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/ndt\/gft332","article-title":"Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis","volume":"29","author":"Lorenz","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biocel.2015.10.014_bib0100","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2015.10.014_bib0105","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrneph.2014.114","article-title":"Inflammatory processes in renal fibrosis","volume":"10","author":"Meng","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0110","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.matbio.2014.01.010","article-title":"Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury","volume":"35","author":"Moreth","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0115","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/01.ASN.0000109672.83594.02","article-title":"Activation of the signal transducer and activator of transcription signaling pathway in renal proximal tubular cells by albumin","volume":"15","author":"Nakajima","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0120","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of Toll-like receptors \u2013 redefining innate immunity","volume":"13","author":"O\u2019Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0125","doi-asserted-by":"crossref","first-page":"C917","DOI":"10.1152\/ajpcell.00401.2005","article-title":"High mobility group box 1 protein interacts with multiple Toll-like receptors","volume":"290","author":"Park","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0130","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1159\/000228077","article-title":"Toll-like receptors and renal disease","volume":"113","author":"Robson","year":"2009","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0135","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.95.2.588","article-title":"A family of human receptors structurally related to Drosophila Toll","volume":"95","author":"Rock","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biocel.2015.10.014_bib0140","doi-asserted-by":"crossref","first-page":"H503","DOI":"10.1152\/ajpheart.00642.2006","article-title":"Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury","volume":"292","author":"Sakata","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0145","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1172\/JCI23755","article-title":"The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages","volume":"115","author":"Schaefer","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biocel.2015.10.014_bib0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ajpath.2010.11.019","article-title":"Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy","volume":"78","author":"Shaw","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0155","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.4049\/jimmunol.178.10.6252","article-title":"TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways","volume":"178","author":"Shigeoka","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0165","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4049\/jimmunol.169.1.10","article-title":"Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins","volume":"169","author":"Takeuchi","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0170","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1681\/ASN.2006050489","article-title":"Toll-like receptors: the interface between innate and adaptive immunity","volume":"17","author":"Tipping","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0175","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.bbadis.2013.05.023","article-title":"ERK-mediated suppression of cilia in cisplatin-induced tubular cell apoptosis and acute kidney injury","volume":"1832","author":"Wang","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biocel.2015.10.014_bib0180","doi-asserted-by":"crossref","first-page":"F138","DOI":"10.1152\/ajprenal.00375.2013","article-title":"Cinacalcet attenuates the renal endothelial-to-mesenchymal transition in rats with adenine-induced renal failure","volume":"306","author":"Wu","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biocel.2015.10.014_bib0185","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/aps.2014.100","article-title":"FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway","volume":"35","author":"Xu","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biocel.2015.10.014_bib0190","doi-asserted-by":"crossref","first-page":"e88894","DOI":"10.1371\/journal.pone.0088894","article-title":"Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells","volume":"9","author":"Yiu","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.biocel.2015.10.014_bib0195","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/ki.2012.188","article-title":"Activation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury","volume":"82","author":"Yuan","year":"2012","journal-title":"Kidney Int."}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272515300376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272515300376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:02:54Z","timestamp":1761202974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272515300376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":39,"alternative-id":["S1357272515300376"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2015.10.014","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLR2\u2013MyD88\u2013NF-\u03baB pathway is involved in tubulointerstitial inflammation caused by proteinuria","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2015.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}