{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:09:22Z","timestamp":1761203362284,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"International Postgraduate Research Scholarship (IPRS)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.biocel.2016.06.013","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T20:27:55Z","timestamp":1466713675000},"page":"229-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Pigment epithelium-derived factor stimulates skeletal muscle glycolytic activity through NADPH oxidase-dependent reactive oxygen species production"],"prefix":"10.1016","volume":"78","author":[{"given":"Revathy","family":"Carnagarin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Carlessi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Newsholme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun M.","family":"Dharmarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crispin R.","family":"Dass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2016.06.013_bib0005","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/jphp.12218","article-title":"Pigment epithelium-derived factor as a natural matrix metalloproteinase inhibitor: a comparison with classical matrix metalloproteinase inhibitors used for cancer treatment","volume":"66","author":"Alcantara","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biocel.2016.06.013_bib0010","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1172\/JCI9900","article-title":"The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle","volume":"106","author":"Benigni","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biocel.2016.06.013_bib0015","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.2337\/db10-0845","article-title":"Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase","volume":"60","author":"Borg","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.biocel.2016.06.013_bib0020","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1096\/fasebj.11.5.9141507","article-title":"Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species","volume":"11","author":"Brand","year":"1997","journal-title":"FASEB J."},{"key":"10.1016\/j.biocel.2016.06.013_bib0025","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.mce.2014.11.006","article-title":"PEDF-induced alteration of metabolism leading to insulin resistance","volume":"401","author":"Carnagarin","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biocel.2016.06.013_bib0030","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.mce.2015.12.010","article-title":"PEDF attenuates insulin-dependent molecular pathways of glucose homeostasis in skeletal myocytes","volume":"422","author":"Carnagarin","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biocel.2016.06.013_bib0035","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1073\/pnas.95.20.11715","article-title":"Mitochondrial reactive oxygen species trigger hypoxia-induced transcription","volume":"95","author":"Chandel","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biocel.2016.06.013_bib0040","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1210\/jc.2010-0727","article-title":"Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study","volume":"95","author":"Chen","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biocel.2016.06.013_bib0045","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jhep.2007.10.012","article-title":"Anti-angiogenic pigment epithelium derivedfactor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)","volume":"48","author":"Chung","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biocel.2016.06.013_bib0050","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.febslet.2005.03.057","article-title":"H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts","volume":"579","author":"Colston","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biocel.2016.06.013_bib0055","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cmet.2009.06.001","article-title":"Pigment epithelium-derived factor contributes to insulin resistance in obesity","volume":"10","author":"Crowe","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.biocel.2016.06.013_bib0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.285.5425.245","article-title":"Pigment epithelium-derived factor: a potent inhibitor of angiogenesis","volume":"285","author":"Dawson","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.biocel.2016.06.013_bib0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s13539-012-0101-7","article-title":"Metabolic derangements in the gastrocnemius and the effect of Compound A therapy in a murine model of cancer cachexia","volume":"4","author":"Der-Torossian","year":"2013","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.biocel.2016.06.013_bib0070","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000046880","article-title":"Mitochondria in exercise-induced oxidative stress","volume":"10","author":"Di Meo","year":"2001","journal-title":"Biol. Signals Recept."},{"key":"10.1016\/j.biocel.2016.06.013_bib0075","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/ijo.2010.212","article-title":"Pigment epithelium-derived factor is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells","volume":"35","author":"Famulla","year":"2011","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.biocel.2016.06.013_bib0080","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1158\/0008-5472.CAN-04-3744","article-title":"Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer","volume":"65","author":"Filleur","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.biocel.2016.06.013_bib0085","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.phrs.2015.07.006","article-title":"Nrf2 activators modulate oxidative stress responses and bioenergetic profiles of human retinal epithelial cells cultured in normal or high glucose conditions","volume":"99","author":"Foresti","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biocel.2016.06.013_bib0090","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cmet.2005.04.003","article-title":"Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila","volume":"1","author":"Gr\u00f6nke","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.biocel.2016.06.013_bib0095","doi-asserted-by":"crossref","first-page":"73734","DOI":"10.1126\/science.1123965","article-title":"Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase","volume":"312","author":"Haemmerle","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.biocel.2016.06.013_bib0100","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1023\/A:1022458010266","article-title":"ADP-Regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism","volume":"29","author":"Herrero","year":"1997","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.biocel.2016.06.013_bib0105","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1152\/japplphysiol.01102.2006","article-title":"The production of reactive oxygen and nitrogen species by skeletal muscle","volume":"102","author":"Jackson","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.biocel.2016.06.013_bib0110","doi-asserted-by":"crossref","first-page":"48968","DOI":"10.1074\/jbc.M407841200","article-title":"Identification, cloning, expression, and purification of three novel human calciumin dependent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities","volume":"279","author":"Jenkins","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2016.06.013_bib0115","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.lfs.2013.12.007","article-title":"Pigment-Epithelium Derived Factor (PEDF) and the human ovary: a role in the generation of ROS in granulosa cells","volume":"97","author":"Kampfer","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.biocel.2016.06.013_bib0120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbadis.2004.11.004","article-title":"Skeletal muscles, heart, and lung are the main sources of oxygen radicals in old rats","volume":"1740","author":"Kozlov","year":"2005","journal-title":"BBA Mol. Basis Dis."},{"key":"10.1016\/j.biocel.2016.06.013_bib0125","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/hh0202.103615","article-title":"Essential role of the NADPH oxidase subunit p47phox in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-(alpha)","volume":"90","author":"Li","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2016.06.013_bib0130","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.expneurol.2006.08.028","article-title":"Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS","volume":"203","author":"Li","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biocel.2016.06.013_bib0135","doi-asserted-by":"crossref","first-page":"24874","DOI":"10.1074\/jbc.M114.581785","article-title":"Arachidonic acid induces direct interaction of the p67phox-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production","volume":"289","author":"Matono","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2016.06.013_bib0140","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/dmrr.820","article-title":"Serum levels of pigment epithelium-derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes","volume":"25","author":"Nakamura","year":"2009","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.biocel.2016.06.013_bib0145","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ijcard.2008.11.169","article-title":"Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension","volume":"143","author":"Nakamura","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biocel.2016.06.013_bib0150","first-page":"2511","article-title":"Bioenergetic profile experiment using C2C12 myoblast cells","volume":"46","author":"Nicholls","year":"2010","journal-title":"J. Vis. Expt."},{"key":"10.1016\/j.biocel.2016.06.013_bib0155","doi-asserted-by":"crossref","first-page":"38022","DOI":"10.1074\/jbc.M600353200","article-title":"Identification of a lipase linked cell membrane receptor for pigment epithelium-derived factor","volume":"281","author":"Notari","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2016.06.013_bib0160","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/bj20030313","article-title":"Pigment-epithelium-derived-factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization","volume":"374","author":"Petersen","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.biocel.2016.06.013_bib0165","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.freeradbiomed.2004.11.011","article-title":"Nox 2 stimulates muscle differentiation via NF-\u03baB\/iNOS pathway","volume":"38","author":"Piao","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biocel.2016.06.013_bib0170","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1152\/physrev.00031.2007","article-title":"Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production","volume":"88","author":"Powers","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biocel.2016.06.013_bib0175","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1210\/en.2014-1591","article-title":"TNF-\u03b1-Induced NF-\u03baB activation stimulates skeletal muscle glycolytic metabolism through activation of HIF-1\u03b1","volume":"156","author":"Remels","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2016.06.013_bib0180","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1517\/14728220903241641","article-title":"Pigment epithelium-derived factor (PEDF) as a therapeutic target in cardiovascular disease","volume":"13","author":"Rychli","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.biocel.2016.06.013_bib0185","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1210\/jc.2010-0630","article-title":"Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss","volume":"95","author":"Sabater","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biocel.2016.06.013_bib0190","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8415","article-title":"DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice","volume":"6","author":"Shi","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biocel.2016.06.013_bib0195","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/sj.embor.7400559","article-title":"ATGL has a key role in lipid droplet\/adiposome degradation in mammalian cells","volume":"7","author":"Smirnova","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biocel.2016.06.013_bib0200","first-page":"145","article-title":"Altered control of carbohydrate metabolism in endotoxemia","volume":"286","author":"Spitzer","year":"1989","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.biocel.2016.06.013_bib0205","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4419-1399-9_4","article-title":"Pigment epithelium-derived factor receptor (PEDF-R): a plasma membrane-linked phospholipase with PEDF binding affinity","volume":"664","author":"Subramanian","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biocel.2016.06.013_bib0210","doi-asserted-by":"crossref","first-page":"47066","DOI":"10.1074\/jbc.M403855200","article-title":"Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis","volume":"279","author":"Villena","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2016.06.013_bib0215","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1210\/jc.2005-2654","article-title":"Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome","volume":"91","author":"Yamagishi","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biocel.2016.06.013_bib0220","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.2174\/092986710791233670","article-title":"Pathophysiological role of pigment epithelium-derived factor (PEDF) in hepatic disorders","volume":"17","author":"Yamagishi","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biocel.2016.06.013_bib0225","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1210\/jc.2010-2140","article-title":"Serum pigment epithelium-derived factor is elevated in women with polycystic ovary syndrome and correlates with insulin resistance","volume":"96","author":"Yang","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biocel.2016.06.013_bib0230","doi-asserted-by":"crossref","first-page":"25385","DOI":"10.1074\/jbc.M203630200","article-title":"Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity: cPLA2 affects translocation but not phosphorylation of p67phox and p47phox","volume":"277","author":"Zhao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2016.06.013_bib0235","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.1100747","article-title":"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272516301534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272516301534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:07:58Z","timestamp":1761203278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272516301534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":47,"alternative-id":["S1357272516301534"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2016.06.013","relation":{},"ISSN":["1357-2725"],"issn-type":[{"type":"print","value":"1357-2725"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pigment epithelium-derived factor stimulates skeletal muscle glycolytic activity through NADPH oxidase-dependent reactive oxygen species production","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2016.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}