{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:09:53Z","timestamp":1790478593428,"version":"4.1.0"},"reference-count":117,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NHMRC (Australia) Senior Research Fellowship"},{"name":"Victorian State Government Operational Infrastructure Support Program"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.biocel.2016.08.003","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T14:18:46Z","timestamp":1470320326000},"page":"14-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"special_numbering":"C","title":["Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1421-8468","authenticated-orcid":false,"given":"Natalie A.","family":"Sims","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.biocel.2016.08.003_bib0005","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/jbmr.354","article-title":"Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model","volume":"26","author":"Alexander","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0010","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/jcp.1041450116","article-title":"Osteoblasts display receptors for and responses to leukemia-inhibitory factor","volume":"145","author":"Allan","year":"1990","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biocel.2016.08.003_bib0015","doi-asserted-by":"crossref","first-page":"15529","DOI":"10.1038\/srep15529","article-title":"Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure","volume":"5","author":"Askmyr","year":"2015","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0020","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/art.24781","article-title":"Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo","volume":"60","author":"Axmann","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.biocel.2016.08.003_bib0025","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/0022034514522485","article-title":"IL-6 alters osteocyte signaling toward osteoblasts but not osteoclasts","volume":"93","author":"Bakker","year":"2014","journal-title":"J. Dent. Res."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0030","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1172\/JCI118432","article-title":"Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal\/osteoblastic cells","volume":"97","author":"Bellido","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0035","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/endo.138.9.5364","article-title":"Activation of the Janus kinase\/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation","volume":"138","author":"Bellido","year":"1997","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.biocel.2016.08.003_bib0040","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1210\/en.2005-0239","article-title":"Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis","volume":"146","author":"Bellido","year":"2005","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.biocel.2016.08.003_bib0045","first-page":"2309","article-title":"Estrogen receptors alpha and beta are differentially expressed in developing human bone","volume":"86","author":"Bord","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.biocel.2016.08.003_bib0050","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1113\/jphysiol.2007.149781","article-title":"Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle","volume":"586","author":"Broholm","year":"2008","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1152\/japplphysiol.01399.2010","article-title":"LIF is a contraction-induced myokine stimulating human myocyte proliferation","volume":"111","author":"Broholm","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.biocel.2016.08.003_bib0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bone.2015.02.016","article-title":"Quantifying the osteocyte network in the human skeleton","volume":"75","author":"Buenzli","year":"2015","journal-title":"Bone"},{"issue":"16","key":"10.1016\/j.biocel.2016.08.003_bib0065","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1158\/1078-0432.CCR-10-0173","article-title":"Interleukin-27 acts as multifunctional antitumor agent in multiple myeloma","volume":"16","author":"Cocco","year":"2010","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0070","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1210\/endo.132.3.8440191","article-title":"The effect of leukemia inhibitory factor on bone in vivo","volume":"132","author":"Cornish","year":"1993","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0075","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/jbmr.1477","article-title":"Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey","volume":"27","author":"Cusick","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0080","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1086\/381715","article-title":"Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve-Wiedemann\/Schwartz-Jampel type 2 syndrome","volume":"74","author":"Dagoneau","year":"2004","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0085","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jbmr.210","article-title":"Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts","volume":"26","author":"Danks","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"11","key":"10.1016\/j.biocel.2016.08.003_bib0090","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1002\/art.22175","article-title":"Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system","volume":"54","author":"De Benedetti","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.biocel.2016.08.003_bib0095","first-page":"1893","article-title":"Interleukin-6: a potential mediator of the massive osteolysis in patients with Gorham-Stout disease","volume":"81","author":"Devlin","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.biocel.2016.08.003_bib0100","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/jbmr.1969","article-title":"Bone and skeletal muscle: neighbors with close ties","volume":"28","author":"DiGirolamo","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0105","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/jbmr.1777","article-title":"Periosteum, bone's smart bounding membrane, exhibits direction-dependent permeability","volume":"28","author":"Evans","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0110","doi-asserted-by":"crossref","first-page":"e73266","DOI":"10.1371\/journal.pone.0073266","article-title":"Cord blood-derived macrophage-lineage cells rapidly stimulate osteoblastic maturation in mesenchymal stem cells in a glycoprotein-130 dependent manner","volume":"8","author":"Fernandes","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.biocel.2016.08.003_bib0115","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S8756-3282(98)00040-4","article-title":"Expression of IL-6 receptor and GP130 in mouse bone marrow cells during osteoclast differentiation","volume":"22","author":"Gao","year":"1998","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/path.4519","article-title":"Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle","volume":"236","author":"Genet","year":"2015","journal-title":"J. Pathol."},{"issue":"18","key":"10.1016\/j.biocel.2016.08.003_bib0125","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1074\/jbc.271.18.10984","article-title":"Stimulation by parathyroid hormone of interleukin-6 and leukemia inhibitory factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction","volume":"271","author":"Greenfield","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biocel.2016.08.003_bib0130","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/stem.1040","article-title":"Induction of osteogenesis in mesenchymal stem cells by activated monocytes\/macrophages depends on oncostatin M signaling","volume":"30","author":"Guihard","year":"2012","journal-title":"Stem Cells"},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0135","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ajpath.2014.11.008","article-title":"Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury","volume":"185","author":"Guihard","year":"2015","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0140","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cmet.2009.12.007","article-title":"Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation","volume":"11","author":"Guo","year":"2010","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0145","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jcp.1041370125","article-title":"Human macrophage colony-stimulating factor inhibits bone resorption by osteoclasts disaggregated from rat bone","volume":"137","author":"Hattersley","year":"1988","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0150","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1096\/fj.03-1259fje","article-title":"Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity","volume":"18","author":"Hiscock","year":"2004","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0155","doi-asserted-by":"crossref","first-page":"E504","DOI":"10.1152\/ajpendo.00520.2010","article-title":"Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth","volume":"301","author":"Hojman","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.biocel.2016.08.003_bib0160","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1210\/endo.139.11.6433","article-title":"Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells","volume":"139","author":"Horwood","year":"1998","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0165","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/bbrc.1999.1623","article-title":"Activated T lymphocytes support osteoclast formation in vitro","volume":"265","author":"Horwood","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biocel.2016.08.003_bib0170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-319-27511-6_3","article-title":"The role of leukemia inhibitory factor receptor signaling in skeletal muscle growth, injury and disease","volume":"900","author":"Hunt","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0175","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.yexcr.2009.11.022","article-title":"Leukemia inhibitory factor-dependent increase in myoblast cell number is associated with phosphotidylinositol 3-kinase-mediated inhibition of apoptosis and not mitosis","volume":"316","author":"Hunt","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biocel.2016.08.003_bib0180","doi-asserted-by":"crossref","first-page":"RRN1277","DOI":"10.1371\/currents.RRN1277","article-title":"Alterations in the expression of leukemia inhibitory factor following exercise: comparisons between wild-type and mdx muscles","volume":"3","author":"Hunt","year":"2011","journal-title":"PLoS Curr."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0185","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00418-012-1018-0","article-title":"An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle","volume":"139","author":"Hunt","year":"2013","journal-title":"Histochem. Cell Biol."},{"issue":"5066","key":"10.1016\/j.biocel.2016.08.003_bib0190","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1621100","article-title":"Increased osteoclast development after estrogen loss: mediation by interleukin-6","volume":"257","author":"Jilka","year":"1992","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0195","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/jbmr.2159","article-title":"The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation","volume":"29","author":"Johnson","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biocel.2016.08.003_bib0200","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bone.2014.03.053","article-title":"Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation","volume":"64C","author":"Johnson","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.biocel.2016.08.003_bib0205","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bone.2015.08.005","article-title":"Glycoprotein130 (Gp130)\/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone","volume":"81","author":"Johnson","year":"2015","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0210","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.imlet.2011.02.022","article-title":"IL-27 suppresses RANKL expression in CD4+ T cells in part through STAT3","volume":"138","author":"Kamiya","year":"2011","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0215","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.semarthrit.2012.01.004","article-title":"IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT00106522)","volume":"42","author":"Karsdal","year":"2012","journal-title":"Semin. Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.biocel.2016.08.003_bib0220","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1210\/endo.138.11.5534","article-title":"Osteoclasts are present in gp130-deficient mice","volume":"138","author":"Kawasaki","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.biocel.2016.08.003_bib0225","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1038\/ncomms6215","article-title":"Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts","volume":"5","author":"Keller","year":"2014","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0230","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.bone.2009.07.087","article-title":"Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation","volume":"45","author":"Kido","year":"2009","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013090","article-title":"Mechanical stress activates Smad pathway through PKCdelta to enhance interleukin-11 gene transcription in osteoblasts","volume":"5","author":"Kido","year":"2010","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.biocel.2016.08.003_bib0240","doi-asserted-by":"crossref","first-page":"10905","DOI":"10.1073\/pnas.200294797","article-title":"Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene","volume":"97","author":"Kim","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0245","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1086\/346120","article-title":"Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene","volume":"72","author":"Knappskog","year":"2003","journal-title":"Am. J. Hum. Genet."},{"issue":"6717","key":"10.1016\/j.biocel.2016.08.003_bib0250","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0255","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jbmr.5650110113","article-title":"Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation","volume":"11","author":"Kotake","year":"1996","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0260","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1359\/jbmr.090730","article-title":"Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice","volume":"25","author":"Kramer","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(02)00915-8","article-title":"Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism","volume":"32","author":"Kudo","year":"2003","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0270","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/jcb.20506","article-title":"Effects of parathyroid hormone on Wnt signaling pathway in bone","volume":"95","author":"Kulkarni","year":"2005","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0275","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1046\/j.1365-2141.1996.4721018.x","article-title":"Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma","volume":"93","author":"Kyrtsonis","year":"1996","journal-title":"Br. J. Haematol."},{"issue":"12","key":"10.1016\/j.biocel.2016.08.003_bib0280","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1359\/jbmr.070804","article-title":"Control of the SOST bone enhancer by PTH using MEF2 transcription factors","volume":"22","author":"Leupin","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.biocel.2016.08.003_bib0285","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1359\/jbmr.070104","article-title":"Effects of a one-month treatment with PTH(1\u201334) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium","volume":"22","author":"Lindsay","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0290","first-page":"666","article-title":"Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation","volume":"123","author":"Lotinun","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0295","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/0006-291X(89)90851-6","article-title":"Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis","volume":"162","author":"Lowik","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0300","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/jbmr.193","article-title":"Gene expression patterns in bone following mechanical loading","volume":"26","author":"Mantila Roosa","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biocel.2016.08.003_bib0305","series-title":"Osteoporosis","first-page":"361","article-title":"Coupling of bone resorption and formation during bone remodeling","author":"Martin","year":"2001"},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0310","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molmed.2004.12.004","article-title":"Osteoclast-derived activity in the coupling of bone formation to resorption","volume":"11","author":"Martin","year":"2005","journal-title":"Trends Mol. Med."},{"issue":"7","key":"10.1016\/j.biocel.2016.08.003_bib0315","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/jbmr.2276","article-title":"Coupling factors: how many candidates can there be?","volume":"29","author":"Martin","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biocel.2016.08.003_bib0320","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2407-13-16","article-title":"IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells","volume":"13","author":"McCoy","year":"2013","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0325","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00223-010-9337-4","article-title":"Ciliary neurotrophic factor inhibits bone formation and plays a sex-specific role in bone growth and remodeling","volume":"86","author":"McGregor","year":"2010","journal-title":"Calcif. Tissue Int."},{"issue":"15","key":"10.1016\/j.biocel.2016.08.003_bib0330","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1073\/pnas.86.15.5948","article-title":"Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor","volume":"86","author":"Metcalf","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0335","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/gut.36.1.45","article-title":"Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6","volume":"36","author":"Mitsuyama","year":"1995","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.biocel.2016.08.003_bib0340","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/nm.2489","article-title":"Suppression of bone formation by osteoclastic expression of semaphorin 4D","volume":"17","author":"Negishi-Koga","year":"2011","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.biocel.2016.08.003_bib0345","doi-asserted-by":"crossref","first-page":"e39871","DOI":"10.1371\/journal.pone.0039871","article-title":"Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation","volume":"7","author":"Nicolaidou","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.biocel.2016.08.003_bib0350","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1136\/ard.2007.083360","article-title":"Interleukin 27 attenuates collagen-induced arthritis","volume":"67","author":"Niedbala","year":"2008","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0355","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bone.2011.04.001","article-title":"Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys","volume":"49","author":"Ominsky","year":"2011","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0360","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.4049\/jimmunol.169.6.3353","article-title":"IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae","volume":"169","author":"Palmqvist","year":"2002","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.biocel.2016.08.003_bib0365","first-page":"457","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature reviews","volume":"8","author":"Pedersen","year":"2012","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.biocel.2016.08.003_bib0370","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/j.1460-2075.1994.tb06368.x","article-title":"Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion","volume":"13","author":"Poli","year":"1994","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0375","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/jbmr.1485","article-title":"Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization","volume":"27","author":"Poulton","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0380","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1074\/jbc.M110.178251","article-title":"Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment","volume":"286","author":"Quach","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0385","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1006\/cyto.1999.0635","article-title":"Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: synergy with dexamethasone","volume":"12","author":"Richards","year":"2000","journal-title":"Cytokine"},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0390","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biocel.2016.08.003_bib0395","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF02409454","article-title":"Role of osteoblasts in hormonal control of bone resorption\u2013a hypothesis","volume":"33","author":"Rodan","year":"1981","journal-title":"Calcif. Tissue Int."},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0400","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1084\/jem.183.6.2581","article-title":"The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures","volume":"183","author":"Romas","year":"1996","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0405","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1172\/JCI115584","article-title":"Interleukin 6. A potential autocrine\/paracrine factor in Paget's disease of bone","volume":"89","author":"Roodman","year":"1992","journal-title":"J. Clin. Invest."},{"issue":"26","key":"10.1016\/j.biocel.2016.08.003_bib0410","doi-asserted-by":"crossref","first-page":"10068","DOI":"10.1073\/pnas.0509598103","article-title":"Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient","volume":"103","author":"Rousseau","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"24","key":"10.1016\/j.biocel.2016.08.003_bib0415","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1038\/sj.emboj.7601430","article-title":"Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling","volume":"25","author":"Ryu","year":"2006","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0420","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/79683","article-title":"Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis","volume":"6","author":"Sabatakos","year":"2000","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.biocel.2016.08.003_bib0425","doi-asserted-by":"crossref","first-page":"e116209","DOI":"10.1371\/journal.pone.0116209","article-title":"Oncostatin M maintains the hematopoietic microenvironment in the bone marrow by modulating adipogenesis and osteogenesis","volume":"9","author":"Sato","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0430","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00223-013-9790-y","article-title":"Osteocytes: master orchestrators of bone","volume":"94","author":"Schaffler","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.biocel.2016.08.003_bib0435","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00043.2013","article-title":"The cytokine response of primary human myotubes in an in vitro exercise model","author":"Scheler","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0440","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1210\/en.2003-0839","article-title":"Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro","volume":"145","author":"Shin","year":"2004","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0445","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12018-011-9121-7","article-title":"Regulation of sclerostin expression by paracrine and endocrine factors","volume":"10","author":"Sims","year":"2012","journal-title":"Clin. Rev. Bone Miner. Metab."},{"key":"10.1016\/j.biocel.2016.08.003_bib0450","doi-asserted-by":"crossref","DOI":"10.1038\/bonekey.2013.215","article-title":"Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit","volume":"3","author":"Sims","year":"2014","journal-title":"Bonekey. Rep."},{"key":"10.1016\/j.biocel.2016.08.003_bib0455","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/bonekey.2014.22","article-title":"Osteoimmunology: oncostatin M as a pleiotropic regulator of bone formation and resorption in health and disease","volume":"3","author":"Sims","year":"2014","journal-title":"Bonekey. Rep."},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0460","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1172\/JCI10753","article-title":"Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5","volume":"106","author":"Sims","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0465","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S8756-3282(01)00622-6","article-title":"Regulating DeltaFosB expression in adult tet-off-DeltaFosB transgenic mice alters bone formation and bone mass","volume":"30","author":"Sims","year":"2002","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0470","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1172\/JCI19872","article-title":"Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways","volume":"113","author":"Sims","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.biocel.2016.08.003_bib0475","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1359\/JBMR.050209","article-title":"Interleukin-11 receptor signaling is required for normal bone remodeling","volume":"20","author":"Sims","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biocel.2016.08.003_bib0480","series-title":"Osteoimmunology: Interactions of the Immune and Skeletal Systems","first-page":"169","article-title":"Coupling between immune and bone cells","author":"Sims","year":"2015"},{"issue":"5","key":"10.1016\/j.biocel.2016.08.003_bib0485","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cytogfr.2015.07.014","article-title":"Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders","volume":"26","author":"Sims","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0490","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1096\/fj.03-1100fje","article-title":"Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow","volume":"18","author":"Song","year":"2004","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.biocel.2016.08.003_bib0495","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/jcb.21245","article-title":"Oncostatin M promotes osteogenesis and suppresses adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells","volume":"101","author":"Song","year":"2007","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0500","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/JOE-14-0424","article-title":"gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation","volume":"223","author":"Standal","year":"2014","journal-title":"J. Endocrinol."},{"issue":"24","key":"10.1016\/j.biocel.2016.08.003_bib0505","doi-asserted-by":"crossref","first-page":"11924","DOI":"10.1073\/pnas.90.24.11924","article-title":"Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6","volume":"90","author":"Tamura","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0510","first-page":"921","article-title":"Early effects of IL-6 receptor inhibition on bone homeostasis: a pilot study in women with rheumatoid arthritis","volume":"29","author":"Terpos","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"issue":"10","key":"10.1016\/j.biocel.2016.08.003_bib0515","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1210\/endo.140.10.7037","article-title":"Breast cancer cells interact with osteoblasts to support osteoclast formation","volume":"140","author":"Thomas","year":"1999","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0520","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone"},{"issue":"9","key":"10.1016\/j.biocel.2016.08.003_bib0525","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1138\/20040135","article-title":"Mechanical loading and bone formation","volume":"1","author":"Turner","year":"2004","journal-title":"IBMS Bonekey"},{"issue":"5","key":"10.1016\/j.biocel.2016.08.003_bib0530","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1084\/jem.182.5.1461","article-title":"Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors","volume":"182","author":"Udagawa","year":"1995","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.biocel.2016.08.003_bib0535","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1359\/jbmr.080706","article-title":"Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling","volume":"23","author":"Walker","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.biocel.2016.08.003_bib0540","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI40568","article-title":"Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice","volume":"120","author":"Walker","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.biocel.2016.08.003_bib0545","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/jbmr.1506","article-title":"Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo","volume":"27","author":"Walker","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.biocel.2016.08.003_bib0550","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1242\/dev.121.5.1283","article-title":"Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death","volume":"121","author":"Ware","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.biocel.2016.08.003_bib0555","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M710462200","article-title":"Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes","author":"White","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biocel.2016.08.003_bib0560","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/art.21537","article-title":"Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis","volume":"54","author":"Wong","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biocel.2016.08.003_bib0565","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/bonekey.2014.66","article-title":"Osteocyte expression of caspase-3, COX-2, IL-6 and sclerostin are spatially and temporally associated following stress fracture initiation","volume":"3","author":"Wu","year":"2014","journal-title":"Bonekey. Rep."},{"issue":"10","key":"10.1016\/j.biocel.2016.08.003_bib0570","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.biocel.2016.08.003_bib0575","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.bone.2007.07.022","article-title":"Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice","volume":"41","author":"Yang","year":"2007","journal-title":"Bone"},{"issue":"24","key":"10.1016\/j.biocel.2016.08.003_bib0580","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.1073\/pnas.83.24.9739","article-title":"Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells","volume":"83","author":"Zarling","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.biocel.2016.08.003_bib0585","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bone.2011.04.020","article-title":"Osteoblast\/osteocyte-specific inactivation of Stat3 decreases load-driven bone formation and accumulates reactive oxygen species","volume":"49","author":"Zhou","year":"2011","journal-title":"Bone"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272516302126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272516302126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:10:31Z","timestamp":1761203431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272516302126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":117,"alternative-id":["S1357272516302126"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2016.08.003","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2016.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}